|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Peginterferon Alfa-2a Plus Ribavirin for the Treatment of Dual Chronic Infection With Hepatitis B and C Viruses显示文摘 | Chun–Jen Liu Wan–Long Chuang Chuan–Mo Lee Ming–Lung Yu Sheng–Nan Lu Shun–Sheng Wu Li–Ying Liao Chi–Ling Chen Hsing–Tao Kuo You–Chen Chao Shui–Yi Tung Sien–Sing Yang Jia–Horng Kao Chen–Hua Liu Wei–Wen Su Chih–Lin Lin Yung–Ming Jeng Pei–Jer Chen Ding–Shinn | 2009 | Gastroenterology2009，，2： | 3 |
| 2 | Intensity and wavelength-division multiplexing FBG sensor system using a tunable multiport fiber ring laser显示文摘 | Peng peng-chun Lin Jia-he Chi Sien | 2004 | IEEE Photonics Technology Letters2004，16，1： | 1 |
| 3 | Characterization of liquefaction resistance in gravelly soil : large hammer penetration test and shear wave velocity approach 显示文摘 | Lin Ping Sien Chang Chi Wen Chang Wen Jong | 2004 | Soil Dynamics and Earthquake Engineering2004，24，： | 1 |
| 4 | Surface decoration of development-inspired synthetic N-cadherin motif via Ac-BP promotes osseointegration of metal implants显示文摘Research works on the synergistic effect of surface modified bioactive molecules and bone metal implants have been highlighted.N-cadherin is regarded as a key factor in directing cell-cell interactions during the mesenchymal condensation preceding the osteogenesis in the musculoskeletal system.In this study,the N-cadherin mimetic peptide(Cad)was biofunctionalized on the titanium metal surface via the acryloyl bisphosphonate(Ac-BP).To learn the synergistic effect of N-cadherin mimetic peptide,when tethered with titanium substrates,on promoting osteogenic differentiation of the seeded human mesenchymal stem cells(hMSCs)and the osseointegration at the bone-implant interfaces.Results show that the conjugation of N-cadherin mimetic peptide with Ac-BP promoted the osteogenic gene markers expression in the hMSCs.The biofunctionalized biomaterial surfaces promote the expression of the Wnt/β-catenin downstream axis in the attached hMSCs,and then enhance the in-situ bone formation and osseointegration at the bone-implant interfaces.We conclude that this N-cadherin mimetic peptide tethered on Ti surface promote osteogenic differentiation of hMSCs and osseointegration of biomaterial implants in vitro and in vivo.These findings demonstrate the importance of the development-inspired surface bioactivation of metal implants and shed light on the possible cellular mechanisms of the enhanced osseointegration. | Meiling Zhu Kunyu Zhang Lu Feng Sien Lin Qi Pan Liming Bian Gang Li | 2021 | Bioactive Materials2021，6，5： | 1 |
| 5 | Piperine activates human pregnane X receptor to induce the expression of cytochrome P450 3A4 and multidrug resistance protein 1显示文摘 | Yue-Ming Wang Wenwei Lin Sergio C. Chai Jing Wu Su Sien Ong Erin G. Schuetz Taosheng Chen | 2013 | Toxicology and Applied Pharmacology2013，，： | 1 |
| 6 | Regression model for evaluating liquefaction potential by discriminant analysis of SPT N value 显示文摘 | Sheng- Yao La Ping- Sien Lin | 2005 | J Can Geotech2005，42，3： | 1 |
| 7 | Enhancing cartilage repair with optimized supramolecular hydrogel-based scaffold and pulsed electromagnetic field显示文摘Functional tissue engineering strategies provide innovative approach for the repair and regeneration of damaged cartilage.Hydrogel is widely used because it could provide rapid defect filling and proper structure support,and is biocompatible for cell aggregation and matrix deposition.Efforts have been made to seek suitable scaffolds for cartilage tissue engineering.Here Alg-DA/Ac-β-CD/gelatin hydrogel was designed with the features of physical and chemical multiple crosslinking and self-healing properties.Gelation time,swelling ratio,biodegradability and biocompatibility of the hydrogels were systematically characterized,and the injectable self-healing adhesive hydrogel were demonstrated to exhibit ideal properties for cartilage repair.Furthermore,the new hydrogel design introduces a pre-gel state before photo-crosslinking,where increased viscosity and decreased fluidity allow the gel to remain in a semi-solid condition.This granted multiple administration routes to the hydrogels,which brings hydrogels the ability to adapt to complex clinical situations.Pulsed electromagnetic fields(PEMF)have been recognized as a promising solution to various health problems owing to their noninvasive properties and therapeutic potentials.PEMF treatment offers a better clinical outcome with fewer,if any,side effects,and wildly used in musculoskeletal tissue repair.Thereby we propose PEMF as an effective biophysical stimulation to be 4th key element in cartilage tissue engineering.In this study,the as-prepared Alg-DA/Ac-β-CD/gelatin hydrogels were utilized in the rat osteochondral defect model,and the potential application of PEMF in cartilage tissue engineering were investigated.PEMF treatment were proven to enhance the quality of engineered chondrogenic constructs in vitro,and facilitate chondrogenesis and cartilage repair in vivo.All of the results suggested that with the injectable self-healing adhesive hydrogel and PEMF treatment,this newly proposed tissue engineering strategy revealed superior clinical potential for cartilage defect treatment. | Yucong Li Linlong Li Ye Li Lu Feng Bin Wang Ming Wang Haixing Wang Meiling Zhu Yongkang Yang Erik IWaldorff Nianli Zhang Ingmar Viohl Sien Lin Liming Bian Wayne Yuk-Wai Lee Gang Li | 2023 | Bioactive Materials2023，，4： | 1 |
