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| 1 | Adsorption of benzene, cyclohexane and hexane on ordered mesoporous carbon显示文摘Ordered mesoporous carbon(OMC) with high specific surface area and large pore volume was synthesized and tested for use as an adsorbent for volatile organic compound(VOC)disposal. Benzene, cyclohexane and hexane were selected as typical adsorbates due to their different molecular sizes and extensive utilization in industrial processes. In spite of their structural differences, high adsorption amounts were achieved for all three adsorbates, as the pore size of OMC is large enough for the access of these VOCs. In addition, the unusual bimodal-like pore size distribution gives the adsorbates a higher diffusion rate compared with conventional adsorbents such as activated carbon and carbon molecular sieve. Kinetic analysis suggests that the adsorption barriers mainly originated from the difficulty of VOC vapor molecules entering the pore channels of adsorbents. Therefore, its superior adsorption ability toward VOCs, together with a high diffusion rate, makes the ordered mesoporous carbon a promising potential adsorbent for VOC disposal. | Gang Wang Baojuan Dou Zhongshen Zhang Junhui Wang Haier Liu Zhengping Hao | 2015 | Journal of Environmental Sciences2015，27，4： | 15 |
| 2 | MicroRNAs:Promising chemoresistance biomarkers in gastric cancer with diagnostic and therapeutic potential显示文摘Gastric cancer(GC) is the fourth most common cancer worldwide and ranks second in global cancer mortality statistics. Perioperative chemotherapy plays an important role in the management and treatment of advanced stage disease. However,response to chemotherapy varies widely,with some patients presenting no or only minor response to treatment. Hence,chemotherapy resistance is a major clinical problem that impacts on outcome. Unfortunately,to date there are no reliable biomarkers available that predict response to chemotherapy before the start of the treatment,or that allow modification of chemotherapy resistance. MicroRNAs(miRNAs) could provide an answer to this problem. miRNAs are involved in the initiation and progression of a variety of cancer types,and there is evidence that miRNAs impact on resistance towards chemotherapeutic drugs as well. This current review aims to provide an overview about the potential clinical applicability of miRNAs as biomarkers for chemoresistance in GC.The authors focus in this context on the potential of miRNAs to predict sensitivity towards different chemotherapeutics,and on the potential of miRNAs to modulate sensitivity and resistance towards chemotherapy in GC. | Christiane Matuszcak Joerg Haier Richard Hummel Kirsten Lindner | 2014 | World Journal of Gastroenterology2014，20，38： | 11 |
| 3 | MicroRNA signatures in chemotherapy resistant esophageal cancer cell lines显示文摘AIM:To investigate expression of microRNA(miRNA)and potential targets in chemotherapy resistant esoph-ageal cancer cell lines.METHODS:An in-vitro model of acquired chemotherapy resistance in esophageal adeno-(EAC)and squamous cell carcinoma(ESCC)cells was used,and microRNA expression profiles for cisplatin or 5-fluorouracil(5-FU)resistant variants vs chemotherapy sensitive controls were compared using microarray and quantitative real-time polymerase chain reaction(PCR).The expression of chemotherapy-relevant genes potentially targeted by the dysregulated microRNAs in the chemotherapy resistant variants was also evaluated.RESULTS:Chemotherapy resistant sublines were found to have specific miRNA signatures,and these miRNA signatures were different for the cisplatin vs 5-FU resistant cells from the same tumor cell line,and also for EAC vs ESCC cells with resistance to the same specific chemotherapy agent.Amongst others,miR-27b-3p,miR-193b-3p,miR-192-5p,miR-378 a-3p,miR-125a-5p and miR-18a-3p were dysregulated,consistent with negative posttranscriptional control of KRAS,TYMS,ABCC3,CBL-B and ERBB2 expression via these miRNAs.CONCLUSION:The current study supports the hypothesis that microRNA expression has an impact on chemotherapy resistance in esophageal cancer. | Richard Hummel Corina Sie David I Watson Tingting Wang Alfiya Ansar Michael Z Michael Mark Van der Hoek Joerg Haier Damian J Hussey | 2014 | World Journal of Gastroenterology2014，20，40： | 8 |
