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| 1 | Measurement of prostaglandin metabolites is useful in diagnosis of small bowel ulcerations显示文摘BACKGROUND We recently reported on a hereditary enteropathy associated with a gene encoding a prostaglandin transporter and referred to as chronic enteropathy associated with SLCO2 A1 gene(CEAS). Crohn's disease(CD) is a major differential diagnosis of CEAS, because these diseases share some clinical features. Therefore, there is a need to develop a convenient screening test to distinguish CEAS from CD.AIM To examine whether prostaglandin E major urinary metabolites(PGE-MUM) can serve as a biomarker to distinguish CEAS from CD.METHODS This was a transactional study of 20 patients with CEAS and 98 patients with CD.CEAS was diagnosed by the confirmation of homozygous or compound heterozygous mutation of SLCO2 A1. We measured the concentration of PGEMUM in spot urine by radioimmunoassay, and the concentration was compared between the two groups of patients. We also determined the optimal cut-off value of PGE-MUM to distinguish CEAS from CD by receiver operating characteristic(ROC) curve analysis.RESULTS Twenty Japanese patients with CEAS and 98 patients with CD were enrolled.PGE-MUM concentration in patients with CEAS was significantly higher than that in patients with CD(median 102.7 vs 27.9 μg/g × Cre, P < 0.0001). One log unit increase in PGE-MUM contributed to 7.3 increase in the likelihood for the diagnosis of CEAS [95% confidence interval(CI) 3.2-16.7]. A logistic regression analysis revealed that the association was significant even after adjusting confounding factors(adjusted odds ratio 29.6, 95%CI 4.7-185.7). ROC curve analysis revealed the optimal PGE-MUM cut-off value for the distinction of CEAS from CD to be 48.9 μg/g × Cre with 95.0% sensitivity and 79.6% specificity.CONCLUSION PGE-MUM measurement is a convenient, non-invasive and useful test for the distinction of CEAS from CD. | Yuichi Matsuno Junji Umeno Motohiro Esaki Yoichiro Hirakawa Yuta Fuyuno Yasuharu Okamoto Atsushi Hirano Shigeyoshi Yasukawa Fumihito Hirai Toshiyuki Matsui Shuhei Hosomi Kenji Watanabe Naoki Hosoe Haruhiko Ogata Tadakazu Hisamatsu Shunichi Yanai Shuji Kochi Koichi Kurahara Tsuneyoshi Yao Takehiro Torisu Takanari Kitazono Takayuki Matsumoto | 2019 | World Journal of Gastroenterology2019，25，14： | 5 |
| 2 | 吸烟状况与急性缺血性脑卒中后功能结局的关系显示文摘吸烟是脑卒中的既定危险因素;然而,脑卒中前吸烟状态是否会影响急性缺血性脑卒中的临床预后尚不确定。该研究旨在阐明吸烟状态与急性缺血性脑卒中后功能预后的关系。研究者获取一项基于日本多中心医院的脑卒中登记资料,调查了2007年7-12月期间住院的10825例急性缺血性脑卒中患者,这些患者在脑卒中发作之前生活能够自理。吸烟状况分为从未吸烟者(不吸烟者),曾经吸烟者和现在吸烟者。临床结局包括3个月时功能转归不良(改良的Rankin量表评分≥2)和功能性依赖(改良的Rankin量表评分2~5)。 | 刘青(译) 刘莉(摘、审校) Matsuo R Ago T Kiyuna F Sato N Nakamura K Kuroda J Wakisaka Y Kitazono T | 2020 | 中华高血压杂志2020，28，2： | 4 |
| 3 | Rare histological subtype of invasive micropapillary carcinoma in the ampulla of Vater: A case report显示文摘BACKGROUND Carcinoma of the ampulla of Vater is an uncommon ampullo-pancreatobiliary neoplasm,and the most common histological type is adenocarcinoma with a tubular growth pattern.Invasive micropapillary carcinoma(IMPC)is an aggressive variant of adenocarcinoma in several organs that is associated with lymph node metastasis and poor prognosis.IMPC was first described as a histological subtype of breast cancer;however,IMPC of the ampulla of Vater is extremely rare,with only three articles reported in the English literature.CASE SUMMARY We have reported a case of IMPC of the ampulla of Vater in an 80-year-old man.Microscopically,the surface area of the carcinoma was composed of tubulopapillary structures mimicking intra-ampullary papillary-tubular neoplasm,and the deep invasive front area exhibited a pattern of IMPC.The carcinoma showed lymphatic invasion and extensive lymph node metastasis.The immunohistochemical study revealed mixed intestinal and gastric/pancreatobiliary phenotypes.CONCLUSION This rare subtype tumor in the ampulla of Vater showed a histologically mixed phenotype and exhibited aggressive behavior. | Hirotsugu Noguchi Michiyo Higashi Tetsuya Idichi Hiroshi Kurahara Yuko Mataki Takashi Tasaki Ikumi Kitazono Takao Ohtsuka Akihide Tanimoto | 2021 | World Journal of Clinical Cases2021，9，11： | 2 |
