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| 1 | Development of an internally braced prosthesis for total talus replacement显示文摘Total loss of talus due to trauma or avascular necrosis,for example,still remains to be a major challenge in foot and ankle surgery with severely limited treatment options.Implantation of a custom made total talar prosthesis has shown promising results so far.Most important factors for long time success are degree of congruence of articular surfaces and ligamentous stability of the ankle.Therefore,our aim was to develop an optimized custom made prosthesis for total talus replacement providing a high level of primary stability.A custom made hemiprosthesis was developed using computed tomography and magnetic resonance imaging data of the affected and contralateral talus considering the principles and technology for the development of the S.T.A.R.prosthesis(Stryker).Additionally,four eyelets for fixation of artificial ligaments were added at the correspondent footprints of the most important ligaments.Two modifications can be provided according to the clinical requirements:A tri-articular hemiprosthesis or a bi-articular hemiprosthesis combined with the tibial component of the S.T.A.R.total ankle replacement system.A feasibility study was performed using a fresh frozen human cadaver.Maximum range of motion of the ankle was measured and ligamentous stability was evaluated by use of standard X-rays after application of varus,valgus or sagittal stress with 150 N.Correct implantation of the prosthesis was technically possible via an anterior approach to the ankle and using standard instruments.Malleolar osteotomies were not required.Maximum ankle dorsiflexion and plantarflexion were measured as 22-0-28 degrees.Maximum anterior displacement of the talus was 6 mm,maximum varus tilt 3 degrees and maximum valgus tilt 2 degrees.Application of an internally braced prosthesis for total talus replacement in humans is technically feasible and might be a reasonable procedure in carefully selected cases with no better alternatives left. | Markus Regauer Mirjam Lange Kevin Soldan Steffen Peyerl Sebastian Baumbach Wolfgang Bocker Hans Polzer | 2017 | World Journal of Orthopedics2017，8，3： | 4 |
| 2 | The risk of hepatitis B virus infection by transfusion in Kumasi,Ghana显示文摘 | Allain JP Candotti D Soldan K | 2003 | Blood2003，101，5： | 1 |
| 3 | Estimation of the risk of hepatitis B virus, hepatitis C virus and human immunodeficiency virus infectious donations en- tering the blood supply in England, 1993-2001显示文摘 | Soldan K Barbara JAJ Ramsay ME | 2003 | Vox Sang2003，84，4： | 1 |
| 4 | Severe fever with thrombocytopenia virus glycoproteins are targeted by neutralizing antibodies and can use DC-SIGN as a receptor for pH-dependent entry into human and animal cell lines显示文摘 | Hofmann H Li X X Zhang X A Liu W Kühl A Kaup F Soldan S S González-Scarano F Weber F He Y X Phlmann S | 2013 | J Virol2013，87，8： | 1 |
| 5 | Simultaneous follow-up of mouse colon lesions by colonoscopy and endoluminal ultrasound biomicroscopy显示文摘AIM:To evaluate the potential use of colonoscopy and endoluminal ultrasonic biomicroscopy(eUBM)to track the progression of mouse colonic lesions.METHODS:Ten mice were treated with a single azoxy-methane intraperitoneal injection(week 1)followed by seven days of a dextran sulfate sodium treatment in their drinking water(week 2)to induce inflammationassociated colon tumors.eUBM was performed simultaneously with colonoscopy at weeks 13,17-20 and21.A 3.6-F diameter 40 MHz mini-probe catheter was used for eUBM imaging.The ultrasound mini-probe catheter was inserted into the accessory channel of a pediatric flexible bronchofiberscope,allowing simultaneous acquisition of colonoscopic and eUBM images.During image acquisition,the mice were anesthetized with isoflurane and kept in a supine position over a stainless steel heated surgical waterbed at 37℃.Both eUBM and colonoscopic images were captured and stored when a lesion was detected by colonoscopy or when the eUBM image revealed a modified colon wall anatomy.During the procedure,the colon was irrigated with water that was injected through a flush port on the mini-probe catheter and that acted as the ultrasound coupling medium between the transducer and the colon wall.Once the acquisition of the last eUBM/colonoscopy section for each animal was completed,the colons were fixed,paraffin-embedded,and stained with hematoxylin and eosin.Colon images acquired at the first time-point for each mouse were compared with subsequent eUBM/colonoscopic images of the same sites obtained in the following acquisitions to evaluate lesion progression.RESULTS:All 10 mice had eUBM and colonoscopic images acquired at week 13(the first time-point).Two animals died immediately after the first imaging acquisition and,consequently,only 8 mice were subjected to the second eUBM/colonoscopy imaging acquisition(at the second time-point).Due to the advanced stage of colonic tumorigenesis,5 animals died after the second time-point image acquisition,and thus,only three were subjected to the third eUBM/colonoscopy imaging acquisition(the third time-point).eUBM was able to detect the four layers in