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| 1 | Regulatory science for hernia mesh: Current status and future perspectives显示文摘Regulatory science for medical devices aims to develop new tools,standards and approaches to assess the safety,effectiveness,quality and performance of medical devices.In the field of biomaterials,hernia mesh is a class of implants that have been successfully translated to clinical applications.With a focus on hernia mesh and its regulatory science system,this paper collected and reviewed information on hernia mesh products and biomaterials in both Chinese and American markets.The current development of regulatory science for hernia mesh,including its regulations,standards,guidance documents and classification,and the scientific evaluation of its safety and effectiveness was first reported.Then the research prospect of regulatory science for hernia mesh was discussed.New methods for the preclinical animal study and new tools for the evaluation of the safety and effectiveness of hernia mesh,such as computational modeling,big data platform and evidence-based research,were assessed.By taking the regulatory science of hernia mesh as a case study,this review provided a research basis for developing a regulatory science system of implantable medical devices,furthering the systematic evaluation of the safety and effectiveness of medical devices for better regulatory decision-making.This was the first article reviewing the regulatory science of hernia mesh and biomaterial-based implants.It also proposed and explained the concepts of evidence-based regulatory science and technical review for the first time. | Wenbo Liu Yajie Xie Yudong Zheng Wei He Kun Qiao Haoye Meng | 2021 | Bioactive Materials2021，6，2： | 5 |
| 2 | A novel bioactive polyurethane with controlled degradation and L-Arg release used as strong adhesive tissue patch for hemostasis and promoting wound healing显示文摘Effective strategy of hemostasis and promoting angiogenesis are becoming increasingly urgent in modern medicine due to millions of deaths caused by tissue damage and inflammation. The tissue adhesive has been favored as an optimistic and efficient path to stop bleeding, while, current adhesive presents limitations on wound care or potential degradation safety in clinical practice. Therefore, it is of great clinical significance to construct multifunctional wound adhesive to address the issues. Based on pro-angiogenic property of L-Arginine (L-Arg), in this study, the novel tissue adhesive (G-DLPUs) constructed by L-Arg-based degradable polyurethane (DLPU) and GelMA were prepared for wound care. After systematic characterization, we found that the G-DLPUs were endowed with excellent capability in shape-adaptive adhesion. Moreover, the L-Arg released and the generation of NO during degradation were verified which would enhance wound healing. Following the in vivo biocompatibility was verified, the hemostatic effect of the damaged organ was tested using a rat liver hemor-rhage model, from which reveals that the G-DLPUs can reduce liver bleeding by nearly 75% and no obvious inflammatory cells observed around the tissue. Moreover, the wound care effect was confirmed in a mouse full-thickness skin defect model, showing that the hydrogel adhesive significantly improves the thickness of newly formed dermis and enhance vascularization (CD31 staining). In summary, the G-DLPUs are promising candidate to act as multifunctional wound care adhesive for both damaged organ and trauma. | Faxing Zou Yansen Wang Yudong Zheng Yajie Xie Hua Zhang Jishan Chen M.Irfan Hussain Haoye Meng Jiang Peng | 2022 | Bioactive Materials2022，7，11： | 2 |
| 3 | Effects of Gasoline Research Octane Number on Premixed Low- Temperature Combustion of Wide Distillation Fuel by Gasoline/Diesel Blend 显示文摘 | LIU Haoye WANG Zhi WANG Jianxin | 2014 | Fuel2014，134，： | 1 |
| 4 | Combustion and Emission Characteristics of Direct Injection Compression Ignition Engine Fueled With Full Distillation Fuel (FDF) 显示文摘 | WANG Jianxin WANG Zhi LIU Haoye | 2015 | Fuel2015，140，： | 1 |
