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| 1 | CREMa overexpression decreases IL-2 production,induces a TH17 phenotype and accelerates autoimmunity显示文摘Dear Editor,External cytokines produced by cells of the innate immune system induce the dif-ferentiation of CD4+T cells into helper T cell subsets with distinct functions and cytokine profiles.Apart from TH1 and TH2 cells a third subset of helper T cells has been described,which is characterized by increased expression of IL-17A,IL-17F,IL-21 and IL-22(TH17 cells). | Ralph Lippe Kim Ohl Georg Varga Thomas Rauen Jose C.Crispin Yuang-Taung Juang Stefanie Kuerten Frank Tacke Marc Wolf Kirsten Roebrock Thomas Vogl Eva Verjans Nora Honke Jan Ehrchen Dirk Foell Boris Skryabin Norbert Wagner George C.Tsokos Johannes Roth Klaus Tenbrock | 2012 | Journal of Molecular Cell Biology2012，4，2： | 2 |
| 2 | Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12/15-Lipoxygenase Dependent- and AIF-Mediated Cell Death显示文摘 | Alexander Seiler Manuela Schneider Heidi F?rster Stephan Roth Eva K. Wirth Carsten Culmsee Nikolaus Plesnila Elisabeth Kremmer Olof R?dmark Wolfgang Wurst Georg W. Bornkamm Ulrich Schweizer Marcus Conrad | 2008 | Cell Metabolism2008，，3： | 2 |
| 3 | Effect of cultivation parameters on growth and pigment biosynthesis in flagellated cells of Haematococcus pluvialis显示文摘 | Christoph Hagen Kay Grünewald Marco Xyl?nder Eva Rothe | 2001 | Journal of Applied Phycology2001，，1： | 1 |
| 4 | Albuminuria induces a proinflammatory and profibrotic response in cortical collecting ducts via the 24p3 receptor显示文摘 | Eva Dizin Udo Hasler Stellor Nlandu-Khodo Marc Fila Isabelle Roth Thomas Ernandez Alain Doucet Pierre-Yves Martin Eric Feraille Sophie de Seigneux | 2013 | AJP: Renal Physiology2013，，7： | 1 |
| 5 | A discussion of the use of the sustainability index:'ecological footprint' for aquaculture production显示文摘 | Eva Roth Harald Rosenthal Peter Burbridge | 2000 | Aquat Living Resour2000，13，： | 1 |
| 6 | A Discussion of the Use of the Sustainability Index: ' Ecological Footprint' for Aquaculture Production 显示文摘 | Eva Roth Harald Rosenthal Peter Burbridge | 2000 | Aquatic Living Resources2000，，13： | 1 |
| 7 | Gene expression patterns unveil a new level of molecular heterogeneity in colorectal cancer显示文摘 | Eva Budinska Vlad Popovici Sabine Tejpar Giovanni D’Ario Nicolas Lapique Katarzyna Otylia Sikora Antonio Fabio Di Narzo Pu Yan John Graeme Hodgson Scott Weinrich Fred Bosman Arnaud Roth Mauro Delorenzi | 2013 | J. Pathol2013，，1： | 1 |
| 8 | A discussion of the use of the sustainability index:'ecological footprint ' for aquaculture production显示文摘 | Eva Roth | 2000 | Living Resource2000，，13： | 1 |
| 9 | Gene expression patterns unveil a new level of molecular heterogeneity in colorectal cancer显示文摘 | Eva Budinska Vlad Popovici Sabine Tejpar Giovanni D’Ario Nicolas Lapique Katarzyna Otylia Sikora Antonio Fabio Di Narzo Pu Yan John Graeme Hodgson Scott Weinrich Fred Bosman Arnaud Roth Mauro Delorenzi | 2013 | J Pathol2013，，1： | 1 |
| 10 | Effect of cultivation parameters on growth and pigment biosynthesis in flagellated cells of Haematococcus pluvialis显示文摘 | Christoph Hagen Kay Grünewald Marco Xyl?nder Eva Rothe | 2001 | Journal of Applied Phycology2001，，1： | 1 |
| 11 | CD52 expression in peripheral T-cell lymphomas determined by combined immunophenotyping using tumor cell specific T-cell receptor antibodies显示文摘 | Eva Geissinger Irina Bonzheim Sabine Roth | | 0，，06： | 1 |
| 12 | Effect of cultivation parameters on growth and pigment biosynthesis in flagellated cells of Haematococcus pluvialis显示文摘 | Christoph Hagen Kay Grünewald Marco Xyl?nder Eva Rothe | 2001 | Journal of Applied Phycology2001，，1： | 1 |
| 13 | Loss of LAT1 sex-dependently delays recovery after caerulein-induced acute pancreatitis显示文摘BACKGROUND The expression of amino acid transporters is known to vary during acute pancreatitis(AP)except for LAT1(slc7a5),the expression of which remains stable.LAT1 supports cell growth by importing leucine and thereby stimulates mammalian target of rapamycin(mTOR)activity,a phenomenon often observed in cancer cells.The mechanisms by which LAT1 influences physiological and pathophysiological processes and affects disease progression in the pancreas are not yet known.AIM To evaluate the role of LAT1 in the development of and recovery from AP.METHODS AP was induced with caerulein(cae)injections in female and male mice expressing LAT1 or after its knockout(LAT1 Cre/LoxP).The development of the initial AP injury and its recovery were followed for seven days after cae injections by daily measuring body weight,assessing microscopical tissue architecture,mRNA and protein expression,protein synthesis,and enzyme activity levels,as well as by testing the recruitment of immune cells by FACS and ELISA.RESULTS The initial injury,evaluated by measurements of plasma amylase,lipase,and trypsin activity,as well as the gene expression of dedifferentiation markers,did not differ between the groups.However,early metabolic adaptations that support regeneration at later stages were blunted in LAT1 knockout mice.Especially in females,we observed less mTOR reactivation and dysfunctional autophagy.The later regeneration phase was clearly delayed in female LAT1 knockout mice,which did not regain normal expression of the pancreas-specific differentiation markers recombining binding protein suppressor of hairless-like protein(rbpjl)and basic helixloop-helix family member A15(mist1).Amylase mRNA and protein levels remained lower,and,strikingly,female LAT1 knockout mice presented signs of fibrosis lasting until day seven.In contrast,pancreas morphology had returned to normal in wild-type littermates.CONCLUSION LAT1 supports the regeneration of acinar cells after AP.Female mice lacking LAT1 exhibited more pronounced alterations than male mice,indicating a sexual dimorphism of amino acid metabolism. | Cristina M Hagen Eva Roth Theresia Reding Graf François Verrey Rolf Graf Anurag Gupta Giovanni Pellegrini Nadège Poncet Simone Mafalda Rodrigues Camargo | 2022 | World Journal of Gastroenterology2022，28，10： | 0 |
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