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| 1 | Natural Variation in the Promoter of GSE5 Contributes to Grain Size Diversity in Rice显示文摘自然基因变化的利用极大地在庄稼贡献重要农学的特点的改进。为谷物尺寸的自然变化理解基因基础能帮助 breeders 开发产量很高的米饭变化。在这研究,我们识别以前未被认出的基因,命名 GSE5,与功能的分析在由联合染色体宽的协会控制米饭谷物尺寸的 qSW5/GW5 地点学习。GSE5 编码血浆有 IQ 领域的联系膜的蛋白质,与米饭 calmodulin 蛋白质交往, OsCaM1-1。我们发现 GSE5 功能的损失引起了宽、重的谷物,当 GSE5 的 overexpression 导致了狭窄的谷物时。我们证明 GSE5 由在小穗状花小穗壳影响房间增长主要调整谷物尺寸。GSE5 的三主要 haplotypes (GSE5, GSE5 DEL1+IN1 , 和 GSE5 在栽培米饭的 DEL2 ) 在它的倡导者区域基于删除 / 插入类型被识别。我们表明了那在带 GSE5 在带 GSE5 haplotype 和 1212-bp 删除(DEL2 )> 与 GSE5 的减少的表示联系的 DEL2 haplotype,导致宽谷物。进一步的分析显示野米饭就职包含 GSE5 的所有三 haplotypes,建议在栽培米饭在场的 GSE5 haplotypes 是可能的从在米饭驯服期间的不同野米饭就职发源。一起拿,我们的结果显示在 qSW5/GW5 地点的以前未被认出的 GSE5 基因,被米饭 breeders 广泛地利用,控制谷物缩放,并且表明在 GSE5 的倡导者区域的那个自然变化在米饭贡献谷物尺寸差异。 | Penggen Duan Jinsong Xu Dali Zeng Baolan Zhang Mufan Geng Guozheng Zhang Ke Huang Luojiang Huang Ran Xu Song Ge Qian Qian Yunhai Li | 2017 | Molecular Plant2017，10，5： | 31 |
| 2 | Chinese Multidisciplinary Expert Consensus on the Diagnosis and Treatment of Hyperuricemia and Related Diseases显示文摘 | Zou, He-Jian Wu, Hu-Sheng Zhou, Jing-Guo Zeng, Xue-Jun Dai, Lie Wu, Hua-Xiang Zhu, Xiao-Xia Mei, Chang-Lin Hao, Chuan-Ming Chen, Nan Liu, Bi-Cheng Chen, Jiang-Hua Yang, Li Nie, Jing Yu, Chen Peng, Ai Yu, Sheng-Qiang Li, Lin Ge, Jun-Bo Huo, Yong Zhang, Shu-Yang Chen, Yun-Dai Dong, Yu-Gang Liang, Chun Dai, Yu-Xiang Gao, Xin Li, Chang-Gui Zhao, Jia-Jun Chen, Hai-Bing Cheng, Zhi-Feng Lin, Huan-Dong Guan, Yang-Tai Wang, Kai Luo, Ben-Yan Dai, Ruo-Lian Jiang, Quan Xue, Luan Liang, Chao-Chao Chen, Ming Fan, Song | 2017 | Chinese Medical Journal2017，，20： | 30 |
| 3 | An optimization strategy of controlled electric vehicle charging considering demand side response and regional wind and photovoltaic显示文摘Renewable energy,such as wind and photovoltaic(PV),produces intermittent and variable power output.When superimposed on the load curve,it transforms the load curve into a‘load belt’,i.e.a range.Furthermore,the large scale development of electric vehicle(EV)will also have a significant impact on power grid in general and load characteristics in particular.This paper aims to develop a controlled EV charging strategy to optimize the peak-valley difference of the grid when considering the regional wind and PV power outputs.The probabilistic model of wind and PV power outputs is developed.Based on the probabilistic model,the method of assessing the peak-valley difference of the stochastic load curve is put forward,and a two-stage peak-valley price model is built for controlled EV charging.On this basis,an optimization model is built,in which genetic algorithms are used to determine the start and end time of the valley price,as well as the peak-valley price.Finally,the effectiveness and rationality of the method are proved by the calculation result of the example. | Hong LIU Pingliang ZENG Jianyi GUO Huiyu WU Shaoyun GE | 2015 | Journal of Modern Power Systems and Clean Energy2015，3，2： | 23 |
| 4 | Treatment and outcomes of 1041 pediatric patients with neuroblastoma who received multidisciplinary care in China显示文摘Importance:Neuroblastoma is the most common extracranial malignant solid tumor in children.Multidisciplinary care is critical to improving the survival of pediatric patients with neuroblastoma.Objective:To systematically summarize the clinical characteristics of children with neuroblastoma and evaluate their prognosis with multidisciplinary care provided in a single center.Methods:This retrospective study analyzed the clinical data of 1041 patients with neuroblastoma who were diagnosed,treated,and followed-up in