| 5 | Effects of Gasoline Re- search Octane Number on Premixed Lowtemperature Combustion of Wide Distillation Fuel by Gasoline/Diesel Blend 显示文摘 | Liu Haoye Wang Zhi Wang Jianxin | 2014 | Fuel2014，134，： | 1 |
| 6 | Imbalancebetweensubpopula-tionsofregulatoryTcellsinCOPD显示文摘 | HouJ SunY HaoY etal | 2013 | Thorax2013，12，7： | 1 |
| 7 | Identificationofantiangiogenicandantiinflammatoryproteinsinhumanamnioticmembrane显示文摘 | HaoY MaDH HwangDG etal | 2000 | Cornea2000，19，05： | 1 |
| 8 | DegradationunderhighGfieldstressandgatestressofAlGaN/GaN HEMTs显示文摘 | GuW HaoY ZhangJ etal | 2009 | ChineseJournalofPhysics2009，58，1： | 1 |
| 9 | Divergent responses of soil carbon and nitrogen pools to short-term nitrogen addition between two plantations in Northeast China显示文摘Nitrogen(N)deposition has a profound influence on forest soil carbon(C)and N pools,but there was no consensus on the responses of different C and N components in different forest types.In this study,a two-year simulated N deposition experiment with four levels of N(NH4NO3)-addition treatments(0,50,100,and 150 kg N/hm^(2)·a)were conducted in Larix gmelinii(LG)and Quercus mongolica(QM)plantation in Northeast China,in order to investigate the C and N pool dynamics under continuously enhanced N deposition.Soil organic carbon(SOC),soil total N(STN)and their active components(readily oxidizable C,ROC;dissolved organic C,DOC;microbial biomass C,MBC,dissolved organic N,DON;microbial biomass N,MBN)of the forest soil were measured monthly from May to October 2017.C and N contents in LG were observed higher than in QM.N addition had no effect on SOC and STN of LG,but significantly increased SOC and STN of QM at low N addition level.Low N addition generally raised active C components(ROC,DOC,and MBC)in both plantations,whereas high N addition did not significantly affect these components,or even decreased ROC in LG soil.Low N addition also increased STN and MBN of QM,while no significant change in STN and MBN of LG was observed.DON was directly affected by N addition and increased significantly with elevated N addition levels.The results indicated that N addition,especially of low rate,might enhance the C sequestration capacity of the forest soils and mitigate climate change. | Yedong Li Bo Wang Sen Dou Haoyue Shen Liyong Mei Yang Zhang Ximing Zeng Yaya Zhang Yameng Pei Haoye Ren Shimin Wu | 2019 | International Journal of Agricultural and Biological Engineering2019，12，6： | 1 |
| 10 | Acellular nerve xenografts based on supercritical extraction technology for repairing long-distance sciatic nerve defects in rats显示文摘Compared to conventional artificial nerve guide conduits (NGCs) prepared using natural polymers or synthetic polymers, acellular nerve grafts (ACNGs) derived from natural nerves with eliminated immune components have natural bionic advantages in composition and structure that polymer materials do not have. To further optimize the repair effect of ACNGs, in this study, we used a composite technology based on supercritical carbon dioxide (scCO_(2)) extraction to process the peripheral nerve of a large mammal, the Yorkshire pig, and obtained an innovative Acellular nerve xenografts (ANXs, namely, CD + scCO_(2) NG). After scCO_(2) extraction, the fat and DNA content in CD + scCO_(2) NG has been removed to the greatest extent, which can better supported cell adhesion and proliferation, inducing an extremely weak inflammatory response. Interestingly, the protein in the CD + scCO_(2) NG was primarily involved in signaling pathways related to axon guidance. Moreover, compared with the pure chemical decellularized nerve graft (CD NG), the DRG axons grew naturally on the CD + scCO_(2) NG membrane and extended long distances. In vivo studies further revealed that the regenerated nerve axons had basically crossed the CD + scCO_(2) NG 3 weeks after surgery. 12 weeks after surgery, CD + scCO_(2) NG was similar to autologous nerves in improving the quality of nerve regeneration, target muscle morphology and motor function recovery and was significantly better than hollow NGCs and CD NG. Therefore, we believe that the fully decellularized and fat-free porcine ACNGs may be the most promising “bridge” for repairing human nerve defects at this stage and for some time to come. | Shuai Wei Qian Hu Jianxiong Ma Xiu Dai Yu Sun Gonghai Han Haoye Meng Wenjing Xu Lei Zhang Xinlong Ma Jiang Peng Yu Wang | 2022 | Bioactive Materials2022，7，12： | 1 |
