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| 1 | Female hepatology:Favorable role of estrogen in chronic liver disease with hepatitis B virus infection显示文摘Chronic hepatitis B virus (HBV) infection is the most common cause of hepatic fibrosis and hepatocellular carcinoma (HCC),mainly as a result of chronic necroinflammatory liver disease. A characteristic feature of chronic hepatitis B infection,alcoholic liver disease and nonalcoholic fatty liver disease (NAFLD) is hepatic steatosis. Hepatic steatosis leads to an increase in lipid peroxidation in hepatocytes,which,in turn,activates hepatic stellate cells (HSCs). HSCs are the primary target cells for inflammatory and oxidative stimuli,and these cells produce extracellular matrix components. Chronic hepatitis B appears to progress more rapidly in males than in females,and NAFLD,cirrhosis and HCC are predominately diseases that tend to occur in men and postmenopausal women. Premenopausal women have lower hepatic iron stores and a decreased production of proinflammatory cytokines. Hepatic steatosis has been observed in aromatase-deficient mice,and has been shown to decrease in animals after estradiol treatment. Estradiol is a potent endogenous antioxidant which suppresses hepatic fibrosis in animal models,and attenuates induction of redox sensitive transcription factors,hepatocyte apoptosis and HSC activation by inhibiting a generation of reactive oxygen species in primary cultures. Variant estrogen receptors are expressed to a greater extent in male patients with chronic liver disease than in females. These lines of evidence suggest that the greater progression of hepatic fibrosis and HCC in men and postmenopausal women may be due,at least in part,to lower production of estradiol and a reduced response to the action of estradiol. A better understanding of the basic mechanisms underlying the sex-associated differences in hepatic fibrogenesis and carciogenesis may open up new avenues for the prevention and treatment of chronic liver disease. | Ichiro Shimizu Nao Kohno Katsuyoshi Tamaki Masayuki Shono Hui-Wei Huang Jiang-Hong He Deng-Fu Yao | 2007 | World Journal of Gastroenterology2007，13，32： | 49 |
| 2 | Effects of estradiol and progesterone on the proinflammatory cytokine production by mononuclear cells from patients with chronic hepatitis C显示文摘AIM:To investigate the effects of estradiol (E2) and progesterone on the unstimulated and oxidative stressstimulated production of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-8, and macrophage chemotactic protein (MCP)-1 by peripheral blood mononuclear cells (PBMCs) from patients with chronic hepatitis C and healthy controls. METHODS:The PBMCs were separated from agematched 72 males and 71 females with and without chronic hepatitis C, who were divided into two groups based on a mean menopausal age of 50 years. Oxidative stress was induced by hydrogen peroxide in the cells incubated in serum-free media. Cytokines in the culture supernatant were measured by an enzyme-linked immunosorbent assay. RESULTS:The highest levels of the spontaneous production of TNF-α, IL-1β, IL-8, and MCP-1 by the unstimulated PBMCs were in the older male patients with chronic hepatitis C and the lowest levels were in the premenopausal female healthy controls. E2 inhibited the cytokine production by the unstimulated PBMCs from the older male and post-menopausal female patients, which was further stimulated by progesterone. The exposure to hydrogen peroxide in the PBMCs from the younger male and pre-menopausal female healthy subjects induced the production of cytokines. The change rates of the hydrogen peroxide-stimulated cytokine production were suppressed by E2 and enhanced by progesterone. CONCLUSION:These findings suggest that E2 may play a favorable role in the course of persistent liver injury by preventing the accumulation of monocytes-macrophages and by inhibiting proinflammatory cytokine production, whereas progesterone may counteract the favorable E2 effects. | Ying Yuan Ichiro Shimizu Mi Shen Eriko Aoyagi Hidetaka Takenaka Tatuzo Itagaki Mari Urata Katsutaka Sannomiya Nao Kohno Katsuyoshi Tamaki Masayuki Shono Tetsuji Takayama | 2008 | World Journal of Gastroenterology2008，14，14： | 5 |
