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| 1 | Thiopurine-methyltransferase variants in inflammatory bowel disease:Prevalence and toxicity in Brazilian patients显示文摘AIM:To analyze the prevalence of thiopurine-methyltransferase(TPMT)genotypes and their associationwith drug toxicity in inflammatory bowel disease(IBD)patients from southeastern Brazil.METHODS:A total of 219 consecutive patients with IBD,of which 146 had Crohn’s disease and 73 had ulcerative colitis,regularly seen at the outpatient unit of the Division of Gastroenterology at the University Hospital Pedro Ernesto of the State University of Rio de Janeiro,a tertiary referral center,were enrolled in this study from February 2009 to January 2011.We analyzed the presence of major TPMT genetic variants(TPMT*2,*3A,*3C)in IBD patients by means of a specific allele and RFLP-PCR.Genomic DNA was isolated from peripheral blood leukocytes by proteinase-K/Sodium Dodecyl Sulfate digestion and phenol-chloroform extraction.TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes were detected by real-time polymerase chain reaction followed by direct sequencing with specific primers.Clinical data were systematically recorded,and correlated with the genotype results.RESULTS:The distribution of the selected TPMT gene polymorphism TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes was 3.6%,5.4%,and 7.7%of the patients,respectively.Among the side effects recorded from patients taking azathioprine,14 patients presented with pancreatitis and/or an elevation of pancreatic enzymes,while 6 patients had liver toxicity,and 2 patients exhibited myelosuppression/neutropenia.TPMT polymorphisms were detected in 37/219 patients(8 heterozygous for*2,11 heterozygous for*3A,and 18 heterozygous for*3C).No homozygotic polymorphisms were found.Despite the prevalence of the TPMT*3C genotype,no differences among the genotype frequencies were significant.Although no association was detected regarding myelotoxicity or hepatotoxicity,a trend towards the elevation of pancreatic enzymes was observed for TPMT*2 and TPMT*3C genotypes.CONCLUSION:The prevalence of TPMT genotypes was high among Brazilian patients.Variants genes*2and*3C may be associated with azathioprine pancreatic toxicity in a IBD southeastern Brazilian population. | Ana Teresa P Carvalho Barbara C Esberard Renata S B Fróes Davy C M Rapozo Ana B Grinman Tatiana A Simo Juliana C V C Santos Antonio José V Carneiro Luis Felipe Ribeiro-Pinto Heitor S P de Souza | 2014 | World Journal of Gastroenterology2014，20，12： | 3 |
| 2 | Up Close: Family Therapy Challenges and Innovations Around the World显示文摘 | Janine Roberts Khawla Abu‐Baker Cristina Diez Fernández Nelly Chong Garcia Glenda Fredman Hugo Kamya Yolanda Martín Higarza Jacqueline Fortes de Leff Philip Messent Shin‐Ichi Nakamura Fatma Torun Reid Timothy Sim Chitra Subrahmanian Roxana Zevallos Vega | 2014 | Fam. Proc2014，，： | 2 |
| 3 | Antiherpetic activity of a sulfated polysaccharide from Agaricus brasiliensis mycelia显示文摘 | Francielle Tramontini Gomes de Sousa Cardozo Carla Maísa Camelini Alessandra Mascarello Márcio José Rossi Ricardo José Nunes Célia Regina Monte Barardi Margarida Matos de Mendon?a Cláudia Maria Oliveira Sim?es | 2011 | Antiviral Research2011，，1： | 2 |
| 4 | Proprmlolol Ibr severe infantile he- nmngiomas : Follow - up retport 显示文摘 | Sims V de la Roque ED Berge J | 2009 | Pediturics2009，124，3： | 1 |
| 5 | Importance of phenolic compounds for the characterization of fruit juices显示文摘 | Brí gida Fern á ndez de Simó n Javier P é rez-Ilzarbe | 1992 | J Agric Food Chem1992，40，： | 1 |
