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| 1 | 帕博利珠单抗单用或与放疗联用治疗转移性非小细胞肺癌:两个随机试验的汇总分析显示文摘背景放疗可以提高整个机体对免疫治疗的应答。在Ⅱ期PEMBRO-RT研究和Ⅰ/Ⅱ期MDACC研究中,患有转移性非小细胞肺癌(NSCLC)的患者被随机分配入组,接受免疫治疗(帕博利珠单抗)+放疗联合疗法,或免疫治疗单一疗法。当上述2个研究单独分析时,联合疗法组显示出潜在获益。由于每个研究的样本量较小,缓解率和结局并未显示出统计学意义,然而却有显著的临床获益。因此,本研究进行汇总分析,来判断放疗是否会改善转移性NSCLC患者的免疫治疗应答。方法PEMBRO-RT和MDACC研究纳入标准:患者年龄≥18岁,患有转移性NSCLC,且有≥1处未经放疗照射的病灶,以便进行射野外应答监测。PEMBRO-RT研究纳入曾接受过化疗患者,MDACC研究纳入曾接受过治疗或新诊断患者。2个研究中的患者均未接受过免疫治疗。在PEMBRO-RT研究中患者被等比例随机分配入组,并根据吸烟状态进行分层(分为<10年组和≥10年组)。MDACC研究的患者根据放疗计划可行性被等比例随机分配入2个受试组。由于联合治疗组的干预本质,每个研究中的放疗均不适用盲法。在2个研究中,不论是否进行放疗,均静脉滴入帕博利珠单抗(每3周200 mg)。在PEMBRO-RT研究中,在放疗(24 Gy 3次分割照射)结束后1周给予第1剂帕博利珠单抗。在MDACC研究中,在第1次放疗(50 Gy 4次分割照射或45 Gy 15次分割照射)同时给予帕博利珠单抗。仅检测未经照射病灶的应答。本研究的终点为最佳射野外(远隔)应答率(ARR)、最佳射野外疾病控制率(ACR)、12周时ARR、12周时ACR、无进展生存期(PFS)和总生存期(OS)。2个研究的意向治疗(ITT)人群均纳入分析。PEMBRO-RT研究(NCT02492568)和MDACC研究(NCT02444741)均在ClinicalTrials.gov上注册。发现纳入148例患者,76例接受帕博利珠单抗治疗,72例接受帕博利珠单抗+放疗治疗。所有患者随访时间中位数为33个月[四分位距(IQR):32.4~33.6]。148例患者中124例(84%)组织学特征为非鳞癌,111例(75%)患者曾经接受过化疗。组间没有基线特征差异,包括PD-L1表达状态和转移灶体积。最常见的照射部位为肺转移灶(39%,28/72)、胸腔内淋巴结(21%,15/72)和非原发灶(17%,12/72)。帕博利珠单抗组和联合治疗组的最佳ARR分别为19.7%(15/76)和41.7%(30/72),OR=2.96,95%CI:1.42~6.20,P=0.0039;最佳ACR分别为43.4%(33/76)和65.3%(47/72),OR=2.51,95%CI:1.28~4.91,P=0.0071;PFS中位数分别为4.4(IQR:2.9~5.9)和9.0个月(IQR:6.8~11.2),HR=0.67,95%CI:0.45~0.99,P=0.045;OS中位数分别为8.7(IQR:6.4~11.0)和19.2个月(IQR:14.6~23.8),OR=0.67,95%CI:0.54~0.84,P=0.0004。在汇总分析中没有发现新的安全问题。解读帕博利珠单抗免疫疗法+放疗显著提高转移性NSCLC患者的应答和改善治疗结局。这些结果需要在三期临床试验中进行验证。 | 陈大卫(翻译) 于金明(校对) Willemijn S M E Theelen Vivek Verma Brian P Hobbs Heike M U Peulen Joachim G J V Aerts Idris Bahce Anna Larissa N Niemeijer Joe Y Chang Patricia M de Groot Quynh-Nhu Nguyen Nathan I Comeaux George R Simon Ferdinandos Skoulidis Steven H Lin Kewen He Roshal Patel John Heymach Paul Baas James W Welsh | 2021 | 中华肿瘤防治杂志2021，28，24： | 49 |
| 2 | Incidence and mortality of primary liver cancer in England and Wales: Changing patterns and ethnic variations显示文摘AIM: To explore recent trends, modes of diagnosis, ethnic distribution and the mortality to incidence ratio of primary liver cancer by subtypes in England and Wales. METHODS: We obtained incidence(1979-2008) and mortality(1968-2008) data for primary liver cancer for England and Wales and calculated age-standardised incidence and mortality rates. Trends in age-standardised mortality(ASMR) and incidence(ASIR) rates and basis of diagnosis of primary liver cancer and subcategories: hepatocellular carcinoma, intrahepatic bile duct and unspecified liver tumours, were analysed over the study period. Changes in guidelines for the diagnosis of primary liver cancer(PLC) may impact changing trends in the rates that may be obtained. We thus explored changes in the mode of diagnosis as reported to cancer registries. Furthermore, we examined the distribution of these tumours by ethnicity. Most of the statistical manipulations of these data was carried out in Microsoft excel(Seattle, Washington, United Sttaes). Additional epidemiological statistics were done in Epi Info software(Atlanta, GA, United Sttaes). To define patterns of change