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| 1 | 中国东北麻山杂岩晚泛非期变质的锆石SHRIMP年龄证据及全球大陆再造意义显示文摘中国东北地区佳木斯地块南部麻山杂岩正、副片麻岩 7个样品的锆石 SHRIMP年龄数据首次明确地表明 ,东北地区存在 500 Ma的晚泛非期高级变质作用事件。峰期麻粒岩相变质导致柳毛地区 (502± 10)Ma (2σ )深熔花岗岩的形成。正、副片麻岩变质年龄的一致性表明它们已在变质前发生了构造叠置。西麻山副片麻岩中含有在后期麻粒岩相变质过程中未重结晶的碎屑锆石,由此形成从协和一致的 550 Ma到弱不一致 1 900 Ma的较大 207Pb/206Pb年龄变化范围,表明其原岩具有从新元古代到中元古代-古元古代的年龄。柳毛地区变质的片麻状闪长岩中所含的古老锆石的 207Pb/206Pb年龄为 546~ 1 460 Ma表明,该闪长岩大约在 1 400 Ma就位,并受到 500 Ma变质事件的影响,从而说明柳毛地区存在中元古代基底。然而,与以前的认识相反,麻山杂岩不存在具有太古宙基底的同位素证据。晚泛非期变质事件年龄的确定对重塑晚前寒武纪-显生宙早期麻山杂岩和佳木斯地块的古地理位置具有重要意义。根据目前获得的有关证据,认为佳木斯地块可能曾经位于冈瓦纳大陆北缘的华北克拉通附近。 | Simon A Wilde 吴福元 张兴洲 | 2001 | 地球化学2001，30，1： | 90 |
| 2 | Hepatocellular carcinoma: Epidemiology, risk factors and pathogenesis显示文摘Hepatocellular carcinoma (HCC) is the commonest primary malignant cancer of the liver in the world. Given that the burden of chronic liver disease is expected to rise owing to increasing rates of alcoholism, hepatitis B and C prevalence and obesity-related fatty liver disease, it is expected that the incidence of HCC will also increase in the foreseeable future. This article summarizes the international epidemiology, the risk factors and the pathogenesis of HCC, including the roles of viral hepatitis, toxins, such as alcohol and aflatoxin, and insulin resistance. | Asmaa Ibrahim Gomaa Shahid A Khan Mireille B Toledano Imam Waked Simon D Taylor- Robinson | 2008 | World Journal of Gastroenterology2008，14，27： | 78 |
| 3 | 中国东北~500Ma泛非期孔兹岩带的确定及其意义显示文摘东北地区的变质基底,如佳木斯地块的麻山群、兴安地块的兴华渡口群等岩石组合是以(含石墨)大理岩、夕线石榴片麻岩、斜长角闪岩等为主要标志的孔兹岩系。在额尔古纳、兴安和佳木斯-兴凯地块的夕线石榴片麻岩分别得到锆石U-Pb年龄,证明这些高级变质岩的原岩年龄以新元古代(600~850Ma)为主,变质年龄为~500Ma,因此东北地区的变质基底记录了从Rodinia到Gondwana大陆的聚合与离散的过程。泛非期高级变质岩及其同期岩浆岩在额尔古纳、兴安、松辽、佳木斯和兴凯地块等断续分布,总体出露范围>1300km,并沿虎头、鸡西、萝北、兴华渡口和漠河一线总体北西向沿黑龙江断续分布,因此我们命名为'中国东北泛非期孔兹岩带'。'中国东北泛非期孔兹岩带'的提出和进一步研究,对深入探讨东北地区各地块基底组成的异同性以及陆块聚合的过程,以及东北地区的构造演化历史及其在Gondwana大陆重建中的位置都具有重要的科学意义。 | 周建波 张兴洲 Simon A WILDE 郑常青 | 2011 | 岩石学报2011，27，4： | 78 |
| 4 | 黑龙江杂岩的碎屑锆石年代及其大地构造意义显示文摘黑龙江杂岩带位于佳木斯地体西缘,为佳木斯地体向西与松嫩地体之间俯冲、拼贴、碰撞而形成的高压变质带。黑龙江杂岩沿牡丹江断裂分布,其构造-岩石组合、变质变形特征等显示其为佳木斯地体向松嫩地体俯冲拼帖的过程中形成的增生杂岩,目前保存下来的杂岩带应为大规模增生楔仰冲到佳木斯地体之上的残余部分。88颗碎屑锆石的全部样品SHRIMPU-Pb年代学测试结果显示三个主要年龄区间:170~220Ma,峰值年龄为183Ma;240~338Ma,峰值年龄为256Ma;450~520Ma,峰值年龄为470Ma。而28个碎屑锆石谐和年龄的年龄谱为两组:240~338Ma,峰值年龄为256Ma;450~500Ma,峰值年龄为470Ma。碎屑锆石年龄数据分析得到,240~338Ma峰期年龄为256Ma的年龄应代表黑龙江杂岩主体岩石的沉积年龄上限;而450~500Ma的年龄谱对应于佳木斯地体的基底变质岩年龄,显示佳木斯地体的基底变质岩曾为黑龙江杂岩的物源区;而170~210Ma,峰期年龄为183Ma的不谐和年龄应为受印支期-早侏罗世构造热事件的扰动年龄,与该区变质单矿物的Ar-Ar年龄相一致,应代表了该区陆-陆碰撞的时代。上述年龄为黑龙江杂岩的形成与演化提供了重要的地质年代学制约,即黑龙江杂岩的原岩成岩时代上限为早三叠世,佳木斯地体向西的俯冲时代主体为印支期,而陆-陆拼贴及碰撞过程主要为晚印支期并可能持续到早侏罗世。这些结果将为揭示我国东北地区构造演化的年代学格架以及三叠纪古亚洲构造域向环太平洋构造域叠加和转换的动力学背景研究提供新的基本地质事实依据。 | 周建波 张兴洲 Simon A WILDE 郑常青 金魏 陈红 韩杰 | 2009 | 岩石学报2009，25，8： | 55 |
