|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Uterine Rbpj is required for embryonic-uterine orientation and decidual remodeling via Notch pathway-independent and -dependent mechanisms显示文摘协调的子宫胚胎的轴形成并且蜕膜的改变是哺乳动物的培植以后的胚胎开发的特点。胚胎子宫的取向在起始的培植被决定并且与蜕膜的开发同步。然而,控制这些事件的分子的机制留下尽管有它的发现逃犯很长时间以前。在现在的学习,我们发现了 Rbpj 的那子宫特定的删除,槽口发信号的原子变换器,在培植以后的阶段导致了反常胚胎子宫的取向和蜕膜的 patterning,导致实质的胚胎损失。我们进一步表明在胚胎附件以前, Rbpj 授与在时间上经由身体上与子宫的雌激素受体交往的子宫的腔形状转变(ERα) 以一种槽口小径无关的方式,它为在有子宫的轴的排列的胚胎取向的起始的建立是必要的。当时在培植以后的阶段, Rbpj 直接以一种槽口小径依赖者方式调整子宫的矩阵 metalloproteinase 的表示,它为正常被要求培植以后的蜕膜的改变。这些结果证明子宫的 Rbpj 为经由指示起始的胚胎子宫的取向并且以一种阶段特定的方式保证正常蜕膜的 patterning 的正常胚胎开发是必要的。我们的数据也证实正常哺乳动物的胚胎子宫的取向要求的概念合适的指导从发展地控制了子宫的发信号。 | Shuang Zhang Shuangbo Kong Bingyan Wang Xiaohong Cheng Yongjie Chen Weiwei Wu Qiang Wang Junchao Shi Ying Zhang Shumin Wang Jinhua Lu John P Lydon Francesco DeMayo Warren S Pear Hua Han Haiyan Lin Lei Li Hongmei Wang Yan-ling Wang Bing Li Qi Chen Enkui Duan Haibin Wang | 2014 | Cell Research2014，24，8： | 12 |
| 2 | Near-surface absorption compensation technology and its application in the Daqing Oilfields显示文摘高周波的地震数据部件能严重在 unconsolidated 在震波繁殖期间被稀释(低速度) 层,导致减少的地震分辨率和 signal-to-noise (S/N ) 比率。在这篇论文,基于维纳过滤器理论,首先,为近表面的吸收变细赔偿的反的过滤器计算被直接波浪的分析完成光谱从不同距离的部件接近表面。直接波浪被雷管产生在在洞射击上面并且被接收装置在表面上获得。空间地变化的反的过滤器被设计补偿因为 3D 的频率变细预先叠 CRG (普通接收装置集合) 数据。在把过滤器用于 CRG 数据以后,高频率部件被补偿,低频率维持了。地震决定和 S/N 比率与合成震动图更好被提高并且匹配并且更好满足地质的解释的需要。 | Shi Zhanjie Tian Gang Wang Bangbing Chert Shumin | 2009 | Applied Geophysics2009，6，2： | 5 |
| 3 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 4 | Removal of p-Nitrophenol Using Persulfate Activated by Biochars Prepared from Different Biomass Materials显示文摘 | SHI Chenfei LI Yumeng FENG Haiyao JIA Shumin XUE Ruijie LI Gang WANG Guoxiang | 2018 | Chemical Research in Chinese Universities2018，34，1： | 4 |
| 5 | Integrating Pronunciation into Chinese-Vietnamese Statistical Machine Translation显示文摘Statistical machine translation for low-resource language suffers from the lack of abundant training corpora. Several methods, such as the use of a pivot language, have been proposed as a bridge to translate from one language to another. However, errors will accumulate during the extensive translation pipelines. In this paper,we propose an approach to low-resource language translation by exploiting the pronunciation correlations between languages. We find that the pronunciation features can improve both Chinese-Vietnamese and VietnameseChinese translation qualities. Experimental results show that our proposed model yields effective improvements,and the translation performance(bilingual evaluation understudy score) is improved by a maximum value of 1.03. | Anh Tran Huu Heyan Huang Yuhang Guo Shumin Shi Ping Jian | 2018 | Tsinghua Science and Technology2018，23，6： | 2 |
| 6 | Optimizing pH-sensitive and time-dependent polymer formula of colonic pH-responsive pellets to achieve precise drug release显示文摘Time-sensitive and pH-dependent polymers are generally employed to prepare colon-site delivery system, and their coating thickness and order are very important in controlling the drug release. The traditional colon-site delivery systems consist of time-dependent polymers as inner layer and pH-sensitive polymers as outer layer. However, they suffer from low drug-loading rate and immature drug release. In this study, total alkaloids of sophora alopecuroides(TASA)-loaded pellets were prepared by extrusion-spheronization method and coated with Eudragit RS30D and Eudragit S100. Pellets using Eudragit RS30D as inner layer and Eudragit S100 as outer layer were named as ERS-ES100 TCO, while pellets with Eudragit S100 as inner layer and Eudragit RS30D as outer layer were ES100-ERS NCO. Both types of formulations with varying coating ratios and orders of Eudragit S100 and Eudragit RS30D were designed and prepared. The following in vitro drug release and SEM studies indicated that ERS-ES100 TCO(F2) with 12.8% Eudragit RS30D as inner