over time, we evaluated trends in ASMR and ASIR of PLC and intrahepatic bile duct carcinoma(IHBD) using a least squares regression line fitted to the natural logarithm of the mortality and incidence rates. We estimated the patterns of survival over subsequent 5 and 10 years using complement of mortality to incidence ratio(1-MIR). RESULTS: Age-standardised mortality rate of primary liver cancer increased in both sexes: from 2.56 and 1.29/100000 in 1968 to 5.10 and 2.63/100000 in 2008 for men and women respectively. The use of histology for diagnostic confirmation of primary liver cancer increased from 35.7% of registered cases in 1993 to plateau at about 50% during 2005 to 2008. Reliance on cytology as a basis of diagnosis has maintained a downward trend throughout the study period. Although approximately 30% of the PLC registrations had information on ethnicity, there was a relatively higher registration of the major tumour subtypes in patients whose ethnic backgrounds were from high incident regions of the world. Survival from PLC is estimated to get poorer in 10 years(2018) relative to 2008, particularly as a result of IHBD. CONCLUSION: Incidence and mortality of PLC, and particularly IHBD, have continued to rise in England and Wales. Changes in the modes of diagnosis may be contributing. | Nimzing G Ladep Shahid A Khan Mary ME Crossey Andrew V Thillainayagam Simon D Taylor-Robinson Mireille B Toledano | 2014 | World Journal of Gastroenterology2014，20，6： | 15 |
| 3 | Heart Disease and Stroke Statistics—2011 Update: A Report From the American Heart Association显示文摘 | Véronique L. Roger Alan S. Go Donald M. Lloyd-Jones Robert J. Adams Jarett D. Berry Todd M. Brown Mercedes R. Carnethon Shifan Dai Giovanni de Simone Earl S. Ford Caroline S. Fox Heather J. Fullerton Cathleen Gillespie Kurt J. Greenlund Susan M. Hailpern | 2011 | Circulation2011，，4： | 4 |
| 4 | Imaging of liver cancer显示文摘Improvements in imaging technology allow exploitation of the dual blood supply of the liver to aid in the identif ication and characterisation of both malignant and benign liver lesions. Imaging techniques available include contrast enhanced ultrasound, computed tomography and magnetic resonance imaging. This review discusses the application of several imaging techniques in the diagnosis and staging of both hepatocellular carcinoma and cholangiocarcinoma and outlines certain characteristics of benign liver lesions. The advantages of each imaging technique are highlighted, while underscoring the potential pitfalls and limitations of each imaging modality. | Ben Ariff Claire R Lloyd Sameer Khan Mohamed Shariff Andrew V Thillainayagam Devinder S Bansi Shahid A Khan Simon D Taylor-Robinson Adrian KP Lim | 2009 | World Journal of Gastroenterology2009，15，11： | 4 |
| 5 | 人乳头瘤病毒与鼻咽癌显示文摘目前,关于人乳头瘤病毒(HPV)与鼻咽癌(NPC)相关性的研究报道较少。该文作者通过检索国家癌症数据库(NCDB)的资料,对2004-2013年间的数据进行回顾分析,采用逻辑回归方法检测HPV阳性患者的相关因素,Kaplan-Meier法评估HPV+/-患者与总生存率(OS)的相关性。结果 :纳入研究的956例患者中,32%HPV+,68%HPV-。 | Verma V Simone CB 2nd Lin C 张凌 | 2018 | 中国口腔颌面外科杂志2018，16，2： | 2 |