| 5 | 吉林—黑龙江高压变质带的初步厘定:证据和意义显示文摘本文定义的吉林——黑龙江高压变质带是指我国东北地区佳木斯——兴凯地块西缘和南缘共同发育的呈弧形展布的高压变质带,具体包括佳木斯——兴凯地块西缘增生杂岩带(黑龙江蓝片岩带和张广才——小兴安岭增生杂岩带)和佳木斯——兴凯地块南缘的长春——延吉增生杂岩带。其中佳木斯——兴凯地块西缘增生杂岩带形成于晚三叠——早侏罗世(180~210Ma),为佳木斯——兴凯地块向西冲增生而形成的高压变质带;而长春——延吉增生杂岩带由一系列特征性俯冲——增生杂岩组成,包括石头口门——烟筒山红帘石片岩带、呼兰群变质杂岩、色洛河群变质杂岩、青龙村群变质杂岩和开山屯变质杂岩等,形成时代为187~230Ma,峰期为220~230Ma。长春——延吉增生杂岩带曾被认为是西拉木伦河断裂带的东延部分,但是区域构造分析表明,它们形成的动力学背景与佳木斯——兴凯地块西缘增生杂岩带相同,均为太平洋板块三叠纪——早侏罗世的西向俯冲导致佳木斯-兴凯地块自东向西的'剪刀式'闭合过程。我们将佳木斯——兴凯地块西缘和南缘发育的三叠纪——早侏罗世增生杂岩带作为统一的构造单元来考虑,结合该区发育有典型的高压变质带,因此命名为'吉林——黑龙江高压变质带,简称吉黑高压带'。吉黑高压带形成于太平洋板块三叠纪——早侏罗世的西向俯冲导致佳木斯——兴凯地块自东向西的'剪刀式'闭合的过程,同时该带记录了古亚洲构造域的结束和太平洋俯冲开始的关键时期,为两大构造域叠加与转换的关键性地质证据。 | 周建波 韩杰 Simon A WILDE 郭晓丹 曾维顺 曹嘉麟 | 2013 | 岩石学报2013，29，2： | 59 |
| 6 | Diagnosis of hepatocellular carcinoma显示文摘Hepatocellular carcinoma (HCC) is one of the commonest cancers worldwide, particularly in parts of the developing world, and is increasing in incidence. This article reviews the current modalities employed for the diagnosis of HCC, including serum markers, radiological techniques and histological evaluation, and summarises international guidelines for the diagnostic approach to HCC. | Asmaa I Gomaa Shahid A Khan Edward LS Leen Imam Waked Simon D Taylor-Robinson | 2009 | World Journal of Gastroenterology2009，15，11： | 44 |
| 7 | 辽宁丹东地区侏罗纪花岗岩的变形时代:^(40)Ar/^(39)Ar年代学制约显示文摘辽东半岛出露大量片麻状花岗岩,其锆石U-Pb年龄为180~157Ma,该套岩石的最大特点表现在岩石明显经历了早期上盘向NW推覆和后期近EW向伸展作用的韧性改造,然而其变形时代却一直未得到确定。本文以丹东市西南部黑沟二云母二长花岗岩岩体为例,通过激光^(40)Ar/^(39)Ar年代学研究探讨该岩体的变形时代。激光^(40)Ar/^(39)Ar定年结果表明,黑沟岩体经历的早期推覆、挤压事件发生在~143Ma,而后期地壳伸展作用则发生在121~113Ma,并且该区在早白垩纪期间经历了快速冷却、抬升过程。从而表明在晚侏罗纪-早白垩纪期间(143~113Ma)辽东半岛经历了区域构造体制变革。结合前人大地构造研究成果,本文认为辽东半岛晚侏罗纪-早白垩纪NW向推覆、挤压事件是古太平洋板块向欧亚大陆俯冲作用的结果,而晚期(早白垩纪)的地壳伸展事件是古太平洋板块俯冲作用的转向和变速、华北东部岩石圈较薄以及挤压后地壳松弛等综合作用的结果。 | 杨进辉 吴福元 罗清华 钟孙霖 张艳斌 Simon A Wilde | 2004 | 岩石学报2004，20，5： | 38 |
| 8 | 中国两栖动物保护需求总述显示文摘通过对中国两栖动物物种生物多样性现状的全面分析,与世界许多国家相比,中国是一个重要的全球优先保护地区.横断山区、南岭山区和武夷山区3个区域的两栖动物物种多样性特别丰富.有尾两栖类物种较无尾类受胁程度更高.几个物种数相对较少的铃蟾科、隐腮鲵科、小鲵科和蝾螈科显示出了高的受胁倾向.像世界其它地方一样,高海拔地区溪流繁殖的森林物种受胁程度更高.对中国两栖动物而言,生境丧失、污染和过度捕捉是最主要的致危因素.过度捕捉虽然影响不如生境丧失深远,但它更可能导致一个物种种群的快速衰落.针对5个方面的保护挑战,提出了优先研究领域和保护行动方面的建议. | 谢锋 刘惠宁 Simon N Stuart Janice S Chanson Neil A Cox Debra L Fischman | 2006 | 中国科学(C辑)2006，36，6： | 28 |
| 9 | 鞍山地区铁架山花岗岩及表壳岩的锆石SHRIMP年代学和Hf同位素组成显示文摘辽宁鞍山中太古代铁架山花岗岩是华北克拉通时代最古老、分布范围最大的富钾质花岗岩。具相对高钾(4.77~5.75%)低钠(3.16~3.52%)、强烈负铕负钡异常(Eu/Eu*=0.40~0.51,Ba/Ba*=0.15~0.26)的组成特征,且高t_(DM)(Nd) (3.42~3.38Ga),低ε_(Nd)(t)(-3.61~-2.51)。花岗岩样品A9837和A0433岩浆锆石年龄分别为2992±10Ma和2983±10Ma。结合前人定年结果,可把铁架山花岗岩主体形成时代限制在2.96~2.99Ga之间。另一花岗岩样品A9825岩浆锆石年龄为2914±4Ma,可能代表了铁架山花岗岩形成后局部深熔作用的时代。首次在铁架山花岗岩中获得残余锆石年龄,其最大达3759Ma。2个花岗岩样品(A9837,A9825)岩浆锆石的t_(DM)(Hf)和ε_(Hf)(t)分别为3.48~3.32Ga和-7.85~-2.29.残余锆石的t_(DM)(Hf)和ε_(Hf)(t)分别为3.89~3.47Ga和-19.5~-6.2。这些资料为铁架山花岗岩形成于古老陆壳物质再循环提供了直接证据。存在于铁架山花岗岩中的表壳岩主要为变质沉积岩,其地球化学组成特征与铁架山花岗岩类似。3个变质沉积岩样品(A9819,A0435,A0436)的碎屑锆石年龄大都为~3.0Ga,其中2个样品(A0435,A0436)的碎屑锆石ε_(Hf)(t)和t_(DM)(Hf)分别为-9.93~-2.29和3672~3297Ma,与铁架山花岗岩中的岩浆锆石类似。表明这些变质沉积岩形成于铁架山花岗岩之后,而不是以前认为的那样为铁架山花岗岩中的包体。 | 万渝生 刘敦一 殷小艳 Simon A Wilde 谢烈文 杨岳衡 周红英 伍家善 | 2007 | 岩石学报2007，23，2： | 26 |
