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| 1 | Systematic review on the surgical treatment for T1 gallbladder cancer显示文摘AIM:To evaluate the efficacy of simple and extended cholecystectomy for mucosa(T1a) or muscularis(T1b) gallbladder(GB) cancer. METHODS:Original studies on simple and extended cholecystectomy for T1a or T1b GB cancer were searched from MEDLINE(PubMed) ,Cochrane Library,EMBase,and CancerLit using the search terms of GB,cancer/carcinoma/tumor/neoplasm. RESULTS:Twenty-nine out of the 2312 potentially relevant publications met the eligibility criteria.Of the 1266 patients with GB cancer included in the publications,706(55.8%) and 560(44.2%) had T1a and T1b GB cancer,respectively.Simple cholecystectomy for T1a and T1b GB cancer was performed in 590(83.6%) and 375(67.0%) patients,respectively(P<0.01) .In most series,the treatment of choice was simple cholecystectomy for T1a GB cancer patients with a 5-year survival rate of 100%.Lymph node metastasis was detected in 10.9% of the T1b GB cancer patients and in 1.8%of the T1a GB cancer patients,respectively(P<0.01) .Eight patients(1.1%) with T1a GB cancer and 52 patients(9.3%) with T1b GB cancer died of recurrent GB cancer(P<0.01) . CONCLUSION:Simple cholecystectomy represents the adequate treatment of T1a GB cancer.There is no definite evidence that extended cholecystectomy is advantageous over simple cholecystectomy for T1b GB cancer. | Seung Eun Lee Jin-Young Jang Chang-Sup Lim Mee Joo Kang Sun-Whe Kim | 2011 | World Journal of Gastroenterology2011，17，2： | 69 |
| 2 | 在Cu/ZnO/Al_2O_3催化剂上进行甲醇蒸气重整的动力学研究显示文摘采用平推流反应器 ,在三种不同的Cu ZnO Al2 O3催化剂上对甲醇的蒸气重整制备氢气反应进行了研究。在常压 ,温度 180℃~ 2 4 0℃的条件下 ,在三种不同催化剂上对反应的动力学进行了测定 ,所获结果符合反应速率幂数模型 ,不同的催化剂相对于甲醇和水的反应级数分别均为 0 60及 0 4 5 ,对于ICI5 2 1,ICI5 3 1以及MDK 2 0催化剂所获得的活化能分别为 :92 8kJ mol、96 2kJ mol及 87 9kJ mol,与文献值吻合较好。所获动力学模型为甲醇重整反应条件优化以及反应器的数学模拟提供了一定的基础。 | 蒋元力 黄强 王福安 Kim Dong Hyun Lim Mee Sook | 2001 | 燃料化学学报2001，29，4： | 22 |
| 3 | Histopathology and TB-PCR kit analysis in differentiating the diagnosis of intestinal tuberculosis and Crohn’s disease显示文摘AIM: To compare the histopathologic features of intestinal tuberculosis (ITB) and Crohn’s disease (CD) and to identify whether polymerase chain reaction for Mycobacterium tuberculosis (TB-PCR) would be helpful for differential diagnosis between ITB and CD.METHODS: We selected 97 patients with established diagnoses (55 cases of ITB and 42 cases of CD) who underwent colonoscopic biopsies.Microscopic features of ITB and CD were reviewed,and eight pathologic parameters were evaluated.Nine cases of acid fast bacilli culture-positive specimens and 10 normal colonic tissue specimens were evaluated as the positive and negative control of the TB-PCR test,respectively.PCR assays were done using two commercial kits: kit detected IS6110 and MPB64,and kit detected IS6110 only;a manual in-house PCR method was also performed on formalin-fi xed,paraffi n-embedded colonoscopic biopsy specimens.RESULTS: Statistically significant differences were noted between ITB and CD with regard histopathologic criteria: size of granulomas (P = 0.000),giant cells (P = 0.015),caseation necrosis (P = 0.003),confluent granulomas (P = 0.001),discrete granulomas (P = 0.000),and granulomas with lymphoid cuffs (P = 0.037).However,29 cases (52.7%) of ITB showed less than fi ve kinds of pathologic parameters,resulting in confusion with CD.The sensitivities and specificities of the TB-PCR test by kit ,kit ,and the in-house PCR method were 88.9% and 100%,88.9% and 100%,and 66.7% and 100% in positive and negative controls,respectively.The PCR test done on endoscopic