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| 1 | Effect of alternative antibiotics in treatment of cefotaxime resistant spontaneous bacterial peritonitis显示文摘AIM:To evaluate effective alternative antibiotics in treatment of cefotaxime-resistant spontaneous bacterial peritonitis.METHODS:One hundred cirrhotic patients with spontaneous bacterial peritonitis [ascitic fluid polymorphonuclear cell count(PMNLs) ≥ 250 cells/mm 3 at admission] were empirically treated with cefotaxime sodium 2 g/12 h and volume expansion by intravenous human albumin.All patients were subjected to history taking,complete examination,laboratory tests(including a complete blood cell count,prothrombin time,biochemical tests of liver and kidney function,and fresh urine sediment),chest X-ray,a diagnostic abdominal paracentesis,and the sample subjected to total and differential cell count,chemical examination,aerobic and anaerobic cultures.Patients were divided after 2 d by a second ascitic PMNL count into group Ⅰ;patients sensitive to cefotaxime(n = 81),group Ⅱ(n = 19);cases resistant to cefotaxime(less than 25% decrease in ascitic PMNL count).Patients of group Ⅱ were randomly assigned into meropenem(n = 11) or levofloxacin(n = 8) subgroups.All patients performed an end of treatment ascitic PMNL count.Patients were considered improved when:PMNLs decreased to < 250 cells/mm 3,no growth in previously positive culture cases,and improved clinical manifestations with at least 5 d of antibiotic therapy.RESULTS:Age,sex,and Child classes showed no significant difference between group Ⅰ and group Ⅱ.Fever and abdominal pain were the most frequent manifestations and were reported in 82.7% and 80.2% of patients in group Ⅰ and in 94.7% and 84.2% of patients in group Ⅱ,respectively.Patients in group Ⅱ had a more severe ascitic inflammatory response than group Ⅰ and this was demonstrated by more ascitic lactate dehydrogenase(LDH) [median:540 IU/L(range:150-1200 IU/L) vs median:240 IU/L(range:180-500 IU/L),P = 0.000] and PMNL [median:15 000 cell/mm 3(range:957-23 822 cell/mm 3) vs 3400 cell/mm 3(range:695-26 400 cell/mm 3),P = 0.000] counts.Ascitic fluid culture was positive in 32% of cases.Cefotaxime failed in 19% of patients;of these patients,11(100%) responded to meropenem and 6(75%) responded to levofloxacin.Two patients with failed levofloxacin therapy were treated according to the in vitro culture and sensitivity(one case was treated with vancomycin and one case was treated with ampicillin/sulbactam).In group Ⅱ the meropenem subgroup had higher LDH(range:108-860 IU/L vs 120-491 IU/L,P = 0.042) and PMNL counts(range:957-23 822 cell/mm 3 vs 957-15 222 cell/mm 3,P = 0.000) at initiation of the alternative antibiotic therapy;there was no significant difference in the studied parameters between patients responsive to meropenem and patients responsive to levofloxacin at the end of therapy(mean ± SD:316.01 ± 104.03PMNLs/mm 3 vs 265.63 ± 69.61 PMNLs/mm 3,P = 0.307).The isolated organisms found in group Ⅱ were;enterococci,acinetobacter,expanded-spectrum β-lactamase producing Escherichia coli,β-lactamase producing Enterobacter and Staphylococcus aureus.CONCLUSION:Empirical treatment with cefotaxime is effective in 81% of cases;meropenem is effective in cefotaxime-resistant cases. | Ahmed Abouelkhair Badawy Tarik Ibrahim Zaher Samar Mahmoud Sharaf Mohamed Hassan Emara Noha Elsaid Shaheen Talaat Fathy Aly | 2013 | World Journal of Gastroenterology2013，19，8： | 13 |
| 2 | Vascular calcification:When should we interfere in chronic kidney disease patients and how?显示文摘Chronic kidney disease(CKD) patients are endangered with the highest mortality rate compared to other chronic diseases. Cardiovascular events account for up to 60% of the fatalities. Cardiovascular calcifications affect most of the CKD patients. Most of this calcification is related to disturbed renal phosphate handling. Fibroblast growth factor 23 and klotho deficiency were incriminated in the pathogenesis of vascular calcification through different mechanisms including their effects on endothelium and arterial wall smooth muscle cells. In addition, deficient klotho gene expression, a constant feature of CKD, promotes vascular pathology and shares in progression of the CKD. The role of gut in the etio-pathogenesis of systemic inflammation and vascular calcification is a newly discovered mechanism. This review will cover the medical history, prevalence, pathogenesis, clinical relevance, different tools used to diagnose, the ideal timing to prevent or to withhold the progression of vascular calcification and the different medications and medical procedures that can help to prolong the survival of CKD patients. | Usama Abdel Azim Sharaf El Din Mona Mansour Salem Dina Ossama Abdulazim | 2016 | World Journal of Nephrology2016，5，5： | 10 |
