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| 1 | Mitochondria-mediated apoptosis in mammals显示文摘调停线粒体的 caspase 激活小径是 mitochondrial 描绘的一条主要 apoptotic 小径外部膜 permeabilization (MOMP ) 和进细胞质到的细胞色素 c 的随后的版本激活 caspases。MOMP 被蛋白质的 Bcl-2 家庭调整。这条小径不仅在正常开发,组织动态平衡的维护和免疫系统的规定,而且在象有免疫力的混乱, neurodegeneration 和癌症那样的人的疾病起重要作用。在过去的十年,这条小径和规章的机制的分子的基础包括地被学习了,然而,很多新证据显示从线粒体的那个细胞色素 c 版本总是不导致激活能也有的不可逆的房间死亡,和那 caspase 非死亡功能。因此,许多未解决的问题和新挑战正在尚待。而且,涉及癌症开发的这条小径的机能障碍是明显的,并且作为治疗学的策略指向小径广泛地被探索了,但是指向的治疗的功效仍然在开发中。在这评论,我们将讨论调停线粒体的 apoptosis 小径和它的生理的角色和治疗学的含意。 | Shunbin Xiong Tianyang Mu Guowen Wang Xuejun Jiang | 2014 | Protein & Cell2014，5，10： | 31 |
| 2 | Broadband ultrafast nonlinear optical response of few-layers graphene: toward the mid-infrared regime显示文摘Gapless linear energy dispersion of graphene endows it with unique nonlinear optical properties, including broadband nonlinear absorption and giant nonlinear refractive index. Herein, we experimentally observed that fewlayers graphene has obvious nonlinear absorption and large nonlinear refraction, as investigated by the Z-scan technique in the mid-infrared(mid-IR) regime. Our study may not only, for the first time to our knowledge, verify the giant nonlinear refractive index of graphene(~10-7cm2∕W) at the mid-IR, which is 7 orders of magnitude larger than other conventional bulk materials, but also provide some new insights for graphene-based mid-IR photonics,potentially leading to the emergence of several new conceptual mid-IR optoelectronics devices. | Lili Miao Yaqin Jiang Shunbin Lu Bingxin Shi Chujun Zhao Han Zhang Shuangchun Wen | 2015 | Photonics Research2015，3，5： | 7 |
| 3 | Physical location of rice Gm-6,Pi-5(t) genes in O.officinalis with BAC-FISH显示文摘A fluorescence in situ hybridization (FISH) procedure was adopted to physically map two rice BAC clones 24E21 and 4F22 linked to Gm-6 and Pi-5(t) in O. offi-cinalis. FISH results showed that the two BAC clones were located at 4L. The percentage distance from the centromere to the hybridization sites was 72 ± 2.62 for 24E21 and 54± 5.43 for 4F22, the detection rates were 52.70% and 61.2%. The results obtained from the BAC and plasmid clones, RG214 and RZ565 of cultivated rice and O. officinalis were the same. This suggested that the markers, RG214 and RZ565 of cultivated rice and O. officinalis were in the same BAC clones. The homologous sequences of Gm-6 and Pi-5(t) in O. officinalis were positions that signals existed on the 4L. Many signals were observed when no Cot-1 DNA blocked. This also showed that repetitive sequences were some ho-molgous between cultivated rice and O. officinalis. The identification of chromosome 4 of O. officinalis is based on Jena et al. (1994). In our study, we discussed | QIN Rui WEI Wenhui JIN Weiwei HE Guangcun NING Shunbin YU Shunwu SONG Yunchun | 2001 | Chinese Science Bulletin2001，46，8： | 6 |
| 4 | Clinical and Genetic Investigation of a Multi-generational Chinese Family Afflicted with Von Hippel-Lindau Disease显示文摘 | Jingyao Zhang Jie Ma Xiaoyun Du Dapeng Wu Hong Ai Jigang Bai Shunbin Dong Qinling Yang Kai Qu Yi Lyu Robert K Valenzuela Chang Liu | 2015 | Chinese Medical Journal2015，，1： | 6 |
| 5 | Developing individual tree-based models for estimating aboveground biomass of five key coniferous species in China显示文摘Estimating individual tree biomass is critical to forest carbon accounting and ecosystem service modeling.In this study,we developed one-(tree diameter only) and two-variable(tree diameter and height) biomass equations,biomass conversion factor(BCF) models,and an integrated simultaneous equation system(ISES) to estimate the aboveground biomass for five conifer species in China,i.e.,Cunninghamia lanceolata(Lamb.) Hook.,Pinus massoniana Lamb.,P.yunnanensis Faranch,P.tabulaeformis Carr.and P.elliottii Engelm.,based on the field measurement data of aboveground biomass and stem volumes from 1055 destructive sample trees across the country.We found that all three methods,including