the Hematology-Oncology Center of Beijing Children’s Hospital from 2007 to 2019.Results:The median age at diagnosis was 34 months;80.8%of the patients were younger than 5 years of age.Notably,243 patients(23.3%)were classified as low-risk,249 patients(23.9%)were classified as intermediate-risk,and 549(52.7%)were classified as high-risk.Furthermore,956 patients underwent surgical resections;986(94.7%)patients received chemotherapy;and 176 patients with high-risk neuroblastoma received hematopoietic stem cell transplantation.The 5-year event-free survival(EFS)rate was 91.3%and 5-year overall survival(OS)rate was 97.5%in low-risk group;in the intermediate-risk group,these rates were 85.1%and 96.7%,respectively,while they were 37.7%and 48.9%in the high-risk group(P<0.001 for both).The 5-year EFS and OS rates were significantly higher in patients diagnosed between 2015 and 2019 than in patients diagnosed between 2007 and 2014(P<0.001).In total,278 patients(26.7%)exhibited tumor relapse or progression;the median interval until relapse or progression was 14 months.Of the 233 patients who died,83%died of relapse or progression of neuroblastoma and 4.3%died of therapy-related complications.Interpretation:The 5-year OS rate was low in high-risk patients,compared with low-and intermediate-risk patients.Multidisciplinary care is critical for improvement of survival in pediatric patients with neuroblastoma.Additional treatment strategies should be sought to improve the prognosis of patients with high-risk neuroblastoma. | Yan Su Hong Qin Chenghao Chen Shengcai Wang Shihan Zhang Dawei Zhang Mei Jin Yun Peng Lejian He Xiaoman Wang Suyun Qian Maoquan Qin Ming Ge Fuquan Zhang Qi Zeng Huanmin Wang Xiaoli Ma Xin Ni | 2020 | Pediatric Investigation2020，4，3： | 16 |
| 5 | Effects of continuously regenerating diesel particulate filters on regulated emissions and number-size distribution of particles emitted from a diesel engine显示文摘The effects of continuously regenerating diesel particulate filter (CRDPF) systems on regulated gaseous emissions, and number-size distribution and mass of particles emanated from a diesel engine have been investigated in this study. Two CRDPF units (CRDPF-1 and CRDPF-2) with different specifications were separately retrofitted to the engine running with European steady-state cycle (ESC). An electrical low pressure impactor (ELPI) was used for particle number-size distribution measurement and mass estimation. The conversion/reduction rate (R CR ) of hydrocarbons (HC) and carbon monoxide (CO) across CRDPF-1 was 83% and 96.3%, respectively. Similarly, the R CR of HC and CO and across CRDPF-2 was 91.8% and 99.1%, respectively. The number concentration of particles and their concentration peaks; nuclei mode, accumulation mode and total particles; and particle mass were highly reduced with the CRDPF units. The nuclei mode particles at downstream of CRDPF-1 and CRDPF-2 decreased by 99.9% to 100% and 97.8% to 99.8% respectively; and the particle mass reduced by 73% to 92.2% and 35.3% to 72.4%, respectively, depending on the engine conditions. In addition, nuclei mode particles increased with the increasing of engine speed due to the heterogeneous nucleation initiated by the higher exhaust temperature, while accumulation mode particles were higher at higher loads due to the decrease in the air-to-fuel ratio (A/F) at higher loads. | Zhihua Liu Asad Naeem Shah Yunshan Ge Yan Ding, Jianwei Tan Lei Jiang Linxiao Yu Wei Zhao Chu Wang Tao Zeng | 2011 | Journal of Environmental Sciences2011，23，5： | 15 |
