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| 1 | Histone modifications:Targeting head and neck cancer stem cells显示文摘Head and neck squamous cell carcinoma(HNSCC) is the sixth most common cancer worldwide, and is responsible for a quarter of a million deaths annually. The survival rate for HNSCC patients is poor, showing only minor improvement in the last three decades. Despite new surgical techniques and chemotherapy protocols, tumor resistance to chemotherapy remains a significant challenge for HNSCC patients. Numerous mechanisms underlie chemoresistance, including genetic and epigenetic alterations in cancer cells that may be acquired during treatment and activation of mitogenic signaling pathways, such as nuclear factor kappa-light-chain-enhancer-of activated B cell, that cause reduced apoptosis. In addition to dysfunctional molecular signaling, emerging evidence reveals involvement of cancer stem cells(CSCs) in tumor development and in tumor resistance to chemotherapy and radiotherapy. These observations have sparked interest in understanding the mechanisms involved in the control of CSC function and fate. Post-translational modifications of histones dynamically influence gene expression independent of alterations to the DNA sequence. Recent findings from our group have shown that pharmacological induction of posttranslational modifications of tumor histones dynamically modulates CSC plasticity. These findings suggest that a better understanding of the biology of CSCs in response to epigenetic switches and pharmacological inhibitors of histone function may directly translate to the development of a mechanism-based strategy to disrupt CSCs. In this review, we present and discuss current knowledge on epigenetic modifications of HNSCC and CSC response to DNA methylation and histone modifications. In addition, we discuss chromatin modifications and their role in tumor resistance to therapy. | John M Le Cristiane H Squarize Rogerio M Castilho | 2014 | World Journal of Stem Cells2014，6，5： | 6 |
| 2 | Aspects of forest restoration and hydrology:the hydrological function of litter显示文摘Although forests play important roles in the hydrological cycle,there is little information that relates the water retention capacity of litter in areas under passive restoration,especially in Cerrado savannas.This study relates litter levels to water holding capacity and effective water retention among forest fragments under different passive restoration stages:46,11,and 8 years to better understand litter hydrological functions in the Cerrado.Water retention capacity and effective water retention capacity of litters(unstructured materials,branches and leaves)in the field were monitored on a monthly basis.Total litter accumulation at 46 years was significantly higher than that of the other succession stages.Unstructured litter mass was significantly higher than that of leaves and branches.The 46-year stage had the highest water holding capacity in the leaf fraction,followed by unstructured material and branches.Although the water holding capacity was lower in the oldest resto-ration,this site showed the highest efficiency under field conditions.The process was quickly reestablished,as the 11-year restoration showed results closer to that for the 46-year stage in comparison to the area at 8 years.Thus,passive restoration plays a key role in soil water mainte-nance due to the influence of litter in Cerrado savannas.Deforestation and the imminent need of restoring degraded sites,highlight the need for further studies focused on bet-ter understanding of the process of forest restoration and its temporal effect on soil water recovery dynamics. | Luara Castilho Pereira Leonardo Balbinot Marcelle Teodoro Lima Julieta Bramorski Kelly Cristina Tonello | 2022 | Journal of Forestry Research2022，33，2： | 3 |