| 3 | Estimation of the Collection Efficiency of the AxialFlow Cyclone Dust Collector with the Fixed Guide Vanes显示文摘In order to estimate the cut-size Xc and the mechanically balanced particles in the axial flow cyclonewith the slit-separation method, the tangential velocity distributions were calculated by the finitedifference method. In comparison of the calculated results of the total collection efficiency with theexperimental results, the calculated results showed a little higher than the experimental results due tothe re-entrainment of the collected particles by turbulence. The effect of the slit for promoting thecollection efficiency was not recognized. | Akira OGAWA(Department of Mechanical Engineering, College of Engineering, Nihon University T-963, Tokusada,Tamura-machi, Kooriyama-shi, Japan)Tetzuya IWANAMI Hideki SHONO(Mikuni Comp., Japan) | 1997 | Journal of Thermal Science1997，6，1： | 3 |
| 4 | Stability of Posterior Spinal Instrumentation and Its Effects on Adjacent Motion Segments in the Lumbosacral Spine显示文摘 | Yasuhiro Shono Kiyoshi Kaneda Kuniyoshi Abumi Paul C. McAfee Bryan W. Cunningham | 1998 | Spine1998，，14： | 2 |
| 5 | Endoscopic retrograde cholangiopancreatography for bile duct stones in patients with a performance status score of 3 or 4显示文摘BACKGROUND As the aging population grows worldwide,the rates of endoscopic retrograde cholangiopancreatography(ERCP)for common bile duct stones(CBDS)in older patients with a poor performance status(PS)have been increasing.However,the data on the safety and efficacy of ERCP for CBDS in patients with a PS score of 3 or 4 are lacking,with only a few studies having investigated this issue among patients with poor PS.AIM To examine the safety and efficacy of ERCP for CBDS in patients with a PS score of 3 or 4.METHODS This study utilized a retrospective multi-centered design of three institutions in Japan for 8 years to identify a total of 1343 patients with CBDS having native papillae who underwent therapeutic ERCP.As a result,1113 patients with a PS 0-2 and 230 patients with a PS 3-4 were included.One-to-one propensity-score matching was performed to compare the safety and efficacy of ERCP for CBDS between patients with a PS 0-2 and those with a PS 3-4.RESULTS The overall ERCP-related complication rates in all patients and propensity score-matched patients with a PS 0-2 and 3-4 were 9.0%(100/1113)and 7.0%(16/230;P=0.37),and 4.6%(9/196)and 6.6%(13/196;P=0.51),respectively.In the propensity score-matched patients,complications were significantly more severe in the group with a PS 3-4 than in the group with a PS 0-2 group(P=0.042).Risk factors for complications were indications of ERCP and absence of antibiotics in the multivariate analysis.Therapeutic success rates,including complete CBDS removal and permanent biliary stent placement,in propensity score-matched patients with a PS 0-2 and 3-4 were 97.4%(191/196)and 97.4%(191/196),respectively(P=1.0).CONCLUSION ERCP for CBDS can be effectively performed in patients with a PS 3 or 4.Nevertheless,the indication for ERCP in such patients should be carefully considered with prophylactic antibiotics. | Hirokazu Saito Yoshihiro Kadono Takashi Shono Kentaro Kamikawa Atsushi Urata Jiro Nasu Haruo Imamura Ikuo Matsushita Tatsuyuki Kakuma Shuji Tada | 2022 | World Journal of Gastrointestinal Endoscopy2022，14，4： | 2 |
