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| 1 | 基于资源的学习环境设计显示文摘本文针对数字化时代基于资源的学习需求,论述了基于资源的学习环境(RBLEs)的定义和特点,描述和分析了RBLEs的基本结构,讨论了RBLEs在未来发展所面临的挑战和机遇,从而为RBLEs提供了一个设计框架。 | Michael Hannafin 钟志贤(编译) | 2009 | 远程教育杂志2009，27，1： | 19 |
| 2 | Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population:Role of serine protease inhibitor Kazal 1type and alcohol显示文摘AIM: To test the hypothesis that calcium sensing receptor (CASR) polymorphisms are associated with chronic pancreatitis (CP), and to determine whether serine protease inhibitor Kazal 1type (SPINK1) N34S oralcohol are necessary co-factors in its etiology. METHODS: Initially, 115 subjects with pancreatitis and 66 controls were evaluated, of whom 57 patients and 21 controls were predetermined to carry the high-risk SPINK1 N34S polymorphism. We sequenced CASR gene exons 2, 3, 4, 5 and 7, areas containing the majority of reported polymorphisms and novel mutations. Based on the initial results, we added 223 patients and 239 controls to analyze three common nonsynonymous single nucleotide polymorphisms (SNPs) in exon 7 (A986S, R990G, and Q1011E). RESULTS: The CASR exon 7 R990G polymorphism was signifi cantly associated with CP (OR, 2.01; 95% CI, 1.12-3.59; P = 0.015). The association between CASR R990G and CP was stronger in subjects who reported moderate or heavy alcohol consumption (OR, 3.12; 95% CI, 1.14-9.13; P = 0.018). There was no association between the various CASR genotypes and SPINK1 N34S in pancreatitis. None of the novel CASR polymorphisms reported from Germany and India was detected. CONCLUSION: Our United States-based study confirmed an association of CASR and CP and for the first time demonstrated that CASR R990G is a signifi cant risk factor for CP. We also conclude that the risk of CP with CASR R990G is increased in subjects with moderate to heavy alcohol consumption. | Venkata Muddana Janette Lamb Julia B Greer Beth Elinoff Robert H Hawes Peter B Cotton Michelle A Anderson Randall E Brand Adam Slivka David C Whitcomb | 2008 | World Journal of Gastroenterology2008，14，28： | 7 |
| 3 | Accuracy of training blood volume quantifi cation using a visual estimation tool显示文摘BACKGROUND:We investigated whether the use of a specially designed visual estimation tool may improve accuracy in quantifying blood volumes related to surface spreading.METHODS:A prospective,paired-control,single-blinded experimental study was performed at a medical university.Anesthesiologists and emergency medical personnel estimated various blood volumes on surfaces with varying absorptivity(carpet,towel,polyvinyl chloride,wooden fl ooring)in an experimental setting.We assessed the sensitivity of training blood volume quantifi cation using a self-designed visual estimation tool by comparing the accuracy of visual blood volume estimations before and after practical training with the tool.RESULTS:A total of 352 estimations by 44 participants were evaluated.Accurate estimations improved significantly from pre-training to post-training(P<0.05).The sensitivity of blood volume quantifi cation was 33.0%after training with the visual estimation tool.Estimations did not depend on age,profession,gender or years of the estimator’s professional experience.CONCLUSIONS:Training with a visual estimation tool by professional rescuers can improve the estimation accuracy of blood volumes spread on surfaces with varying absorptivity. | Janett Kreutziger Philip Puchner Stefan Schmid Wolfgang Mayer Harald Prossliner Wolfgang Lederer | 2021 | World Journal of Emergency Medicine2021，12，3： | 5 |