| 11 | SomeresultsonamodifiedmanniterativeschemeinareflexiveBanachspace显示文摘 | HaoY | 2013 | FixedPointTheoryAppl2013，72，12： | 1 |
| 12 | Effects of gasoline research octane number on premixed low- temperature combustion of wide distillation fuel by gaso- line/diesel blend显示文摘 | Liu Haoye Wang Zhi Wang Jianxin | 2014 | Fuel2014，134，： | 1 |
| 13 | Investigations on spikelet formation in hybrid rice as affected by elevated tropospheric ozone concentration in China显示文摘 | Yunxia Wang Lianxin Yang Kazuhiko Kobayashi Jianguo Zhu Charles P. Chen Kaifang Yang Haoye Tang Yulong Wang | 2012 | Agriculture Ecosystems and Environment2012，，： | 1 |
| 14 | A system for free-air ozone concentration elevation with rice and wheat: Control performance and ozone exposure regime显示文摘 | Haoye Tang Gang Liu Yong Han Jianguo Zhu Kazuhiko Kobayashi | 2011 | Atmospheric Environment2011，，35： | 1 |
| 15 | Impact of elevated ozone concentration on yield of four Chinese rice cultivars under fully open-air field conditions显示文摘 | Guangyao Shi Lianxin Yang Yunxia Wang Kazuhiko Kobayashi Jianguo Zhu Haoye Tang Shiting Pan Tao Chen Gang Liu Yulong Wang | 2009 | Agriculture Ecosystems and Environment2009，，3： | 1 |
| 16 | The influential factors of urban PM2 5concentrations in China: A spatial econometric analysis 显示文摘 | HaoY Liu Y M | 2016 | Journal of Cleaner Production2016，112，： | 1 |
| 17 | Arbitrarily polarized bound states in the continuum with twisted photonic crystal slabs显示文摘Arbitrary polarized vortex beam induced by polarization singularity offers a new platform for both classical optics and quantum entanglement applications.Bound states in the continuum(BICs)have been demonstrated to be associated with topological charge and vortex polarization singularities in momentum space.For conventional symmetric photonic crystal slabs(PhCSs),BIC is enclosed by linearly polarized far fields with winding angle of 2π,which is unfavorable for high-capacity and multi-functionality integration-optics applications.Here,we show that by breakingσz-symmetry of the PhCS,asymmetry in upward and downward directions and arbitrarily polarized BIC can be realized with a bilayer-twisted PhCS.It exhibits elliptical polarization states with constant ellipticity angle at every point in momentum space within the vicinity of BIC.The topological nature of BIC reflects on the orientation angle of polarization state,with a topological charge of 1 for any value of ellipticity angle.Full coverage of Poincarésphere(i.e.,-π/4≤X≤4 and-π/2≤ψ≤π/2)and higher-order Poincarésphere can be realized by tailoring the twist angles.Our findings may open up new avenues for applications in structured light,quantum optics,and twistronics for photons. | Haoye Qin Zengping Su Mengqi Liu Yixuan Zeng Man-Chung Tang Mengyao Li Yuzhi Shi Wei Huang Cheng-Wei Qiu Qinghua Song | 2023 | Light(Science & Applications)2023，12，4： | 0 |
| 18 | Proton magnetic resonance spectroscopy in substance use disorder: recent advances and future clinical applications显示文摘Proton magnetic resonance spectroscopy(1H-MRS)now is widely used in clinical researches for the measurement of compounds or metabolites in vivo,especially in neuropsychiatric diseases/disorders.Recently,there are many studies on substance use disorders utilizing 1H-MRS to explore the mechanism of brain metabolites.It is found that metabolites levels in substance users are changed compared with healthy controls.Furthermore,these changes also relate to behavior indices,and provide evidence for the impact on neuronal health,energy metabolism and membrane turnover.However,1H-MRS is not yet a mature detection technology,and it still has many challenges in the application of the neuropsychiatric disorder area.The settings of test parameters and the inconsistency of results across different studies still plague the clinicians and technicians.This article is intended to provide an overview of basic theory and methods of 1H-MRS,and the literature reporting metabolites alterations in substance dependence,as well as the related neuropsychological performance.At last,we will discuss the forthcoming challenges and possible future direction in this area. | Tianzhen CHEN Haoye TAN Huiting LEI Hang SU Min ZHAO | 2020 | Science China(Information Sciences)2020，63，7： | 0 |
