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| 1 | Bisphenol A in combination with TNF-a selectively induces Th2 cell-promoting dendritic cells in vitro with an estrogen-like activity显示文摘Bisphenol A(BPA)is a monomer used in manufacturing a wide range of chemical products,including epoxy resins and polycarbonate.BPA,an important endocrine disrupting chemical that exerts estrogen-like activities,is detectable at nanomolar levels in human serum worldwide.The pregnancy associated doses of 17b-estradiol(E2)plus tumor-necrosis factor-a(TNF-a)induce distorted maturation of human dendritic cells(DCs)that result in an increased capacity to induce T helper(Th)2 responses.The current study demonstrated that the presence of BPA during DC maturation influences the function of human DCs,thereby polarizing the subsequent Th response.In the presence of TNF-a,BPA treatment enhanced the expression of CC chemokine ligand 1(CCL1)in DCs.In addition,DCs exposed to BPA/TNF-a produced higher levels of IL-10 relative to those of IL-12p70 on CD40 ligation,and preferentially induced Th2 deviation.BPA exerts the same effect with E2 at the same dose(0.01–0.1 mM)with regard to DC-mediated Th2 polarization.These findings imply that DCs exposed to BPA will provide one of the initial signals driving the development and perpetuation of Th2-dominated immune response in allergic reactions. | Hongchuan Guo Tianyi Liu Yasushi Uemura Shunchang Jiao Deqing Wang Zilin Lin Yayoi Narita Motoharu Suzuki Narumi Hirosawa Yasuko Ichihara Osamu Ishihara Hirosato Kikuchi Yasushi Sakamoto Satoru Senju Qiuhang Zhang Feng Ling | 2010 | Cellular & Molecular Immunology2010，7，3： | 6 |
| 2 | Achieving exceptional activity and durability toward oxygen reduction based on a cobalt-free perovskite for solid oxide fuel cells显示文摘In response to the shortcomings of cobalt-rich cathodes, iron-based perovskite oxides appear as promising alternatives for solid oxide fuel cells (SOFCs). However, their inferior electrochemical performance at reduced temperatures (<700 ℃) becomes a major bottleneck for future progress. Here, a novel cobalt-free perovskite Ba_(0.75)Sr_(0.25)Fe_(0.875)Ga_(0.125)O_(3−δ) (BSFG) is developed as an efficient oxygen reduction electrode for SOFCs, featuring cubic-symmetry structure, large oxygen vacancy concentration and fast oxygen transport. Benefiting from these merits, cells incorporated with BSFG achieve exceptionally high electrochemical performance, as evidenced by a low polarization area-specific resistance of 0.074 Ω cm^(2) and a high peak power density of 1145 mW cm^(−2) at 600 ℃. Meanwhile, a robust short-term performance stability of BSFG cathode can be ascribed to the stable crystalline structure and favorable thermal expansion behavior. First-principles computations are also conducted to understanding the superior activity and durability toward oxygen reduction reaction. These pave the way for rationally developing highly active and robust cobalt-free perovskite-type cathode materials for reduced-temperature SOFCs. | Feifei Dong Zhenghui Gao Bingkai Zhang Lu Li Ziqi Kong Zilin Ma Meng Ni Zhan Lin | 2021 | Journal of Energy Chemistry2021，30，11： | 1 |
| 3 | New norlignan enantiomers from the fruit of Crataegus pinnatifida with neuroprotective activities显示文摘(±)-Crataegusnorin A(la/1b) and B(2a/2b),two pairs of rare 8,9’-epoxy-type norlignan enantiomers featuring a y-butyrolactone ring,were isolated from the fruit of Crataegus pinnatifida.Their structures were determined via extensive spectroscopic analyses.Gauge-independent atomic orbital(GIAO) NMR chemical shift calculations,combined with the advanced statistical method DP4+were employed to establish the relative configurations of four compounds.Next,chiral separation was accomplished by chiral chromatographic column and the absolute configurations of the four compounds were unambiguously assigned by comparison between their experimental electronic circular dichroism curves with the quantum-mechanically calculated