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| 1 | Application of Traditional Chinese Medicine injection in treatment of primary liver cancer:a review显示文摘OBJECTIVE:To investigate the application of Traditional Chinese Medicine Injections(TCMIs) for treatment of primary liver cancer(PLC).METHODS:A literature review was conducted using PubMed/Medline,Cochrane Library Controlled Clinical Trials Database,China National Knowledge Infrastructure(CNKI),China Scientific Journal Database(CSJD) and China Biology Medicine(CBM).Online websites including journal websites and databases of ongoing trials,as well as some Traditional Chinese Medicine journals that are not indexed in the electronic databases were also searched.RESULTS:The literature review showed that TCMIs as adjunctive medication for the treatment of PLC could regulate patient immunity,reduce bone marrow suppression,relieve clinical symptoms,and improve quality of life,as well as control disease progression and prolong survival time.CONCLUSION:Within the limitations of this review,we conclude that application of TCMIs as adjunctive medication may provide benefits for patients with PLC.Further large,high-quality trials are warranted. | Mouduo Li Cuixia Qiao Liping Qin Junyong Zhang Changquan Ling | 2012 | Journal of Traditional Chinese Medicine2012，32，3： | 22 |
| 2 | The Lanshantou Kyanite-bearing Eclogite with Coesite Inclusions in the Sulu Ultrahigh-Pressure Metamorphic Belt and Its PTt Path显示文摘Coesite inclusions are found in kyanite from the Lanshantoueclogite in the Sulu ultrahigh-pressure (UHP) metamorphic belt. This discovery extends the stable region of kyanite to over 2.4 GPa. As an important UHP metamorphic belt in China, the Sulu eclogite belt is the product of A-subduction induced by strong compression of the Yellow Sea terrane to the Jiaodong-northereastem Jiangsu terrane during the interaction of the Eurasian plate and Palaeo-Pacific plate in the Indosinian. It stretches about 350 km and contains over 1000 eclogite bodies. Most eclogites in this belt belong to Groups B and C in the classification of Coleman et al., and commonly contain kyanite, while the Lanshantou eclogite belongs to Group A and contains coesite. The MgO, CaO and FeO contents in garnet and pyroxene show regular variation from the core to the rim, which reveals the PTt paths of progressive metamorphism during the Early Mesozoic (240-200 Ma) and retrogressive metamorphism during the Late Mesozoic and Cenozoic exhumation. | HU Shouxi, SUN Jinggui, LING Hongfei, YE Ying, Fang Changquan and ZHAO Yiying Department of Earth Sciences, Nanjing University, Nanjing 210008, Jiangsu Department of Earth Sciences, Zhejiang University, Hangzhou 310027, Zhejiang | 2001 | Acta Geologica Sinica(English Edition)2001，75，4： | 5 |
| 3 | Phase Ⅲ Clinical Trials of the Cell Differentiation Agent-2 (CDA-2): Therapeutic Efficacy on Breast Cancer, Non-Small Cell Lung Cancer and Primary Hepatoma显示文摘 | Fengyi Feng Qing Lu Changquan Ling Yang Zhang Fengzhan Qin Huaqing Wang Wenxia Huang Shunchang Jiao Qiang Chen Mingzhong Li Yunzhong Zhu Meizhen Zhou Jun Ren Yetao Gao Jingpo Zhao Rongsheng Zheng Wenhua Zhao Zhiqiang Meng Fang Li Qizhong Zhang Dongli Zhao Liyan Xu Yongqiang Zhang Yanjun Zhang Zhenjiu Wang Shuonqi Liu Ming C. Liau | 2005 | Chinese Journal of Clinical Oncology2005，2，4： | 3 |
| 4 | Effectiveness of Jiedu granule(解毒颗粒) on gut microbiota in patients with advanced hepatocellular carcinoma:a randomized controlled trial显示文摘OBJECTIVE:To observe whether Jiedu granule(解毒颗粒,JDG)modulates the composition of the gut microbiota during advanced hepatocellular carcinoma(HCC).METHODS:A randomized controlled trial was conducted.Sixty-two advanced HCC participants were randomly allocated to receive JDG or placebo.The median overall survival(OS)times of patients and the variation of relative abundance of bacteria over time were used as main outcome measures.RESULTS:Patients who received JDG demonstrated significantly longer median OS times compared with the placebo group.Pyrosequencing of the V3 regions of 16S r RNA genes revealed a dose dependent deviation of gut microbiota in response to JDG treatment.Redundancy analysis identified Clostridium XI and Peptostreptococcaceae which related to the onset of liver cancer disappeared after 1-month and 2-month JDG treatment,while in control group,no significant changes of these two bacteria were found.The variation tendency of relative abundance of Bacteroides(essential in immunoblocking therapy of tumor)in JDG group was not obvious while in control group,it was decreased significantly with time.The relative abundance of Roseburia(correlated with the occurrence of liver cancer)was increased in JDG group and was decreased in control group over time.CONCLUSION:Changes in the gut microbiota may be associated with the efficiency of JDG on survival period of advanced HCC patients.Trial registration:Chinese Clinical TRIAL Registry Chi CTR-OOC-16008002. | FAN Yifu ZHAO Hetong ZHANG Yani YIN Zifei DU Juan LING Changquan | 2022 | Journal of Traditional Chinese Medicine2022，42，6： | 1 |
