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1Molecular mechanisms of peritoneal dissemination in gastric cancer显示文摘Peritoneal dissemination represents a devastating form of gastric cancer(GC) progression with a dismal prognosis. There is no effective therapy for this condition. The 5-year survival rate of patients with peritoneal dissemination is 2%, even including patients with only microscopic free cancer cells without macroscopic peritoneal nodules. The mechanism of peritoneal dissemination of GC involves several steps: detachment of cancer cells from the primary tumor, survival in the free abdominal cavity, attachment to the distant peritoneum, invasion into the subperitoneal space and proliferation with angiogenesis. These steps are not mutually exclusive, and combinations of different molecular mechanisms can occur in each process of peritoneal dissemination. A comprehensive understanding of the molecular events involved in peritoneal dissemination is important and should be systematically pursued. It is crucial to identify novel strategies for the prevention of this condition and for identification of markers of prognosis and the development of molecular-targeted therapies. In this review, we provide an overview of recently published articles addressing the molecular mechanisms of peritoneal dissemination of GC to provide an update on what is currently known in this field and to propose novel promising candidates for use in diagnosis and as therapeutic targets.Mitsuro Kanda Yasuhiro Kodera 2016World Journal of Gastroenterology2016,22,30:15
2胃癌肿瘤基因标志物研究进展显示文摘本文综述了近期胃癌肿瘤基因标志物相关研究进展。在新发现的具有胃癌肿瘤标志物特性的基因中,表达量增加的有GDF15、MMP7及miR-200、AC130710、IN HBA、NS、CTHRC1、SRPX2、MMP-2、NEDD9,表达量降低的有IncRNA-AA174084、GAS5、GDDR。刘君 王立平 2015世界最新医学信息文摘2015,15,75:0
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