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| 1 | Effectiveness of therapeutic barium enema for diverticular hemorrhage显示文摘AIM:To evaluate the effectiveness of barium impaction therapy for patients with colonic diverticular bleeding.METHODS:We reviewed the clinical charts of patients in whom therapeutic barium enema was performed for the control of diverticular bleeding between August2010 and March 2012 at Yokohama Rosai Hospital.Twenty patients were included in the review,consisting of 14 men and 6 women.The median age of the patients was 73.5 years.The duration of the followup period ranged from 1 to 19 mo(median:9.8 mo).Among the 20 patients were 11 patients who required the procedure for re-bleeding during hospitalization,6patients who required it for re-bleeding that developed after the patient left the hospital,and 3 patients who required the procedure for the prevention of rebleeding.Barium(concentration:150 w%/v%)was administered per the rectum,and the leading edge of the contrast medium was followed up to the cecum by fluoroscopy.After confirmation that the ascending colon and cecum were filled with barium,the enema tube was withdrawn,and the patient’s position was changed every 20 min for 3 h.RESULTS:Twelve patients remained free of rebleeding during the follow-up period(range:1-19mo)after the therapeutic barium enema,including 9men and 3 women with a median age of 72.0 years.Re-bleeding occurred in 8 patients including 5 men and 3 women with a median age of 68.5 years:4developed early re-bleeding,defined as re-bleeding that occurs within one week after the procedure,and the remaining 4 developed late re-bleeding.The DFI(disease-free interval)decreased 0.4 for 12 mo.Only one patient developed a complication from therapeutic barium enema(colonic perforation).CONCLUSION:Therapeutic barium enema is effective for the control of diverticular hemorrhage in cases where the active bleeding site cannot be identified by colonoscopy. | Mizue Matsuura Masahiko Inamori Atsushi Nakajima Yasuhiko Komiya Yumi Inoh Keigo Kawasima Mai Naitoh Yuji Fujita Akiko Eduka Noriyoshi Kanazawa Shiori Uchiyama Rie Tani Kennichi Kawana Setsuya Ohtani Hajime Nagase | 2015 | World Journal of Gastroenterology2015，21，18： | 2 |
| 2 | Environmental regulation and geographical adaptation of diapause in Cotesia plutellae (Hymenoptera: Braconidae) , a parasitoid of the diamondback moth larvae 显示文摘 | Shah MA Setsuya M | 1994 | Applied Entomology and Zoology1994，29，1： | 1 |
| 3 | Hypertrophic growth of cultured neonatal rat heart cells mediated by vasopressin V 1A receptor显示文摘 | Yasuhiro Nakamura Takashi Haneda Junzo Osaki Setsuya Miyata Kenjiro Kikuchi | 2000 | European Journal of Pharmacology2000，，1： | 1 |
| 4 | Comparison of the distribution and numbers of antigen-presenting cells among T-lymphocyte-mediated dermatoses显示文摘 | Masatoshi Deguchi Setsuya Aiba Haruo Ohtani Hiroshi Nagura Hachiro Tagami | 2002 | Archives of Dermatological Research2002，，7： | 1 |
| 5 | Gastric small cell carcinoma with marked response to neoadjuvant chemotherapy显示文摘 | Yasuhiro Nakamura Setsuya Otani Michiro Otaka Tomoyuki Shimada Satsuki Takahashi Masahiro Saito Tohru Takahashi Masahumi Komatsu Toshie Suzuki Shunji Okubo Masato Hayashi Hironobu Sasano | 2005 | International Journal of Clinical Oncology2005，，5： | 1 |
| 6 | Notch signaling:Its role in epidermal homeostasis and in the pathogenesis of skin diseases显示文摘 | Ryuhei O Hachiro T Setsuya A | 2008 | Dermatol2008，49，3： | 1 |