layer and 21% Eudragit S100 as outer layer released up to 42% drug in 5 h. Interestingly, ES100-ERS NCO(F4) coated with 12.8% Eudragit S100 and 14.8% Eudragit RS30D showed optimal drug release in colon. In conclusion, ES100-ERS NCO colonic delivery system achieved reduced coating thickness and improved colonic targeting compared with traditional delivery system(ERS-ES100 TCO). In addition, the similarity factors( f 2) value of sophoridine and matrine for investigated formulation were within 50–100 and > 80, demonstrating that sophoridine and matrine in all formulations achieved a synchronous release. | Lijun Song Liping Liang Xiaoying Shi Honglang Chen Shumin Zhao Wenfeng Chen Ruoxia Zhou Wenchang Zhao | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，4： | 1 |
| 7 | Ion microprobe zircon U-Pb age and geochemistry of the Myanmar jadeitite 显示文摘 | Shi Guanghai Cui Wenyuan Cao Shumin Jiang Neng Jian Ping Liu Dunyi Miao Laicheng Chu Bingbing | 2008 | Journal of the Geological Society2008，165，1： | 1 |
| 8 | Phase characterisation of metalenses显示文摘Metalenses have emerged as a new optical element or system in recent years,showing superior performance and abundant applications.However,the phase distribution of a metalens has not been measured directly up to now,hindering further quantitative evaluation of its performance.We have developed an interferometric imaging phase measurement system to measure the phase distribution of a metalens by taking only one photo of the interference pattern.Based on the measured phase distribution,we analyse the negative chromatic aberration effect of monochromatic metalenses and propose a feature size of metalenses.Different sensitivities of the phase response to wavelength between the Pancharatnam-Berry phase-based metalens and propagation phase-reliant metalens are directly observed in the experiment.Furthermore,through phase distribution analysis,it is found that the distance between the measured metalens and the brightest spot of focusing will deviate from the focal length when the metalens has a low nominal numerical aperture,even though the metalens is ideal without any fabrication error.We also use the measured phase distribution to quantitatively characterise the imaging performance of the metalens.Our phase measurement system will help not only designers optimise the designs of metalenses but also fabricants distinguish defects to improve the fabrication process,which will pave the way for metalenses in industrial applications. | Maoxiong Zhao Mu Ku Chen Ze-Peng Zhuang Yiwen Zhang Ang Chen Qinmiao Chen Wenzhe Liu Jiajun Wang Ze-Ming Chen Bo Wang Xiaohan Liu Haiwei Yin Shumin Xiao Lei Shi Jian-Wen Dong Jian Zi Din Ping Tsai | 2021 | Light(Science & Applications)2021，10，4： | 1 |
| 9 | PD-1 abrogates the prolonged persistence of CD8+CAR-T cells with 4-1BB co-stimulation显示文摘Dear Editor,The central memory differentiation critically dictates CAR-T cell persistence,which is closely associated with the therapeutic effectiveness in the clinic.It is well accepted that 4-1BB costimulation is superior over CD28 to promote the central memory differentiation and persistence of CAR-T cells.1 However,it is also noticed that CAR-T cells with either co-stimulations are comparably differentiated and persisted,2 especially under immunosuppressive conditions.Factors contributing to the discrepancy remain unknown.Mounting evidences show that programmed cell death protein 1(PD-1)directly affects memory differentiation of T cells upon PD-L1 engagement,3 in addition to limiting proliferation.It is unclear whether PD-1 is involved in the diminished difference in memory differentiation and persistence between CAR-T cells with different co-stimulations.Herein,we examined the memory differentiation of CAR-T cells when PD-1 is activated or not,and consequently the persistence and anti-tumor effects. | Feng Li Zhen Zhang Yujing Xuan Daiqun Zhang Jinyan Liu Aitian Li Shumin Wang Ting Li Xiaojuan Shi Yi Zhang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 1 |
