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| 1 | Primary malignant melanoma of the esophagus:A case report显示文摘The authors present the clinical case of an 87-year-old Caucasian male admitted to the emergency room with hematemesis. He had a history of intermittent dys-phagia during the previous month. Endoscopic evaluation revealed an eccentric,soft esophageal lesionlocated 25-35 cm from the incisors,which appeared asa protrusion of the esophagus wall,with active bleeding. Biopsies were acquired. Tissue evaluation wascompatible with a melanoma. After excluding other sites of primary neoplasm,the definitive diagnosis of Primary Malignant Melanoma of the Esophagus(PMME) was made. The patient developed a hospital-acquired respiratory infection and died before tumor-directed treatment could begin. Primary malignant melanoma represents only 0.1% to 0.2% of all esophageal ma-lignant tumors. Risk factors for PMME are not defined.A higher incidence of PMME has been described in Japan. Dysphagia,predominantly for solids,is the most frequent symptom at presentation. Retrosternal orepigastric discom fort or pain,melena or hemate mesishave also been described. The characteristic endoscopic finding of PMME is as a polypoid lesion,with variablesize,usually pigmented. The neoplasm occurs in thelower two-thirds of the esophagus in 86% of cases.PMME metastasizes via hematogenic and lymphatic pathways. At diagnosis,50% of the patients present with distant metastases to the liver,the mediastinum,the lungs and the brain. When possible,surgery(curative or palliative) ,is the preferential method of treatment. There are some reports in the literature where chemotherapy,chemohormon otherapy,radiotherapy and immunotherapy,with or without surgery,wereused with variable efficacy. The prognosis is poor;themean survival after surgery is less than 15 mo. | Joana Machado Paula Ministro Ricardo Araújo Eugénia Cancela António Castanheira Américo Silva | 2011 | World Journal of Gastroenterology2011，17，42： | 6 |
| 2 | Nat Med:靶向两分子或有助于彻底治愈白血病显示文摘科学家在癌细胞内发现两个信号蛋白能够让癌细胞抵抗化疗。研究表明阻断这两种蛋白能够增强化疗对人类白血病小鼠模型的治疗效果。相关研究结果发表在国际学术期刊NatureMedicine上。研究人员发现在治疗中阻断c-Fos和Dusp1这两个蛋白能够治愈一些受激酶驱动且抵抗治疗的白血病和实体瘤。 | Meenu Kesarwani, Zachary Kincaid, Ahmed Gomaa, Erika Huber, Sara Rohrabaugh, Zain Siddiqui, Muhammad F Bouso, Kakajan Komurov, James C Mulloy, Jose A Cancelas, H Leighton Grimes Mohammad Azam Tahir Latif Ming Xu H Leighton Grimes Mohammad Azam | 2017 | 现代生物医学进展2017，17，17： | 4 |
| 3 | Ecological quality assessment of small estuaries from the Portuguese coast based on fish assemblages indices显示文摘 | Inês Cardoso Miguel Pessanha Pais Sofia Henriques Luís Cancela da Fonseca Henrique N. Cabral | 2011 | Marine Pollution Bulletin2011，，5： | 1 |
| 4 | Effect of chronic variable stress on monoamine receptors:influence of imipramine administration显示文摘 | Volosin M Cancela L | 1990 | Pharmacol Biochem Behav1990，35，2： | 1 |
| 5 | Effects of two different exercise programs on gait parameters in individuals with Parkinson's disease: a pilot study显示文摘 | Ayan C Cancela JM Gutierrez-Santiago A | 2014 | Gait Posture2014，39，1： | 1 |
| 6 | Flow injection determination of copper and iron in seafoods by a continuous ultrasound- assisted extraction system coupled to FAAS显示文摘 | YEBRA M D MORENO-CID A CANCELA S | 2005 | International Journal of Environmental Analytical Chemistry2005，85，45： | 1 |
| 7 | Stem cell mobilization by beta2-agonists显示文摘 | WILLIAMS D A | 2006 | Nat Med2006，12，3： | 1 |
| 8 | On how Rac controls hematopoietic stem cell activity 显示文摘 | Cancelas J A | 2011 | Transfusion2011，51，4： | 1 |
| 9 | Gla-Rich Protein, a New Player in Tissue calcification?显示文摘 | Leonor Cancela M Conc e i c ao N La i z e V | 2012 | Adv Nut r2012，3，： | 1 |
| 10 | Continuous uhrasound-assisted extraction of cadmium from legumes and dried fruit samples coupled with online concentration-flame atomic absorption spectrometry显示文摘 | Yebra M C Cancela S | 2005 | Anal Bioanal Chem2005，382，4： | 1 |
| 11 | Concomitant life threatening lesions in a cirrhotic patient:the value of endoscopic treatment显示文摘 | Cancela E Ministro P Peixoto P | 2010 | Rev Esp Enferm-Dig2010，102，10： | 1 |
| 12 | Leukaemia: niche retreats for stem cells显示文摘 | Williams DA Cancelas JA | 2006 | Nature2006，444，7121： | 1 |
| 13 | Osteological devel- opment and abnormalities of the vertebral column and caudal skele- ton in larval and juvenile stages of hatchery-reared Senegal sole (Solea senegalensis) 显示文摘 | GAVAIA P J DINIS M T CANCELA M L | 2002 | Aquaculture2002，211，1234： | 1 |
| 14 | Short-term, serum-free, static culture of cord blood-derived CD+34 cells:effects of FLT3-L and MIP-1alpha on in vitro expansion of hematopoietic progenitor cells 显示文摘 | Capmany G Querol S Cancelas JA | 1999 | Haematologica1999，84，8： | 1 |
| 15 | Rho GT- Pases in hematopoiesis and hemopathies 显示文摘 | MULLOY J C CANCELAS J A FILIPPI M D | 2010 | Blood2010，115，： | 1 |
| 16 | Early control of PTH and FGF23 in normophosphatemie CKD patients: a new target in CKI)-MBD therapy? 显示文摘 | Oliveira RB Cancela AL Graciolli FG | 2010 | Clin J Am Soc Nephrol2010，5，： | 1 |
| 17 | Effect of temperature and concentration on carboxymethylcellulose with sucrose theology 显示文摘 | Cancela M A Alvarez E Maceiras R | 2005 | Journal of Food Engineering2005，71，： | 1 |
| 18 | Epidemiology of cancer from the oral cavity and oropharynx显示文摘 | Lambert R Sauvaget C de Camargo Cancela M | | 0，，08： | 1 |
| 19 | Oral Cavity cancer in developed and in developing countries:population-based incidence显示文摘 | De Camargo Cancela M Voto L Guerra-Yi M | 2010 | Head Neck2010，32，3： | 1 |
| 20 | R-Ras and Rac GTPase crosstalk regulates hematopoietic progenitor cell migration, homing and mobilization显示文摘 | Shang X Cancelas JA Li L | 2011 | J Biol Chem2011，，： | 1 |
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