| 10 | Autophagy is required for self-renewal and differentiation of adult human stem cells显示文摘 | Souzan Salemi Shida Yousefi Mihai A Constantinescu Martin F Fey Hans-Uwe Simon | 2012 | Cell Research2012，22，2： | 17 |
| 11 | Incidence and mortality of primary liver cancer in England and Wales: Changing patterns and ethnic variations显示文摘AIM: To explore recent trends, modes of diagnosis, ethnic distribution and the mortality to incidence ratio of primary liver cancer by subtypes in England and Wales. METHODS: We obtained incidence(1979-2008) and mortality(1968-2008) data for primary liver cancer for England and Wales and calculated age-standardised incidence and mortality rates. Trends in age-standardised mortality(ASMR) and incidence(ASIR) rates and basis of diagnosis of primary liver cancer and subcategories: hepatocellular carcinoma, intrahepatic bile duct and unspecified liver tumours, were analysed over the study period. Changes in guidelines for the diagnosis of primary liver cancer(PLC) may impact changing trends in the rates that may be obtained. We thus explored changes in the mode of diagnosis as reported to cancer registries. Furthermore, we examined the distribution of these tumours by ethnicity. Most of the statistical manipulations of these data was carried out in Microsoft excel(Seattle, Washington, United Sttaes). Additional epidemiological statistics were done in Epi Info software(Atlanta, GA, United Sttaes). To define patterns of change over time, we evaluated trends in ASMR and ASIR of PLC and intrahepatic bile duct carcinoma(IHBD) using a least squares regression line fitted to the natural logarithm of the mortality and incidence rates. We estimated the patterns of survival over subsequent 5 and 10 years using complement of mortality to incidence ratio(1-MIR). RESULTS: Age-standardised mortality rate of primary liver cancer increased in both sexes: from 2.56 and 1.29/100000 in 1968 to 5.10 and 2.63/100000 in 2008 for men and women respectively. The use of histology for diagnostic confirmation of primary liver cancer increased from 35.7% of registered cases in 1993 to plateau at about 50% during 2005 to 2008. Reliance on cytology as a basis of diagnosis has maintained a downward trend throughout the study period. Although approximately 30% of the PLC registrations had information on ethnicity, there was a relatively higher registration of the major tumour subtypes in patients whose ethnic backgrounds were from high incident regions of the world. Survival from PLC is estimated to get poorer in 10 years(2018) relative to 2008, particularly as a result of IHBD. CONCLUSION: Incidence and mortality of PLC, and particularly IHBD, have continued to rise in England and Wales. Changes in the modes of diagnosis may be contributing. | Nimzing G Ladep Shahid A Khan Mary ME Crossey Andrew V Thillainayagam Simon D Taylor-Robinson Mireille B Toledano | 2014 | World Journal of Gastroenterology2014，20，6： | 15 |