| 10 | Pathological Networks Involving Dysmorphic Neurons in Type ⅡFocal Cortical Dysplasia显示文摘Focal cortical dysplasia(FCD)is one of the most common causes of drug-resistant epilepsy.Dysmorphic neurons are the major histopathological feature of typeⅡFCD,but their role in seizure genesis in FCD is unclear.Here we performed whole-cell patch-clamp recording and morphological reconstruction of cortical principal neurons in postsurgical brain tissue from drug-resistant epilepsy patients.Quantitative analyses revealed distinct morphological and electrophysiological characteristics of the upper layer dysmorphic neurons in typeⅡFCD,including an enlarged soma,aberrant dendritic arbors,increased current injection for rheobase action potential firing,and reduced action potential firing frequency.Intriguingly,the upper layer dysmorphic neurons received decreased glutamatergic and increased GABAergic synaptic inputs that were coupled with upregulation of the Na^(+)-K^(+)-Cl^(−)cotransporter.In addition,we found a depolarizing shift of the GABA reversal potential in the CamKⅡ-cre::PTENflox/flox mouse model of drug-resistant epilepsy,suggesting that enhanced GABAergic inputs might depolarize dysmorphic neurons.Thus,imbalance of synaptic excitation and inhibition of dysmorphic neurons may contribute to seizure genesis in typeⅡFCD. | Yijie Shao Qianqian Ge Jiachao Yang Mi Wang Yu Zhou Jin-Xin Guo Mengyue Zhu Jiachen Shi Yiqi Hu Li Shen Zhong Chen Xiao-Ming Li Jun-Ming Zhu Jianmin Zhang Shumin Duan Jiadong Chen | 2022 | Neuroscience Bulletin2022，38，9： | 1 |
| 11 | Petroleum Geological Map of Igneous Rocks in the Basins of China and Adjacent Areas显示文摘There are much information such as fault structure,stratigraphic distribution and filling features,basal features and igneous rock distribution which are concealed inside the basins of China and adjacent regions. | SHI Yongmin CHEN Shumin WANG Lei SHI Xiang DU Shuheng | 2016 | Acta Geologica Sinica(English Edition)2016，90，S1： | 0 |
| 12 | The associated evolution of raptorial foreleg and mantispid diversification during 200 million years显示文摘Adaptive evolution of predatory structure grants carnivores selective advantages[1],which evokes questions regarding the mechanism of functional adaptation via morphological variation and their potential impact on lineage diversification.Raptorial foreleg,as a key predatory structure in insects,is typically characterized by elongate coxae and stout femora possessing spines,and has evolved independently in many lineages[2]. | Dahang Lai Peichao Chen Shumin Li Xianzhe Xiang Haohong Ou Nuoyao Kang Jingtao Yang Hong Pang ChungKun Shih Conrad C.Labandeira Dong Ren Qiang Yang Chaofan Shi | 2023 | National Science Review2023，10，12： | 0 |
| 13 | Improving Parallel Corpus Quality for Chinese-Vietnamese Statistical Machine Translation显示文摘The performance of a machine translation system heavily depends on the quantity and quality of the bilingual language resource. However,getting a parallel corpus,which has a large scale and is of high quality,is a very difficult task especially for low resource languages such as Chinese-Vietnamese. Fortunately,multilingual user generated contents( UGC),such as bilingual movie subtitles,provide us access to automatic construction of the parallel corpus. Although the amount of UGC parallel corpora can be considerable,the original corpus is not suitable for statistical machine translation( SMT) systems. The corpus may contain translation errors,sentence mismatching,free translations,etc. To improve the quality of the bilingual corpus for SMT systems,three filtering methods are proposed: sentence length difference,the semantic of sentence pairs,and machine learning. Experiments are conducted on the Chinese to Vietnamese translation corpus.Experimental results demonstrate that all the three methods effectively improve the corpus quality,and the machine translation performance( BLEU score) can be improved by 1. 32. | Huu-anh Tran Yuhang Guo Ping Jian Shumin Shi Heyan Huang | 2018 | Journal of Beijing Institute of Technology2018，27，1： | 0 |