| 3 | Stop chronic kidney disease progression: Time is approaching显示文摘Progression of chronic kidney disease(CKD) is inevitable. However, the last decade has witnessed tremendous achievements in this field. Today we are optimistic; the dream of withholding this progression is about to be realistic. The recent discoveries in the field of CKD management involved most of the individual diseases leading the patients to end-stage renal disease. Most of these advances involved patients suffering diabetic kidney disease, chronic glomerulonephritis, polycystic kidney disease, renal amyloidosis and chronic tubulointerstitial disease. The chronic systemic inflammatory status and increased oxidative stress were also investigated. This inflammatory status influences the antisenescence Klotho gene expression. The role of Klotho in CKD progression together with its therapeutic value are explored. The role of gut as a major source of inflammation, the pathogenesis of intestinal mucosal barrier damage, the role of intestinal alkaline phosphatase and the dietary and therapeutic implications add a novel therapeutic tool to delay CKD progression. | Usama Abdel Azim Sharaf El Din Mona Mansour Salem Dina Ossama Abdulazim | 2016 | World Journal of Nephrology2016，5，3： | 6 |
| 4 | Path planning for moving target tracking by fixed-wing UAV显示文摘For the automatic tracking of unknown moving targets on the ground,most of the commonly used methods involve circling above the target.With such a tracking mode,there is a moving laser spot on the target,which will bring trouble for cooperative manned helicopters.In this paper,we propose a new way of tracking,where an unmanned aerial vehicle(UAV) circles on one side of the tracked target.A circular path algorithm is developed for monitoring the relative position between the UAV and the target considering the real-time range and the bearing angle.This can determine the center of the new circular path if the predicted range between the UAV and the target does not meet the monitoring requirements.A transition path algorithm is presented for planning the transition path between circular paths that constrain the turning radius of the UAV.The transition path algorithm can generate waypoints that meet the flight ability.In this paper,we analyze the entire method and detail the scope of applications.We formulate an observation angle as an evaluation index.A series of simulations and evaluation index comparisons verify the effectiveness of the proposed algorithms. | Song-lin Liao Rong-ming Zhu Nai-qi Wu Tauqeer Ahmed Shaikh Mohamed Sharaf Almetwally M.Mostafa | 2020 | Defence Technology(防务技术)2020，16，4： | 6 |
| 5 | The Role of Endoscopy in the Assessment and Treatment of Esophageal Cancer显示文摘 | J.A. Evans D.S. Early V. Chandraskhara K.V. Chathadi R. Fanelli D.A. Fisher K. Foley J.H. Hwang T.L. Jue S. Pasha R. Sharaf A. Shergill J.A. Dominitz B.D. Cash | 2012 | Gastrointestinal Endoscopy2012，，： | 2 |
| 6 | Production of High Quality Functional Labneh Cheese Using Exopolysaccharides Producing Encapsulated Lactobacillus Bulgaricus显示文摘 | Kawther EI-Shafei Fayza M. Assem Azzat B. Abd-EI-Khalek Osama M. Sharaf | 2011 | Journal of Life Sciences2011，5，2： | 2 |
| 7 | Appropriate use of GI endoscopy显示文摘 | Dayna S. Early Tamir Ben-Menachem G. Anton Decker John A. Evans Robert D. Fanelli Deborah A. Fisher Norio Fukami Joo Ha Hwang Rajeev Jain Terry L. Jue Khalid M. Khan Phyllis M. Malpas John T. Maple Ravi S. Sharaf Jason A. Dominitz Brooks D. Cash | 2012 | Gastrointestinal Endoscopy2012，，6： | 2 |