biopsy specimens of ITB and CD were signifi cantly different with kit (P = 0.000) and kit (P = 0.000).The sensitivities and specifi cities of TB-PCR were 45.5% and 88.1%,36.4% and 100%,and 5.8% and 100%,for kit and kit and inhouse PCR method on endoscopic biopsy specimens.Among the 29 cases of histopathologically confusing CD,10 cases assayed using kit and 6 cases assayed using kit were TB-PCR positive.A combination of histologic fi ndings and TB-PCR testing led to an increase of diagnostic sensitivity and the increase (from 47.3% to 58.2) was statistically signifi cant with kit (P = 0.000).CONCLUSION: The TB-PCR test combined with histopathologic factors appears to be a helpful technique in formulating the differential diagnosis of ITB and CD in endoscopic biopsy samples. | Joon Mee Kim Hyung Kil Kim Lucia Kim Suk Jin Choi In Suh Park Jee Young Han Young Chae Chu Kye Sook Kwon Eun Joo Kim | 2010 | World Journal of Gastroenterology2010，16，20： | 20 |
| 4 | Primary endoscopic approximation suture under cap-assisted endoscopy of an ERCP-induced duodenal perforation显示文摘Duodenal perforation during endoscopic retrograde cholangiopancreatography(ERCP) is a rare complication,but it has a relatively high mortality risk.Early diagnosis and prompt management are key factors for the successful treatment of ERCP-related perforation.The management of perforation can initially be conservative in cases resulting from sphincterotomy or guide wire trauma.However,the current standard treatment for duodenal free wall perforation is surgical repair.Recently,several case reports of endoscopic closure techniques using endoclips,endoloops,or fully covered metal stents have been described.We describe four cases of iatrogenic duodenal bulb or lateral wall perforation caused by the scope tip that occurred during ERCP in tertiary referral centers.All the cases were simply managed by endoclips under transparent capassisted endoscopy.Based on the available evidence and our experience,endoscopic closure was a safe and feasible method even for duodenoscope-induced perforations.Our results suggest that endoscopists may be more willing to use this treatment. | Tae Hoon Lee Byoung Wook Bang Jee In Jeong Hyung Gil Kim Seok Jeong Seon Mee Park Don Haeng Lee Sang-Heum Park Sun-Joo Kim | 2010 | World Journal of Gastroenterology2010，16，18： | 19 |
| 5 | 激光干涉气液两相流测量图像自动辨读方法的研究显示文摘在能源、化工、炼油、制药、机械制造等领域中广泛存在着气液颗粒两相流的测量问题,因此气液两相流测量技术一直是国内外的重点研究课题。该文将介绍一种气液两相流测量的新技术一激光干涉气液两相流测量技术(ILIDS),它具有提取两相流参数全、测量精度高和测量区域较大等优 点。该技术利用高干涉性片状激光束照射气液两相流,粒子将激光以折射和反射的方式散射,用高速数码相机(120万象素)收集并汇聚散射光成像,折射光与反射光之间因存在相位差会在汇聚成像系统的失焦平面上形成干涉条纹图,图中包含粒子的粒径和空间信息。利用作者开发的图像处理软件对两相流干涉图像进行数据处理,自动高速提取两相流信息,将处理结果与人工辨读比较,有效粒子信息提取率高于90%,粒子定位及粒径计算误差小于5%。实验证明本图像处理技术具有工业在线测量的潜力。 | 浦世亮 浦兴国 袁镇福 岑可法 Loic MEES Denis LEBRUN | 2004 | 中国电机工程学报2004，24，2： | 14 |
| 6 | Prognosis of hepatocellular carcinoma expressing cytokeratin 19:Comparison with other liver cancers显示文摘AIM:To investigate whether expressing biliary phenotype predicted poor outcome after the surgical treatment in primary liver cancers. METHODS:Out of 204 patients that underwent liver resection due to hepatocellular carcinoma (HCC), liver specimens of 70 patients with HCC were evaluated for biliary components by cytokeratin (CK) 19 immunostain (CK19 - HCC and CK19 + HCC). CK19 positivity was defined as membranous and/or cytoplasmic expression in ≥ 5% of tumor cells with moderate or strong intensity. Patients with other primary liver cancers, such as com- bined HCC and cholangiocarcinoma (cHCC-CC), intrahe- patic cholangiocarcinoma (ICC) who received curative liver resection, were also included in