| 3 | CD24 + Liver Tumor-Initiating Cells Drive Self-Renewal and Tumor Initiation through STAT3-Mediated NANOG Regulation显示文摘 | Terence Kin Wah Lee Antonia Castilho Vincent Chi Ho Cheung Kwan Ho Tang Stephanie Ma Irene Oi Lin Ng | 2011 | Cell Stem Cell2011，，1： | 2 |
| 4 | miR-130b Promotes CD133 + Liver Tumor-Initiating Cell Growth and Self-Renewal via Tumor Protein 53-Induced Nuclear Protein 1显示文摘 | Stephanie Ma Kwan Ho Tang Yuen Piu Chan Terence K. Lee Pak Shing Kwan Antonia Castilho Irene Ng Kwan Man Nathalie Wong Ka-Fai To Bo-Jian Zheng Paul B.S. Lai Chung Mau Lo Kwok Wah Chan Xin-Yuan Guan | 2010 | Cell Stem Cell2010，，： | 2 |
| 5 | Semaphorin 4D provides a link between axon guidance processes and tumorinduced angiogenesis显示文摘 | Basile J R Castilho R M Williams V P | 2006 | Proc Natl Acad Sci USA2006，103，24： | 1 |
| 6 | Trends in the analytical methods for the determinationof trans fatty acids content in foods显示文摘 | ALBUQUERQUE T G COSTA H S CASTILHO M C | 2011 | Trends in Food Scienceand Technology2011，22，11： | 1 |
| 7 | Long-term exposure to high glucose increases the content of several exocy- totic proteins and of vesicular GABA transporter in cultured retinal neural cells显示文摘 | BAPTISTA F I CASTILHO A F GASPAR J M | 2015 | Nenrosci Lett2015，602，： | 1 |
| 8 | Mass tourism scheme beached in Costa Rica显示文摘 | C | 1994 | Panoscope1994，，6： | 1 |
| 9 | Immunohisto-chemical evidence of PTEN in oral squamous cell carcinoma and its correlation with the histological malignancy grading system显示文摘 | Squarize C H Castilho R M Santos P D Jr | 2002 | J Oral Pathol Med2002，31，： | 1 |
| 10 | Mitochondrial permeability transition and oxidative stress 显示文摘 | Kowaltowski A J Castilho RF Vercesi AE | 2001 | FEBS Lett2001，495，12： | 1 |
| 11 | Chemonucleolysis in lumbar disc herniation:a meta-analysis显示文摘 | Couto JM Castilho EA Menezes PR | | 0，，： | 1 |
| 12 | Virus-like parti- cles in vaccine development 显示文摘 | Roldio A Mellado MC Castilho LR | 2010 | Expert Rev Vaccines2010，9，10： | 1 |
| 13 | Influence of family environ- menton on children' soral health : a systematic review 显示文摘 | Castilho AR Mialhe FL Barbosa TS | 2013 | J Pediatr (Rio J)2013，89，2： | 1 |
| 14 | Retroelements,transposons and methylation status in the genome of oil palm (Elaeis guineensis) and the relationship to somaclonal variation显示文摘 | Kubis SE Castilho AM Vershinin AV | 2003 | Plant Mole Biol2003，52，1： | 1 |
| 15 | CD24( + ) livertumor-initiating cells drive self-renewal and tumor initia-tion through STAT3-mediated NANOG regulation 显示文摘 | Lee TK Castilho A Cheung VC | 2011 | CellStem Cell2011，9，： | 1 |
| 16 | Immunohistochemical evidence of PTEN in oral squamous cell carcinoma and its correlation with the histological malignancy grading system显示文摘 | Squarize CH Castilho RM Santos D | 2002 | J Oral Pathol Med2002，31，7： | 1 |
| 17 | mTOR mediates Wnt-induced epidermal stem cell exhaustion and aging显示文摘 | Castilho RM Squarize CH Chodosh LA | 2009 | Cell Stem Cell2009，5，3： | 1 |
| 18 | Lupeol targets liver tumor-initiating cells through phosphatase and tensin homolog modulation显示文摘 | Lee TK Castilho A Cheung VC | 2011 | Hepatology2011，53，1： | 1 |
| 19 | 4,6-Dinitro-o-cresol uncouples oxidative phosphorylation and induces membrane permeability transition in rat liver mitochondria显示文摘 | Castilho RF Vicente JA Kowahowski A J | 1997 | Int J Biochem Cell Biol1997，29，： | 1 |
| 20 | Mi-tochondria and reactive oxygen species显示文摘 | Kowaltowski AJ de Souza-Pinto NC Castilho RF Vercesi AE | | 0，，： | 1 |
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