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| 1 | Long-term effects of lamivudine treatment in Japanese chronic hepatitis B patients显示文摘AIM:To analyze the association between the emergence of tyrosine-methionine-asparatate-asparatate(YMDD) mutants(reverse transcription;rtM204I/V) and deterioration of liver function during long-term lamivudine treatment of Japanese patients with chronic hepatitis B virus(HBV) infection.METHODS:The data of 61 consecutive Japanese patients with chronic hepatitis B who underwent continuous lamivudine treatment for more than 24 mo and had a virological response were analyzed.Analysis of YMDD mutants was done by real-time polymerase chain reaction with LightCycler probe hybridization assay for up to 90 mo(mean,50.8 mo;range,24-90 mo).RESULTS:A mixed mutant-type(YMDD + tyrosine-isoleucine-asparatate-asparatate:YIDD or tyrosine-valineasparatate-asparatate:YVDD) or a mutant-type(YIDD or YVDD) were found in 57.4% of 61 patients at 1 year,78.7% of 61 patients at 2 years,79.6% of 49 patients at 3 years,70.5% of 34 patients at 4 years,68.4% of 19 patients at 5 years,57.1% of 14 patients at 6 years,and 33.3% of 6 patients at 7 years.Of the 61 patients,56(92%) had mixed mutant-or a mutant-type.Only 5(8%) had no mutants at each observation point.Virological breakthrough was found in 26(46.4%) of 56 patients with YMDD mutants,20 of whom had a hepatitis flare-up:the remaining 30(53.6%) had neither a virological breakthrough nor a flare-up.All 20 patients who developed a hepatitis flare-up had a biochemical and virological response after adefovir was added to the lamivudine treatment.CONCLUSION:Our results suggest that it is possible to continue lamivudine treatment,even after the emergence of YMDD mutants,up to the time that the patients develop a hepatitis flare-up. | Masayuki Murata Norihiro Furusyo Mami Unno Eiichi Ogawa Kazuhiro Toyoda Hiroaki Taniai Hachiro Ohnishi Jun Hayashi | 2011 | World Journal of Gastroenterology2011，17，24： | 3 |
| 2 | Repair of doublechambered right ventricles surgical results and long-tem follow-up显示文摘 | Hachiro Y Takagi N Koyanagi T | 2001 | Ann Thorac Surg2001，72，5： | 1 |
| 3 | The effects of ruthenium on the phase stability of fourth generation Ni-base single crystal superalloys显示文摘 | Atsushi Sato Hiroshi Harada Tadaharu Yokokawa Takao Murakumo Yutaka Koizumi Toshiharu Kobayashi Hachiro Imai | 2006 | Scripta Materialia2006，，9： | 1 |
| 4 | Donepezil hydrochloride(E-2020) and other AchEIs显示文摘 | Yoshiharu Yamanishi Youichi Iimura | 2000 | Curr Med Chem2000，7，3： | 1 |
| 5 | Scavenging capacities of pollen extracts from cistus ladaniferus on autoxidation, superoxide radicals, hydroxyl radicals, and DPPH radicals显示文摘 | Takeshi Nagai Reiji Inoue Hachiro Inoue Nobutaka Suzuki | 2002 | Nutrition Research2002，，4： | 1 |
| 6 | Effect on carotid atherosclerosis of probucol plus levofloxacin for Chlamydia pneumoniae infection显示文摘 | Yasunori Sawayama Masafumi Tatsukawa Kensuke Kikuchi Shinji Maeda Hachiro Ohnishi Norihiro Furusyo Jun Hayashi | 2007 | Journal of Infection and Chemotherapy2007，，2： | 1 |
| 7 | Composite graft replace-ment after aortic valvuloplasty in Takayasu arteritis显示文摘 | Harada H Honma Y Hachiro Y | 2002 | Ann Tho-rac Surg2002，73，2： | 1 |
| 8 | Organic nonlinear optical DAST crystals for electro-optic measurement and terahertz wave generation显示文摘 | Yoshinori Takahashi Hiroaki Adachi Tetsuo Taniuchi Masayuki Takagi Youichiroh Hosokawa Shinji Onzuka Srinivasan Brahadeeswaran Masashi Yoshimura Yusuke Mori Hiroshi Masuhara Takatomo Sasaki Hachiro Nakanishi | 2006 | Journal of Photochemistry & Photobiology, A: Chemistry2006，，3： | 1 |
| 9 | Comparison of the distribution and numbers of antigen-presenting cells among T-lymphocyte-mediated dermatoses显示文摘 | Masatoshi Deguchi Setsuya Aiba Haruo Ohtani Hiroshi Nagura Hachiro Tagami | 2002 | Archives of Dermatological Research2002，，7： | 1 |
| 10 | Notch signaling:Its role in epidermal homeostasis and in the pathogenesis of skin diseases显示文摘 | Ryuhei O Hachiro T Setsuya A | 2008 | Dermatol2008，49，3： | 1 |
| 11 | Repair of double-chambered right wentricle:surgical resules and long-term fllowup显示文摘 | Hachiro Y Takagi N Koyanagi T | 2002 | Ann Thorac Surg2002，72，5： | 1 |
| 12 | Aluminum potassium sulfate and tannic Acid injection in the treatment of total rectal prolapse:early outcomes显示文摘 | Hachiro Y Kunimoto M Abe T | 2007 | Dis Colon Rectum2007，50，： | 1 |
| 13 | Anovel antihypertensive peptide derived from ovalbumin induces nitric oxide-mediated vasorclaxation in an isolated SHR mesentericartery显示文摘 | NOBYUUKI M HACHIRO U HIROYUKI F | 1999 | FEBS Letters1999，452，： | 1 |
| 14 | Aluminum potassium sulfate and tannic acid(ALTA)injection as the mainstay of treatment for internal hemorrhoids显示文摘 | Hachiro Y Kunimoto M Abe T | 2011 | Surg Today2011，41，6： | 1 |
| 15 | Preparation and Solid-state Polymerization of Dipyridyloctatetrayne Derivatives显示文摘 | Tiesheng Li Shuji Okada Hachiro Nakanishi | 2003 | Polymer Bulletin2003，，2： | 1 |
| 16 | Scavenging capacities of pollen extracts from cistusladaniferus on autoxidation, superoxide radicals,hydroxylradicals, and DPPH radicals 显示文摘 | TAKESHI NAGAI REIJI INOUE HACHIRO INOUE | 2002 | Nutrition Research2002，22，： | 1 |
| 17 | The new approach in development of anti-Alzheimei' s disease drugs via the cholinergic hypothesis 显示文摘 | Hachiro Sugimoto | 2008 | Chemico-Biological Interactions2008，，175： | 1 |
| 18 | Ischemia/reperfusion-induced death of cardiac myocytes:possible involvement of nitric oxide in the coordination of ATP supply and demand during ischemia显示文摘 | Kawahara K Hachiro T Yokokawa T | 2006 | Mol Cell Cardiol2006，40，： | 1 |
| 19 | Glial cell linederived neurotropic factor stimulates Sertoli cell proliferation in the early postnatal period of rat testis development显示文摘 | HU Jian-guo HIROKI S HACHIRO N | 2006 | Endocrinology2006，140，8： | 1 |
| 20 | Scavenging capacities of pollen extracts from cistus ladaniferus on autoxidation, superoxide radicals, hydroxyl radicals, and DPPH radicals 显示文摘 | Takeshi N Reiji L Hachiro L | 2002 | Nutrition Research2002，22，4： | 1 |
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