curves based on time-dependent density functional theory(TDDFT).All the isolates were evaluated fo r their neuroprotective activities against H2O2-induced cell injury in human neuroblastoma SH-SY5Y cells.The results showed that two pairs of enantiomers 1a/1b and 2a/2b displayed diff;erent effect on neuroprotective activity.Among them,compound 2a displayed the most potent neuroprotective effect Further flow cytometry analysis indicated that 2a could protect SH-SY5Y cells from oxidative damage through inhibiting cell apoptosis. | Rui Guo Tianming Lv Fengying Han Zilin Hou Guodong Yao Bin Lin Xiaobo Wang Xiaoxiao Huang Shaojiang Song | 2020 | Chinese Chemical Letters2020，31，5： | 1 |
| 4 | Magnesium incorporation activates perovskite cobaltites toward efficient and stable electrocatalytic oxygen evolution显示文摘Cobalt-rich perovskite oxides play a paramount role in catalyzing oxygen evolution reaction(OER)on account of their acceptable intrinsic activity but are still challenging due to the high costs and undesired stability.In response to the defects,herein,the Mg-incorporated perovskite cobaltite SrCo_(0.6)Fe_(0.3M)g_(0.1)O_(3-δ)(SCFM-0.1)is proposed as a novel earth-abundant and durable OER electrocatalyst.A well-consolidated cubic-symmetry structure and more active oxygen intermediates are enabled upon Mg substitution.Hence,the optimized SCFM-0.1 perovskite oxide achieves prominent OER electrocatalytic performance,that is,a low overpotential of only 320 mV at 10 mA cm^(-2),a small Tafel slope of 65 mV dec^(-1),as well as an outstanding durability within 20 h,substantially outperforming that of the pristine SrCo_(0.7)Fe_(0.3)O_(3-δ)and benchmark Ba_(0.5)Sr_(0.5)Co_(0.8)Fe_(0.2)O_(3-δ)and IrO_(2) catalysts.The strong pHdependent behavior associated with lattice oxygen activation mechanism for SCFM-0.1 catalyst is also confirmed.This work paves a unique avenue to develop cost-effective and robust perovskite cobaltites for efficient OER electrocatalysis. | Siyu Pan Zilin Ma Wenying Yang Biaokui Dongyang Huizhi Yang Shimin Lai Feifei Dong Xixian Yang Zhan Lin | 2023 | Materials Reports(Energy)2023，3，3： | 0 |
| 5 | Development of metal-recycling technology in waste crystalline-silicon solar cells显示文摘Solar energy is currently one of the most promising clean energy sources and the use of solar energy has led to a rapid increase in the number of solar cells.As one of the fastest-growing electronic wastes,the resource treatment of solar cells at the end of their life should not be neglected.This review discusses the trend for the market development of crystalline-silicon solar cells and analyzes their physical structure and composition.It also discusses the current domestic and international recycling technologies for crystalline-silicon solar cells,including manual dismantling,inorganic acid dissolution,the combination of heat-treatment and chemical methods,and organic solvent dissolution.The shortcomings of the above treatment methods are discussed and some views on the recycling of waste crystalline-silicon solar cells are presented.Constructive suggestions for the green and sustainable development of crystalline-silicon solar cells are put forward by comparing different treatment-recycling processes. | Dehai Lin Zilin Liu Xiaoduan Li Zixiong Cao Rihua Xiong | 2023 | Clean Energy2023，7，3： | 0 |
| 6 | Shanghai Autism Early Development:An Integrative Chinese ASD Cohort显示文摘Why Was the Cohort Set Up?Autism spectrum disorder(ASD)is a child neurodevelopmental disorder,the onset of which is generally within 3 years of age,and often leads to lifelong impaired social and cognitive functions,which impose significant mental pressure and economic burdens on the family and society. | Yuan Dai Yuqi Liu Lingli Zhang Tai Ren Hui Wang Juehua Yu Xin Liu Zilin Chen Lin Deng Minyi Tao Hangyu Tan Chu‑Chung Huang Jiaying Zhang Qiang Luo Jianfeng Feng Miao Cao Fei Li | 2022 | Neuroscience Bulletin2022，38，12： | 0 |
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