the study. Clinical characteristics of CK19-HCC and CK19 + HCC patients, including survival outcome after curative liver resection, were compared with that of cHCC-CC and ICC patients. RESULTS: The overall survival (OS) rate of CK19 - HCC(n = 49) after the curative surgical treatment was 90.7%, and 80.4% at 1 and 5 years after the resection. OS rate of CK19 + HCC (n = 21) was 74.3%, 28.9% and OS rate of cHCC-CC (n = 22) was 66.7%, 32.2% at 1 and 5 years after the surgery. For ICC (n = 19), 1 and 5-year-OS rate was 50.2% and 14.3% after the cura-tive resection. The OS rates of CK19 + HCC and cHCC-CC were significantly lower than that of CK19-HCC, but higher than the OS rate of ICC (P = 0.000). There was no statistically significant difference in OS rate between CK19 + HCC and cHCC-CC. The disease free survival (DFS) rate of CK19-HCC was 72.0% and 54.5% at 1 and 3 years after the surgical treatment. DFS rate of CK19 + HCC was 53.3%, 34.3% and DFS rate of cHCC- CC was 51.5%, 39.2% at 1 and 3 years after the resection. For ICC, 1 and 3-year-DFS rate was 28.0% and 14.0% after the curative resection. DFS rate of CK19-HCC was significantly higher than that of ICC (P = 0.017), but marginally higher than DFS rate of either CK19 + HCC or cHCC-CC (P = 0.097, P = 0.089, respec-tively). Predictors of outcome after the surgery of primary liver cancer were pathology of the resected mass, existence of microvascular invasion and accompanying satellite nodule. CONCLUSION: Primary liver cancers with biliary components tended to show poorer surgical outcome. This suggested that immuno-phenotype of liver cancers was as important as their morphological classification. | Jung Il Lee Jin-Woo Lee Joon Mee Kim Ja Kyung Kim Hyun Jung Chung Young Soo Kim | 2012 | World Journal of Gastroenterology2012，18，34： | 10 |
| 7 | Urgent ERCP for acute cholangitis reduces mortality and hospital stay in elderly and very elderly patients显示文摘BACKGROUND: Acute cholangitis in old people is a cause of mortality and prolonged hospital stay. We evaluated the effects of methods and timing of biliary drainage on the outcomes of acute cholangitis in elderly and very elderly patients.METHODS: We analyzed 331 patients who were older than 75 years and were diagnosed with acute calculous cholangitis. They were admitted to our hospital from 2009 to 2014. Patients' demographics, severity grading, methods and timing of biliary drainage, mortality, and hospital stay were retrospectively obtained from medical records. Clinical parameters and outcomes were compared between elderly(75-80 years, n=156) and very elderly(≥81 years, n=175) patients. We analyzed the effects of methods [none, endoscopic retrograde cholangiopancreatography(ERCP), percutaneous transhepatic biliary drainage, or failure] and timing(urgent or early) of biliary drainage on mortality and hospital stay in these patients.RESULTS: Acute cholangitis in older patients manifested as atypical symptoms characterized as infrequent Charcot's triad(4.2%) and comorbidity in one-third of the patients. Patients were graded as mild, moderate, and severe cholangitis in 104(31.4%), 175(52.9%), and 52(15.7%), respectively. Urgent biliary drainage(≤24 hours) was performed for 80.5%(247/307) of patients. Very elderly patients tended to have more severe grades and were treated with sequential procedures of transient biliary drainage and stone removal at different sessions. Hospital stay was related to methods and timing of biliary drainage. Mortality was very low(1.5%) and not related to patient age but rather to the success or failure of biliary drainage and severity grading of the acute cholangitis.CONCLUSIONS: The methods and timing used for biliary drainage and severity of cholangitis are the major determinants of mortality and hospital stay in elderly and very elderly patients with acute cholangitis. Urgent successful ERCP is mandatory for favorable prognosis in these patients. | Chan Sun Park Hee Seok Jeong Ki Bae Kim Joung-Ho Han Hee Bok Chae Sei Jin Youn Seon Mee Park | 2016 | Hepatobiliary & Pancreatic Diseases International2016，15，6： | 9 |