| 6 | Design of the Full-disk Magneto Graph (FMG) onboard the ASO-S显示文摘The Full-disk Magneto Graph(FMG),a payload onboard the Advanced Space Solar Observatory(ASO-S),will measure the vector magnetic field in the photosphere.The instrument consists of a frontwindow filter,a telescope,an LCVR polarimeter,an image-stabilization system,a seven-stage tunable Lyot filter,a CMOS camera with 4096×4096 pixels and a pair of calibration/focus wheels.In this paper,we describe the design of the FMG instrument and provide a summary of test observations carried out with the FMG prototype. | Yuan-Yong Deng Hai-Ying Zhang Jian-Feng Yang Fu Li Jia-Ben Lin Jun-Feng Hou Zhen Wu Qian Song Wei Duan Xian-Yong Bai Dong-Guang Wang Juan Lv Wei Ge Jia-Ning Wang Zhao-Ying Zheng Chen-Jie Wang Nan-Ge Wang Hou-Kun Ni Yi-Zhong Zeng Yang Zhang Xiao Yang Ying-Zi Sun Zhi-Yong Zhang Xiao-Fan Wang | 2019 | Research in Astronomy and Astrophysics2019，19，11： | 14 |
| 7 | In situ preparation of g-C3N4/Bi4O5I2 complex and its elevated photoactivity in Methyl Orange degradation under visible light显示文摘A graphite carbon nitride(g-C3N4)modified Bi4O5I2 composite was successfully prepared insitu via the thermal treatment of a g-C3N4/Bi OI precursor at 400°C for 3 hr.The as-prepared g-C3N4/Bi4O5I2 showed high photocatalytic performance in Methyl Orange(MO)degradation under visible light.The best sample presented a degradation rate of 0.164 min^-1,which is 3.2 and 82 times as high as that of Bi4O5I2 and g-C3N4,respectively.The g-C3N4/Bi4O5I2 was characterized by X-ray powder diffractometer(XRD),scanning electron microscopy(SEM),transmission electron microscopy(TEM),Raman,X-ray photoelectron spectroscopy(XPS),ultraviolet-visible diffuse reflectance spectra(DRS),electrochemical impedance spectroscopy(EIS)and transient photocurrent response in order to explain the enhanced photoactivity.Results indicated that the decoration with a small amount of g-C3N4 influenced the specific surface area only slightly.Nevertheless,the capability for absorbing visible light was improved measurably,which was beneficial to the MO degradation.On top of that,a strong interaction between g-C3N4 and Bi4O5I2 was detected.This interplay promoted the formation of a favorable heterojunction structure and thereby enhanced the charge separation.Thus,the g-C3N4/Bi4O5I2 composite presented greater charge separation efficiency and much better photocatalytic performance than Bi4O5I2.Additionally,g-C3N4/Bi4O5I2 also presented high stability.·O2^- and holes were verified to be the main reactive species. | Zhe Feng Lin Zeng Qingle Zhang Shifeng Ge Xinyue Zhao Hongjun Lin Yiming He | 2020 | Journal of Environmental Sciences2020，32，1： | 12 |
| 8 | The prognostic value of serum C-reactive protein-bound serum amyloid A in early-stage lung cancer显示文摘Background:Elevated levels of serum C-reactive protein(CRP) have been reported to have prognostic significance in lung cancer patients.This study aimed to further identify CRP-bound components as prognostic markers for lung cancer and validate their prognostic value.Methods:CRP-bound components obtained from the serum samples from lung cancer patients or healthy controls were analyzed by differential proteomics analysis.CRP-bound serum amyloid A(CRP-SAA) was evaluated by coimmunoprecipitation(IP).Serum samples from two independent cohorts with lung cancer(retrospective cohort,242patients;prospective cohort,222 patients) and healthy controls(159 subjects) were used to evaluate the prognostic value of CRP-SAA by enzyme-linked immunosorbent assay.Results:CRP-SAA was identified specifically in serum samples from lung cancer patients by proteomic analysis.CRP binding to SAA was confirmed by co-IP in serum samples from lung cancer