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| 1 | Successful surgical management of ruptured umbilical hernias in cirrhotic patients显示文摘Acute umbilical hernia rupture in patients with hepatic cirrhosis and ascites is an unusual,but potentially lifethreatening complication,with postoperative morbidity about 70% and mortality between 60%-80% after supportive care and 6%-20% after urgent surgical repair.Management options include primary surgical repair with or without concomitant portal venous system decompression for the control of the ascites.We present a retrospective analysis of our centre's experience over the last 6 years.Our cohort consisted of 11 consecutive patients(median age:53 years,range:36-63 years) with advanced hepatic cirrhosis and refractory ascites.Appropriate patient resuscitation and optimisation with intravenous fluids,prophylactic antibiotics and local measures was instituted.One failed attempt for conservative management was followed by a successful primary repair.In all cases,with one exception,a primary repair with non-absorbable Nylon,interrupted sutures,without mesh,was performed.The perioperative complication rate was 25% and the recurrence rate 8.3%.No mortality was recorded.Median length of hospital stay was 14 d(range:4-31 d).Based on our experience,the management of ruptured umbilical hernias in patients with advanced hepatic cirrhosis and refractory ascites is feasible without the use of transjugular intrahepatic portosystemic shunt routinely in the preoperative period,provided that meticulous patient optimisation is performed. | Nikolaos A Chatzizacharias J Andrew Bradley Simon Harper Andrew Butler Asif Jah Emmanuel Huguet Raaj K Praseedom Michael Allison Paul Gibbs | 2015 | World Journal of Gastroenterology2015，21，10： | 4 |
| 2 | Iron in the NEEM ice core relative to Asian loess records over the last glacial–interglacial cycle显示文摘Mineral dust can indirectly affect the climate by supplying bioavailable iron(Fe)to the ocean.Here,we present the records of dissolved Fe(DFe)and total Fe(TDFe)in North Greenland Eemian Ice Drilling(NEEM)ice core over the past 110 kyr BP.The Fe records are significantly negatively correlated with the carbon-dioxide(CO_(2))concentrations during cold periods.The results suggest that the changes in Fe fluxes over the past 110 kyr BP in the NEEM ice core are consistent with those in Chinese loess records because the mineral-dust distribution is controlled by the East Asian deserts.Furthermore,the variations in the dust input on a global scale are most likely driven by changes in solar radiation during the last glacial–interglacial cycle in response to Earth’s orbital cycles.In the last glacial–interglacial cycle,the DFe/TDFe ratios were higher during the warm periods(following the post-Industrial Revolution and during the Holocene and last interglacial period)than during the main cold period(i.e.the last glacial maximum(LGM)),indicating that the aeolian input of iron and the iron fertilization effect on the oceans have a non-linear relationship during different periods.Although the burning of biomass aerosols has released large amounts of DFe since the Industrial Revolution,no significant responses are observed in the DFe and TDFe variations during this period,indicating that severe anthropogenic contamination has no significant effect on the DFe(TDFe)release in the NEEM ice core. | Cunde Xiao Zhiheng Du Mike J Handley Paul A Mayewski Junji Cao Simon Schüpbach Tong Zhang Jean-Robert Petit Chuanjin Li Yeongcheol Han Yuefang Li Jiawen Ren | 2021 | National Science Review2021，8，7： | 2 |
| 3 | Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling显示文摘 | Jones Simon A Scheller Jürgen Rose-John Stefan | 2011 | Journal of Clinical Investigation2011，，9： | 2 |
| 4 | Alternative treatments to inhibit VEGF in age-related choroidal neovascularisation: 2-year findings of the IVAN randomised controlled trial显示文摘 | Usha Chakravarthy Simon P Harding Chris A Rogers Susan M Downes Andrew J Lotery Lucy A Culliford Barnaby C Reeves | 2013 | The Lancet2013，，： | 2 |
| 5 | Spinal metastases:indications for and results of percutaneous injection of acrylic surgical cement显示文摘 | Chiras J Simon JM | 1996 | Radiology1996，199，： | 1 |
| 6 | A population-based European cohort study of persistence in newly diagnosed hypertensive patients显示文摘 | Hasford J Mimran A Simons WR | 2002 | J Hum Hypertens2002，16，8： | 1 |
| 7 | Effects of age, gender and race/ethnicity on the pharmacokinetics of posaconazole in healthy volunteers 显示文摘 | Sansone- Parsons A Krishna G Simon J | 2007 | Antimicrob Agents Chemother2007，51，2： | 1 |
| 8 | Non-stoichiometric perovskites derived from BaTiO3 with a ferroelectric relaxor behaviour 显示文摘 | Ravez J Simon A | 2000 | Phys Stat Sol2000，178，： | 1 |
| 9 | Residual-effeeted homogeneous charge compression ignition at a low compression ratio using exhaust reinduetion显示文摘 | Citon P A Simon A J Jerdes J C | 2003 | Int J Engine Res2003，4，3： | 1 |
| 10 | Non-stoichiometric perovskites derived from BaTiO3 with a ferroelectric relaxor behavior 显示文摘 | RAVEZ J SIMON A | 2000 | Phys Stat Sol2000，178，： | 1 |
| 11 | Description of ultrasonic vocalizations of the mouse lemur(Microcebus murinus)and the fat-tailed dwarf lemur ( Cheirogaleus medius) 显示文摘 | CHERRY J A IZARD M K SIMONS E | 1987 | Am J Primatol1987，13，： | 1 |
| 12 | Complex plaques in the proximal descending aorta:an underestimated embolic source of stroke显示文摘 | Harloff A Simon J Brendecke S | 2010 | Stroke2010，41，： | 1 |
| 13 | Pre - B - cell colo- ny - enhancing factor as a potential novel biomarker in acute lung in- jury显示文摘 | YE S Q SIMON B A MALONEY J P | 2005 | Am J Respir Crit Care Med2005，171，4： | 1 |
| 14 | Magmatic--hydrothermal origin of Ne- vada~ s Carlin- type gold deposits显示文摘 | Muntean J L J S Cline A C Simon | 2011 | Nature Geoscience2011，4，12： | 1 |
| 15 | Intima-media thickness:a new tool for diagnosis and treatment of cardiovascular risk显示文摘 | Simon A Gariepy J Chironi G | | J Hyp0，，： | 1 |
| 16 | Alteration of the quality of milk by expression of sheep beta-lactoglobulin in transgenic mice显示文摘 | Simons J P McClenaghan M Clark A J | 1987 | Nature1987，328，： | 1 |
| 17 | Pre-B-cell colony-enhancing factor as a potential novelbiomarker in acute lung injury 显示文摘 | YE S Q SIMON B A MALONEY J P | 2005 | Am J RespirCrit Care Med2005，171，4： | 1 |
| 18 | Protein kinase C inhibitor sotrastaurin in de novo liver transplant recipients: A randomized phase II trial 显示文摘 | Pascher A De Simone P Pratschke J | 2015 | Am J Transplantation2015，15，5： | 1 |
| 19 | Nuclear karyo- pherin a2:a novel biomarker for infiltrative astrocytomas 显示文摘 | GOUSIAS K BECKER A J SIMON M | 2012 | J Neurooneol2012，109，3： | 1 |
| 20 | The relation of postmenopausal hormone therapy to serum uric acid and the risk of coronary heart disease events: the Heart and Estrogen-Progestin Replacement Study (HERS) 显示文摘 | SIMON J A LIN F VITTINGHOFF E | 2006 | Ann Epidemiol2006，16，： | 1 |
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