| 8 | Therapeutic effect of acupuncture point injection with placental extract in knee osteoarthritis显示文摘OBJECTIVE:This study evaluated the effectiveness of acupuncture point injection(API) with placental extract on pain reduction and joint function in patients with knee osteoarthritis(OA).METHODS:Fifty-two patients with knee OA,with an average age of 64,and having a symptom duration of more than 3 months were studied in this report.Placental extract was injected weekly into acupuncture point ST35,BL23,BL24 and BL25 for 5 weeks;8 mL of placental extract into ST35 on the affected side,and 1 mL of placental extract to BL23,BL24 and BL25 bilaterally.RESULTS:After a five-week treatment of API with placental extract,pain was substantially decreased in patients of all Kellgren-Lawrence(KL) grades.Improvement of knee joint swelling was also apparent.Decrease of pain and joint swelling improved daily working productive time among patients of all KL grades.CONCLUSION:Study results imply that API with placental extract is a potentially useful therapy to control pain and maintain joint functions in knee OA patients. | Kyeong Mee Park Tae Hwan Cho | 2017 | Journal of Integrative Medicine2017，15，2： | 8 |
| 9 | TT virus and hepatitis G virus infections in Korean blood donors and patients with chronic liver disease显示文摘AIM: To determine the prevalences of TTV and HGV infections among blood donors and patients with chronic liver disease in Korea, to investigate the association of TTV and HGV infections with blood transfusion, and to assess the correlation between TTV and HGV viremia and hepatic damage.METHODS: A total of 391 serum samples were examined in this study. Samples were obtained from healthy blood donors (n= 110), hepatitis B surface antigen (HBsAg)-positive donors (n=112), anti-hepatitis C virus (anti-HCV)-positive donors (n=69), patients with type B chronic liver disease (n=81), and patients with type C chronic liver disease (n= 19).TTV DNA was detected using the hemi-nested PCR. HGV RNA was tested using RT-PCR. A history of blood transfusion and serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were also determined.RESULTS: TTV DNA was detected in 8.2 % of healthy blood donors, 16.1% of HBsAg-positive donors, 20.3 % of antiHCV-positive donors, 21.0 % of patients with type B chronic liver disease, and 21.1% of patients with type C chronic liver disease. HGV RNA was detected in 1.8 % of healthy blood donors, 1.8 % of HBsAg-positive donors, 17.4 % of anti-HCV-positive donors, 13.6% of patients with type B chronic liver disease, and 10.5% of patients with type C chronic liver disease. The prevalence of TTV and HGV infections in HBV- or HCV-positive donors and patients was significantly higher than in healthy blood donors (P<0.05),except for the detection rate of HGV in HBsAg-positive donors which was the same as for healthy donors. There was a history of transfusion in 66.7% of TTV DNA-positive patients and 76.9% of HGV RNA-positive patients (P<0.05). No significant increase in serum ALT and AST was detected in the TTV- or HGV-positive donors and patients.CONCLUSION: TTV and HGV infections are more frequently found in donors and patients infected with HBV or HCV than in healthy blood donors. However, there is no significant association between TTV or HGV infections and liver injury. | Mee Juhng Jeon Jong Hee Shin Soon Pal Suh Young Chai Lim Dong Wook Ryang | 2003 | World Journal of Gastroenterology2003，9，4： | 7 |