patients and cell culture media.The level of CRP-SAA was significantly higher in patients than in healthy controls(0.37 ± 0.58 vs.0.03 ± 0.04,P < 0.001).Elevated CRP-SAA levels were significantly associated with severe clinical features of lung cancer.The elevation of CRPSAA was associated with lower survival rates for both the retrospective(hazard ration[HR]= 2.181,95%confidence interval[CI]= 1.641-2.897,P < 0.001) and the prospective cohorts(HR = 2.744,95%CI = 1.810-4.161,P < 0.001).Multivariate Cox analysis showed that CRP-SAA was an independent prognostic marker for lung cancer.Remarkably,in stages l-ll patients,only CRP-SAA,not total SAA or CRP,showed significant association with overall survival in two cohorts.Moreover,univariate and multivariate Cox analyses also showed that only CRP-SAA could be used as an independent prognostic marker for early-stage lung cancer patients.Conclusion:CRP-SAA could be a better prognostic marker for lung cancer than total SAA or CRP,especially in earlystage patients. | Xue-Yan Zhang Ge Zhang Ying Jiang Dan Liu Man-Zhi Li Qian Zhong Shan-Qi Zeng Wan-Li Liu Mu-Sheng Zeng | 2015 | Chinese Journal of Cancer2015，34，8： | 10 |
| 9 | First proof-of-principle experiment with the post-accelerated isotope separator on-line beam at BRIF:measurement of the angular distribution of ^(23)Na+^(40)Ca elastic scattering显示文摘The reaction dynamics of exotic nuclei near the drip line is one of the main research topics of current interest.Elastic scattering is a useful probe for investigating the size and surface diffuseness of exotic nuclei.The development of rare isotope accelerators offers opportunities for such studies.To date,many relevant measurements have been performed at accelerators using the projectile fragmentation technique,while the measurements at accelerators using isotope separator on-line(ISOL)systems are still quite scarce.In this work,we present the first proof-of-principle experiment with a post-accelerated ISOL beam at the Beijing Radioactive Ion Beam Facility(BRIF)by measuring the angular distribution of elastic scattering for the stable nucleus^(23)Na from the doubly magic nucleus^(40)Ca at energies above the Coulomb barrier.The angular distribution measured by a silicon strip detector array in a scattering chamber using the ISOL beam at BRIF is in good agreement with that measured by the high-precision Q3 D magnetic spectrograph using the nonISOL beam at nearly the same energy.This work provides useful background for making BRIF a powerful tool for the investigation of the reaction dynamics of exotic nuclei. | Wei Nan Bing Guo Cheng-Jian Lin Lei Yang Dong-Xi Wang Yang-Ping Shen Bing Tang Bao-Qun Cui Tao Ge Yin-Long Lyu Hui-Ming Jia Yun-Ju Li Chen Chen Li-Hua Chen Qi-Wen Fan Xin-Yue Li Gang Lian Jian-Cheng Liu Tian-Peng Luo Nan-Ru Ma Rui-Gang Ma Xie Ma Ying-Jun Ma Wei-Ke Nan Dan-Yang Pang You-Bao Wang Pei-Wei Wen Feng Yang Yong-Jin Yao Sheng Zeng Hao Zhang Fu-Peng Zhong Shan-Hao Zhong Zhi-Hong Li Tian-Jue Zhang Wei-Ping Liu BRIF Collaboration | 2021 | Nuclear Science and Techniques2021，32，5： | 9 |
| 10 | Catastrophic Debris Flows on July 10^(th) 2013 along the Min River in Areas Seriously-hit by the Wenchuan Earthquake显示文摘Over 240 debris flows occurred in hillslopes, gullies( indicated those with single-channel)and watersheds(indicated those with tributaries and channels) on July 10 th 2013 in the Wenchuan county,and caused 29 casualties and about 633×106 USD losses. This work aimed to analyze characteristics,hazards and causes of these events and explore mitigating measures based on field investigation and remote sensing images interpretation. The