| 7 | Phyllanthus acidus(L.) Skeels and Rhinacanthus nasutus(L.) Kurz leaf extracts suppress melanogenesis in normal human epidermal melanocytes and reconstitutive skin culture显示文摘Objective: To determine the effect of extracts from Phyllanthus acidus(P. acidus)(L.) Skeels and Rhinacanthus nasutus(R. nasutus)(L.) Kurz leaves on melanogenesis and the underlying mechanism in normal human epidermal melanocytes(NHEM) and a reconstitutive skin model. Methods: NHEM and a reconstitutive skin model were stimulated with ethanol extracts of P. acidus(L.) Skeels and R. nasutus(L.) Kurz leaves. mRNA expression of microphthalmiaassociated transcription factor(MITF), tyrosinase(TYR), tyrosinase-related protein 1(TYRP1) and dopachrome tautomerase(DCT) were examined by real-time PCR. The melanin content in NHEM was also measured. Moreover, protein levels of tyrosinase were determined using western blot analysis.Results: In NHEM and the reconstitutive skin model, ethanol extracts from P. acidus(at 12.5 and 25.0 μg/mL) and R. nasutus(at 6.25 and 12.50 μg/mL) significantly diminished mRNA expression of MITF, TYR, TYRP1 and DCT in a concentration-dependent manner. P. acidus and R. nasutus extracts also reduced the amount of melanin in α-MSH-stimulated NHEM. Moreover, P. acidus and R. nasutus extracts markedly suppressed tyrosinase at the translational level in the reconstitutive skin model. Conclusions: P. acidus and R. nasutus extracts significantly reduced melanogenesis in NHEM and the reconstitutive skin model, suggesting that P. acidus and R. nasutus extracts can inhibit melanin synthesis through downregulation of MITF, TYR, TYRP1 and DCT. Therefore, the ethanol extracts of P. acidus and R. nasutus contain compounds that have the potential for development as a skin lightening agent for the treatment of hyperpigmentation disorder or melasma. | Moragot Chatatikun Takeshi Yamauchi Kenshi Yamasaki Anchalee Chiabchalard Setsuya Aiba | 2019 | Asian Pacific Journal of Tropical Medicine2019，12，3： | 1 |
| 8 | Unzen drilling progress and plan 显示文摘 | Setsuya N | 2004 | ICDP Newsletter2004，6，： | 1 |
| 9 | Scientific results of conduit drilling in the Unzen Scientific Drilling Project (USDP) 显示文摘 | Setsuya N Kozo U Sumio S John C E Hiroshi S | 2005 | Scientific Drilling2005，1，： | 1 |
| 10 | Diagnostic and therapeutic problems of giant cell tumor in the proximal femur显示文摘 | Kenshi Sakayama Yoshifumi Sugawara Teruki Kidani Joji Miyawaki Taketsugu Fujibuchi Setsuya Kamei Junichi Aizawa Haruyasu Yamamoto | 2007 | Archives of Orthopaedic and Trauma Surgery2007，，10： | 1 |
| 11 | Synthesis of 2-imidazolidinylidene propanedinitrile derivatives as stimulators of gastrointestinal motility显示文摘 | Sasho Setsuya Obase Hiroyuki Ichikawa Shunji | 1993 | Journal of Medicinal Chemistry1993，36，5： | 1 |
| 12 | Disseminated Intra-abdominal Cystic Lymphangiomatosis with Severe Intestinal Bleeding: A Case Report显示文摘 | Akira Iwabuchi Michiro Otaka Atsushi Okuyama Mario Jin Setsuya Otani Satoshi Itoh Hideaki Sasahara Masaru Odashima Hitoshi Kotanagi Masahiro Satoh Hirotake Masuda Osamu Masamune | 1997 | Journal of Clinical Gastroenterology1997，，1： | 1 |
| 13 | Unzen Drilling Progress and Plan显示文摘 | Setsuya Nakada | 2004 | ICDP Newsletter2004，634，： | 1 |
| 14 | Water Contents and Hydrogen Isotopic Ratios of Rocks and Minerals From the 1991 Eruption of Unzen Volcauo显示文摘 | NORU KUSAKABE HIROAKI SATO SETSUYA NAKADA | 1999 | Journal of Volcanology and geothermal Research1999，89，： | 1 |
| 15 | Relationship between S100β and GFAP expression in astrocytes during infarction and glial scar formation after mild transient ischemia显示文摘 | Yuko Yasuda Narito Tateishi Taiji Shimoda Souichi Satoh Eriko Ogitani Setsuya Fujita | 2004 | Brain Research2004，，1： | 1 |
| 16 | Analytical Studies on Growth of Human Gastric Cancer显示文摘 | Yoshihiro Kohli Keiichi Kawai Setsuya Fujita | 1981 | Journal of Clinical Gastroenterology1981，，2： | 1 |
| 17 | Immununistogic studies reaction in the lesional epidermis显示文摘 | Setsuya A Hachiro T | 1985 | Arch Dermatol1985，121，： | 1 |
| 18 | Immununistogic studies reaction in the lesional epidermis 显示文摘 | Setsuya A Hachiro T | 1985 | Arch Dermatol1985，121，： | 1 |
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