| 10 | Clinical and endoscopic characteristics of drug-induced esophagitis显示文摘AIM: To investigate clinical, endoscopic and pathological characteristics of drug-induced esophagitis.METHODS: Data for patients diagnosed with drug-induced esophagitis from April 2002 to May 2013 was reviewed. Patients diagnosed with malignancy, viral or fungal esophagitis were excluded. Clinical, endoscopic and pathological characteristics of patients diagnosed with drug-induced esophagitis were analyzed.RESULTS: Seventy-eight patients were diagnosed with drug-induced esophagitis. Their mean age was 43.9 ± 18.9 years and 35.9% were male. Common symptoms were chest pain(71.8%), odynophagia(38.5%) and dysphagia(29.5%). The endoscopic location was in the middle third of esophagus in 78.2%. Endoscopic findings were ulcer(82.1%), erosion(17.9%), ulcer with bleeding(24.4%), coating with drug material(5.1%), impacted pill fragments(3.8%) and stricture(2.6%). Kissing ulcers were observed in 43.6%. The main causative agents were antibiotics and non-steroidal antiinflammatory drugs. All the patients were treated with proton pump inhibitors(PPIs) or sucralfate, and the causative drugs were discontinued. Nineteen patients with drug-induced esophagitis were followed up with endoscopy and revealed normal findings, scars or healing ulcers.CONCLUSION: Drug-induced esophagitis mainly presents as chest pain, odynophagia and dysphagia, and may be successfully treated with PPIs and discontinuation of the causative drug. Kissing ulcers were observed in 43.6%. | Su Hwan Kim Ji Bong Jeong Ji Won Kim Seong-Joon Koh Byeong Gwan Kim Kook Lae Lee Mee Soo Chang Jong Pil Im Hyoun Woo Kang Cheol Min Shin | 2014 | World Journal of Gastroenterology2014，20，31： | 7 |
| 11 | 均匀球形液滴二阶和五阶彩虹的重建及应用显示文摘从理论和实验两方面研究了不同温度下球形液滴的彩虹强度分布及在粒度测量中的应用。研究结果表明折射率为 1.33附近液滴在 117°~ 134°散射角范围内的散射强度分布不是单一的二阶彩虹强度分布 ,而是二阶和五阶彩虹的干涉强度分布。基于散射强度频谱特点 ,提出了一种从干涉强度谱中重建二阶和五阶彩虹强度分布的方法 :逆快速傅里叶变换 (IFFT)。利用洛伦兹米理论 (LMT)模拟计算了温度为 2 0℃和 80℃下水粒子二阶彩虹的高频结构与粒子直径的关系 ,获得了经验公式。该关系式可用来测量确定温度下均匀水粒子直径。还利用激光彩虹测试系统测量了水柱二阶彩虹角度范围内的散射强度分布。上述理论研究结果与实验结果进行了比较 ,两者吻合得很好。基于上述研究 ,可以从单一阵列探测器获取的彩虹信号提取不同阶次彩虹分布 ,用于液滴多参量的反演测量。 | 姜会芬 韩香娥 任宽芳 潘凤艳 MEES Loic | 2004 | 光学学报2004，24，11： | 6 |
| 12 | Rescue endoscopic band ligation of iatrogenic gastric perforations following failed endoclip closure显示文摘Iatrogenic gastric perforation is one of the most serious complications during therapeutic endoscopy,despite significant advances in endoscopic techniques and devices.This case study evaluated the clinical efficacy and safety of the rescue endoscopic band ligation (EBL) technique in iatrogenic gastric wall perforation following the failure of primary endoclip closure.Five patients were enrolled in this study.These patients underwent emergency endoscopy following the onset of acute gastric wall perforation during endoscopic procedures.The outcome measurements were primary technical success and immediate or delayed procedure-related complications.Successful endoscopic closure using band ligation was reported in all patients,with no complication occurring.We conclude that EBL may be a feasible and safe alternate technique for the management of acute gastric perforation,especially in cases where closure is difficult with endoclips. | Joung-Ho Han Tae Hoon Lee Yunho Jung Suck-Ho Lee Hyun Kim Hye-Suk Han Heebok Chae Seon Mee Park Seijin Youn | 2013 | World Journal of Gastroenterology2013，19，6： | 5 |