healthy segments of colon:the mucosa(the first hyperechoic layer moving away from the mini-probe axis),followed by the muscularis mucosae(hypoechoic),the submucosa(the second hyperechoic layer)and the muscularis externa(the second hypoechoic layer).Hypoechoic regions between the mucosa and the muscularis externa layers represented lymphoid infiltrates,as confirmed by the corresponding histological images.Pedunculated tumors were represented by hyperechoic masses in the mucosa layer.Among the lesions that decreased in size between the first and third time-points,one of the lesions changed from a mucosal hyperplasia with ulceration at the top to a mucosal hyperplasia with lymphoid infiltrate and,finally,to small signs of mucosal hyperplasia and lymphoid infiltrate.In this case,while lesion regression and modification were observable in the eUBM images,colonoscopy was only able to detect the lesion at the first and second time-points,without the capacity to demonstrate the presence of lymphoid infiltrate.Regarding the lesions that increased in size,one of them started as a small elevation in the mucosa layer and progressed to a pedunculated tumor.In this case,while eUBM imaging revealed the lesion at the first time-point,colonoscopy was only able to detect it at the second time-point.All colonic lesions(tumors,lymphoid infiltrate and mucosal thickening)were identified by eUBM,while colonoscopy identified just76%of them.Colonoscopy identified all of the colonic tumors but failed to diagnose lymphoid infiltrates and increased mucosal thickness and failed to differentiate lymphoid infiltrates from small adenomas.During the observation period,most of the lesions(approximately67%)increased in size,approximately 14%remained unchanged,and 19%regressed.CONCLUSION:Combining eUBM with colonoscopy improves the diagnosis and the follow-up of mouse colonic lesions,adding transmural assessment of the bowel wall. | Rossana C Soletti Kelly Z Alves Marcelo AP de Britto Dyanna G de Matos Mnica Soldan Helena L Borges Joo C Machado | 2013 | World Journal of Gastroenterology2013，19，44： | 1 |
| 6 | Toxie risk of surface water pollution-six year of experience 显示文摘 | soldan P | 2002 | Enviroment International2002，966，： | 1 |
| 7 | Estimates of the frequency of HBV, HCV, and HIV infectious donations entering the blood supply in the United Kingdom, 1996 to 2003显示文摘 | Soldan K Davison K Dow B | 2005 | Euro Surveill2005，10，2： | 1 |
| 8 | Estimates of the frequency of HBV, HCV and HIV infectious donations entering the blood supply in the United Kingdom, 1996 to 2003 显示文摘 | Soldan K Davison K Dow B | 2005 | Eurosurveillanee2005，10，2： | 1 |
| 9 | Hydroxyapa- tite-collagen-hyaluronic acid composite 显示文摘 | Bakos D Soldan M Hermandez-Fuentes I | 1999 | Biomateri- als1999，20，2： | 1 |
| 10 | Features of In Vitro Ultrasound Biomicroscopic Imaging and Colonoscopy for Detection of Colon Tumor in Mice显示文摘 | Kelly Z. Alves Helena L. Borges Rossana C. Soletti Anália L.P. Viana Lorena I. Petrella M?nica Soldan Vera L. Chagas Alberto Schanaider Jo?o C. Machado | 2011 | Ultrasound in Medicine & Biology2011，，12： | 1 |
| 11 | Relationship of cognitive reserve and APOE status to the emergence of clinical symptoms in preclinical Alzheimer's disease显示文摘 | Pettigrew C Soldan A Li S | 2013 | Cogn Neurosci2013，4，： | 1 |
| 12 | Two-dimensional electrophoresis :a powerful method to elucidate cellular responses to toxic compounds显示文摘 | Moiler A Soldan M Volker U | 2001 | Toxicology2001，160，13： | 1 |
| 13 | Cognitive changes preceding clinical symptom onset of mild cognitive impairment and relationship to ApoE genotype 显示文摘 | Albert M Soldan A Gottesman R | 2014 | Curr Alzheimer Res2014，11，8： | 1 |
| 14 | Antiviral Autophagy Restricts Rift Valley Fever Virus Infection and Is Conserved from Flies to Mammals显示文摘 | Ryan H. Moy Beth Gold Jerome M. Molleston Veronica Schad Kilangsungla Yanger Mary-Virginia Salzano Yoshimasa Yagi Katherine A. Fitzgerald Ben Z. Stanger Samantha S. Soldan Sara Cherry | 2013 | Immunity2013，，： | 1 |
| 15 | Hydroxyapa-tite-collagen-hyaluronic acid composite 显示文摘 | Bakos D Soldan M Hernandez-Fuentes I | 1999 | Biomateri-als1999，20，： | 1 |
| 16 | Estimation of the risk ofhepatitis B virus,hepatitis C virus and human immunodeficiency virus infectious donations entering the blood supply in England显示文摘 | Soldan K Barbara JA Ramsay ME | | 0，，04： | 1 |
| 17 | Estimation of the risk of hepatitis B virus,hepatitis C virus and human immunodeficiency virus infectious donations entering the blood supply in England,1993~2001显示文摘 | Barbara JA Ramsay ME | 2003 | Vox Sang2003，84，4： | 1 |
| 18 | Association of human herpes virus (HHV-6)with multiple sclerosis:increased IgM response to HHV-6 early antigen and detection of serum HHV-6 DNA显示文摘 | SOLDAN SS BERTI R SALEM N | 1997 | Nat Med1997，3，12： | 1 |
| 19 | Estimation of the risk of hepatitis B virus,hepatitis C virus and human immunodeficiency virus infections donations entering the blood supply in England,1993-2001显示文摘 | Soldan K Bar bara JA Ramsay ME | 2003 | Vox Sang2003，84，： | 1 |
| 20 | Deconstructing Dictators 显示文摘 | Paz Soldan Edmundo | 2002 | Foreign Policy2002，，130： | 1 |
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