| 6 | Global service supply chains: An empirical study of current practices and challenges of a cruise line corporation显示文摘 | Simon Véronneau Jacques Roy | 2008 | Tourism Management2008，，1： | 2 |
| 7 | TRUST VIOLATION IN ELECTRONIC COMMERCE: CUSTOMER CONCERNS AND REACTIONS显示文摘 | Goles Tim Lee Simon Rao Srinivasan V Warren John | 2009 | The Journal of Computer Information Systems2009，，4： | 2 |
| 8 | Activation and early parthenogenesis of bovine oocytes treated with ethanol and strontium显示文摘 | Simone C M Claudia L V L Joaquim M G | 2004 | Animal Reproduction Science2004，81，： | 1 |
| 9 | Early on-treatment prediction of response to peginterferon alfa-2a for HBeAg-negative chronic hepatitisB using HBsAg and HBV DNA levels 显示文摘 | Rijckborst V Hansen BE Cakaloglu Y Ferenci P Tabak F Akdogan M Simon K Akarca US Flisiak R Verhey E Van Vuuren AJ Boucher CA ter Borg MJ Janssen HL | 2010 | Hepatology2010，52，2： | 1 |
| 10 | P0tential of low- molecular chitosan as a DNAdelivery system : biocompatility, bo- dydistribution and ability to complex and protect DNA显示文摘 | Simon C W R Hanno V J K Ruth D | 1999 | Inter- national Journal of Pharrnacentics1999，178，： | 1 |
| 11 | LFB1 and LFB3 homeoproteins are sequentially expressed during kidney development显示文摘 | Lazzaro D De Simone V De Magistris | 1999 | Development1999，114，： | 1 |
| 12 | Decreased rhythmic GABA ergic septal activity and memory-associated oscillations after hippocampal amyloid-βpathologyin the rat显示文摘 | VILLETTE V POINDESSOUS-JAZAT F SIMON A | 2010 | J Neurosci2010，30，10： | 1 |
| 13 | Efficiency of the coagulation/ flocculation method for the treatment of dye bath effluent 显示文摘 | Golab V Vinder A Simonic M | 2005 | Dyes and Pigments2005，67，2： | 1 |
| 14 | A study of the effect of acetylation and propionylation surface treatments on natural fibres 显示文摘 | Tserki V Zafeiropoulos N E Simon F | 2005 | Composites Part A: Applied Science and Manufacturing2005，36，8： | 1 |
| 15 | The emerging role of the CTLA-4 gene in autoimmune endoerinopathics 显示文摘 | Biiay V Simon P | 2004 | Eur J Endoerinol2004，150，5： | 1 |
| 16 | VOC photodegradation at the gas-solid interface of a TiO2 photo-catalyst part I :1 - butanol and 1 - butylanmine 显示文摘 | Benoit Marqui6 F Wilkenh6ner U Simon V | 2000 | Journal of Photochemistry and Photobiology A: Chemistry2000，132，3： | 1 |
| 17 | Ambulatory blood pressure and metabolic abnormalities in hypertensive subjects with inappropriately high left ventricular mass 显示文摘 | Palmieri V de Simone G Roman MJ | 1999 | Hypertension1999，34，5： | 1 |
| 18 | Influence of manufacturing tolerances on the electro- motive force in permanent-magnet motors 显示文摘 | SIMON - SEMPERE V BURGOS - PAYAN M CERQUIDES - BUENO J R | 2013 | IEEE Transactions on Magnetics2013，49，11： | 1 |
| 19 | Reprogramming of the ERR c and ERa target gene landscapetriggers tamoxifen resistance in breast cancer显示文摘 | Thewes V Simon R Schroeter P | 2015 | Cancer Res2015，75，4： | 1 |
| 20 | Intrinsic host restrictions to HIV-1 and mechanisms of viral escape 显示文摘 | Simon V Bloch N Landau N R | 2015 | Nat Immunol2015，16，6： | 1 |
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