| 8 | Construction of Armored RNA Containing Long-Size Chimeric RNA by Increasing the Number and Affinity of the Pac Site in Exogenous RNA and Sequence Coding Coat Protein of the MS2 Bacteriophage显示文摘 | Wei Baojun Wei Yuxiang Zhang Kuo Yang Changmei Wang Jing Xu Ruihuan Zhan Sien Lin Guigao Wang Wei Liu Min Wang Lunan Zhang Rui Li Jinming | 2008 | Intervirology2008，，2： | 1 |
| 9 | Hallmarks of peripheral nerve function in bone regeneration显示文摘Skeletal tissue is highly innervated.Although different types of nerves have been recently identified in the bone,the crosstalk between bone and nerves remains unclear.In this review,we outline the role of the peripheral nervous system(PNS)in bone regeneration following injury.We first introduce the conserved role of nerves in tissue regeneration in species ranging from amphibians to mammals.We then present the distribution of the PNS in the skeletal system under physiological conditions,fractures,or regeneration.Furthermore,we summarize the ways in which the PNS communicates with bone-lineage cells,the vasculature,and immune cells in the bone microenvironment.Based on this comprehensive and timely review,we conclude that the PNS regulates bone regeneration through neuropeptides or neurotransmitters and cells in the peripheral nerves.An in-depth understanding of the roles of peripheral nerves in bone regeneration will inform the development of new strategies based on bone-nerve crosstalk in promoting bone repair and regeneration. | Ranyang Tao Bobin Mi Yiqiang Hu Sien Lin Yuan Xiong Xuan Lu Adriana C.Panayi Gang Li Guohui Liu | 2023 | Bone Research2023，11，1： | 1 |
| 10 | Nutritional status in non-alcoholic subclinical porto-systemic encephalopathy显示文摘NTRODUCTIONProteincaloriemalnutritioniscommoninpatientswithcirrhosis[1-4].Manyfactors,includingreducednutrientingestion,mala... | YANG Sien Sing 1, WU Chi Hwa 1, CHEN Li Lin 2, MO San Chu 2 and CHEN Der Fang 2 | 1998 | World Journal of Gastroenterology1998，4，5： | 1 |
| 11 | Logistic regression model for evaluation soil liquefaction probability using CPT data显示文摘 | Sheng- Yao Lai Wen- Jong Chang Ping -Sien Lin | 2006 | Journal of Geotechuical and Geoenvironment Engineering2006，132，6： | 1 |
| 12 | A bioactive compliant vascular graft modulates macrophage polarization and maintains patency with robust vascular remodeling显示文摘Conventional synthetic vascular grafts are associated with significant failure rates due to their mismatched mechanical properties with the native vessel and poor regenerative potential.Though different tissue engineering approaches have been used to improve the biocompatibility of synthetic vascular grafts,it is still crucial to develop a new generation of synthetic grafts that can match the dynamics of native vessel and direct the host response to achieve robust vascular regeneration.The size of pores within implanted biomaterials has shown significant effects on macrophage polarization,which has been further confirmed as necessary for efficient vascular formation and remodeling.Here,we developed biodegradable,autoclavable synthetic vascular grafts from a new polyurethane elastomer and tailored the grafts’interconnected pore sizes to promote macrophage populations with a pro-regenerative phenotype and improve vascular regeneration and patency rate.The synthetic vascular grafts showed similar mechanical properties to native blood vessels,encouraged macrophage populations with varying M2 to M1 phenotypic expression,and maintained patency and vascular regeneration in a one-month rat carotid interposition model and in a four-month rat aortic interposition model.This innovative bioactive synthetic vascular graft holds promise to treat clinical vascular diseases. | Alexander Stahl Dake Hao Janos Barrera Dominic Henn Sien Lin Seyedsina Moeinzadeh Sungwoo Kim William Maloney Geoffrey Gurtner Aijun Wang Yunzhi Peter Yang | 2023 | Bioactive Materials2023，，1： | 0 |
| 13 | Histone demethylase Kdm5c regulates osteogenesis and bone formation via PI3K/Akt/HIF1α and Wnt/β-catenin signaling pathways显示文摘Fractures have an extraordinarily negative impact on individuals'quality of life and functional status.Nonunion or disability of fracture is a major health issue with important clinical,social,and economic implications.1 Mesenchymal stem cells(MSCs)play an indispensable role in the initiation of the fracture repair process including the formation of a callus which is replaced by new bone.The use of MSCs in the treatment of fractures is very attractive as they can reduce the time of healing and occurrence of nonunion. | Ying Li Lingli Ding Yage Zhang Bingyu Zhou Gene Chi Wai Man Min Wang Jinglan Li Yamei Liu Weiping Lin Haibin Wang Sien Lin Liangliang Xu | 2024 | Genes & Diseases2024，11，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员