| 12 | Conservation needs of amphibians in China: A review显示文摘The conservation status of all the amphibians in China is analyzed,and the country is shown to be a global priority for conservation in comparison to many other countries of the world.Three Chinese regions are particularly rich in amphibian diversity:Hengduan,Nanling,and Wuyi mountains.Sala-manders are more threatened than frogs and toads.Several smaller families show a high propensity to become seriously threatened:Bombinatoridae,Cryptobranchidae,Hynobiidae and Salamandridae.Like other parts of the world,stream-breeding,high-elevation forest amphibians have a much higher likeli-hood of being seriously threatened.Habitat loss,pollution,and over-harvesting are the most serious threats to Chinese amphibians.Over-harvesting is a less pervasive threat than habitat loss,but it is more likely to drive a species into rapid decline.Five conservation challenges are mentioned with recommendations for the highest priority research and conservation actions. | Michael Wai Neng LAU Simon N STUART Janice S CHANSON Neil A COX Debra L FISCHMAN | 2007 | Science China(Life Sciences)2007，50，2： | 12 |
| 13 | Relationship between adipose tissue dysfunction, vitamin D deficiency and the pathogenesis of non-alcoholic fatty liver disease显示文摘Non-alcoholic fatty liver disease(NAFLD)is the most common chronic liver disease worldwide.Its pathogenesis is complex and not yet fully understood.Over the years many studies have proposed various pathophysiological hypotheses,among which the currently most widely accepted is the'multiple parallel hits'theory.According to this model,lipid accumulation in the hepatocytes and insulin resistance increase the vulnerability of the liver to many factors that act in a coordinated and cooperative manner to promote hepatic injury,inflammation and fibrosis.Among these factors,adipose tissue dysfunction and subsequent chronic low grade inflammation play a crucial role.Recent studies have shown that vitamin D exerts an immune-regulating action on adipose tissue,and the growing wealth of epidemiological data is demonstrating that hypovitaminosis D is associated with both obesity and NAFLD.Furthermore,given the strong association between these conditions,current findings suggest that vitamin D may be involved in the relationship between adipose tissue dysfunction and NAFLD.The purpose of this review is to provide an overview of recent advances in the pathogenesis of NAFLD in relation to adipose tissue dysfunction,and in the pathophysiology linking vitamin D deficiency with NAFLD and adiposity,together with an overview of the evidence available on the clinical utility of vitamin D supplementation in cases of NAFLD. | Flavia A Cimini Ilaria Barchetta Simone Carotti Laura Bertoccini Marco G Baroni Umberto Vespasiani-Gentilucci Maria-Gisella Cavallo Sergio Morini | 2017 | World Journal of Gastroenterology2017，23，19： | 9 |