the one-and two-variable equations,could adequately estimate aboveground biomass with a mean prediction error less than 5%,except for Pinus yunnanensis which yielded an error of about 6%.The BCF method was slightly poorer than the biomass equation and the ISES methods.The average coefficients of determination(R^2) were 0.944,0.938 and 0.943 and the mean prediction errors were 4.26,4.49 and 4.29% for the biomass equation method,the BCF method and the ISES method,respectively.The ISES method was the best approach for estimating aboveground biomass,which not only had high accuracy but also could estimate stocking volumes simultaneously that was compatible with aboveground biomass.In addition,we found that it is possible to develop a species-invariant one-variable allometric model for estimating aboveground biomass of all the five coniferous species.The model had an exponent parameter of 7/3 and the intercept parameter a_0 could be estimated indirectly from stem basic density(a_0= 0.294 q). | Weisheng Zeng Liyong Fu Ming Xu Xuejun Wang Zhenxiong Chen Shunbin Yao | 2018 | Journal of Forestry Research2018，29，5： | 5 |
| 6 | Comparative genome research between maize and rice using genomic in situ hybridization显示文摘Using the genomic DNAs of maize and rice as probes respectively, the homology of maize and rice genomes was assessed by genomic in situ hybridization. When rice genomic DNAs were hybridized to maize, all chromosomes displayed many multiple discrete regions, while each rice chromosome delineated a single consecutive chromosomal region after they were hybridized with maize genomic DNAs. The results indicate that the genomes of maize and rice share high homology, and confirm the proposal that maize and rice are diverged from a common ancestor. | Shunbin Ning Weiwei Jin Ling Wang Yi Ding Yunchun Song | 2001 | Chinese Science Bulletin2001，46，8： | 5 |
| 7 | Determination of copy number for 5S rDNA and centromeric sequence RCS2 in rice by Fiber-FISH显示文摘The copy number of 5S rDNA and centromerie sequence RCS2 was determined by extended DNA fiber based fluorescence in situ hybridization (Fiber-FISH) in rice (Oryza sativa ssp. indica cv. Guangluai No. 4) genome. In order to determine the copy number, it is necessary to know the basepair number that a given length DNA fiber contains under a microscope. Therefore, the length of two DNA frag-ments, in which the basepair number had been already known, was measured. The insert sequence of the tested BAC 38D17 was 136 kb and its extended DNA was 56.4 μm long, 2.41 kb/μm on average, while that of the tested BAC 44B4 was 144.5 kb in total and 55.7 μm long, 2.60 kb/μm on average under the microscope. They were very close to the theoretical value of B-DNA in the Watson-Crick DNA model, which is 2.97 kb/μm. According to the average value of basepair number per μm of the two samples mentioned above, that is, 2.51 kb/μm, it could be estimated that the copy number was about 686 for 5S rDNA and 286-1121 for the | Zongyun Li Siluo Huang Weiwei Jin Shunbin Ning Yunchun Song Lijia Li | 2002 | Chinese Science Bulletin2002，47，3： | 5 |
| 8 | Ultrafast nonlinear absorption and nonlinear refraction in few-layer oxidized black phosphorus显示文摘We experimentally investigated the nonlinear optical response in few-layer oxidized black phosphorus(OBP) by the femtosecond Z-scan measurement technique, and found that OBP not only possesses strong ultrafast saturable absorption but also a nonlinear self-defocusing effect that is absent in black phosphorus(BP). The saturable absorption property originates mainly from the direct band structure, which is still maintained in OBP. The emergence of self-defocusing might originate from the combined consequences of the oxygen-induced defects in BP. Our experimental findings might constitute the first experimental evidence on how to dynamically tune its nonlinear property, offering an inroad in tailoring its optical properties through chemical modification(oxidation, introducing defects, etc.). The versatile ultrafast nonlinear optical properties(saturable absorption and self-defocusing) imply a significant potential of the layered OBP in the development of unprecedented optoelectronic devices, such as mode lockers, optical switches, laser beam shapers, and wavelength converters. | Shunbin Lu Yanqi Ge Zhengbo Sun Zongyu Huang Rui Cao Chujun Zhao Shuangchun Wen Dianyuan Fan Jianqing Li Han Zhang | 2016 | Photonics Research2016，4，6： | 5 |
