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| 1 | Disruption of the TWEAK/Fn14 pathway prevents 5-fluorouracil-induced diarrhea in mice显示文摘AIM To clarify the roles of TWEAK and its receptor Fn14 in 5-fluorouracil(5-FU)-induced diarrhea.METHODS Diarrhea was induced in wild-type(WT), Fn14 knockout(KO), and IL-13 receptor(IL-13R)α1 KO BALB/c mice using a single injection of 5-FU. Histological analysis, cytokine analysis, and flow cytometry was performed on ileal tissues and cells. Murine colon carcinomabearing mice were co-treated with an anti-TWEAK antibody and 5-FU. Embryonic fibroblast response to cytokines was also analyzed.RESULTS5-FU induced high Fn14 expression in epithelial cells. The severity of 5-FU-induced diarrhea was lower in Fn14 KO mice compared with WT mice. Administration of anti-TWEAK antibody reduced 5-FU-induced diarrhea without affecting the antitumor effects of 5-FU in vivo. 5-FU-induced expression of IL-13, IL-17 A, TNF-α, and IFN-γ in the ileum was Fn14 dependent. The severity of 5-FU-induced diarrhea was lower in IL-13Rα1 KO mice, indicating major role for IL-13 signaling via IL-13Rα1 in pathogenesis. We found that IL-13Rα2, an IL-13 neutralizing/cell protective receptor, was strongly induced by IL-33 in vitro and in vivo. IL-13Rα2 was upregulated in the ileum of 5-FU-treated Fn14 KO mice. Thus, the deletion of Fn14 upregulated IL-13Rα2 expression, which reduced IL-13 expression and activity. CONCLUSION Disruption of the TWEAK/Fn14 pathway affects several interconnected pathways, including those associated with IL-13, IL-33, and IL-13Rα2, to attenuate 5-FUinduced intestinal side effects. | Takuhito Sezaki Yuki Hirata Teruki Hagiwara Yuki I Kawamura Tadashi Okamura Rieko Takanashi Kenta Nakano Miwa Tamura-Nakano Linda C Burkly Taeko Dohi | 2017 | World Journal of Gastroenterology2017，23，13： | 3 |
| 2 | Pharmacological profile of hydroxy fasudil as a selective rho kinase inhibitor on ischemic brain damage显示文摘 | Shin-ichi Satoh Tatsuma Utsunomiya Kazuyuki Tsurui Teruki Kobayashi Ichiro Ikegaki Yasuo Sasaki Toshio Asano | 2001 | Life Sciences2001，，12： | 2 |
| 3 | Millimeter-scale Dense liquid droplet formation and crystallization in glycine solution induced by photon pressure显示文摘 | Kenichi Yuyana Teruki Sugiyama Hiroshi Masuhara | 1992 | Langmuir1992，8，2： | 1 |
| 4 | Hopeful new liquid phenol resin-benzoxazines显示文摘 | Aizawa Teruki | 1997 | Kyoka Purasuchikkusu1997，43，3： | 1 |
| 5 | Geochemical constraints on the origin and stability of the Tono u- ranium deposit: Japan显示文摘 | Randolph C A Teruki I Eiji S | 2006 | Geological Society of Lon- don2006，6，1： | 1 |
| 6 | Proliferative ac tivity of osteosarcoma cells:comparison of osteoblastic and nonosteoblastic regions显示文摘 | Kenshi S Taketsugu F Teruki K | 2003 | J Orthop Sci2003，8，： | 1 |
| 7 | Po- tentiostatieally deposited nanostruetured a-Co ( OH ) 2 : A high performance electrode material for redox-eapacitors 显示文摘 | Gupta Vinay Kusahara Teruki Toyama Hiroshi | 2007 | Eleetrochem Commun2007，9，： | 1 |