| 19 | Effects of tissue heterogeneity on trabecular micromechanics examined by microCT-based finite element analysis and digital volume correlation显示文摘Trabecular bone is natural material with heterogeneous tissue properties.The effect of tissue heterogeneity on the micromechanical behavior of trabecular bone is commonly evaluated by microCT-based finite element(microFE)analysis.Results from prior work remain inconclusive and lack of experimental validation.To address these issues,we combined microFE analysis with mechanical testing and microCT-based digital volume correlation(DVC),as a validation for the microFE approach.Porcine trabecular specimens were tested in compression as sequential microCT scans were taken.DVC was performed to extract“realistic”boundary conditions that were applied to microFE models,and to measure microstructural deformation and strain of the trabecular specimens.Heterogeneous and homogeneous microFE models of each trabecular specimen were created and compared with the experimentally measured microstructural displacement and strains.Results showed strong correlations between DVC-measured and microFE-predicted trabecular displacement and strain fields(R^(2)>0.9,p<0.05),regardless of heterogeneous or homogeneous material assignments.The heterogeneous and homogeneous models predicted similar magnitudes for maximum or minimum principal strains(R^(2)=1,p<0.05).However,incorporation of tissue heterogeneity decreased more than 16.5%in the overall stress level of the trabecular tissues.Regardless,very strong correlations were found between the heterogeneous and homogeneous model-predicted principal strains or stresses.These results together suggest that tissue heterogeneity may have little effect on microFE modeling of typical elastic displacement and strains in the trabecular bone,suggesting that homogeneous material models might be sufficient to predict general trabecular micromechanics. | Jizhi Fu Haoye Meng Changhao Zhang Youjun Liu Duanduan Chen Aiyuan Wang Russell P.Main Haisheng Yang | 2021 | Medicine in Novel Technology and Devices2021，，3： | 0 |
| 20 | Polylysine-decorated macroporous microcarriers laden with adipose-derived stem cells promote nerve regeneration in vivo显示文摘Cell transplantation is an effective strategy to improve the repair effect of nerve guide conduits(NGCs).However,problems such as low loading efficiency and cell anoikis undermine the outcomes.Microcarriers are efficient 3D cell culture scaffolds,which can also prevent cell anoikis by providing substrate for adhesion during transplantation.Here,we demonstrate for the first time microcarrier-based cell transplantation in peripheral nerve repair.We first prepared macroporous chitosan microcarriers(CSMCs)by the emulsion-phase separation method,and then decorated the CSMCs with polylysine(pl-CSMCs)to improve cell affinity.We then loaded the pl-CSMCs with adipose-derived stem cells(ADSCs)and injected them into electrospun polycaprolactone/chitosan NGCs to repair rat sciatic nerve defects.The ADSCs-laden pl-CSMCs effectively improved nerve regeneration as demonstrated by evaluation of histology,motor function recovery,electrophysiology,and gastrocnemius recovery.With efficient cell transplantation,convenient operation,and the multiple merits of ADSCs,the ADSCs-laden pl-CSMCs hold good potential in peripheral nerve repair. | Yi Sun Xiaoqi Chi Haoye Meng Mengjiao Ma Jing Wang Zhaoxuan Feng Qi Quan Guodong Liu Yansen Wang Yajie Xie Yudong Zheng Jiang Peng | 2021 | Bioactive Materials2021，6，11： | 0 |
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