debris flows contained clay content of 0.1%~3.56%, having densities of 1.72~2.14 t/m3, velocities of 5.0~12.7 m/s,discharges of 335~2353 m3/s and sediment yields of0.10~1.26×106 m3, and also numerously occurred in large watersheds with the area over 10 km2. Large debris flows formed 3 hazard-chains in slopes, gullies,watersheds and rivers, which all evolved in dammed lakes and outburst flood, and 26 dammed lakes and10 newly ones were generated along the rivers of Min and Yuzi. The remarkable spatial difference of loose solid materials accumulation and intense rainfall,with the cumulative of about or more than 150 mm and the hourly of over 16 mm, caused debris flows in the sections from Yingxiu to Miansi and Gengda. The damages on buildings, reconstructions, highways,factories and hydro power station originated from the impacting, scouring, burying of debris flows, the submerging of dammed lake and the scouring of outburst flood, and the huge losses came from the ruinous destructions of control engineering works of debris flows as well as the irrational location and lowresistant capabilities of reconstructions. For hazards mitigating of debris flows in long term, the feasible measures for short term, including risk-reassessing of foregone and potential hazard sites, regional alarming system establishing and integrated control in disastrous sites, and middle-long term, including improving reconstruction standard, rationally disposing river channel bed rise and selecting appropriate reconstruction time and plans, were strongly suggested. | GE Yong-gang CUI Peng ZHANG Jian-qiang ZENG Chao SU Feng-huan | 2015 | Journal of Mountain Science2015，12，1： | 8 |
| 11 | Geometrical feature analysis and disaster assessment of the Xinmo landslide based on remote sensing data显示文摘At 5:39 am on June 24, 2017, a landslide occurred in the village of Xinmo in Maoxian County, Aba Tibet and Qiang Autonomous Prefecture(Sichuan Province, Southwest China). On June 25, aerial images were acquired from an unmanned aerial vehicle(UAV), and a digital elevation model(DEM) was processed. Landslide geometrical features were then analyzed. These are the front and rear edge elevation, accumulation area and horizontal sliding distance. Then, the volume and the spatial distribution of the thickness of the deposit were calculated from the difference between the DEM available before the landslide, and the UAV-derived DEM collected after the landslide. Also, the disaster was assessed using high-resolution satellite images acquired before the landslide. These include Quick Bird, Pleiades-1 and GF-2 images with spatial resolutions of 0.65 m, 0.70 m, and 0.80 m, respectively, and the aerial images acquired from the UAV after the landslide with a spatial resolution of 0.1 m. According to the analysis, the area of the landslide was 1.62 km2, and the volume of the landslide was 7.70 ± 1.46 million m3. The average thickness of the landslide accumulation was approximately 8 m. The landslide destroyed a total of 103 buildings. The area of destroyed farmlands was 2.53 ha, and the orchard area was reduced by 28.67 ha. A 2-km section of Songpinggou River was blocked and a 2.1-km section of township road No. 104 was buried. Constrained by the terrain conditions, densely populated and more economically developed areas in the upper reaches of the Minjiang River basin are mainly located in the bottom of the valleys. This is a dangerous area regarding landslide, debris flow and flash flood events Therefore, in mountainous, high-risk disaster areas, it is important to carefully select residential sites to avoid a large number of casualties. | FAN Jian-rong ZHANG Xi-yu SU Feng-huan GE Yong-gang Paolo TAROLLI YANG Zheng-yin ZENG Chao ZENG Zhen | 2017 | Journal of Mountain Science2017，14，9： | 8 |
