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| 1 | Semiparametric Quantile Modelling of Hierarchical Data显示文摘 | Mao Zai TIAN Man Lai TANG Ping Shing CHAN | 2009 | Acta Mathematica Sinica,English Series2009，25，4： | 7 |
| 2 | Overview of the Shenzhen Emergency Medical Service Call Pattern显示文摘BACKGROUND:In Shenzhen,the Emergency Medical Service(EMS) system has been in service since 1997.This study aims to examine the operation of Shenzhen 120 EMS center and to identify the reasons of calling EMS.METHODS:In this retrospective quantitative descriptive study,the data from the Shenzhen 120 EMS registry in 2011 were analyzed.RESULTS:Shenzhen 120 EMS center is a communication command center.When the number of 120 are dialed,it is forwarded to the closest appropriate hospital for ambulance dispatch.In2011,the Shenzhen 120 EMS center received 153 160 ambulance calls,with an average of 420 calls per day.Calling emergency services was mainly due to traffic accidents.Trauma and other acute diseases constituted a majority of ambulance transports.The adult patients aged 15-60 years are the principal users of EMS.There are no recognized 'paramedic' doctors and nurses.The pre-hospital emergency service is under the operation of emergency departments of hospitals.Shenzhen at present does not have specialized pre-hospital training for doctors and nurses in posttrauma management.Moreover,specialized pre-hospital training,financial support,and public health education on proper use of EMS should be emphasized.CONCLUSION:The Shenzhen 120 EMS center has its own epidemiology characteristics.Traumatic injury and traffic accident are the main reasons for calling ambulance service.In-depth study emphasizing the distribution and characteristics of trauma patients is crucial to the future development of EMS. | Shuk Man Lo Yi Min Yu Lap Yip Larry Lee Mi Ling Eliza Wong Sek Ying Chair Edward J Kalinowski Tak Shing Jimmy Chan | 2012 | World Journal of Emergency Medicine2012，3，4： | 4 |
| 3 | Identification of Ca2+ signaling components in neural stem/progenitor cells during differentiation into neurons and glia in intact and dissociated zebrafish neurospheres显示文摘The development of the CNS in vertebrate embryos involves the generation of different sub-types of neurons and glia in a complex but highly-ordered spatio-temporal manner. Zebrafish are commonly used for exploring the development, plasticity and regeneration of the CNS, and the recent development of reliable protocols for isolating and culturing neural stem/progenitor cells(NSCs/NPCs) from the brain of adult fish now enables the exploration of mechanisms underlying the induction/specification/differentiation of these cells. Here, we refined a protocol to generate proliferating and differentiating neurospheres from the entire brain of adult zebrafish. We demonstrated via RT-qPCR that some isoforms of ip3 r, ryr and stim are upregulated/downregulated significantly in differentiating neurospheres, and via immunolabelling that 1,4,5-inositol trisphosphate receptor(IP3 R) type-1 and ryanodine receptor(RyR) type-2 are differentially expressed in cells with neuron-or radial glial-like properties. Furthermore, ATP but not caffeine(IP3 R and RyR agonists, respectively), induced the generation of Ca^(2+) transients in cells exhibiting neuron-or glial-like morphology. These results indicate the differential expression of components of the Ca^(2+) -signaling toolkit in proliferating and differentiating cells. Thus, given the complexity of the intact vertebrate brain, neurospheres might be a useful system for exploring neurodegenerative disease diagnosis protocols and drug development using Ca^(2+) signaling as a read-out. | Man Kit Tse Ting Shing Hung Ching Man Chan Tiffany Wong Mike Dorothea Catherine Leclerc Marc Moreau Andrew L.Miller Sarah E.Webb | 2018 | Science China(Life Sciences)2018，61，11： | 4 |