| 14 | On a class of skew distribution functions 显示文摘 | Simon I-I A | 1955 | Biometrika1955，42，： | 7 |
| 15 | 血浆游离DNA水平增高可作为预测重型颅脑损伤患者死亡率的独立指标(英文)显示文摘Trauma is the leading cause of death under 45 years worldwide and up to 50% of trauma fatalities are due to brain injury.Prediction of outcome is one of the major problems associated with severe TBI and research efforts have focused on the investigation of biomarkers with prognostic value following TBI. Therefore,our aim was to investigate whether cell-free DNA concentrations correlated to short-term primary outcome( survivor or death) and GCS scores following severe TBI. A total of 188 victims of severe TBI were enrolled in this prospective study,outcome variables comprised: survival and neurological assessment using the GCS at ICU discharge. Control blood samples were obtained from 25 healthy volunteers. Peripheral venous blood was collected at admission in the ICU. Plasma DNA was measured using a real-time quantitative PCR assay for the β-globin gene. There was correlation between higher DNA levels and both fatal outcome and lower hospital admission GCS scores. Plasma DNA concentrations at the chosen cut- off point( ≥171,381 kilogenomesequivalents /L) predicted mortality with a specificity of 90% and a sensitivity of 43%. Logistic regression analysis showed that elevated plasma DNA levels were independently associated with death( P < 0. 001). In conclusion,high cell-free DNA concentration was a predictor of short-term mortality following severe TBI. | Rodrigues Filho EM1 Simon D Ikuta N Klovan C Dannebrock F de Oliveira CO Regner A | 2014 | 中华神经外科疾病研究杂志2014，13，3： | 6 |
| 16 | 鞍山地区铁架山花岗岩中表壳岩的碎屑锆石SHRIMP年龄及其地质意义显示文摘鞍山地区3.0Ga铁架山花岗岩是华北克拉通时代最古老、分布范围最大的钾质花岗岩,其中存在较多成熟度高的变泥沙质岩石表壳岩,其元素和Nd同位素组成与铁架山花岗岩十分相似。以往研究把它们作为铁架山花岗岩中的表壳岩包体,认为铁架山花岗岩形成于它们的部分熔融。本文利用碎屑锆石SHRI MP U-Pb定年方法对鞍山铁架山花岗岩中变泥沙质表壳岩的形成时代进行了制约,证实表壳岩形成于铁架山花岗岩之后,为遭受强烈变质变形地区变泥沙质岩石时代研究提供了一个新的实例。 | 殷小艳 万渝生 刘敦一 Simon A Wilde 周红英 伍家善 | 2006 | 岩石矿物学杂志2006，25，4： | 6 |
| 17 | Lipid dysregulation in hepatitis C virus, and impact of statin therapy upon clinical outcomes显示文摘The hepatitis C virus(HCV) is one of the most common causes of chronic liver disease and the leading indication for liver transplantation worldwide. Every aspect of the HCV life cycle is closely tied to human lipid metabolism. The virus circulates as a lipid-rich particle, utilizing lipoprotein cell receptors to gain entry into the hepatocyte. It has also been shown to upregulate lipid biosynthesis and impair lipid degradation, resulting in significant intracellular lipid accumulation and circulating hypocholesterolemia. Patients with chronic hepatitis C(CHC) are at increased risk of hepatic steatosis, fibrosis, and cardiovascular disease including accelerated atherosclerosis. HMG Co A Reductase inhibitors, or statins, have been shown to play an important role in the modulation of hepatic steatosis and fibrosis, and recent attention