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| 1 | Novel treatment options for perforations of the upper gastrointestinal tract:Endoscopic vacuum therapy and over-the-scope clips显示文摘Endoscopic management of leakages and perforations of the upper gastrointestinal tract has gained great importance as it avoids the morbidity and mortality of surgical intervention.In the past years,covered selfexpanding metal stents were the mainstay of endoscopic therapy.However,two new techniques are now available that enlarge the possibilities of defect closure:endoscopic vacuum therapy(EVT),and over-the-scope clip(OTSC).EVT is performed by mounting a polyurethane sponge on a gastric tube and placing it into the leakage.Continuous suction is applied via the tube resulting in effective drainage of the cavity and the induction of wound healing,comparable to the application of vacuum therapy in cutaneous wounds.The system is changed every 3-5 d.The overall success rate of EVT in the literature ranges from 84%to 100%,with a mean of 90%;only few complications have been reported.OTSCs are loaded on a transparent cap which is mounted on the tip of a standard endoscope.By bringing the edges of the perforation into the cap,by suction or by dedicated devices,such as anchor or twin grasper,the OTSC can be placed to close the perforation.For acute endoscopy associated perforations,the mean success rate is 90%(range:70%-100%).For other types of perforations(postoperative,other chronic leaks and fistulas)success rates are somewhat lower(68%,and59%,respectively).Only few complications have been reported.Although first reports are promising,further studies are needed to define the exact role of EVT and OTSC in treatment algorithms of upper gastrointestinal perforations. | Rudolf Mennigen Norbert Senninger Mike G Laukoetter | 2014 | World Journal of Gastroenterology2014，20，24： | 25 |
| 2 | Expression of tight and adherens junction proteins in ulcerative colitis associated colorectal carcinoma: upregulation of claudin-1, claudin-3, claudin-4, and β-catenin显示文摘 | S. T. Mees R. Mennigen T. Spieker E. Rijcken N. Senninger J. Haier M. Bruewer | 2009 | International Journal of Colorectal Disease2009，，： | 2 |
| 3 | Probiotic mixture VSL#3 protects the epithelial barrier by maintaining tight junction protein expression and preventing apoptosis in a murine model of colitis显示文摘 | Mennigen R Nolte K Rijcken E | | 0，，： | 1 |
| 4 | Effect of probiotics on intestinal barrier function显示文摘 | Mennigen R Bruewer M | | 0，，： | 1 |
| 5 | Probiotic mixtureVSL#3 protects the epithelial barrier by maintaining tight junciong protein expression and preventing apoptosis in a murine model of colitis显示文摘 | Mennigen R Nolte K Rijcken E | 2009 | Am J Physiol Gastrointest Liver Physiol2009，296，5： | 1 |
| 6 | Expression of tight and adherens junction proteins in ulcerative colitis asso- ciated carcinoma: up regulation of claudin-1, claudin-3, claudin-4, and beta-catenin显示文摘 | MEES S T MENNIGEN R SPIEKER T | 2009 | International Journal of Colorectal Disease2009，24，4： | 1 |
| 7 | Defining global neuroendocrine gene expression patternsassociated with reproductive seasonality in fish显示文摘 | Zhang D P Xiong H L Mennigen J A | 2009 | PLos ONE2009，4，6： | 1 |
| 8 | Effect of probiotics on intestinal barrier function显示文摘 | Mennigen R Bruewer M | 2009 | Annal of the New York Academy of Science2009，1165，： | 1 |
| 9 | Expression of tight and adherens junction proteins in ulcerative colitis associated colorectal carcinoma : upregulation of claudin - 1, claudin - 3, claudin - 4, and beta - catenin显示文摘 | Mees ST Mennigen R Spieker T | 2009 | Int J Colorectal Dis2009，24，4： | 1 |
| 10 | Expression of tight and adherens junction proteins in ulcerative colitis associated colorectal carcinoma: upregulation of claudin-1, claudin-3, claudin-4, and β-catenin显示文摘 | Mees ST Mennigen R Spieker T | 2009 | Int J Colorectal Dis2009，24，4： | 1 |
| 11 | Probi- otic mixture VSL#3 protects the Epithelial barrier by maintaining tight junction protein expression and pre- venting apoptosis in a rnurine model of colitis 显示文摘 | MENNIGEN R NOLTE K RIJCKEN E | 2009 | A- merican Journal of Physiology2009，296，5： | 1 |
| 12 | Post-prandial regulation of hepatic glucokinase and li- pogenesis requires the activation of TORC1 signalling in rainbow trout ( Oncorhynchus mykiss ) 显示文摘 | DAI W W PANSERAT S MENNIGEN J A | 2013 | Journal of Experimental Biology2013，216，23： | 1 |
| 13 | Effect of probiotics on intestinal barrier function显示文摘 | Mennigen R Bruewer M | 2009 | Ann N Y Acad Sci2009，1165，： | 1 |
| 14 | Endocytosis and recycling of tight junction proteins in inflammation 显示文摘 | Utech M Mennigen R Bruewer M | 2010 | J Biomed Biotechnol2010，2010，48： | 1 |
| 15 | Effect of probioties on interstinal barrier function显示文摘 | Mennigen R Bruewer M | 2009 | Ann N Y Aead Sei2009，1165，： | 1 |
| 16 | Treatment of thoracic esophageal anastomotic leaks and esophageal perforations with endoluminal stents:efficacy and current limitations显示文摘 | Tuebergen D Rijcken E Mennigen R | 2008 | J Gastrointest Surg2008，12，7： | 1 |
| 17 | PECAM-1(CD31)mediates transendothelial leukocyte migration in experimental colitis显示文摘 | Rijcken E Mennigen RB Schaefer SD | 2007 | Am J Physiol Gastrointest Liver Physiol2007，293，2： | 1 |
| 18 | Probiotic mixture VSL# 3 protects the epithelial barrier by maintaining tight junction protein expression and preventing apoptosis in a murine model of colitis显示文摘 | MENNIGEN R NOLTE K RIJCKEN E | | 0，，05： | 1 |
| 19 | Effect of probiotics on intestinal barrier function显示文摘 | MENNIGEN R BRUEWER M | 2009 | Ann N Y Acad Sci2009，，1165： | 1 |
| 20 | Postprandial regulation of hepatic microRNAs predicted to target the insulin pathway in rainbow trout 显示文摘 | Mennigen J A Panserat S Larquier M | 2012 | Plos One2012，7，38： | 1 |
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