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| 1 | Prognostic Significance of Tumor-infiltrating CD8^+ or CD3^+ T Lymphocytes and Interleukin-2 Expression in Radically Resected Non-small Cell Lung Cancer显示文摘 | Chuntao Tian Shixin Lu Qingxia Fan Weijie Zhang Shunchang Jiao Xiao Zhao Zhiyong Wu Liang Sun Liuxing Wang | 2015 | Chinese Medical Journal2015，，1： | 11 |
| 2 | An isoflavone derivative potently inhibits the angiogenesis and progression of triple-negative breast cancer by targeting the MTA2/SerRS/VEGFA pathway显示文摘Objective:Angiogenesis plays a vital role in tumor growth and metastasis.Here,we aimed to find novel efficient antiangiogenic molecules targeting vascular endothelial growth factor A(VEGFA)at the transcriptional level to treat triple-negative breast cancer(TNBC).Methods:We used a cell-based seryl tRNA synthetase(SerRS)promoter-driven dual-luciferase reporter system to screen an in-house library of 384 naturally occurring small molecules and their derivatives to find candidate molecules that could upregulate the expression of SerRS,a potent transcriptional repressor of VEGFA.The levels of SerRS and VEGFA were examined by quantitative RT-PCR(qRT-PCR),western blotting,and/or ELISAs in TNBC cells after candidate molecule administration.Zebrafish,the Matrigel plug angiogenesis assay in mice,the TNBC allograft,and xenograft mouse models were used to evaluate thein vivoanti-angiogenic and anti-cancer activities.Furthermore,the potential direct targets of the candidates were identified by proteomics and biochemical studies.Results:We found the most active compound was 3-(4-methoxyphenyl)quinolin-4(1H)-one(MEQ),an isoflavone derivative.In TNBC cells,MEQ treatment resulted in increased SerRS mRNA(P<0.001)and protein levels and downregulated VEGFA production.Both the vascular development of zebrafish and Matrigel plug angiogenesis in mice were inhibited by MEQ.MEQ also suppressed the angiogenesis in TNBC allografts and xenografts in mice,resulting in inhibited tumor growth and prolonged overall survival(P<0.05).Finally,we found that MEQ regulated SerRS transcription by interacting with MTA2(Metastasis Associated 1 Family Member 2).Conclusions:Our findings suggested that the MTA2/SerRS/VEGFA axis is a drug-treatable anti-angiogenic target,and MEQ is a promising anti-tumor molecule that merits further investigation for clinical applications. | Xiaotong Zhang Gengyi Zou Xiyang Li Lun Wang Tianyu Xie Jin Zhao Longlong Wang Shunchang Jiao Rong Xiang Haoyu Ye Yi Shi | 2020 | Cancer Biology & Medicine2020，17，3： | 6 |
| 3 | Antigenically dominant proteins within the human liver mitochondrial proteome identified by monoclonal antibodies显示文摘Analysis of the mitochondrial proteome would provide valuable insight into the function of this important organelle, which plays key roles in energy metabolism, apoptosis, free radical production, thermogenesis, and calcium signaling. It could also increase our understanding about the mechanisms that promote mitochondrial disease. To identify proteins that are antigenically dominant in human liver mitochondria, we generated >240 hybridoma cell lines from native mitochondrial proteins after cell fusion, screening, and cloning. Antibodies that recognized mitochondrial proteins were identified by screening human liver cDNA expression libraries. In this study, we identified 6 major antigens that were recognized by at least 2 different monoclonal antibodies (mAbs). The proteins that were antigenically dominant were: acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase), aldehyde dehydrogenase 1 family member A1, carbamoyl phosphate synthetase 1, dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex), enoyl coenzyme A hydratase 1, and hydroxysteroid (11-beta) dehydrogenase 1. We also determined the subcellular localizations of these enzymes within the mitochondria using immunohistocytochemistry. We believe that these well-characterized antibodies will provide a valuable resource for the Human Liver Proteome Project (HLPP), and will make studies aimed at investigating liver mitochondrial function far easier to perform in future. Our results provide strong evidence that, (i) depletion of dominant proteins from liver mitochondrial samples is possible and, (ii) the approaches adopted in this study can be used to explore or validate protein-protein interactions in this important organelle. | JU YanFang YANG JinJu LIU Rong LIU XiaoLan DU XueMei LIU Li CHEN ZhiCheng CHI Jun LIU ShuEr GAO Yuan GAO JianEn JIAO ShunChang HE FuChu SUN QiHong | 2011 | Science China(Life Sciences)2011，54，1： | 6 |