| 4 | New insights into the pathophysiology of achalasia and implications for future treatment显示文摘Idiopathic achalasia is an archetype esophageal motor disorder, causing significant impairment of eating ability and reducing quality of life. The pathophysiological underpinnings of this condition are loss of esophageal peristalsis and insufficient relaxation of the lower esophageal sphincter(LES). The clinical manifestations include dysphagia for both solids and liquids, regurgitation of esophageal contents, retrosternal chest pain, cough, aspiration, weight loss and heartburn. Even though idiopathic achalasia was first described more than 300 years ago, researchers are only now beginning to unravel its complex etiology and molecular pathology. The most recent findings indicate an autoimmune component, as suggested by the presence of circulating anti-myenteric plexus autoantibodies, and a genetic predisposition, as suggested by observed correlations with other well-defined genetic syndromes such as Allgrove syndrome and multiple endocrine neoplasia type 2 B syndrome. Viral agents(herpes, varicella zoster) have also been proposed as causative and promoting factors. Unfortunately, the therapeutic approaches available today do not resolve the causes of the disease, and only target the consequential changes to the involved tissues, such as destruction of the LES, rather than restoring or modifying the underlying pathology. New therapies should aim to stop the disease at early stages, thereby preventing the consequential changes from developing and inhibiting permanent damage. This review focuses on the known characteristics of idiopathic achalasia that will help promote understanding its pathogenesis and improve therapeutic management to positively impact the patient's quality of life. | Janette Furuzawa-Carballeda Samuel Torres-Landa Miguel ángel Valdovinos Enrique Coss-Adame Luis A Martín del Campo Gonzalo Torres-Villalobos | 2016 | World Journal of Gastroenterology2016，22，35： | 4 |
| 5 | Efficacy of Anal Fistula Plug vs. Fibrin Glue in Closure of Anorectal Fistulas显示文摘 | Eric K. Johnson Janette U. Gaw David N. Armstrong | 2006 | Diseases of the Colon & Rectum2006，，3： | 4 |
| 6 | Viral respiratory infections among Hajj pilgrims in 2013显示文摘Middle East respiratory syndrome coronavirus(MERS-Co V) has emerged in the Arabian Gulf region, with its epicentre in Saudi Arabia, the host of the ‘Hajj' which is the world's the largest mass gathering. Transmission of MERS-Co V at such an event could lead to its rapid worldwide dissemination. Therefore, we studied the frequency of viruses causing influenza-like illnesses(ILI) among participants in a randomised controlled trial at the Hajj 2013. We recruited 1038 pilgrims from Saudi Arabia, Australia and Qatar during the first day of Hajj and followed them closely for four days. A nasal swab was collected from each pilgrim who developed ILI. Respiratory viruses were detected using multiplex RT-PCR. ILI occurred in 112/1038(11%) pilgrims. Their mean age was 35 years, 49(44%) were male and 35(31%) had received the influenza vaccine pre-Hajj. Forty two(38%) pilgrims had laboratory-confirmed viral infections; 28(25%) rhinovirus, 5(4%) influenza A, 2(2%) adenovirus, 2(2%) human coronavirus OC43/229 E, 2(2%) parainfluenza virus 3, 1(1%) parainfluenza virus 1, and 2(2%) dual infections. No MERS-Co V was detected in any sample. Rhinovirus was the commonest cause of ILI among Hajj pilgrims in 2013. Infection control and appropriate vaccination are necessary to prevent transmission of respiratory viruses at Hajj and other mass gatherings. | Osamah Barasheed Harunor Rashid Mohammad Alfelali Mohamed Tashani Mohammad Azeem Hamid Bokhary Nadeen Kalantan Jamil Samkari Leon Heron Jen Kok Janette Taylor Haitham El Bashir Ziad A.Memish Elizabeth Haworth Edward C.Holmes Dominic E Dwyer Atif Asghar Robert Booy | 2014 | Virologica Sinica2014，29，6： | 3 |