| 6 | Diagnosis of boundary in early gastric cancer显示文摘Endoscopic submucosal dissection (ESD) is an advanced therapeutic endoscopic technique,which allowsresection of larger superficial tumors in the esophagus,stomach,and colon.Precise diagnosis of the boundary between tumor and the non-tumorous surrounding portion is especially important before starting ESD,because too much resection can potentially take more time and can induce a higher complication rate,while too little resection can result in a non-curative resection.The boundary diagnosis is often difficult for early gastric cancer,mainly because of the underlying condition of chronic gastritis.Due to recent developments in endoscopy,including magnified endoscopy and narrow band endoscopy,the boundary diagnosis is becoming easy and more accurate.We have also applied magnified endoscopy combined with narrow band imaging to fresh specimens immediately after resection using thetiling method and XY stage. | Yasutoshi Ochiai Shin Arai Masamitsu Nakao Takashi Shono Hiroto Kita | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，3： | 2 |
| 7 | Cyclooxygenase-2 expression in human glioma:prognostic significance and molecular correlations显示文摘 | Shono T Tofilon PJ Bruner JM | 2001 | Cancer Res2001，61，11： | 1 |
| 8 | Molecular and physiological evaluation of transgenic tobacco plants expressing a maize phospho enol pyruvate carboxylase gene under the control of the cauliflower mosaic virus 35S promoter显示文摘 | Hiroyuki Kogami Mariko Shono Takayoshi Koike Syuuichi Yanagisawa Katsura Izui Naoki Sentoku Shigeyuki Tanifuji Hirofumi Uchimiya Seiichi Toki | 1994 | Transgenic Research1994，，5： | 1 |
| 9 | Complications of pedicle screw fixation in reconstructive surgery of the cervical spine显示文摘 | Abumi K Shono Y Ito M | 2000 | Spine2000，25，8： | 1 |
| 10 | Posterior occipitocervical reconstruction using cervical pedicle screws and plate-rod systems 显示文摘 | Abumi K Takada T Shono Y | 1999 | Spine1999，24，14： | 1 |
| 11 | Computer-assisted screw insertion for cervical disorders in rheumatoid arthritis 显示文摘 | Takahashi J Shono Y Nakamura I | 2007 | Eur Spine J2007，16，4： | 1 |
| 12 | Podocin participates in the assembly of tight junctions between foot processes in nephrotic podocytes 显示文摘 | Shono A Tsukaguchi H Yaoita E | 2007 | J Am Soc Nephrol2007，18，9： | 1 |
| 13 | Room Temperature Ferromagnetism in Transparent Transition Metaldoped Titanium Dioxide 显示文摘 | MATSUMOTO Y MWRAKAMI M SHONO T | 2001 | Science2001，291，： | 1 |
| 14 | Methylation of inorganic anions for gas chromatographic determination 显示文摘 | Funazo K Tanaka M Shono T | 1981 | J Chromatogr1981，211，3： | 1 |
| 15 | Prediction of foodeffects on the absorption of celecoxib based on biorelevantdissolution testing coupled with physiologically basedpharmacokinetic modeling 显示文摘 | Shono Y Jantratid E Janssen N | 2009 | European Journal of Pharmaceuticsand Biopharmaceutics2009，73，1： | 1 |
| 16 | Stability of posterior spinal instrumentation and its effects on adjacent motion segments in the lumbosacral spine显示文摘 | Shono Y Kaneda K Abumi K | | 0，，1976： | 1 |
| 17 | Computer-assis ted screw insertion for cervical disorders in rheumatoid arthritis显示文摘 | Takahashi J Shono Y Nakamura I | | 0，，04： | 1 |
| 18 | Testicular ascent after laparoscopic percutaneous extraperitoneal closure for inguinal hernias显示文摘 | SHONO T IZAKI T NAKAHORI R | 2015 | Eur J Pediatr Surg2015，25，1： | 1 |
| 19 | Static and clical biomechanical analysis of pedicle screw spinal construsts显示文摘 | Sefter JC Shono Y | 1993 | spine1993，18，12： | 1 |
| 20 | Complication of pedicle screw fixation in recons motive surgery of the cervical spine显示文摘 | Shono Y Ito H | 2000 | Spine2000，25，8： | 1 |
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