| 4 | Bisphenol A in combination with TNF-a selectively induces Th2 cell-promoting dendritic cells in vitro with an estrogen-like activity显示文摘Bisphenol A(BPA)is a monomer used in manufacturing a wide range of chemical products,including epoxy resins and polycarbonate.BPA,an important endocrine disrupting chemical that exerts estrogen-like activities,is detectable at nanomolar levels in human serum worldwide.The pregnancy associated doses of 17b-estradiol(E2)plus tumor-necrosis factor-a(TNF-a)induce distorted maturation of human dendritic cells(DCs)that result in an increased capacity to induce T helper(Th)2 responses.The current study demonstrated that the presence of BPA during DC maturation influences the function of human DCs,thereby polarizing the subsequent Th response.In the presence of TNF-a,BPA treatment enhanced the expression of CC chemokine ligand 1(CCL1)in DCs.In addition,DCs exposed to BPA/TNF-a produced higher levels of IL-10 relative to those of IL-12p70 on CD40 ligation,and preferentially induced Th2 deviation.BPA exerts the same effect with E2 at the same dose(0.01–0.1 mM)with regard to DC-mediated Th2 polarization.These findings imply that DCs exposed to BPA will provide one of the initial signals driving the development and perpetuation of Th2-dominated immune response in allergic reactions. | Hongchuan Guo Tianyi Liu Yasushi Uemura Shunchang Jiao Deqing Wang Zilin Lin Yayoi Narita Motoharu Suzuki Narumi Hirosawa Yasuko Ichihara Osamu Ishihara Hirosato Kikuchi Yasushi Sakamoto Satoru Senju Qiuhang Zhang Feng Ling | 2010 | Cellular & Molecular Immunology2010，7，3： | 6 |
| 5 | Phase Ⅲ Clinical Trials of the Cell Differentiation Agent-2 (CDA-2): Therapeutic Efficacy on Breast Cancer, Non-Small Cell Lung Cancer and Primary Hepatoma显示文摘 | Fengyi Feng Qing Lu Changquan Ling Yang Zhang Fengzhan Qin Huaqing Wang Wenxia Huang Shunchang Jiao Qiang Chen Mingzhong Li Yunzhong Zhu Meizhen Zhou Jun Ren Yetao Gao Jingpo Zhao Rongsheng Zheng Wenhua Zhao Zhiqiang Meng Fang Li Qizhong Zhang Dongli Zhao Liyan Xu Yongqiang Zhang Yanjun Zhang Zhenjiu Wang Shuonqi Liu Ming C. Liau | 2005 | Chinese Journal of Clinical Oncology2005，2，4： | 3 |
| 6 | Advance in yellowing mechanism and the regulation technology of post-harvested broccoli显示文摘Yellowing is one of the main problems of quality deterioration in the storage,transportation,and sales of post-harvested broccoli,which seriously affects the commodity value of broccoli.Therefore,it is of significance to understand the mechanism of the process and develop effective regulation technology.In this review,we expounded the changes in the appearance of the flower ball,bud morphology,and calyx cell structure,as well as endogenous pigment metabolism,accompanying the yellowing process of broccoli.In addition,recent research on the molecular mechanism of yellowing was summarized from the aspects of transcriptome analysis and transcription regulation.Finally,the progress on the control technology of broccoli yellowing was reviewed. | Feng Luo Huixin Fang Baodong Wei Shunchang Cheng Qian Zhou Xin Zhou Xuan Zhang Yingbo Zhao Shujuan Ji | 2020 | Food Quality and Safety2020，4，3： | 2 |
| 7 | Efficacy of pemetrexed combined with erlotinib/gefitinib in advanced non-small cell lung cancer patients during tyrosine kinase inhibitor treatment显示文摘Objective We aimed to evaluate the efficacy and safety of pemetrexed combined with erlotinib/gefitinib in advanced non-small cell lung cancer(NSCLC) patients during tyrosine kinase inhibitor(TKI) treatment. Methods Thirty-two patients with advanced NSCLC were divided into two groups. Patients in the control group received continuous daily epidermal growth factor receptor tyrosine kinase inhibitor(EGFRTKI) treatment, and patients in the experimental group received continuous daily EGFR-TKI along with pemetrexed treatment, which was administered on day 1 at 500 mg/m2. Erlotinib(150 mg) or gefitinib(250 mg) was administered daily from day 1 to day 21, with a cycle of every 21 days. Dexamethasone, folic acid, and vitamin B12 were also administered during the treatment. The endpoint of the primary study was the disease control rate. Results The objective response rate was 21.9%(95% CI: 7.6% to 36.3%) in the control group, whereas the disease control rate was 84.4%(95% CI: 71.8% to 97.0%) in the experimental group. The median progression-free survival was 6.2(95% CI: 2.4 to 10.0). Grades 3 or 4 adverse effects of leucopenia(15.6%), neutropenia(12.5%), anemia(3.1%), and nausea or vomiting(3.1%) were found in the experimental group.Conclusion The administration of pemetrexed combined with erlotinib or gefitinib showed a higher efficacy in TKI-resistant NSCLC patients. Further, the adverse effects of this drug combination were well tolerated by the patients. Pemetrexed combined with TKI treatment might provide a satisfactory therapeutic strategy for advanced NSCLC patients after TKI treatment. | Guanzhong Zhang Zhaozhe Liu Tao Han Xiaodong Xie Shunchang Jiao | 2017 | Oncology and Translational Medicine2017，3，3： | 2 |