| 8 | Towards an integrated management framework for emerging disaster risks in Japan 显示文摘 | Saburo Ikeda Teruko Sato Teruki Fukuzono | 2003 | Natural Hazards2003，，28： | 1 |
| 9 | Genistein induces Gadd45 gene and G2/M cell cycle arrest in the DU145 human prostate cancer cell line显示文摘 | Teruki Oki Yoshihiro Sowa Tohru Hirose | 2004 | FEBS Letters2004，，577： | 1 |
| 10 | Gd-EOB-DTPA-enhanced MR imaging: Evaluation of hepatic enhancement effects in normal and cirrhotic livers显示文摘 | Tsutomu Tamada Katsuyoshi Ito Atsushi Higaki Koji Yoshida Akihiko Kanki Tomohiro Sato Hiroki Higashi Teruki Sone | | European Journal of Radiology0，，： | 1 |
| 11 | Cholangiocarcinoma with skin metastases显示文摘 | Teruki Yanagi Tetsuri Matsumura Naohito Yoshizaki | 2007 | Journal of the American Academy of Dermatology2007，，2： | 1 |
| 12 | Diagnostic and therapeutic problems of giant cell tumor in the proximal femur显示文摘 | Kenshi Sakayama Yoshifumi Sugawara Teruki Kidani Joji Miyawaki Taketsugu Fujibuchi Setsuya Kamei Junichi Aizawa Haruyasu Yamamoto | 2007 | Archives of Orthopaedic and Trauma Surgery2007，，10： | 1 |
| 13 | Diagnostic criteria for primary osteoporosis: year 2000 revision显示文摘 | Hajime Orimo Yasufumi Hayashi Masao Fukunaga Teruki Sone Saeko Fujiwara Masataka Shiraki Kazuhiro Kushida Shigehito Miyamoto Satoshi Soen Junji Nishimura Yasuo Oh-hashi Takayuki Hosoi Itsuo Gorai Hiroyuki Tanaka Tetsuo Igai Hideaki Kishimoto | 2001 | Journal of Bone and Mineral Metabolism2001，，6： | 1 |
| 14 | A case of cutaneous Paragonimiasis with pleural effusion显示文摘 | Teruki Dainichi Tsuyoshi Nakahara Yoichi Moroi | 2003 | International Journal of Dermatology2003，42，： | 1 |
| 15 | T2-weighted MR imaging of prostate cancer: multishot echo-planar imaging vs fast spin-echo imaging显示文摘 | Tsutomu Tamada Teruki Sone Kiyohisa Nagai Yoshimasa Jo Masayuki Gyoten Shigeki Imai Yasumasa Kajihara Masao Fukunaga | 2004 | European Radiology2004，，2： | 1 |
| 16 | Non‐alcoholic fatty liver disease: Factors associated with its presence and onset显示文摘 | Teruki Miyake Teru Kumagi Shinya Furukawa Yoshio Tokumoto Masashi Hirooka Masanori Abe Yoichi Hiasa Bunzo Matsuura Morikazu Onji | 2013 | J Gastroenterol Hepatol2013，，： | 1 |
| 17 | The influence of aliphatic amines,diamines and amino acids on the polymorph of calcium carbonate precipitated by the introduction of carbon dioxide gas into calcium hydroxide aqueous suspensions显示文摘 | Wittaya Chuajiw Dazumasa Takatori Teruki Igarashi | 2014 | Crustal Growth2014，386，： | 1 |
| 18 | Diffusion‐weighted MRI and its role in prostate cancer显示文摘 | Tsutomu Tamada Teruki Sone Yoshimasa Jo Akira Yamamoto Katsuyoshi Ito | 2014 | NMR Biomed2014，，1： | 1 |
| 19 | Hopeful new liquide phenol resin-benzoxazines显示文摘 | AIZAWA TERUKI | 1997 | Kyoka Purasuchikkusu1997，43，3： | 1 |
| 20 | Hopeful new liquide phenol resin - benzoxazines显示文摘 | AIZAWA TERUKI | 1997 | Kyoka Purasuchikkusu1997，43，3： | 1 |
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