has focused upon their potential therapeutic role in CHC. This article reviews the hepatitis C viral life cycle as it impacts host lipoproteins and lipid metabolism. It then describes the pathogenesis of HCV-related hepatic steatosis, hypocholesterolemia and atherosclerosis, and finally describes the promising anti-viral and anti-fibrotic effects of statins, for the treatment of CHC. | Tracey G Simon Adeel A Butt | 2015 | World Journal of Gastroenterology2015，21，27： | 5 |
| 18 | Esophageal tissue engineering:A new approach for esophageal replacement显示文摘A number of congenital and acquired disorders require esophageal tissue replacement.Various surgical techniques,such as gastric and colonic interposition,are standards of treatment,but frequently complicated by stenosis and other problems.Regenerative medicine approaches facilitate the use of biological constructs to replace or regenerate normal tissue function.We review the literature of esophageal tissue engineering,discuss its implications,compare the methodologies that have been employed and suggest possible directions for the future.Medline,Embase,the Cochrane Library,National Research Register and ClinicalTrials.gov databases were searched with the following search terms:stem cell and esophagus,esophageal replacement,esophageal tissue engineering,esophageal substitution.Reference lists of papers identified were also examined and experts in this field contacted for further information.All full-text articles in English of all potentially relevant abstracts were reviewed.Tissue engineering has involved acellular scaffolds that were either transplanted with the aim of being repopulated by host cells or seeded prior to transplantation.When acellular scaffolds were used to replace patch and short tubular defects they allowed epithelial and partial muscular migration whereas when employed for long tubular defects the results were poor leading to an increased rate of stenosis and mortality.Stenting has been shown as an effective means to reduce stenotic changes and promote cell migration,whilst omental wrapping to induce vascularization of the construct has an uncertain benefit.Decellularized matrices have been recently suggested as the optimal choice for scaffolds,but smart polymers that will incorporate signalling to promote cell-scaffold interaction may provide a more reproducible and available solution.Results in animal models that have used seeded scaffolds strongly suggest that seeding of both muscle and epithelial cells on scaffolds prior to implantation is a prerequisite for complete esophageal replacement.Novel approaches need to be designed to allow for peristalsis and vascularization in the engineered esophagus.Although esophageal tissue engineering potentially offers a real alternative to conventional treatments for severe esophageal disease,important barriers remain that need to be addressed. | Giorgia Totonelli Panagiotis Maghsoudlou Jonathan M Fishman Giuseppe Orlando Tahera Ansari Paul Sibbons Martin A Birchall Agostino Pierro Simon Eaton Paolo De Coppi | 2012 | World Journal of Gastroenterology2012，18，47： | 5 |