| 13 | NUMERICAL WAVE FLUME WITH IMPROVED SMOOTHED PARTICLE HYDRODYNAMICS显示文摘This paper presents an improved Nearest Neighboring Particle Searching(NNPS) technique for numerical modeling of water waves with the Smoothed Particle Hydrodynamics(SPH) method.The proposed technique differs from others by introducing the concept of Inner and Outer Particle Searching(IOPS) and shifting most of advanced CPU operations into simple addition operations.The IOPS method is shown to significantly improve the computational efficiency and reduce the CPU time especially for large number of particles,based on comparisons with other two NNPS methods.This method is implemented in a 2DV numerical wave flume conducted by the SPH method.Three test cases are examined,including generations and propagations of dam-breaking induced waves,solitary wave and irregular wave.Calculated results are in good agreements with experimental data and theoretical solutions with fairly satisfactory CPU time-consuming.The wave motions observed in physical facilities are successfully reproduced by the SPH numerical wave flume,revealing its robust capability of modeling realistic wave propagation and substantial potential for a wide variety of hydrodynamic problems. | ZHENG Jin-hai SOE Mee Mee ZHANG Chi HSU Tai-Wen | 2010 | Journal of Hydrodynamics2010，22，6： | 5 |
| 14 | Effect of preoperative biliary drainage on surgical results after pancreaticoduodenectomy in patients with distal common bile duct cancer:Focused on the rate of decrease in serum bilirubin显示文摘AIM: To examine if the rate of decrease in serum bilirubin after preoperative biliary drainagecan be used as a predicting factor for surgical complications and postoperative recovery after pancreaticoduodenectomy in patients with distal common bile duct cancer.METHODS: A retrospective study was performed in 49 consecutive patients who underwent pancrea-ticoduodenectomy for distal common bile duct cancer. Potential risk factors were compared between the complicated and uncomplicated groups. Also, the rates of decrease in serum bilirubin were compared pre- and postoperatively. RESULTS: Preoperative biliary drainage (PBD) was performed in 40 patients (81.6%). Postoperative morbidity and mortality rates were 46.9% (23/49) and 6.1% (3/49), respectively. The presence or absence of PBD was not different between the complicated and uncomplicated groups. In patients with PBD, neither the absolute level nor the rate of decrease in serum bilirubin was significantly different. Patients with rapid decrease preoperatively showed faster decrease during the first postoperative week (5.5 ± 4.4 μmol/L vs -1.7 ± 9.9 μmol/L, P = 0.004).CONCLUSION: PBD does not affect the surgical outcome of pancreaticoduodenectomy in patients with distal common bile duct cancer. There is a certain group of patients with a compromised hepatic excretory function, which is represented by the slow rate of decrease in serum bilirubin after PBD. | Yun Mee Choi Eung-Ho Cho Keon-Young Lee Seung-Ik Ahn Sun Keun Choi Sei Joong Kim Yoon Seok Hur Young Up Cho Kee-Chun Hong Seok-Hwan Shin Kyung Rae Kim Ze-Hong Woo | 2008 | World Journal of Gastroenterology2008，14，7： | 5 |
| 15 | Endocrine Regulation of Energy Metabolism by the Skeleton显示文摘 | Na Kyung Lee Hideaki Sowa Eiichi Hinoi Mathieu Ferron Jong Deok Ahn Cyrille Confavreux Romain Dacquin Patrick J. Mee Marc D. McKee Dae Young Jung Zhiyou Zhang Jason K. Kim Franck Mauvais-Jarvis Patricia Ducy Gerard Karsenty | 2007 | Cell2007，，3： | 5 |