| 14 | Weighted Aggregator for the Open-World Knowledge Graph Completion显示文摘Open-world knowledge graph completion aims to find a set of missing triples through entity description,where entities can be either in or out of the graph.However,when aggregating entity description’s word embedding matrix to a single embedding,most existing models either use CNN and LSTM to make the model complex and ineffective,or use simple semantic averaging which neglects the unequal nature of the different words of an entity description.In this paper,an aggregator is proposed,adopting an attention network to get the weights of words in the entity description.This does not upset information in the word embedding,and make the single embedding of aggregation more efficient.Compared with state-of-the-art systems,experiments show that the model proposed performs well in the open-world KGC task. | Yueyang Zhou Shumin Shi Heyan Huang | 2020 | 国际计算机前沿大会会议论文集2020，，1： | 0 |
| 15 | Utilizing Crowdsourcing for the Construction of Chinese-Mongolian Speech Corpus with Evaluation Mechanism显示文摘Crowdsourcing has been used recently as an alternative to traditional costly annotation by many natural language processing groups. In this paper, we explore the use of Wechat Official Account Platform (WOAP) in order to build a speech corpus and to assess the feasibility of using WOAP followers (also known as contributors) to assemble speech corpus of Mongolian. A Mongolian language qualification test was used to filter out potential non-qualified participants. We gathered natural speech recordings in our daily life, and constructed a Chinese-Mongolian Speech Corpus (CMSC) of 31472 utterances from 296 native speakers who are fluent in Mongolian, totalling 30.8 h of speech. Then,an evaluation experiment was performed, in where the contributors were asked to choose a correct sentence from a multiple choice list to ensure the high-quality of corpus. The results obtained so far showed that crowdsourcing for constructing CMSC with an evaluation mechanism could be more effective than traditional experiments requiring expertise. | Rihai Su Shumin Shi Meng Zhao Heyan Huang | 2017 | 国际计算机前沿大会会议论文集2017，，2： | 0 |
| 16 | Unsupervised Style Control for Image Captioning显示文摘We propose a novel unsupervised image captioning method.Image captioning involves two fields of deep learning,natural language processing and computer vision.The excessive pursuit ofmodel evaluation results makes the caption style generated by the model too monotonous,which is difficult to meet people’s demands for vivid and stylized image captions.Therefore,we propose an image captioning model that combines text style transfer and image emotion recognition methods,with which the model can better understand images and generate controllable stylized captions.The proposed method can automatically judge the emotion contained in the image through the image emotion recognition module,better understand the image content,and control the description through the text style transfermethod,thereby generating captions thatmeet people’s expectations.To our knowledge,this is the first work to use both image emotion recognition and text style control. | Junyu Tian Zhikun Yang Shumin Shi | 2022 | 国际计算机前沿大会会议论文集2022，，1： | 0 |