| 6 | N omega-nitro-L-arginine methyl ester inhibits inflammatory liver injury induced by interleukin-2 显示文摘 | Lentsch AB Edwards MJ Sims DE | 1998 | J Leukoc Biol1998，63，1： | 1 |
| 7 | Laser phototherapy as topical prophylaxis against radiation-induced xerostomia显示文摘 | Simǒes A de Campos L de Souza DN | | 0，，03： | 1 |
| 8 | NRAS codon 61 mutation is associated with distant metastasis in patients with tbllicular thyroid carcinoma 显示文摘 | Jang EK Song DE Sim SY | 2014 | Thyroid2014，24，8： | 1 |
| 9 | Dynamics in the emergence of dormant and non-dormant herbaceous species from the soil seed bank from a Brazilian dry forest显示文摘在干旱的热带森林中,草本植物可能具有休眠机制,并在土壤中形成持续和短暂的种子库。这一由进化而获得的机制对草本植物的建植和生存,特别是在气候不可预测的森林生态系统中,具有重要生态适应意义。因此,本研究的目的是验证草本植物是否具备物理休眠机制,以及这些植物是如何克服这些自然屏障的,并最终理解巴西干旱热带森林土壤种子库中种子萌发时间动态。本研究选择巴西Caatinga森林中的5种本地草本植物的种子,经过发芽前处理来验证是否存在物理休眠。连续4年在雨季和旱季收集土壤样品,并监测这些草本植物种子在温室中的萌发动态。利用广义线性模型验证种子萌发和出苗率的差异。研究结果表明Caatinga森林中的草本植物种子存在着物理休眠和非物理休眠;而且草本植物从土壤种子库中出苗的种内和种间存在着年份和季节的差异。对于多年生草本植物,不同季节和年份频繁出现不出苗的现象,这可能与物理休眠机制和克服种皮障碍所需的环境条件有关。在这些物种中,种子的二态性和休眠可能给它们的生存带来额外的优势。此外,在一年生植物中出现中等水平的物理休眠可能是对降雨不可预测性的进化调整。相比之下,我们发现没有休眠的一年生草本植物对季节和年际气候变化更敏感,这可以从土壤种子库中其出苗率的增加和显著减少得到证明。这些通过进化获得的种子休眠差异有利于那些分布在气候变化无常的半干旱地区草本植物种群的建立。 | José Djalma de Souza Bruno Ayron de Souza Aguiar Danielle Melo dos Santos Vanessa Kelly Rodrigues de Araujo Júlia Arruda Simões Juliana Ramos de Andrade Elcida de Lima Araújo | 2020 | Journal of Plant Ecology2020，13，3： | 1 |
| 10 | The IL-1 family: regulators of immunity显示文摘 | Sims JE Smith DE | 2010 | Nat Rev Immunol2010，10，2： | 1 |
| 11 | Interleukin-2 alters the positions of capillary and venule pericytes in rat cremaster muscle 显示文摘 | Sims DE Miller FN Horne MM | 1994 | J Submicrosc Cytol Pathol1994，26，4： | 1 |
| 12 | The IL-1 family:regulators of immunity显示文摘 | Sims JE Smith DE | | 0，，02： | 1 |
| 13 | Some aspects of the behavior of the hypothalamus–pituitary–adrenal axis in patients with uncomplicated Plasmodium falciparum malaria: Cortisol and dehydroepiandrosterone levels显示文摘 | Rosana Maria Feio Libonati Berenice Bilharinho de Mendon?a José Ant?nio Maués Juarez Antonio Sim?es Quaresma José Maria de Souza | 2006 | Acta Tropica2006，，3： | 1 |
| 14 | Is there a 'Big Five' in team- work 显示文摘 | Salas E Sims DE Burke CS | 2005 | Small Group Research2005，36，5： | 1 |
| 15 | Multimethod study of the degree of humifieation of humic substances extracted from different tropical soil profiles in Brazil's Amazonian region显示文摘 | Rosa A H Sim? es M L de Oliveira L C | 2005 | Geoderma2005，127，： | 1 |
| 16 | The genome of Syntrophomonas wolfei: new insights into syntrophic metabolism and biohydrogen production 显示文摘 | Sieber JR Sims DR Han C Kim E Lykidis A Lapidus AL Mcdonnald E Rohlin L Culley DE Gunsalus R Mcinerney MJ | 2010 | Environ Microbiol2010，12，8： | 1 |
| 17 | Ellagitannins in Woods of Spanish ,French and American Oaks显示文摘 | Brígida Fernández de Simón Estrella Cadahía Elvira Conde María Concepción García-Valejo | 1999 | Holzforschung1999，53，： | 1 |
| 18 | Influence of humic substances on the photolysis of aqueous pesticide residues显示文摘 | GARBIN J R DE'BORA M B P MILORI Sim(O)es M L | 2007 | Chemosphere2007，66，： | 1 |
| 19 | Diversity within pericytes显示文摘 | Sims DE | | 0，，： | 1 |
| 20 | Molecular cloning and biological characterization of a novel murine lymphoid growth factor 显示文摘 | Sims JE Williams DE Morrissey PJ | 2000 | J Exp Med2000，192，5： | 1 |
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