| 16 | Simulation of the extreme waves generated by typhoon Bolaven (1215) in the East China Sea and Yellow Sea显示文摘Record-breaking high waves occurred during the passage of the typhoon Bolaven(1215)(TYB) in the East China Sea(ECS) and Yellow Sea(YS) although its intensity did not reach the level of a super typhoon.Winds and directional wave measurements were made using a range of in-situ instruments mounted on an ocean tower and buoys.In order to understand how such high waves with long duration occurred,analyses have been made through measurement and numerical simulations.TYB winds were generated using the TC96 typhoon wind model with the best track data calibrated with the measurements.And then the wind fields were blended with the reanalyzed synoptic-scale wind fields for a wave model.Wave fields were simulated using WAM4.5 with adjustment of C_d for gust of winds and bottom friction for the study area.Thus the accuracy of simulations is considerably enhanced,and the computed results are also in better agreement with measured data than before.It is found that the extremely high waves evolved as a result of the superposition of distant large swells and high wind seas generated by strong winds from the front/right quadrant of the typhoon track.As the typhoon moved at a speed a little slower than the dominant wave group velocity in a consistent direction for two days,the wave growth was significantly enhanced by strong wind input in an extended fetch and non-linear interaction. | JUN Ki Cheon JEONG Weon Mu CHOI Jin Yong PARK Kwang Soon JUNG Kyung Tae KIM Mee Kyung CHAE Jang Won QIAO Fangli | 2015 | Acta Oceanologica Sinica2015，34，12： | 5 |
| 17 | SIMULA在Cu/ZnO/Al_2O_3催化剂上进行甲醇部分氧化蒸气重整制备氢气的模拟研究(英文)显示文摘两个大气压下 ,对管状填充床反应器中在Cu ZnO Al2 O3催化剂上甲醇部分氧化蒸气重整制备氢气进行了实验研究。在Cu ZnO Al2 O3催化剂上进行该反应体系动力学研究的基础上 ,建立了该反应器内的稳态质量和热量衡算方程 ,同时考虑了颗粒内的扩散限制。模型的预测结果与实验结果吻合较好。 | 蒋元力 黄强 王福安 Mee Sook Lim Dong Hyun Kim | 2001 | 燃料化学学报2001，29，3： | 4 |
| 18 | Bile-derived circulating extracellular mi R-30d-5p and mi R-92a-3p as potential biomarkers for cholangiocarcinoma显示文摘Background: Cholangiocarcinoma (CCA) is from cholangiocytes, and therefore bile is a potentially rich source of biomarkers for CCA. The aim of the study was to identify and validate microRNAs (miRNAs) in bile samples that are differentially expressed between benign biliary disease (BBD) and CCA. Methods: Bile samples from 106 patients with obstructive biliary disease were allocated consecutively to a discovery set (10 patients with BBD and 11 with CCA) and then a validation set (48 patients with BBD and 37 with CCA). An miRNA microarray platform was used to screen 1209 miRNAs in the discovery set. Quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR) was used to validate the pro ling results in the discovery and validation sets. In addition, the levels of carbohydrate antigen 19-9 (CA19-9) and carcinoembryonic antigen (CEA) were determined from patient serum samples. Results: Microarray pro ling showed that miR-30d-5p and miR-92a-3p were signi cantly upregulated in bile from the CCA group compared with those from the BBD group. qRT-PCR results indicated that the expression levels of miR-30d-5p and of miR-92a-3p were signi cantly upregulated in the CCA group compared to the BBD group, validating the miRNA microarray results. Pathway analysis suggested that putative target genes of miR-30d-5p and of miR-92a-3p were involved in CCA-associated signalling path- ways, such as Hippo, Wnt, p53, MAPK, and EGFR. Receiver operating curve analysis revealed that the areas under the curve for bile miR-30d-5p, miR-92a-3p, serum