| 12 | Nine-month angiographic and two-year clinical follow-up of polymer-free sirolimus-eluting stent versus durable-polymer sirolimus-eluting stent for coronary artery disease: the Nano randomized trial显示文摘 | Zhang Yaojun Chen Fang Takashi Muramatsu Xu Bo Li Zhanquan Ge Junbo He Qing Yang Zhijian Li Shumei Wang Lefeng Wang Haichang He Ben Li Kang Qi Guoxian Li Tianchang Zeng Hesong Peng Jianjun Jiang Tieming Zeng Qiutang Zhu Jianhua Fu Guosheng Christos V. Bourantas Patrick W. Serruys Huo Yong | 2014 | Chinese Medical Journal2014，，11： | 8 |
| 13 | Myocardial bridging detection by non-invasive multislice spiral computed tomography: comparison with intravascular ultrasound显示文摘背景:侵略血管内超声(IVUS ) 是为心肌的衔接的当前的诊断标准(MB ) 。非侵略多切冠的血管造影术(MSCT ) 技术提供了的计算机化的断层摄影术隧道动脉的一个好解剖看法现在。方法:有为 IVUS 安排的不正常或典型的咽峡炎的 51 个连续病人的一个总数在这研究被注册, MSCT 被执行在 IVUS 前的 7 天。冠的成像用 IVUS 和 MSCT 被确定。四个主要容器(左主要动脉(LMA ) ,左前面的下降(男孩) ,左降声调符号(LCX ) ,恰好冠的动脉(RCA )) 被检验。结果:41 (80%) 从 51,病人们在 MSCT 扫描前收到了 metaprolol (25 mg ) ,他们中的 25 个是当前的贝它块用户。吝啬的心搏率是(64 +/- 3 ) 每分钟跳动。51 个病人的一个总数经历了 IVUS 检查(30 与 MB 并且 21 没有 MB ) 为这研究被选择。28 被 MSCT 正确地从 30 个 MB 盒子诊断,有 MB 的 2 个病人没被检测。有 IVUS 的比较,由 MSCT 的察觉的敏感是 93% ,特性是 100% 。显著地从 MSCT 和 IVUS 导出的隧道动脉的腔直径减少了从(2.9 +/- 0.3 ) 公里到(2.4 +/- 0.4 ) 公里(P <
0.001 ) 并且从(3.3 +/- 0.3 ) 公里到(2.6 +/- 0.5 ) 公里(P <
0.001 ) 分别地。从 MSCT 导出的 MB 的最小、最大的直径是比从 IVUS 的那些显著地小的((2.4 +/- 0.4 ) 公里对(2.6 +/- 0.5 ) 公里, P <
0.05 并且(2.9 +/- 0.3 ) 公里对(3.3 +/- 0.3 ) 公里, P <
0.05 ) 分别地。结论:MSCT 与与侵略 IVUS 可比较的诊断精确性在男孩和动脉粥样硬化诊断为 MB 提供一个可靠非侵略的方法。 | WANG Ming-hui SUN Ai-jun QIAN Ju-ying LING Qing-zhi ZENG Meng-su GE Lei WANG Ke-qiang FAN Bing YAN Wei ZHANG Feng | 2008 | Chinese Medical Journal2008，，1： | 7 |
| 14 | Effect of diosmetin on airway remodeling in a murine model of chronic asthma显示文摘支气管的气喘,最普通的过敏疾病之一,被航线 hyperresponsiveness (AHR ) 描绘,发炎,并且改变。抗氧化剂黄酮 aglycone diosmetin 改善在胰腺炎的发炎,而是很少在气喘上对它的影响被知道。在这研究,长期的气喘上的 diosmetin 的效果在航线在与 ovalbumin (卵) 质问的 BALB/c 老鼠改变的调整上与一个重音被调查。diosmetin 显著地在气喘的老鼠的肺减轻了煽动性的细胞渗入,离脚玻璃杯或瓷杯细胞增生,和骨胶原免职并且显著地在这些动物减少了 AHR,这被发现。全部的房间的导致卵的增加和在 bronchoalveolar lavage 液体的嗜曙红血球计数被颠倒,并且在浆液的卵特定的免疫球蛋白 E 的水平被 diosmetin 管理稀释,暗示 diosmetin 的一项 anti-Th2 活动。而且, diosmetin 显著地压制了光滑的肌肉肌动朊 alpha 链的表示,显示航线上的 diosmetin 的有势力 anti-proliferative 效果光滑的肌肉房间(ASMC ) 。矩阵 metallopeptidase-9,转变生长 factor-1,和脉管的 endothelial 生长因素层次是也由 diosmetin 减轻了,建议航线改变的宽恕可能被归因于这些蛋白质的衰落。一起拿,我们的调查结果向 diosmetin 的新奇侧面提供了改变反的治疗学的好处,在在长期的气喘汇寄 ASMC 增长加亮 diosmetin 的一个新潜力。 | Ai Ge Yanan Liu Xiaoning Zeng Hui Kong Yuan Ma Jiaxiang Zhang Fangfang Bai Mao Huang | 2015 | Acta Biochimica et Biophysica Sinica2015，47，8： | 7 |
| 15 | Relief Effect of Bevacizumab on Severe Edema Induced by Re-irradiation in Brain Tumor Patients显示文摘INTRODUCTION Brain edema is a serious clinical event and could cause various neurological symptoms such as dizziness and headache.Drugs frequently used to relieve brain edema include steroid,dehydrant (e.g.,mannitol),and diuretics.But the effects of these drugs were limited in patients with severe edema.Bevacizumab has been applied in the treatment of cerebral radiation necrosis.[1] Case studies have reported on the application of bevacizumab in the treatment of severe brain edema.[2] In the present study,we describe significant effects of bevacizumab on severe brain edema in patients with re-irradiation. | Ge Shen Ying-Jie Wang Yan-Jun Guan Da-Peng Dong Gang Yang Dan Li Rui-Min Hao Hui-Ru Sun Ming Zhou Kun-Peng Wang Shi-Xiang Zhou Qin-Wen Wang Shi-Kai Wu Yan-Jun Zeng | 2015 | Chinese Medical Journal2015，，15： | 7 |