| 8 | Subtemporal transtentorial petrosalapex approach for giant petroclival meningiomas: analyzation and evaluation of the clinical application显示文摘 | YANG Jun LIU Yanhong MA Shunchang | 2012 | J Neurol Surg B Skull Base2012，73，1： | 1 |
| 9 | Dysferlin mutation in a Chinese pedigree with Miyoshi myopathy显示文摘 | Shunchang S Fan Q Huacheng W | 2006 | Clin Neurol Neurosurg2006，108，： | 1 |
| 10 | Prognostic factors for survival of patients with extensive stage small cell lung cancer - a retrospective single institution snalysis 显示文摘 | Wu Chao Li Fang Jiao Shunchang | 2012 | Asian Pacific J Cancer Prevention2012，13，10： | 1 |
| 11 | Forced responses of cracked cantilever beams subjected to a concentrated moving load显示文摘 | LIN Haiping CHANG Shunchang | 2006 | International Journal of Mechanical Sciences2006，48，12： | 1 |
| 12 | Chaos attitude motion and chaos control in automotive wipers system 显示文摘 | Chang Shunchang | 2004 | International Journal of Solids and Structures2004，41，13： | 1 |
| 13 | Dysferlin mutation in a Chinese pedigree with Miyoshi myopathy显示文摘 | Shunchang S Fan Q Huacheng W | 2006 | Clin Neurol Neurosurg2006，108，： | 1 |
| 14 | Development and genetic mapping of microsatellite markers from genome survey sequences in Brassica napus显示文摘 | Xiaomao Cheng Jinsong Xu Shu Xia Jianxun Gu Yuan Yang Jie Fu Xiaoju Qian Shunchang Zhang Jiangsheng Wu Kede Liu | 2009 | Theoretical and Applied Genetics2009，，6： | 1 |
| 15 | Toxicity and penetration of TiO 2 nanoparticles in hairless mice and porcine skin after subchronic dermal exposure显示文摘 | Jianhong Wu Wei Liu Chenbing Xue Shunchang Zhou Fengli Lan Lei Bi Huibi Xu Xiangliang Yang Fan-Dian Zeng | 2009 | Toxicology Letters2009，，1： | 1 |
| 16 | Chromosomal Transmission in F_2BC_1Hybrid Progenies between Sugarcane and Erianthus fulvus显示文摘[Objective]This study aimed to provide a scientific basis for breeding new sugarcane varieties with hybrid progenies of Erianthus fulvus and modifying existing sugarcane cultivars.[Method]Chromosomal slides of the F2 and F2BC1hybrid progenies between sugarcane and E. fulvus( 2n = 20) and those of parental materials were prepared with the wall degradation hypotonic method,to further analyze the chromosomal transmission in the F2 and F2BC1hybrid progenies and to investigate the chromosome transmission mechanism.[Result]The results showed that,somatic chromosome number varied in various hybrid progenies; chromosomes from parents were transmitted into the somatic cells of F2 hybrids in ' 2n + n' pattern and transmitted into the somatic cells of F2BC1 hybrids in ' n + n' pattern.[Conclusion]This study provided a preliminary cytological basis for further use of these materials in sugarcane breeding. | Xianhong WANG Fusheng LI Lilian HE Hongbo LOU Qinghui YANG Shunchang HE | 2014 | Agricultural Biotechnology2014，3，6： | 1 |
| 17 | Evaluation of docetaxel- and oxaliplatin-based adjuvant chemotherapy in postgastrectomy gastric cancer patients reveals obvious survival benefits in docetaxel-treated mixed signet ring cell carcinoma patients显示文摘 | Li Chen Yan Shi Jing Yuan Qian Wu Yalin Han Rui Qin Baoqing Jia Bo Wei Lixin Wei Guanghai Dai Shunchang Jiao | 2014 | Medical Oncology2014，，9： | 1 |
| 18 | Development and genetic mapping of microsatellite markers from genome survey sequences in Brassica napus显示文摘 | Xiaomao Cheng Jinsong Xu Shu Xia Jianxun Gu Yuan Yang Jie Fu Xiaoju Qian Shunchang Zhang Jiangsheng Wu Kede Liu | 2009 | Theoretical and Applied Genetics2009，，6： | 1 |
| 19 | Synchronization in a steer-by-wire vehi- cle dynamic system 显示文摘 | CHANG Shunchang | 2007 | International Journal of Engineering Science2007，45，28： | 1 |
| 20 | Effects of ARHI on breast cancer cell biological behavior regulated by microRNA-221显示文摘 | Ying Li Mei Liu Yanjun Zhang Chun Han Junhao You Junlan Yang Cheng Cao Shunchang Jiao | 2013 | Tumor Biology2013，，6： | 1 |
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