CA19-9, and CEA were 0.730, 0.652, 0.675, and 0.603, respectively, and bile miR-30d-5p showed the best diagnostic performance with a sensitivity of 81.1% and a speci city of 60.5%. Conclusions: The levels of extracellular miR-30d-5p and miR-92a-3p in bile were signi cantly higher in patients with CCA than those in patients with BBD. Bile-derived circulating extracellular miR-30d-5p and miR-92a-3p are potential biomarkers for discriminating CCA from BBD. | Hye Sook Han Mi Jin Kim Joung-Ho Han Jieun Yun Hee Kyung Kim Yaewon Yang Ki Bae Kim Seon Mee Park | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，1： | 4 |
| 19 | AMPK-associated signaling to bridge the gap between fuel metabolism and hepatocyte viability显示文摘The adenosine monophosphate-activated protein kinase (AMPK) and p70 ribosomal S6 kinase-1 pathway may serve as a key signaling flow that regulates energy metabolism; thus, this pathway becomes an attractive target for the treatment of liver diseases that result from metabolic derangements. In addition, AMPK emerges as a kinase that controls the redox-state and mitochondrial function, whose activity may be modulated by antioxidants. A close link exists between fuel metabolism and mitochondrial biogenesis. The relationship between fuel metabolism and cell survival strongly implies the existence of a shared signaling network, by which hepatocytes respond to challenges of external stimuli. The AMPK pathway may belong to this network. A series of drugs and therapeutic candidates enable hepatocytes to protect mitochondria from radical stress and increase cell viability, which may be associated with the activation of AMPK, liver kinase B1, and other molecules or components. Consequently, the components downstream of AMPK may contribute to stabilizing mitochondrial membrane potential for hepatocyte survival. In this review, we discuss the role of the AMPK pathway in hepatic energy metabolism and hepatocyte viability. This information may help identify ways to prevent and/or treat hepatic diseases caused by the metabolic syndrome. Moreover, clinical drugs and experimental therapeutic candidates that directly or indirectly modulate the AMPK pathway in distinct manners are discussed here with particular emphasis on their effects on fuel metabolism and mitochondrial function. | Yoon Mee Yang Chang Yeob Han Yoon Jun Kim Sang Geon Kim | 2010 | World Journal of Gastroenterology2010，16，30： | 4 |
| 20 | Re-study on Recurrence Period of Stokes Wave Train with High Order Spectral Method显示文摘Owing to the Benjamin-Feir instability,the Stokes wave train experiences a modulation-demodulation process,and presents a recurrence characteristics.Stiassnie and Shemer researched the unstable evolution process and provided a theoretical formulation for the recurrence period in 1985 on the basis of the nonlinear cubic Schr dinger equation(NLS).However,NLS has limitations on the narrow band and the weak nonlinearity.The recurrence period is re-investigated in this paper by using a highly efficient High Order Spectral(HOS) method,which can be applied for the direct phaseresolved simulation of the nonlinear wave train evolution.It is found that the Stiassnie and Shemer's formula should be modified in the cases with most unstable initial conditions,which is important for such topics as the generation mechanisms of freak waves.A new recurrence period formula is presented and some new evolution characteristics of the Stokes wave train are also discussed in details. | 陶爱峰 郑金海 MEE Mee Soe 陈波涛 | 2011 | China Ocean Engineering2011，25，4： | 4 |
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