| 16 | Oral bacteria colonize and compete with gut microbiota in gnotobiotic mice显示文摘The oral microbiota is associated with oral diseases and digestive systemic diseases.Nevertheless,the causal relationship between them has not been completely elucidated,and colonisation of the gut by oral bacteria is not clear due to the limitations of existing research models.The aim of this study was to develop a human oral microbiota-associated (HOMA) mouse model and to investigate the ecological invasion into the gut.By transplanting human saliva into germ-free (GF) mice,a HOMA mouse model was first constructed.16S rRNA gene sequencing was used to reveal the biogeography of oral bacteria along the cephalocaudal axis of the digestive tract.In the HOMA mice,84.78% of the detected genus-level taxa were specific to the donor.Principal component analysis (PCA) revealed that the donor oral microbiota clustered with those of the HOMA mice and were distinct from those of specific pathogen-free (SPF) mice.In HOMA mice,OTU counts decreased from the stomach and small intestine to the distal gut.The distal gut was dominated by Streptococcus,Veillonella,Haemophilus,Fusobacterium,Trichococcus and Actinomyces.HOMA mice and human microbiota-associated (HMA) mice along with the GF mice were then cohoused.Microbial communities of cohoused mice clustered together and were significantly separated from those of HOMA mice and HMA mice.The Source Tracker analysis and network analysis revealed more significant ecological invasion from oral bacteria in the small intestines,compared to the distal gut,of cohoused mice.In conclusion,a HOMA mouse model was successfully established.By overcoming the physical and microbial barrier,oral bacteria colonised the gut and profiled the gut microbiota,especially in the small intestine. | Bolei Li Yang Ge Lei Cheng Benhua Zeng Jinzhao Yu Xian Peng Jianhua Zhao Wenxia Li Biao Ren Mingyun Li Hong Wei Xuedong Zhou | 2019 | International Journal of Oral Science2019，11，3： | 7 |
| 17 | Botulinum toxin type-A injection to treat patients with intractable anismus unresponsive to simple biofeedback training显示文摘AIM:To evaluate the efficacy of botulinum toxin type A injection to the puborectalis and external sphincter muscle in the treatment of patients with anismus unresponsive to simple biofeedback training.METHODS:This retrospective study included 31 patients suffering from anismus who were unresponsive to simple biofeedback training.Diagnosis was made by anorectal manometry,balloon expulsion test,surface electromyography of the pelvic floor muscle,and defecography.Patients were given botulinum toxin type A(BTX-A) injection and pelvic floor biofeedback training.Follow-up was conducted before the paper was written.Improvement was evaluated using the chronic constipation scoring system.RESULTS:BTX-A injection combined with pelvic floor biofeedback training achieved success in 24 patients,with 23 maintaining persistent satisfaction during a mean period of 8.4 mo.CONCLUSION:BTX-A injection combined with pelvic floor biofeedback training seems to be successful for intractable anismus. | Yong Zhang Zhen-Ning Wang Lei He Ge Gao Qing Zhai Zhi-Tao Yin Xian-Dong Zeng | 2014 | World Journal of Gastroenterology2014，20，35： | 7 |
