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| 1 | Causes and consequences of microsatellite instability in gastric carcinogenesis显示文摘Loss of DNA mismatch repair(MMR) function, due to somatic or germline epi/genetic alterations of MMR genes leads to the accumulation of numerous mutations across the genome, creating a molecular phenotype known as microsatellite instability(MSI). In gastric cancer(g C), MSI occurs in about 15% to 30% of the cases. This review summarizes the current knowledge on the molecular mechanisms underlying the acquisition of MSI in g C as well as on the clinic, pathologic and molecular consequences of the MSI phenotype. Additionally, current therapeutic strategies for g C and their applicability in the MSI subset are also discussed. | Sérgia Velho Maria Sofia Fernandes Marina Leite Ceu Figueiredo Raquel Seruca | 2014 | World Journal of Gastroenterology2014，20，44： | 14 |
| 2 | Lack of microRNA‐101 causes E‐cadherin functional deregulation through EZH2 up‐regulation in intestinal gastric cancer显示文摘 | Joana Carvalho Nicole C van Grieken Patricia M Pereira Sónia Sousa Marianne Tijssen Tineke E Buffart Bego?a Diosdado Heike Grabsch Manuel AS Santos Gerrit Meijer Raquel Seruca Beatriz Carvalho Carla Oliveira | 2012 | J Pathol2012，，1： | 3 |
| 3 | Hereditary diffuse gastric cancer – Pathophysiology and clinical management显示文摘 | Hugo Pinheiro Carla Oliveira Raquel Seruca Fátima Carneiro | 2014 | Best Practice & Research Clinical Gastroenterology2014，，6： | 2 |
| 4 | Therapeutic targets associated to E-cadherin dysfunction in gastric cancer显示文摘 | Patrí cia Carneiro Joana Figueiredo Renata Bordeira-Carriç o Maria Sofia Fernandes Joana Carvalho Carla Oliveira Raquel Seruca | 2013 | Expert Opinion on Therapeutic Targets2013，，10： | 2 |
| 5 | Biomarkers for gastric cancer: prognostic, predictive or targets of therapy?显示文摘 | Cecília Dur?es Gabriela M. Almeida Raquel Seruca Carla Oliveira Fátima Carneiro | 2014 | Virchows Archiv2014，，： | 2 |
| 6 | Micrnsatellite instability,mitochandrial DNA large deletions,and mitochondrial DNAmutations in gastric carcinoma显示文摘 | Maxima V Soares P Seruca R | 2001 | Genes Chrom Cancer2001，32，2： | 1 |
| 7 | Modulation of E-cadherin function and dysfunction by N-glycosylation显示文摘 | PinhoSS Seruca R Gartner F | 2011 | Cell Mol Life Sci2011，68，6： | 1 |
| 8 | EGFR regulates RhoAGTP dependent cell motility in E-cadherin mutant cells显示文摘 | Mateus AR Seruca R Machado JC | 2007 | HumMol Genet2007，16，13： | 1 |
| 9 | E-cadherin genetic screening and clinico-pathologic characteristics of early onset gastric cancer显示文摘 | Giovanni Corso Corrado Pedrazzani Hugo Pinheiro Eduardo Fernandes Daniele Marrelli Andrea Rinnovati Valeria Pascale Raquel Seruca Carla Oliveira Franco Roviello | 2010 | European Journal of Cancer2010，，4： | 1 |
| 10 | Evidence of tumor microsatellite instability in gastric cancer with familial aggregation显示文摘 | Corrado Pedrazzani Giovanni Corso Sérgia Velho Marina Leite Valeria Pascale Francesca Bettarini Daniele Marrelli Raquel Seruca Franco Roviello | 2009 | Familial Cancer2009，，3： | 1 |
| 11 | Modulation of E~ cadherin function and dysfunction by N~glycosylation显示文摘 | Pinho SS Seruca R Gartner F | 2011 | Cell Mol Life Sci2011，68，6： | 1 |
| 12 | Spovadic gastvic carcinoma with microstallite instability display a particular clinicopathologic profile显示文摘 | Seruca R Santos NR David L | 1995 | Int J Cancer1995，64，1： | 1 |
| 13 | Helicobacter pylori infection generates genetic instability in gastric cells显示文摘 | Ana Manuel Dantas Machado Céu Figueiredo Raquel Seruca Lene Juel Rasmussen | 2010 | BBA - Reviews on Cancer2010，，1： | 1 |
| 14 | Microsatellite instability at multiple loci in gastric carcinoma:clinicopathologic implications and prognosis显示文摘 | Santos NR Seruca R Constancia M | 1996 | Gastroenterology1996，110，1： | 1 |
| 15 | Genetic screening for hereditary diffuse gastric cancer显示文摘 | Oliveira C Seruca R Caldas C | 2003 | Expert Rev Mol Diagn2003，3，2： | 1 |
| 16 | Modulation of E-cadherin function and dysfunction by N-glycosylation显示文摘 | Pinho S S Seruca R Gartner F | 2011 | Cell Mol Life Sci2011，68，： | 1 |
| 17 | E-cadherin missense mutations,associated with hereditary diffuse gastric cancer (HDGC) syndrome,display distinct invasive behaviors and genetic interactions with the Wnt and Notch pathways in Drosophila epithelia显示文摘 | Pereira PS Teixeira A Pinho S Ferreire P Fernandes J Oliveira C Seruca R Suriano G Casares F | | 0，，10： | 1 |
| 18 | Hereditary gastric cancer显示文摘 | Oliveira C Seruca R Carneiro F | 2009 | Best Pract Res Clin Gastroenterol2009，23，： | 1 |
| 19 | E-cadherin changes in gastric carcimona显示文摘 | Carneiro F Machado JC Seruca R | 1999 | Histopathology1999，35，5： | 1 |
| 20 | EGFR regulates RhoA GTP dependent cell motility in E-cadherin mutant ceils显示文摘 | Mateus AR Seruca R Machado JC | 2007 | Hum Mol Genet2007，16，13： | 1 |
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