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| 1 | Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population:Role of serine protease inhibitor Kazal 1type and alcohol显示文摘AIM: To test the hypothesis that calcium sensing receptor (CASR) polymorphisms are associated with chronic pancreatitis (CP), and to determine whether serine protease inhibitor Kazal 1type (SPINK1) N34S oralcohol are necessary co-factors in its etiology. METHODS: Initially, 115 subjects with pancreatitis and 66 controls were evaluated, of whom 57 patients and 21 controls were predetermined to carry the high-risk SPINK1 N34S polymorphism. We sequenced CASR gene exons 2, 3, 4, 5 and 7, areas containing the majority of reported polymorphisms and novel mutations. Based on the initial results, we added 223 patients and 239 controls to analyze three common nonsynonymous single nucleotide polymorphisms (SNPs) in exon 7 (A986S, R990G, and Q1011E). RESULTS: The CASR exon 7 R990G polymorphism was signifi cantly associated with CP (OR, 2.01; 95% CI, 1.12-3.59; P = 0.015). The association between CASR R990G and CP was stronger in subjects who reported moderate or heavy alcohol consumption (OR, 3.12; 95% CI, 1.14-9.13; P = 0.018). There was no association between the various CASR genotypes and SPINK1 N34S in pancreatitis. None of the novel CASR polymorphisms reported from Germany and India was detected. CONCLUSION: Our United States-based study confirmed an association of CASR and CP and for the first time demonstrated that CASR R990G is a signifi cant risk factor for CP. We also conclude that the risk of CP with CASR R990G is increased in subjects with moderate to heavy alcohol consumption. | Venkata Muddana Janette Lamb Julia B Greer Beth Elinoff Robert H Hawes Peter B Cotton Michelle A Anderson Randall E Brand Adam Slivka David C Whitcomb | 2008 | World Journal of Gastroenterology2008，14，28： | 7 |
| 2 | Postcholecystemy pain syn-drome: Pathogypsiology of abdominal pain in sphincter of Oddi type Ⅲ显示文摘 | Desautel SG Slivka A Hutson WR | 1999 | Gasrtroenterology1999，116，4： | 1 |
| 3 | Pain in chronic pancreatitis and pancreatic cancer 显示文摘 | Fasanella K E Davis B Lyons J Chen Z Lee K K Slivka A | 2007 | Gastroenterol Clin North Am2007，36，： | 1 |
| 4 | High rate of fusion in sheep cervical spines following anterior interbody surgery with absorbable and non- absorbable implant devices显示文摘 | Slivka M A Speneiner D B Seim H B 3rd Welch W C Serhan H A Turner A S | 2006 | Spine2006，31，： | 1 |
| 5 | Safety of ERCP during pregnancy显示文摘 | T.C.K Tham J Vandervoort R.C.K Wong H Montes A.D Roston A Slivka A.P Ferrari D.R Lichtenstein J Van Dam R.D Nawfel R Soetikno D.L Carr-Locke | 2003 | The American Journal of Gastroenterology2003，，2： | 1 |
| 6 | Intraarterial thrombolytic therapy within 3 hours of the onset of stoke显示文摘 | Bourekas E Slivka A | 2004 | Neurosurgery2004，54，： | 1 |
| 7 | Cerebral edema after temporary and permanent middle cerebral artery occlusion in the rat显示文摘 | Slivka A Murphy E Horrocks L | | 0，，6： | 1 |
| 8 | Postcholecystemy pain syn - drome: pathogypsiology of abdominal pain in sphincter of Oddi type Ⅲ 显示文摘 | DESAUTEL S G SLIVKA A HUTSON W R | 1999 | Gasrtroenterology1999，116，4： | 1 |
| 9 | Diagnostic yield and clinical outcomes of capsule endoscopy显示文摘 | Rastogi A Schoen RE Slivka A | | 0，，06： | 1 |
| 10 | Clinical and angiographic features of thunderclap headache显示文摘 | Slivka A Philbrook B | 1995 | Headache1995，35，1： | 1 |
| 11 | Nitric oxide decreases oxidant - mediated hepatocyte injury显示文摘 | Kuo PC Slivka A | 1994 | J Surg Res1994，56，6： | 1 |
| 12 | Endoscopic therapy is effective for patients with chronic pancreatitis 显示文摘 | Clarke B Slivka A Tomizawa Y | 2012 | Clin Gas- truenterol Hepatol2012，10，7： | 1 |
| 13 | Cerebral edema after temporary and per- manent middle cerebral artery occlusion in the rat 显示文摘 | Slivka A Murphy E Horroeks L | 1995 | Stroke1995，26，6： | 1 |
| 14 | Gastric outlet obstruction caused by gallstones:case report and review of the literature显示文摘 | Kaushik N Moser AJ Slivka A | 2005 | Dig Dis Sci2005，50，3： | 1 |
| 15 | Prevalence and time course of microembolic signals in patients with acute stroke显示文摘 | Slivka U Lingnau A Stohlmann WD | 1997 | Stroke1997，28，2： | 1 |
| 16 | Intra-arterial carboplatin and intravenouse toposide for thetreatment of metastatic braintumors显示文摘 | Newton H B Slivka M A Volpi C | 2003 | JNeurooncol2003，61，1： | 1 |
| 17 | Intraarterial thrombolytic therapy within 3 hours of the onset of stoke显示文摘 | Bourekas E Slivka A | 2004 | Neurosurgery2004，54，： | 1 |
| 18 | High rate of fusion in sheep cervical spines following anterior in- terbody surgery with absorbable and nonabsorbable implant devi- ces显示文摘 | Slivka Michael A Spenciner David B Seim Howard B Ⅲ | 2006 | Spine2006，31，： | 1 |
| 19 | High rate of fusion in sheep cervical spines following anterior interbody surgery with absorbable and nonabsorbable implant devices显示文摘 | Slivka M A Spenciner D B Seim H B 3rd Welch W C Serhan H A Turner A S | 2006 | Spine (Phila Pa 1976)2006，31，： | 1 |
| 20 | Intraarterial thrombolytic therapy within 3 hours of the onset of stroke显示文摘 | Bourekas E Slivka A | 2004 | Neurosurgery2004，54，1： | 1 |
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