| 18 | Implementation of a cusp-like for real-time digital pulse shaper in nuclear spectrometry显示文摘Pulse shaping,which improves signal-to-noise ratio excellently,has been extensively used in nuclear signal processing.This paper presents a cusp-like pulse-shaping technique developed through the recursive difference equation in time domain.It can be implemented in field programmable gate array hardware system.Another flat-topped cusp-like shaper is developed to optimize the time constant of pulse shaping and reduce the influence of ballistic deficit.The methods of both baseline restoration and pile-up rejection are described.The ^(137)Cs energy spectra measured with the digital cusp-like shaper are 6.6% energy resolution,while those by traditional analog pulse shaper are 7.2% energy resolution,under the same conditions.This technique offers flexibility,too,in adjusting the pulse shaper parameters. | Jun Liu Jian Yang Guo-Qiang Zeng Kai-Qi Zhang Shi-Long Wei Liang-Quan Ge | 2017 | Nuclear Science and Techniques2017，28，7： | 7 |
| 19 | Thick Miocene eolian deposits on the Huajialing Mountains:The geomorphic evolution of the western Loess Plateau显示文摘The geomorphic evolution of northwestern China during the Cenozoic has been a subject of much geological interest because of its link with the uplift of the Himalayan-Tibetan complex.Much information about these changes is recoverable from the sedimentary sequences of the region.We report here on the thick eolian deposits mantling the Huajialing Mountains,a relatively flat mountain range in the western Loess Plateau.Correlation of magnetic susceptibility stratigraphy with the QA-I Miocene eolian sequence dates a 134.7 m section(NL-VII) for the interval from 18.7 to 11.8 Ma,as confirmed by micro-mammalian fossils.These eolian deposits demonstrate a much wider distribution of the Miocene eolian deposits,and also indicate that the topography contrasts in the western Loess Plateau,including the uplifts of the Huajialing Mountains and the bedrock highlands in the Qinan region,were formed by the early Miocene.The near-continuous Miocene eolian sequence from 18.7 to 11.8 Ma indicates that the substratum of Huajialing had not experienced any intense tectonic changes during this time interval,which suggests further,the relative tectonic stability of the nearby Tibetan Plateau. | ZHAN Tao GUO ZhengTang WU HaiBin GE JunYi ZHOU Xin WU ChunLin ZENG FangMing | 2011 | Science China Earth Sciences2011，54，2： | 7 |
| 20 | Manipulation of Band Degeneracy and Lattice Strain for Extraordinary PbTe Thermoelectrics显示文摘Maximizing band degeneracy and minimizing phonon relaxation time are proven to be successful for advancing thermoelectrics.Alloying with monotellurides has been known to be an effective approach for converging the valence bands of PbTe for electronic improvements,while the lattice thermal conductivity of the materials remains available room for being further reduced.It is recently revealed that the broadening of phonon dispersion measures the strength of phonon scattering,and lattice dislocations are particularly effective sources for such broadening through lattice strain fluctuations.In this work,a fine control of MnTe and EuTe alloying enables a significant increase in density of electron states near the valence band edge of PbTe due to involvement of multiple transporting bands,while the creation of dense in-grain dislocations leads to an effective broadening in phonon dispersion for reduced phonon lifetime due to the large strain fluctuations of dislocations as confirmed by synchrotron X-ray diffraction.The synergy of both electronic and thermal improvements successfully leads the average thermoelectric figure of merit to be higher than that ever reported for p-type PbTe at working temperatures. | Yixuan Wu Pengfei Nan Zhiwei Chen Zezhu Zeng Siqi Lin Xinyue Zhang Hongliang Dong Zhiqiang Chen Hongkai Gu Wen Li Yue Chen Binghui Ge Yanzhong Pei | 2020 | Research2020，，1： | 6 |
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