| 9 | A novel method for in situ detection of apoptotic cell death in plants显示文摘A simple novel protocol suitable for in situ detection of apoptotic plant cell death is presented. This protocol combines the chromosome spreading technique with an extended in situ end labeling version for plants and makes it possible to detect apoptosis directly at chromosome,nuclear and DNA levels simultaneously with high-sensitivity. False positive and nonspecific signals can be efficiently avoided. Moreover, the changes of chromosomes, nuclei and DNA during the process of apoptosis can be characterized in situ. To illustrate this method, salt stress-induced cell death has been investigated in maize root meristematic cells. | Shunbin Ning Yunchun Song Ling Wang Lihua Liu | 1999 | Chinese Science Bulletin1999，44，11： | 4 |
| 10 | Mouse models of Mdm2 and Mdm4 and their clinical implications显示文摘Mdm2 and Mdm4 are two key negative regulators of the tumor suppressor p53.Deletion of either Mdm2 or Mdm4 induces p53-dependent early embryonic lethality in knockout mouse models.The tissuespecific deletion of Mdm2 induces p53-dependent apoptosis,whereas the deletion of Mdm4 induces both p53-dependent apoptosis and cell cycle arrest.Compared to Mdm4 deletion,Mdm2 deletion causes more severe phenotypic defects.Disrupting the Mdm2 and Mdm4 interaction using knockin mice models causes embryonic lethality that can be completely rescued by the concomitant loss of p53,suggesting that Mdm2 and Mdm4 heterodimerization is critical to inhibit p53 activity during embryogenesis.Overexpression of Mdm2 and Mdm4 in mice induces spontaneous tumorigenesis,which clearly indicates that Mdm2 and Mdm4 are bona fide oncogenes.Studies from these mouse models strongly suggest that blocking Mdm2and Mdm4-mediated p53 inhibition is an appealing therapeutic strategy for cancer patients with wild-type p53 alleles. | Shunbin Xiong | 2013 | Chinese Journal of Cancer2013，32，7： | 2 |
| 11 | Ultra-high-resolution detection of Pb2+ ions using a black phosphorus functionalized microfiber coil resonator显示文摘A black phosphorus(BP) functionalized optical fiber sensor based on a microfiber coil resonator(MCR) for Pb^2+ ion detection in an aquatic environment is presented and experimentally demonstrated. The MCR-BP sensor is manufactured by winding a tapered microfiber on a hollow rod composed of a low-refractive-index polycarbonate(PC) resin with the BP deposited on the internal wall of the rod. Based on the propagation properties of the MCR, the chemical interaction between the Pb^2+ ions and the BP alters the refractive index of the ambient environment and thus results in a detectable shift in the transmission spectrum. The resonance wavelength moves towards longer wavelengths with an increasing concentration of Pb^2+ ions, and the sensor has an ultra-high detection resolution of 0.0285 ppb(parts per billion). The temperature dependence is 106.95 pm/°C due to the strong thermo-optic and thermal-expansion effect of the low-refractive-index PC resin. In addition, the sensor shows good stability over a period of 15 days. The local pH also influences the sensor, with the resonance wavelength shift increasing as pH approaches a value of 7 but then decreasing as the pH value increases further due to the effect of the BP layer by H^+ and OH-ions. The sensor shows the potential for high-resolution detection of Pb^2+ ions in a liquid environment with the particular advantages of having a simple structure, ease of fabrication,low cost, low loss, and simple interrogation. | YU YIN SHI LI SHUNBIN WANG SHIJIE JIA JING REN GERALD FARRELL ELFED LEWIS PENGFEI WANG | 2019 | Photonics Research2019，7，6： | 2 |
