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| 1 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 2 | Exogenous cytokinin application to Actinidia chinensis var. deliciosa ‘Hayward’ fruit promotes fruit expansion through water uptake显示文摘Exogenous application of a cytokinin-like compound forchlorfenuron(CPPU)can promote fruit growth,although often at the expense of dry matter(DM),an important indicator of fruit quality.Actinidia chinensis var.deliciosa‘Hayward’fruit are very responsive to CPPU treatments,but the mechanism underlying the significant fruit weight increase and associated decrease in DM is unclear.In this study,we hypothesised that CPPU-enhanced growth increases fruit carbohydrate demand,but limited carbohydrate supply resulted in decreased fruit DM.During fruit development,CPPU effects on physical parameters,metabolites,osmotic pressure and transcriptional changes were assessed under conditions of both standard and a high carbohydrate supply.We showed that CPPU increased fruit fresh weight but the dramatic DM decrease was not carbohydrate limited.Enhanced glucose and fructose concentrations contributed to an increase in soluble carbohydrate osmotic pressure,which was correlated with increased water accumulation in CPPU-treated fruit and up-regulation of water channel aquaporin gene PIP2.4 at 49 days after anthesis.Transcipt analysis suggested that the molecular mechanism contributing to increased glucose and fructose concentrations was altered by carbohydrate supply.At standard carbohydrate supply,the early glucose increase in CPPU fruit was associated with reduced starch synthesis and increased starch degradation.When carbohydrate supply was high,the early glucose increase in CPPU fruit was associated with a general decrease in starch synthesis but up-regulation of vacuolar invertase and fructokinase genes.We conclude that CPPU affected fruit expansion by increasing the osmotically-driven water uptake and its effect was not carbohydrate supply-limited. | Simona Nardozza Helen L Boldingh Mark W Wohlers Andrew P Gleave Zhiwei Luo Guglielmo Costa Elspeth A MacRae Michael J Clearwater Annette C Richardson | 2017 | Horticulture Research2017，4，1： | 2 |
| 3 | Brassica juncea can improve selenite and selenate abatement in selenium contaminated soil through the aid of its rhizospheric bacterial population显示文摘 | Simona D G Silvia L Fernando M | 2006 | Plant Soil2006，285，： | 1 |
| 4 | Valsartan benefits left ventricular structure and function in heart failure: Val-HeFT echocardiographic study显示文摘 | Maylene Wong Lidia Staszewsky Roberto Latini Simona Barlera Alberto Volpi Yann-Tong Chiang Raymond L Benza Sidney O Gottlieb Thomas D Kleemann Franco Rosconi Pieter M Vandervoort Jay N Cohn | 2002 | Journal of the American College of Cardiology2002，，： | 1 |
| 5 | Prediction of fracture callus mechanical properties using micro-CT images and voxel-based finite element analysis显示文摘 | Shefelbinea SJ Simona U Claes L | 2005 | Bone2005，369，3： | 1 |
| 6 | Correlation of the expression of acrB and the regulatory genes marA,soxS and ramA with antimicrobial resistance in clinical isolates of Klebsiella pneumoniae endemic to New York City显示文摘 | Simona B David L Avrille G | 2009 | J Antimicrob Chemother2009，64，2： | 1 |
| 7 | HPLC fingerprint of bioactive compounds and antioxidant activities of Viscum album from differ-ent host trees显示文摘 | SIMONA I V DUMITRIA RA LOREDANA L | 2011 | Not Bot Hort Agrobot Cluj2011，39，1： | 1 |
| 8 | Effects of Gene Deletion of the Tissue Inhibitor of the Matrix Metalloproteinase-type 1 (TIMP-1) on Left Ventricular Geometry and Function in Mice显示文摘 | Lisa Roten Shintaro Nemoto Janet Simsic Mytsi L Coker Vijay Rao Simona Baicu Gilberto Defreyte Paul J Soloway Michael R Zile Francis G Spinale | 2000 | Journal of Molecular and Cellular Cardiology2000，，1： | 1 |
| 9 | Properties and flocculation efficiency of highly cationized starch derivatives 显示文摘 | Dirk-Oliver K Clandia L Simona S | 2006 | Starch/Starke2006，58，： | 1 |
| 10 | Artichoke juice improves endothelial function in hyperlipemia显示文摘 | Graziana L Simona M Rita L | 2004 | Life Sci2004，76，： | 1 |
| 11 | Comparsion of different methods for the detoxification of lignocellulose hydrolyzates of spruce显示文摘 | Simona L Anders R Nils-Olof N | 1999 | Appl Biochem Biotechnol1999，7779，： | 1 |
| 12 | A study of the effect of setup errors and organ motion on prostate cancer with IMRT显示文摘 | Valeria L Biance S Simona M | 2006 | Int J Radiat Oncol Biol Phys2006，65，： | 1 |
| 13 | Comparison of different methods for the detoxification of lignocellulose hydrolyzates of spruce显示文摘 | ANDERS R NILS-OLOF N | 1999 | Applied Biochemistry and Biotechnology1999，7779，： | 1 |
| 14 | Brassiea juneea can improve selenite and selenate abatement in selenium contaminated soils through the aid of its rhizospheric bacterial population 显示文摘 | Simona D G Silvia L Femando M | 2006 | Plant Soil2006，285，： | 1 |
| 15 | Clinostatic hypertension and orthostatic hypotension 显示文摘 | ALFONSO L SIMONA S | 2010 | Clin Cardio|2010，33，6： | 1 |
| 16 | Valsartan for prevention of recur- rent atrial fibrillation显示文摘 | Marcello D Roberto L Simona B | 2009 | N Engl J Med2009，360，16： | 1 |
| 17 | A Pilot Study of Distributed Knowledge Management and Clinical Decision Support in the Cloud 显示文摘 | Dixon BE Simonaitis L Goldberg HS | 2013 | Artificaal Intelligence in Medicine2013，59，1： | 1 |
| 18 | Pro-angiogenetic properties of human myeloma cells: production of angiopoietin-1 and its potential relationship with my elomainduced angiogenesis 显示文摘 | NICOLA G SIMONA C MIRCA L | 2003 | Blood2003，，： | 1 |
| 19 | Molecular evolution of the vertebrate immune system显示文摘 | Simona Bartl David Baltimore Irving L Weissman | 1994 | Proceedings of the National Academy of Sciences of the United States of America1994，91，10： | 1 |
| 20 | Molecular Evolution of the Vertebrate Immune System 显示文摘 | SIMONA B DAVID B IRVING L W | 1994 | PNAS1994，91，10： | 1 |
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