| 5 | MiR-124 suppresses cell proliferation in hepatocellular carcinoma by targeting PIK3CA显示文摘 | Qingbo Lang Changquan Ling | 2012 | Biochemical and Biophysical Research Communications2012，，2： | 1 |
| 6 | Hierarchical structure engineering of brookite TiO2 crystals for enhanced photocatalytic and external antitumor property显示文摘Here we report a hydrothermal approach to build and tailor the hierarchical structure of brookite TiO_2 crystal under multiple hierarchical scales. Benefiting from the hierarchical structure and the existence of oxygen vacancy,these as-prepared hierarchical brookite TiO_2 crystals can not only enhance photocatalytic activity, but also demonstrate their potential in the treatment of superficial malignant tumor. | Zhifei He Yonghua Su Shuang Yang Long Wu Shengyou Liu Changquan Ling Huagui Yang | 2016 | Science Bulletin2016，61，23： | 0 |
| 7 | Additive manufactured polyether-ether-ketone implants for orthopaedic applications:a narrative review显示文摘Polyether-ether-ketone(PEEK)is believed to be the next-generation biomedical material for orthopaedic implants that may replace metal materials because of its good biocompatibility,appropriate mechanical properties and radiolucency.Currently,some PEEK implants have been used successfully for many years.However,there is no customised PEEK orthopaedic implant made by additive manufacturing licensed for the market,although clinical trials have been increasingly reported.In this review article,design criteria,including geometric matching,functional restoration,strength safety,early fixation,long-term stability and manufacturing capability,are summarised,focusing on the clinical requirements.An integrated framework of design and manufacturing processes to create customised PEEK implants is presented,and several typical clinical applications such as cranioplasty patches,rib prostheses,mandibular prostheses,scapula prostheses and femoral prostheses are described.The main technical challenge faced by PEEK orthopaedic implants lies in the poor bonding with bone and soft tissue due to its biological inertness,which may be solved by adding bioactive fillers and manufacturing porous architecture.The lack of technical standards is also one of the major factors preventing additive-manufactured customised PEEK orthopaedic implants from clinical translation,and it is good to see that the abundance of standards in the field of additive-manufactured medical devices is helping them enter the clinical market. | Changning Sun Jianfeng Kang Chuncheng Yang Jibao Zheng Yanwen Su Enchun Dong Yingjie Liu Siqi Yao Changquan Shi Huanhao Pang Jiankang He Ling Wang Chaozong Liu Jianhua Peng Liang Liu Yong Jiang Dichen Li | 2022 | Biomaterials Translational2022，3，2： | 0 |
| 8 | 不能切除肝癌长期生存患者的临床分析(英文)显示文摘Objective:The objectives of this study were to evaluate the long-term results with multimodality therapy, and to clarify the clinicopathologic of features of patients surviving ≥ 3 years for unresectable hepatocellular carcinoma(HCC).Methods:Between 1999 and 2003, a total of 166 patients underwent multimodality therapy for unresectable HCC.All patients underwent multimodality therapy, such as transarterial chemoembolization(TACE), chemotherapy, local ablative therapy, and/ or Chinese traditional medicine.Thirty-nine(23.5%) patients survival ≥ 1 years, and 10(6.0%) patients survived ≥ 3 years.These 39 patients surviving over 1 year were investigated in this study.Eighteen clinical and biologic variables were assessed using univariate and multivariate analyses.Results:TNM staging and tumor extension were isolated by univariate analysis.Only tumor extension was independent risk factors by multiple regression analysis.Of these, 25.6%(10 of 39) survived over 3 years.These 10 patients surviving over 3 years were investigated further.By the end of June 2004, follow-up varied from 3 years and 2 months to 5 years and 1 month.Six patients were still alive with free of disease.Conclusion:Tumor extension was demonstrated to be prognostic of long-term survivors.Multimodality therapy may make a major contribution to achieving long-term survival in patients with unresectable HCC. | Baihong Zhang Xianghui Wang Hongyun Yue Changquan Ling | 2010 | The Chinese-German Journal of Clinical Oncology2010，9，3： | 0 |
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