| 12 | The proliferation and expansion of retinal stem cells require functional Pax6显示文摘 | Shunbin Xu Mary E. Sunderland Brenda L.K. Coles Angela Kam Tamara Holowacz Ruth Ashery-Padan Till Marquardt Roderick R. McInnes Derek van der Kooy | 2007 | Developmental Biology2007，，2： | 1 |
| 13 | Coexpression of Normally Incompatible Developmental Pathways in Retinoblastoma Genesis显示文摘 | Justina McEvoy Jacqueline Flores-Otero Jiakun Zhang Katie Nemeth Rachel Brennan Cori Bradley Fred Krafcik Carlos Rodriguez-Galindo Matthew Wilson Shunbin Xiong Guillermina Lozano Julien Sage Ligia Fu Lotfi Louhibi Jeff Trimarchi Amar Pani Richard Smeyne D | 2011 | Cancer Cell2011，，2： | 1 |
| 14 | Regulation of the transcriptional activity of the IRF7 promoter by a pathway independent of interferon signaling显示文摘 | Shunbin N Leslie E H Joseph S P | 2005 | J Biol Chem2005，280，12： | 1 |
| 15 | FISH analysis of the integration patterns in transgenic rice co-transformed by micro-projectile bombardment显示文摘Using multi-color fluorescence in situ hybridization (FISH), we localized transferred barnase-psl and pHctinG DNA sequences onto chromosomes of two trans-genie rice plants, named Q12 and Q13, both of which were produced by micro-projectile bombardment. In both Q12 and Q13, each detected cell showed 2-3 signal spots on their chromosomes respectively. The signals of both barnase-psl and pHctinG were mostly detected in the adjacent chromosomal sites in which their signals were overlapped and could be recognized by the signal color on the metaphase chromosomes. Fiber FISH further demonstrated that the multiple copies in each of the two DNA sequences distributed adjacently on the DNA fiber in Q13. Combined with the results of Southern hybridization, the possible integration patterns in transgenic rice co-transformed by micro-projectile bombardment have been discussed. | JIN Weiwei LI Zongyun NING Shunbin LING Dinghou LI Lijia SONG Yunchun | 2001 | Chinese Science Bulletin2001，46，23： | 1 |
| 16 | Research on the Key Techniques of TCP Protocol Normalization for Mimic Defense Architecture显示文摘The Mimic Defense(MD)is an endogenous security technology with the core technique of Dynamic Heterogeneous Redundancy(DHR)architecture.It can effectively resist unknown vulnerabilities,backdoors,and other security threats by schedule strategy,negative feedback control,and other mechanisms.To solve the problem that Cyber Mimic Defense devices difficulty of supporting the TCP protocol.This paper proposes a TCP protocol normalization scheme for DHR architecture.Theoretical analysis and experimental results show that this scheme can realize the support of DHR-based network devices to TCP protocol without affecting the security of mimicry defense architecture. | Mingxing Zhu Yansong Wang Ruyun Zhang Tianning Zhang Heyuan Li Hanguang Luo Shunbin Li | 2021 | Journal on Internet of Things2021，3，3： | 0 |
| 17 | Broadband Pulsed Fiber Laser Generation with Topological Insulator: Towards the Mid-Infrared Regime显示文摘In recent years, topological insulators have aroused the attention of a great number of scientists due to their unique electronic structures and peculiar physical properties. Triggered by the similar electronic structures as graphene, the broadband nonlinear absorption properties of topological insulators were investigated. Moreover, the mode-locked or Q-switched fiber lasers based on topological insulators were realized for broadband operating wavelength. Here, we present an overview of the preparation, transferring, linear and nonlinear optical properties, and their applications of topological insulators in pulsed fiber lasers. The pulsed fiber lasers towards midinfrared regimes have been proposed. | Guobao Jiang Lili Miao Yu Chen Shunbin Lu Shuqing Chen Chujun Zhao Han Zhang Shuangchun Wen | 2015 | Journal of Electronic Science and Technology2015，13，4： | 0 |
