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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Osteopathia striata with cranial sclerosis显示文摘 | Barbosa M Perdu B Senra V | 2010 | Acta Med Port2010，23，6： | 1 |
| 3 | Investigation of activity of monoterpenes and phenylpropanoids against immature stages of Amblyomma cajennense and Rhipicephalus sanguineus (Acari: Ixodidae ) 显示文摘 | Senra T O Calmon F Zeringota V | 2013 | Parasitol Res2013，112，10： | 1 |
| 4 | Repellent activity of eugenol on larvae of Rhipicephalus microplus and Dermacentor nitens 显示文摘 | Zeringota V Senra T O Calmon F | 2013 | Parasitol Res2013，112，7： | 1 |
| 5 | Myocardial fibrosis in patients with hypertrophic car-diomyopathy and high risk for sudden death显示文摘 | SHIOZAKI A A SENRA T ARTEAGA E | 2010 | ArqBras Cardiol2010，94，： | 1 |
| 6 | A Rat Model of Acute Lung Injury Induced by Cardiopulmonary Bypass显示文摘 | Senra D F Katz M Passerotti G H | 2001 | Shock2001，16，： | 1 |
| 7 | Validity and Reliability of Two Upper - Body Strength Tests for Preschool Chil- dren 显示文摘 | C AYAN JM CANCELA I SENRA E QUIREZA | 2014 | The Journal of Strength & Conditioning Research2014，28，11： | 1 |
| 8 | Are worry and rumination specific pathways linking neuroticism and symptoms of anxiety and depression in patients with generalized anxiety disorder, major depressive disorder and mixed Anxiety - Depressive disorder? 显示文摘 | Merino H Senra C Ferreiro F | 2016 | PLOS One2016，11，01： | 1 |
| 9 | A fundamental model of wax deposition in subsea oil pipelines 显示文摘 | HUANG Z LEE H S SENRA M | 2011 | AIChE Journal2011，57，11： | 1 |
| 10 | Gender-related Risk and Protective Factors for Depressive Symptoms and Disordered Eating in Adolescence: A 4-year Longitudinal Study显示文摘 | Fátima Ferreiro Gloria Seoane Carmen Senra | 2012 | Journal of Youth and Adolescence2012，，5： | 1 |
| 11 | Recent progress in transition-metal catalyzed C-N cross-couplings: emer- ging approaches towards sustainability 显示文摘 | Senra J D Aguiar L C S Simas A B C | 2011 | Curr Org Synth2011，8，1： | 1 |
| 12 | Serum ceruloplasmin as a diagnostic marker of cancer显示文摘 | SENRA VAREAL A LOPEZ SAEZ J J QUINTELA SENRA D | 1997 | Cancer Lett1997，121，2： | 1 |
| 13 | Use of Molecular Methods in Identification of Candida species and Evaluation of Flueonazole resistance显示文摘 | Meltem Yalinay Cirak A K Senra K | 2003 | Mem Inst Oswaldo Cruz2003，98，8： | 1 |
| 14 | Effect of formic acid, pro pionie acid and pre-drying on the nutritive value of king grass (Pennisetum purpureum) silage显示文摘 | Michelena J B Senra A Fraga C | 2002 | Cuban Journal of Agricultural Science2002，3，： | 1 |
| 15 | Effect of formic acid,propionic acid and pre-drying on the nutritive value of kinggrass(Pennisetum purpureum)silage显示文摘 | Michelena J B Senra A Fraga C | 2002 | Cuban J Agri Sci2002，36，3： | 1 |
| 16 | Myocardial fibrosis in patients with hypertrophic cardiomyopathy and high risk for sudden death显示文摘 | Shiozaki A A Senra T Arteaga E | 2010 | Arq Bras Cardiol2010，94，5： | 1 |
| 17 | Myocardial fibrosis detected by cardiac CT predicts ventricular fibrillation/ventricular tachycardia events in patients with hypertrophic cardiomyopathy显示文摘 | Afonso Akio Shiozaki Tiago Senra Edmundo Arteaga Martino Martinelli Filho Cristiane Guedes Pita Luis Francisco R. ávila José Rodrigues Parga Filho Charles Mady Roberto Kalil-Filho David A. Bluemke Carlos Eduardo Rochitte | 2013 | Journal of Cardiovascular Computed Tomography2013，，3： | 1 |
| 18 | Inhibition of PARP- 1 by olaparib ( AZD2281 ) increases the radiosensitivity of a lung tumor xenograft 显示文摘 | Senra JM Telfer BA Cherry KE | 2011 | Mol Cancer Ther2011，10，10： | 1 |
| 19 | Effect of formic acid, propionic acid and pre-drying on the nutritive value of king grass (Pennisetum purpureum) silage显示文摘 | Michelena J B Senra A Fraga C | 2002 | Cuban Journal of Agricultural Science2002，3，： | 1 |
| 20 | The role of the HIF - 1 ot tran- scription factor in increased cell division at physiological oxygen ten- sions 显示文摘 | Can'era S Senra J Acosta M I | 2014 | PLoS One2014，9，5： | 1 |
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