| 4 | Surgical outcomes for unilateral superior oblique palsy in Chinese population: a retrospective study显示文摘AIM: To evaluate the outcome after surgery for unilateral superior oblique(SO) palsy in Chinese.METHODS: The medical records of 39 patients that underwent surgery for unilateral SO palsy between January 2003 and December 2012 at Caritas Medical Centre, Hong Kong, were retrospectively reviewed. All surgeries were performed by a single surgeon. Pre-operative assessments for vertical deviation, cyclo-deviation, and Knapp's classification were obtained to determine the nature and degree of surgical correction.Vertical deviation was measured at 1wk; 1, 6mo and on last follow-up day post-operatively. Cyclo-deviation was measured on last follow-up day post-operatively.RESULTS: During the 10 y period, 39 subjects were recruited. The most common etiology was congenital(94.9%). Knapp's Type III(66.7%) and Type I(12.8%)classifications were the most common subtypes. To treat SO palsy, the most common surgical procedures were:isolated inferior oblique(IO) anteriorization(41.0%),isolated IO myectomy(10.3%), and isolated IO recession(10.3%). At 3.5 ±2.1y post-operatively, the vertical deviation was significantly reduced(15.1 ±6.2 PD versus0.5±1.4 PD, P <0.0001) without significant improvement in cyclo-deviation(P =0.5). Initial vertical deviation was correlated with cyclo-torsion(r =0.4, P =0.007). Those with over-correction had greater initial vertical deviation(19.4±7.2 PD versus 13.2±4.3 PD, P =0.003). After a single operation, 84.6% of subjects achieved a vertical deviation within ±3 PD.· CONCLUSION: The majority of subjects achieved corrected vertical deviation after a single surgery although there was no improvement in cyclo-deviation.Those with over-correction of primary position deviation had greater preoperative vertical deviation and it may be related to simultaneous multiple muscle surgery. | Gordon Shing Kin Yau Victor Tak Yau Tam Jacky Wai Yip Lee Theo Tak Kwong Chan Can Yin Fun Yuen | 2015 | International Journal of Ophthalmology(English edition)2015，8，1： | 4 |
| 5 | miR-130b Promotes CD133 + Liver Tumor-Initiating Cell Growth and Self-Renewal via Tumor Protein 53-Induced Nuclear Protein 1显示文摘 | Stephanie Ma Kwan Ho Tang Yuen Piu Chan Terence K. Lee Pak Shing Kwan Antonia Castilho Irene Ng Kwan Man Nathalie Wong Ka-Fai To Bo-Jian Zheng Paul B.S. Lai Chung Mau Lo Kwok Wah Chan Xin-Yuan Guan | 2010 | Cell Stem Cell2010，，： | 2 |
| 6 | Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing显示文摘 | Chan K C Allen Jiang Peiyong Zheng Yama W L Liao Gary J W Sun Hao Wong John Siu Shing Shun N Chan Wing C Chan Stephen L Chan Anthony T C Lai Paul B S Chiu Rossa W K Lo Y M D | 2013 | Clinical Chemistry2013，，1： | 2 |
| 7 | Mobile Human Airbag System for Fall Protection Using MEMS Sensors and Embedded SVM Classifier显示文摘 | HI Guangyi CHAN Cheung Shing LI Wen Jung | 2009 | IEEE Sensors2009，9，5： | 1 |
| 8 | A new approach for image enhancement ap plied to low-contrast-low-illumination IC and document images 显示文摘 | Leung Chung-Chu Chan Ka Shing Chan Hoi-Mei | 2005 | Pattern Recognition Letters2005，6，1： | 1 |
| 9 | On allocation of redundancies in two-component series systems显示文摘 | Peng Zhao Ping Shing Chan Long Li Hon Keung Tony Ng | 2013 | Operations Research Letters2013，，6： | 1 |