| 19 | Successful surgical management of ruptured umbilical hernias in cirrhotic patients显示文摘Acute umbilical hernia rupture in patients with hepatic cirrhosis and ascites is an unusual,but potentially lifethreatening complication,with postoperative morbidity about 70% and mortality between 60%-80% after supportive care and 6%-20% after urgent surgical repair.Management options include primary surgical repair with or without concomitant portal venous system decompression for the control of the ascites.We present a retrospective analysis of our centre's experience over the last 6 years.Our cohort consisted of 11 consecutive patients(median age:53 years,range:36-63 years) with advanced hepatic cirrhosis and refractory ascites.Appropriate patient resuscitation and optimisation with intravenous fluids,prophylactic antibiotics and local measures was instituted.One failed attempt for conservative management was followed by a successful primary repair.In all cases,with one exception,a primary repair with non-absorbable Nylon,interrupted sutures,without mesh,was performed.The perioperative complication rate was 25% and the recurrence rate 8.3%.No mortality was recorded.Median length of hospital stay was 14 d(range:4-31 d).Based on our experience,the management of ruptured umbilical hernias in patients with advanced hepatic cirrhosis and refractory ascites is feasible without the use of transjugular intrahepatic portosystemic shunt routinely in the preoperative period,provided that meticulous patient optimisation is performed. | Nikolaos A Chatzizacharias J Andrew Bradley Simon Harper Andrew Butler Asif Jah Emmanuel Huguet Raaj K Praseedom Michael Allison Paul Gibbs | 2015 | World Journal of Gastroenterology2015，21，10： | 4 |
| 20 | Imaging of liver cancer显示文摘Improvements in imaging technology allow exploitation of the dual blood supply of the liver to aid in the identif ication and characterisation of both malignant and benign liver lesions. Imaging techniques available include contrast enhanced ultrasound, computed tomography and magnetic resonance imaging. This review discusses the application of several imaging techniques in the diagnosis and staging of both hepatocellular carcinoma and cholangiocarcinoma and outlines certain characteristics of benign liver lesions. The advantages of each imaging technique are highlighted, while underscoring the potential pitfalls and limitations of each imaging modality. | Ben Ariff Claire R Lloyd Sameer Khan Mohamed Shariff Andrew V Thillainayagam Devinder S Bansi Shahid A Khan Simon D Taylor-Robinson Adrian KP Lim | 2009 | World Journal of Gastroenterology2009，15，11： | 4 |
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