| 17 | Outage Probability Analysis for D2D-Enabled Heterogeneous Cellular Networks with Exclusion Zone:A Stochastic Geometry Approach显示文摘Interference management is one of the most important issues in the device-to-device(D2D)-enabled heterogeneous cellular networks(HetCNets)due to the coexistence of massive cellular and D2D devices in which D2D devices reuse the cellular spectrum.To alleviate the interference,an efficient interference management way is to set exclusion zones around the cellular receivers.In this paper,we adopt a stochastic geometry approach to analyze the outage probabilities of cellular and D2D users in the D2D-enabled HetCNets.The main difficulties contain three aspects:1)how to model the location randomness of base stations,cellular and D2D users in practical networks;2)how to capture the randomness and interrelation of cellular and D2D transmissions due to the existence of random exclusion zones;3)how to characterize the different types of interference and their impacts on the outage probabilities of cellular and D2D users.We then run extensive Monte-Carlo simulations which manifest that our theoretical model is very accurate. | Yulei Wang Li Feng Shumin Yao Hong Liang Haoxu Shi Yuqiang Chen | 2024 | Computer Modeling in Engineering & Sciences2024，138，1： | 0 |
| 18 | Efficient heterogeneous integration of InP/Si and GaSb/Si templates with ultra-smooth surfaces显示文摘Heterogeneous integration of InP and GaS b on Si substrates holds a huge potential interest in near-infrared and mid-infrared optoelectronic devices.In this study,2-inch 180-nm-thick InP and 185-nmthick GaS b thin layers were successfully transferred onto the Si substrates to form high-quality and ultrasmooth InP/Si and GaS b/Si templates using molecular beam epitaxy(MBE)and the ion-slicing technique together with selective chemical etching.The relocation of the implantation-introduced damage in the sacrificial layer enables the transfer of relatively defect-free InP and GaS b thin films.The sacrificial layers were completely etched off by selective chemical etching,leaving ultra-smooth epitaxial surfaces with a roughness of 0.2 nm for the InP/Si template and 0.9 nm for the GaS b/Si template,respectively.Thus,the chemical mechanical polishing(CMP)process was not required to smooth the surface which usually introduces particles and chemical contaminations on the transferred templates.Furthermore,the donor substrate is not consumed and can be recycled to reduce the cost,which provides a paradigm for the sustainable and economic development of the Si integration platform. | Tingting JIN Jiajie LIN Tiangui YOU Xiaolei ZHANG Hao LIANG Yifan ZHU Jialiang SUN Hangning SHI Chaodan CHI Min ZHOU Robert KUDRAWIEC Shumin WANG Xin OU | 2022 | Science China(Information Sciences)2022，65，8： | 0 |
| 19 | Knowledge-enriched joint-learning model for implicit emotion cause extraction显示文摘Emotion cause extraction(ECE)task that aims at extracting potential trigger events of certain emotions has attracted extensive attention recently.However,current work neglects the implicit emotion expressed without any explicit emotional keywords,which appears more frequently in application scenarios.The lack of explicit emotion information makes it extremely hard to extract emotion causes only with the local context.Moreover,an entire event is usually across multiple clauses,while existing work merely extracts cause events at clause level and cannot effectively capture complete cause event information.To address these issues,the events are first redefined at the tuple level and a span-based tuple-level algorithm is proposed to extract events from different clauses.Based on it,a corpus for implicit emotion cause extraction that tries to extract causes of implicit emotions is constructed.The authors propose a knowledge-enriched jointlearning model of implicit emotion recognition and implicit emotion cause extraction tasks(KJ-IECE),which leverages commonsense knowledge from ConceptNet and NRC_VAD to better capture connections between emotion and corresponding cause events.Experiments on both implicit and explicit emotion cause extraction datasets demonstrate the effectiveness of the proposed model. | Chenghao Wu Shumin Shi Jiaxing Hu Heyan Huang | 2023 | CAAI Transactions on Intelligence Technology2023，8，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员