| 10 | Autologous hematopoietic stem cell transplantation for high-risk brain tumors in children显示文摘 | Daniel Ka Leung Cheuk Tsz Leung Lee Alan Kwok Shing Chiang Shau Yin Ha Godfrey Chi Fung Chan | 2008 | Journal of Neuro-Oncology2008，，3： | 1 |
| 11 | Allocation of two redundancies in two‐component series systems显示文摘 | Peng Zhao Ping Shing Chan Long Li Hon Keung Tony Ng | 2013 | Naval Research Logistics2013，，7： | 1 |
| 12 | Optimal allocation of redundancies in series systems显示文摘 | Peng Zhao Ping Shing Chan Hon Keung Tony Ng | 2012 | European Journal of Operational Research2012，，3： | 1 |
| 13 | Cancer-associated histone mutation H2BG53D disrupts DNA–histone octamer interaction and promotes oncogenic phenotypes显示文摘Dear Editor,Recent studies from us and others have deciphered the clinical relevance of a variety of oncohistones1 in different diseases.The H3K27M and H3K36M mutant histones exert dominant-negative effects on methylation levels of histone H3K27 and H3K36 on wildtype histone protein in pediatric brain cancers2–4 and chondroblastoma,5,6 respectively.In contrast to H3K27M and H3K36M that act in trans to cause global reduction of methylation at the respective residues,the H3G34 mutations,including H3G34V/R and H3G34W/L found in pediatric high-grade glioma and giant cell tumor of the bone,affect the H3K36 methylation in cis and alter the H3K36 methylation on the nucleosome containing the H3G34 mutation(s). | Yi Ching Esther Wan Tsz Chui Sophia Leung Dongbo Ding Xulun Sun Jiaxian Liu Lina Zhu Tze Zhen Evangeline Kang Du Yang Yuchen Zhang Jitian Zhang Chengmin Qian Michael Shing Yan Huen Qing Li Maggie Zi Ying Chow Zongli Zheng Junhong Han Ajay Goel Xin Wang Toyotaka Ishibashi Kui Ming Chan | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 1 |
| 14 | Children and adolescents with haemophilia in hong kong:an epidemiological and clinical review显示文摘 | Ling S C Chan G C F Shing M M K | 2006 | HK J Paediatr (New Series)2006，11，1： | 1 |
| 15 | Three-component elastic wave band-gap material显示文摘 | Liu ZhengYou Chan C T Shing Ping | 2002 | Phys Rev2002，65，16： | 1 |
| 16 | A generalized Shapiro-Wilk W statistic for testing high-dimensional normality 显示文摘 | Jiajuan Liang Man-Lai Tang Ping Shing Chan | 2009 | Computational Statistics & Data Analysis2009，53，11： | 1 |
| 17 | The Prognostic Significance of Total Lymph Node Harvest in Patients with T2–4N0M0 Colorectal Cancer显示文摘 | Hsiang-Lin Tsai Chien-Yu Lu Jan-Sing Hsieh Deng-Chyang Wu Chang-Ming Jan Chee-Yin Chai Koung Shing Chu Hon-Man Chan Jaw-Yuan Wang | 2007 | Journal of Gastrointestinal Surgery2007，，5： | 1 |
| 18 | Three-component elastic wave band-gap material 显示文摘 | Liu Zhengyou Chan C T Shing Ping | 2002 | Phys Rev B2002，65，16： | 1 |
| 19 | miR-130b Promotes CD133 + Liver Tumor-Initiating Cell Growth and Self-Renewal via Tumor Protein 53-Induced Nuclear Protein 1显示文摘 | Stephanie Ma Kwan Ho Tang Yuen Piu Chan Terence K. Lee Pak Shing Kwan Antonia Castilho Irene Ng Kwan Man Nathalie Wong Ka-Fai To Bo-Jian Zheng Paul B.S. Lai Chung Mau Lo Kwok Wah Chan Xin-Yuan Guan | 2010 | Cell Stem Cell2010，，： | 1 |
| 20 | Iridium complex of porphycene:a new member of metalloporphycene显示文摘Iridium(Ⅲ)porphycene complex was synthesized and structurally characterized for the first time.The introduction of the posttransition iridium(Ⅲ)ion not only significantly enhances the absorption intensity at the end of visible region,but also displays efficient singlet oxygen quantum yield(76%),which is applicable for photodynamic therapy in living cells. | Yi Chang Fei Zhao Fan Wu Nana Ma Xiaoming Ma Yue Zhao Kin Shing Chan Zhen Shen | 2020 | Science China Chemistry2020，63，5： | 0 |
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