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| 1 | Novel treatment options for perforations of the upper gastrointestinal tract:Endoscopic vacuum therapy and over-the-scope clips显示文摘Endoscopic management of leakages and perforations of the upper gastrointestinal tract has gained great importance as it avoids the morbidity and mortality of surgical intervention.In the past years,covered selfexpanding metal stents were the mainstay of endoscopic therapy.However,two new techniques are now available that enlarge the possibilities of defect closure:endoscopic vacuum therapy(EVT),and over-the-scope clip(OTSC).EVT is performed by mounting a polyurethane sponge on a gastric tube and placing it into the leakage.Continuous suction is applied via the tube resulting in effective drainage of the cavity and the induction of wound healing,comparable to the application of vacuum therapy in cutaneous wounds.The system is changed every 3-5 d.The overall success rate of EVT in the literature ranges from 84%to 100%,with a mean of 90%;only few complications have been reported.OTSCs are loaded on a transparent cap which is mounted on the tip of a standard endoscope.By bringing the edges of the perforation into the cap,by suction or by dedicated devices,such as anchor or twin grasper,the OTSC can be placed to close the perforation.For acute endoscopy associated perforations,the mean success rate is 90%(range:70%-100%).For other types of perforations(postoperative,other chronic leaks and fistulas)success rates are somewhat lower(68%,and59%,respectively).Only few complications have been reported.Although first reports are promising,further studies are needed to define the exact role of EVT and OTSC in treatment algorithms of upper gastrointestinal perforations. | Rudolf Mennigen Norbert Senninger Mike G Laukoetter | 2014 | World Journal of Gastroenterology2014，20，24： | 25 |
| 2 | The consensus on liver autotransplantation from an international panel of experts显示文摘Introduction More than 1.0 million patients worldwide are diagnosed with space-occupying lesions in the liver every year,with the number approaching0.5 million per year in China,and only 20%of the lesions are resectable.^([1,2])Due to a lack of available donors,only a limited number of patients underwent allogeneic liver transplantation,the remaining patients | Qi-Fa Ye Norbert Senninger | 2017 | Hepatobiliary & Pancreatic Diseases International2017，16，1： | 3 |
| 3 | Expression of tight and adherens junction proteins in ulcerative colitis associated colorectal carcinoma: upregulation of claudin-1, claudin-3, claudin-4, and β-catenin显示文摘 | S. T. Mees R. Mennigen T. Spieker E. Rijcken N. Senninger J. Haier M. Bruewer | 2009 | International Journal of Colorectal Disease2009，，： | 2 |
| 4 | Stent migration necessitating surgical intervention显示文摘 | R. Diller N. Senninger G. Kautz D. Tübergen | 2003 | Surgical Endoscopy2003，，11： | 2 |
| 5 | Involvement of CD40 Targeting miR-224 and miR-486 on the Progression of Pancreatic Ductal Adenocarcinomas显示文摘 | Soeren Torge Mees MD Wolf Arif Mardin MD Sonja Sielker Edith Willscher Norbert Senninger PhD Christina Schleicher MD Mario Colombo-Benkmann PhD Joerg Haier PhD | 2009 | Annals of Surgical Oncology2009，，8： | 1 |
| 6 | Immunohistochemical expression of P53 and oncogenes in ulcerative colitis-associated colorectal carcinoma显示文摘 | Bruwer M Schmid KW Senninger N | 2002 | World J Surg2002，26，3： | 1 |
| 7 | Another challenge to the Opie myth 显示文摘 | Moody FG Senninger N Runkel N | 1993 | Gastroenterology1993，104，3： | 1 |
| 8 | Current practice patterns in pancreatic surgery: Results of a multi-institutional analysis of seven large surgical departments in germany with 1454 pancreatic head resections, 1999 to 2004 (german advanced surgical treatment study group)显示文摘 | Frank Makowiec M.D. Stefan Post M.D. Hans-Detlev Saeger M.D. Norbert Senninger M.D. F.A.C.S. Heinz Becker M.D. F.A.C.S. Michael Betzler M.D. Heinz J. Buhr M.D. F.A.C.S. Ulrich T. Hopt M.D | 2005 | Journal of Gastrointestinal Surgery2005，，8： | 1 |
| 9 | Arterial steal: an unusual cause for hepatic hypoperfusion after liver transplantation显示文摘 | M. Manner G. Otto N. Senninger T. Kraus J. Goerich C. Herfarth | 1991 | Transplant International1991，，2： | 1 |
| 10 | Complications due to gallstones lost during laparoscopic cholecystectomy显示文摘 | Brockmann JG Kocher T Senninger NJ | 2002 | Surg Endosc2002，16，8： | 1 |
| 11 | Immunohistochemical expression of p53 and oncogenes in ulcerative colitis-associated colorectal carcinoma显示文摘 | Bruwer M Schmid KW Senninger N | 2002 | World J Surg2002，26，3： | 1 |
| 12 | Cir- culating microRNA-200 Family as Diagnostic Marker in Hepatocellular Carcinoma显示文摘 | DHAYAT S A HUSING A SENNINGER N | 2015 | 10 (10) : e01400662015，10，01： | 1 |
| 13 | Circulating microR- NA-200 family as diagnostic marker in hepatocellular carcinoma 显示文摘 | Dhayat S A Husing A Senninger N | 2015 | PLoSOne2015，10，01： | 1 |
| 14 | Effective prevention of adhesions with hyaluronate显示文摘 | Kramer K Senninger N Herbst H | 2002 | Arch Surg2002，137，3： | 1 |
| 15 | Neoadjuvant chemotherapy in resectable pancreatic: cancer 显示文摘 | Irmscher S Senninger N Schleicher C | 2008 | Ann Surg2008，15，： | 1 |
| 16 | Complications due to gallstones lost during laparoscopic cholecystectomy 显示文摘 | Brockmann JG Kocher T Senninger NJ | 2002 | Surg Endosc2002，16，： | 1 |
| 17 | Arterial steal: an unusual cause for hepatic hypoperfusion after liver transplantation显示文摘 | M. Manner G. Otto N. Senninger T. Kraus J. Goerich C. Herfarth | 1991 | Transplant International1991，，2： | 1 |
| 18 | Immu nohistochemical expression of p53 and oncogenes in ulcerative colitis-associated colorectal carcinoma 显示文摘 | BRUWER M SCHMID K W SENNINGER N | 2002 | World J Surg2002，26，3： | 1 |
| 19 | Esophageal resection for giant leiomyoma:report of two cases and a review of the literature显示文摘 | Rijcken E Kersting C M Senninger N | 2009 | Langenbecks Arch Surg2009，394，4： | 1 |
| 20 | Early Identification of Peritonitis by Peritoneal Cytokine Measurement显示文摘 | Ralf Herwig Bernhard Glodny Christiane Kühle Bernhard Schlüter Olaf A. Brinkmann Hannes Strasser Norbert Senninger Günther Winde | 2002 | Diseases of the Colon & Rectum2002，，4： | 1 |
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