| 18 | Intelligent Orchestrating of IoT Microservices Based on Reinforcement Learning显示文摘With the recent increase in the number of Internet of things(IoT)services,an intelligent scheduling strategy is needed to manage these services.In this paper,the problem of automatic choreography of microservices in IoT is explored.A type of reinforcement learning(RL)algorithm called TD3 is used to generate the optimal choreography policy under the framework of a softwaredefined network.The optimal policy is gradually reached during the learning procedure to achieve the goal,despite the dynamic characteristics of the network environment.The simulation results show that compared with other methods,the TD3 algorithm converges faster after a certain number of iterations,and it performs better than other non-RL algorithms by obtaining the highest reward.The TD3 algorithm can effciently adjust the traffic transmission path and provide qualified IoT services. | WU Yuqin SHEN Congqi CHEN Shuhan WU Chunming LI Shunbin WEI Ruan | 2022 | Chinese Journal of Electronics2022，31，5： | 0 |
| 19 | Lightweight Authentication Protocol Based on Physical Unclonable Function显示文摘In the emerging Industrial Internet of Things(IIoT),authentication problems have become an urgent issue for massive resource-constrained devices because traditional costly security mechanisms are not suitable for them.The security protocol designed for resource-constrained systems should not only be secure but also efficient in terms of usage of energy,storage,and processing.Although recently many lightweight schemes have been proposed,to the best of our knowledge,they are unable to address the problem of privacy preservation with the resistance of Denial of Service(DoS)attacks in a practical way.In this paper,we propose a lightweight authentication protocol based on the Physically Unclonable Function(PUF)to overcome the limitations of existing schemes.The protocol provides an ingenious authentication and synchronization mechanism to solve the contradictions amount forward secrecy,DoS attacks,and resource-constrained.The performance analysis and comparison show that the proposed scheme can better improve the authentication security and efficiency for resource-constrained systems in IIoT. | Hanguang Luo Tao Zou Chunming Wu Dan Li Shunbin Li Chu Chu | 2022 | Computers, Materials & Continua2022，，9： | 0 |
| 20 | Superior optical Kerr effects induced by two-dimensional excitons显示文摘Materials with strong optical Kerr effects(OKEs)are crucial for a broad range of applications,such as all-optical data processing and quantum information.However,the underlying OKE mechanism is not clear in 2D materials.Here,we reveal key insights of the OKE associated with 2D excitons.An admirably succinct formalism is derived for predicting the spectra and the magnitude of the nonlinear refractive index(n_(2))of 2D materials.The predicted n_(2)spectra are consistent with reported experimental data and exhibit pronounced excitonic resonances,which is distinctively different from bulk semiconductors.The n_(2) value is predicted to be 3×10^(−10)cm^(2)/W for a 2D layered perovskite at low temperature as 7 K,which is four orders of magnitude larger than those of bulk semiconductors.The superior OKE induced by 2D excitons would give rise to a narrow refractive index-near-zero region for intense laser light.Furthermore,we demonstrate that the 2D layered perovskite should exhibit the best OKE efficiency(W_(FOM)=1.02,T_(FOM)=0.14)at 1550 nm,meeting the material requirements for all-optical switching.Our findings deepen the understanding of the OKE of 2D semiconducting materials and pave the way for highly efficient all-optical excitonic devices. | Feng Zhou Cacere Jelah Nieva Dianyuan Fan Shunbin Lu Wei Ji | 2022 | Photonics Research2022，10，3： | 0 |
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