| 7 | Stakeholder analysis of the governance framework of a national SDI dataset-whose needs are met in the buildings and address register of the Netherlands?显示文摘National spatial data infrastructures are key to achieving the Digital Earth vision.In many cases,national datasets are integrated from local datasets created and maintained by municipalities.Examples are address,building and topographic information.Integration of local datasets may result in a dataset satisfying the needs of users of national datasets,but is it productive for those who create and maintain the data?This article presents a stakeholder analysis of the Basisregistratie Adressen en Gebouwen(BAG),a collection of base information about addresses and buildings in the Netherlands.The information is captured and maintained by municipalities and integrated into a national base register by Kadaster,the Cadastre,Land Registry and Mapping Agency of the Netherlands.The stakeholder analysis identifies organisations involved in the BAG governance framework,describes their interests,rights,ownerships and responsibilities in the BAG,and maps the relationships between them.Analysis results indicate that Kadaster and the municipalities have the highest relative importance in the governance framework of the BAG.The study reveals challenges of setting up a governance framework that maintains the delicate balance between the interests of all stakeholders.The results provide guidance for SDI role players setting up governance frameworks for national or global datasets. | Serena Coetzee Martijn Odijk Bastiaan van Loenen Janette Storm Jantien Stoter | 2020 | International Journal of Digital Earth2020，13，3： | 2 |
| 8 | Loss of sexual isolation in a hybridizing stickleback species pair显示文摘 | Alycia C. R. LACKEY Janette Wenrick BOUGHMAN | 2013 | Current Zoology2013，59，5： | 2 |
| 9 | Synthesis of Gold Nanoparticles by Some Strains of Arthrobacter Genera显示文摘 | Tamaz Levan Kalabegishvi|i Elena Ivan Kirkesalt Alexander Nikoloz Rcheulishvili Etery Nikoloz Ginturi Ivane Giorgi Murusidze Dodo Trofim Pataraya Manana Amiran Gurielidze Giorgi Ilia Tsertsvadze Vakhtang Nikoloz Gabunia Levan Giorgi Lomidze David Nugzar Gvarialadze Marina VladimirovnaFrontasyeva Sergey Sergeevich Pavlov Inga Ivanovna Zinicovscaia Marianne Janette Raven Ntsoaki Maditselana Francinah Seaga Arnaud Faanhof | 2012 | 材料科学与工程(中英文A版)2012，2，2： | 2 |
| 10 | Improving Online Learning: Student Perceptions of Useful and Challenging Characteristics显示文摘 | Ernise S Singleton Janette R Hill | 2004 | Internet and Higher Education2004，，7： | 1 |
| 11 | Targeted transcriptional activation of silent oct4 pluripotency gene by combining designer TALEs and inhibition of epigenetic modifiers显示文摘 | Sebastian Bultmann Robert Morbitzer Christine S. Schmidt Katharina Thanisch Fabio Spada Janett Elsaesser Thomas Lahaye Heinrich Leonhardt | 2012 | Nucleic Acids Research2012，，12： | 1 |
| 12 | Detection of ehlamydiae in boar semen and genital tracts显示文摘 | Teankum K Pospischil A Janett F | 2006 | Vet Microhiol2006，116，13： | 1 |
| 13 | New Information Management Work in a Changing World: an Australian Survey显示文摘 | Patrieia Willard and Janette Mychalyn | 1998 | International Journal of Information Management1998，18，5： | 1 |
| 14 | Poverty and Place in Britain, 1968 - 99 显示文摘 | Eldin Fahmy David Gordon Danny Dorling Janette Rigby Ben Wheeler | 2011 | Environment and Planning A2011，43，3： | 1 |
| 15 | Early stage of adjuvant arthritis alters behavioral responses in male but not female rats 显示文摘 | Janette SM Olha R Marie P | 2008 | Rheumatol Int2008，28，： | 1 |
| 16 | Seasonal changes in semen quality and freezability in the Warmblood stallion显示文摘 | Janett F Tbun R Niederer K | 2003 | Theriogenology2003，60，3： | 1 |
| 17 | Is the Monocyte Chemotactic Protein-1 ?2518 G Allele a Risk Factor for Severe Acute Pancreatitis?显示文摘 | Georgios I. Papachristou David A. Sass Haritha Avula Janette Lamb Anna Lokshin M. Michael Barmada Adam Slivka David C. Whitcomb | 2005 | Clinical Gastroenterology and Hepatology2005，，5： | 1 |
| 18 | Commodification of Buddhism in con-temporary Burma显示文摘 | Janette Philp David Mercer | 1999 | Annals of Tourism Research1999，26，1： | 1 |
| 19 | Brain differences in ecologically differentiatec sticklebacks显示文摘 | Jason KEAGY Victoria A. BRAITHWAITE Janette W. BOUGHMAN | 2018 | Current Zoology2018，64，2： | 1 |
| 20 | The learning region: The impact of social capital and weak ties on innovation显示文摘 | Christoph Hauser Gottfried Tapeline Janette wailed | 2007 | Regional studies2007，，2： | 1 |
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