| 4 | Effect of fluidity on the manufacturing of open cell magnesium alloy foams显示文摘The effect of fluidity on open cell AZ31 metal foam samples fabricated using a solid state space holder method was investigated.Granule was fabricated by plaster powder and perlite powder.Granules were sieved which compacted layer by layer in casting mold.Preforms which made by granules were then heated to 200℃,300℃,400℃,500℃ under a rough(mechanical)vacuum before pressure infiltration with AZ31 Mg alloy.Samples were infiltrated using vacuum pressure values range of 8-14 KPa.The conditions of pressure and temperature were performed in order to get different fluidity on manufacturer of open cell AZ31 metal foam specimen quantity.It is found that the fluidity plays significant role to determine the open cell AZ31 alloy foam.The fluidity is affected by preheat temperature and infiltration vacuum pressure.The macrostructure,the distribution of the pores,microstructure,infiltration length,and porosity were investigated. | Xue-Zheng Yue Koichi Kitazono Xue-Jie Yue Bo-Young Hur | 2016 | Journal of Magnesium and Alloys2016，4，1： | 2 |
| 5 | Multidrug resistance and the lung resistance-related protein in human colon carcinoma SW-120 cells显示文摘 | Sumizawa T Takebayashi Y | 1999 | J Natl Cancer Inst1999，91，19： | 1 |
| 6 | NOX4 as the major catalytic component of an endothelial NAD(P)H oxidase显示文摘 | Ago T Kitazono T Ouboshi H Iyama T Han YH Takada J | 2004 | Circulation2004，109，2： | 1 |
| 7 | Construction of gene therapy vectors targeting thyroid cells:enhancement of activity and specificity with histone deacetylase inhibitors and agents modulating the cyclic adenosine 3′,5′-monophosphate path-way and demonstration of activity in follicular and anaplastic thyroid carcinoma cells显示文摘 | Kitazono M Chuman Y Aikou T | 2001 | J Clin Endocrinol Metab2001，86，2： | 1 |
| 8 | Dilatation of the basilar artery in response to selective activation of endothelin B receptors in vivo 显示文摘 | KITAZONO T HEISTAD DD FARACI FM | 1995 | J Pharmco Exp Ther1995，273，1： | 1 |
| 9 | Muhidrug resistance and the lung resistance-related protein in human colon carcinoma SW-620 cells 显示文摘 | Kitazono M Sumizawa T Takebayashi Y | 1999 | J Natl Cancer Inst1999，91，19： | 1 |
| 10 | Calcium influx pathways inrat CNS pericytes显示文摘 | Kamouchi M Kitazono T Ago T | 2004 | Brain Res Mol Brain Res2004，126，2： | 1 |
| 11 | Multidrug resistance and the lung resistance- related protein in human colon carcinoma SW-620 cells 显示文摘 | KITAZONO M OKUMURA H IKEDA R | 1999 | J Natl Cancer Inst1999，91，19： | 1 |
| 12 | Inhibition of Na+/H+ exchanger reduces infarct volume of focal cerebral ixchemia in rats显示文摘 | KITAYAMA J KITAZONO T YAO H | 2001 | Brain Res2001，922，2： | 1 |
| 13 | Nox4 as the ma- jor catalytic component of an endothelial NADPH oxidase 显示文摘 | Ago T Kitazono T Ooboshi H | 2004 | Circulation2004，109，2： | 1 |
| 14 | Low concentrations of the histone deacetylase inhibitor,depsipeptide(FR901228),increase expression of the Na+/Ⅰ-symptorter and iodide accu-mulation in poorly differentiated thyroid carcinoma cells显示文摘 | Robery R Zhan Z | 2001 | J Clin Endocrinol Metab2001，86，： | 1 |
| 15 | Novel manufacturing process of closed-cell aluminum foam by accumulative roll-bonding 显示文摘 | KITAZONO K SAYO E KURIBAYASHI K | 2004 | Scripts Materials2004，50，4： | 1 |
| 16 | Prevention of hypoxia-induced apoptosis by the angiogenic factor thymidine phosphorylase显示文摘 | Kitazono M Takebayashi Y Ishitsuka K | 1998 | Biochem Biophys Res Commun1998，253，： | 1 |
| 17 | Antiproliferative action of metformin in human lung cancer cell lines 显示文摘 | Ashinuma H Takiguchi Y Kitazono S | 2012 | Oncol Rep2012，28，1： | 1 |
| 18 | L-arginine restores dilator responses of the basilar artery to ACh during chron ic hypertension显示文摘 | Kitazono T Faraci FM Heistad DD | 1996 | Hypertension1996，27，4： | 1 |
| 19 | Thermal cycling creep behavior of NiAl-Cr alloy显示文摘 | Sundar R A Kitazono K Sato E | 2001 | Intermetallics2001，9，： | 1 |
| 20 | Cardiac myxoma: morphologic, histochemical, and tissue culture studies显示文摘 | Tanimura A Kitazono M Nagayama K | 1988 | Hum Pathol1988，19，3： | 1 |
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