| 4 | MicroRNAs: Predictors and modifiers of chemo- and radiotherapy in different tumour types显示文摘 | Richard Hummel Damian J. Hussey Joerg Haier | 2009 | European Journal of Cancer2009，，2： | 3 |
| 5 | Expression of tight and adherens junction proteins in ulcerative colitis associated colorectal carcinoma: upregulation of claudin-1, claudin-3, claudin-4, and β-catenin显示文摘 | S. T. Mees R. Mennigen T. Spieker E. Rijcken N. Senninger J. Haier M. Bruewer | 2009 | International Journal of Colorectal Disease2009，，： | 2 |
| 6 | PTEN regulates tumor cell adhesion of colon carcinoma cells under dynamic conditions of fluid flow显示文摘 | Haier J Nicolson GL | 2002 | Oncogene2002，21，9： | 1 |
| 7 | PTEN regulates tumor cell adhesion of clon carcinoma cells under dynamic conditions of fluid flow显示文摘 | Haier J Nicolson GL | 2002 | Oncogen2002，21，9： | 1 |
| 8 | PTEN regulates tumor cell adhesion of colon carcinoma cells under dynamic conditions of fluid flow显示文摘 | Haier J Nicolson GL | 2002 | Oncogene2002，21，9： | 1 |
| 9 | Integrins in cancer treatment显示文摘 | Eble JA Haier J | 2006 | Curr Cancer Drug Targets2006，6，2： | 1 |
| 10 | Involvement of CD40 Targeting miR-224 and miR-486 on the Progression of Pancreatic Ductal Adenocarcinomas显示文摘 | Soeren Torge Mees MD Wolf Arif Mardin MD Sonja Sielker Edith Willscher Norbert Senninger PhD Christina Schleicher MD Mario Colombo-Benkmann PhD Joerg Haier PhD | 2009 | Annals of Surgical Oncology2009，，8： | 1 |
| 11 | Time-dependent dephosphorylation through serine/threonine phosphatases is required for stable adhesion of highly and pooly metastatic HT-29 colon carcinoma cell lines to collagen显示文摘 | Haier J Nicoson GL | 2000 | Anticancer Res2000，20，4： | 1 |
| 12 | Different adhesion properties of highly and poorly metastatic HT-29 colon carcinoma cells with extracellular matrix components: role of integrin expression and cytoskeletal components显示文摘 | Haier J Nasralla M Nico|son GL | 1999 | Br J Cancer1999，80，12： | 1 |
| 13 | Exploration techniques of the spatial data warehouses : Overview and application to incendiary domain显示文摘 | Haier Baazaoui Zghal Samifciiz Henda Ben Ghezala | 2001 | IEEE Conference on Computer System2001，7，3： | 1 |
| 14 | Integrins in cancer treatment显示文摘 | Eble J A Haier J | | 0，，： | 1 |
| 15 | MicroRNAs: predictors andmodifiers of chemo- and radiotherapy in different tumour types显示文摘 | Hummel R Hussey DJ Haier J | 2010 | Eur J Cancer2010，46，2： | 1 |
| 16 | The Parieto-Frontal Integration Theory ( P-FIT) of intelligence: converging neuroimaging evidence 显示文摘 | Jung RE Haier RJ | 2007 | Behav Brain Sci2007，30，： | 1 |
| 17 | Individual differences in general intelligence correlate with brain function during nonreasoning tasks 显示文摘 | Haier RJ White NS Alkire MT | 2003 | Intelligence2003，31，： | 1 |
| 18 | Beta1-integrin-mediated dynamic adhesion of colon carcinoma cells to extracellular matrix under laminar flow显示文摘 | Haier J Nasralla MY Nicolson GL | 1999 | Clin Exp Metastasis1999，17，5： | 1 |
| 19 | Levels of homocysteine are increased in metabolic syndrome patients but are not associated with an increased cardiovascular risk,in contrast to patients without the metabolic syndrome显示文摘 | HAIER G R OELIHOEK J K VERHAAR M C | 2007 | Heart2007，93，： | 1 |
| 20 | Time-dependent dephosphorylation through serine/threonine phosphatases is required for stable adhesion of highly and poorly metastatic HT-29 colon carcinoma cell lines to collagen 显示文摘 | Haier J Nicolson GL | 2000 | Anticancer Res2000，20，： | 1 |
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