| 8 | Pre-treatment role of inosine triphosphate pyrophosphatase polymorphism for predicting anemia in Egyptian hepatitis C virus patients显示文摘AIM: To investigate and clarify, for the first time, the role of inosine triphosphate pyrophosphatase (ITPA ) polymorphism in Egyptian chronic hepatitis C virus (HCV) patients.METHODS:The human genomic DNA of all patients was extracted from peripheral blood cells in order to determine the single nucleotide polymorphism (SNP) of ITPA (rs1127354). SNP genotyping was performed by real time polymerase chain reaction (PCR, ABI TaqMan allelic discrimination kit) for 102 treatment-naive Egyptian patients with chronic HCV. All patients had no evidence of cardiovascular or renal diseases. They received a combination treatment of pegylated interferon α (PEG-IFNα) as a weekly subcutaneous dose plus an oral weight-adjusted dose of ribavirin (RBV). The majority received PEG-IFNα2a (70.6%) while 29.4% received PEG-IFNα2b. The planned duration of treatment was 24-48 wk according to the viral kinetics throughout the course of treatment. Pre-treatment liver biopsy was done for each patient for evaluation of fibrosis stage and liver disease activity. The basal viral load level was detected quantitatively by real time PCR while viral load throughout the treatment course was performed qualitatively by COBAS TaqMan assay. RESULTS: Ninety-three patients (91.2%) had ITPA SNP CC genotype and 9 (8.8%) had non-CC genotype (CA and AA). The percentage of hemoglobin (Hb) decline was higher for CC patients than for non-CC patients, particularly at weeks 4 and 8 (P=0.047 and 0.034, respectively). During the first 12 wk of treatment, CC patients had significantly more Hb decline > 3 g/dL than non-CC patients: 64.5% vs 22.2% at weeks 8 and 12, respectively, (P=0.024 and 0.038). Reduction of the amount of the planned RBV dose was significantly higher for CC patients than non-CC patients during the first 12 wk (18% ± 12.1% vs 8.5% ± 10.2%, P=0.021). The percentage of CC patients with RBV dose reduction was significantly greater than that of non-CC patients (77.4% vs 44.4%, P=0.044). Multivariate analysis identified only the percentage of RBV dose as a predictor for Hb decline. Platelet decline was significantly higher in non-CC patients than CC patients at weeks 12, 24 and 48 (P=0.018, 0.009 and 0.026, respectively). CONCLUSION: Rs1127354 ITPA polymorphism plays a decisive role in protecting against treatment-induced anemia and the need for RBV dose reduction in Egyptian HCV patients. | Walaa H Ahmed Norihiro Furusyo Saad Zaky Abeer Sharaf Eldin Hany Aboalam Eiichi Ogawa Masayuki Murata Jun Hayashi | 2013 | World Journal of Gastroenterology2013，19，9： | 2 |
| 9 | Flavone glycosides from Mentha longifolia显示文摘 | Sharaf M El-Ansari MA Saleh NAM | 1999 | Fitoterapia1999，70，6： | 1 |
| 10 | A rule based fuzzy logic controller for a PWM inverter in a stand alone wind energy conversion scheme显示文摘 | Hilloowala R M Sharaf A M | 1996 | IEEE Trans On IE1996，32，1： | 1 |
| 11 | Signalling pathways involved in endocrine resistance in breast cancer and associations with epithelial to mesenchymal transition显示文摘 | A1 Saleh S Sharaf LH Luqmani YA | 2011 | Int J Oncol2011，38，5： | 1 |
| 12 | Signalling pathways involved in endocrine resistance in breast cancer and asso?ciations with epithelial to mesenchymal transition ( Review) 显示文摘 | Al Saleh S Sharaf LH Luqmani YA | 2011 | Int J Oncol2011，38，5： | 1 |
| 13 | A comparative study of chil- dren' s pain reactions and perceptions to AMSA injection using CCLAD versus traditional injections 显示文摘 | Feda M A1 Amoudi N Sharaf A | 2010 | J Clin Pediatr Dent2010，34，3： | 1 |
| 14 | Novel Controllers for the 48-Pulse VSC STATCOM and SSSC for Voltage Regula- tion and Reactive Power Compensation显示文摘 | EI-MOURSI M S SHARAF A M | 2005 | IEEE Trans on Power Systems2005，20，4： | 1 |
| 15 | New flavonoids from Avicennia marina显示文摘 | Sharaf M E1 Anari M A SaLeh N A M | 2000 | Fitoterapia2000，71，： | 1 |
| 16 | New flavonoids from Avicennia marina 显示文摘 | Sharaf M EI-Ansari M A Saleh N A M | 2000 | Fitoterapia2000，71，： | 1 |
| 17 | Coronary microvascular reactivity to adenosine predicts adverse outcome in women evaluated for suspected ischemia results from the National Heart,Lung and Blood Institute WISE(Women's Ischemia Syndrome Evaluation)study显示文摘 | PEPINE C J ANDERSON R D SHARAF B L | 2010 | J Am Coll Cardiol2010，55，： | 1 |
| 18 | Thermal responsive hydrogels based on semi interpenetrating network of poly(NIPAm) and cellulose nanowhiskers显示文摘 | HEBEISH A FARAG S SHARAF S | 2014 | Carbohydrate Polymers2014，102，： | 1 |
| 19 | Two control schemes to enhance the dynamic performance of the STATCOM and SSSC显示文摘 | Norouzi A H Sharaf A M | 2005 | IEEE Transactions on Power Delivery2005，20，1： | 1 |
| 20 | Pheno and genotyping of Pasteurella multocida isolated from goat in Iran显示文摘 | Shayegh J Sharaf J D Namvar H | 2009 | African J Biotechnol2009，8，16： | 1 |
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