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您的检索式：作者名="Mahuya Sengupta"
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| 1 | Hepatoprotective and immunomodulatory properties of aqueous extract of Curcuma longa in carbon tetra chloride intoxicated Swiss albino mice显示文摘Objective:To evaluate the hepatoprotective and immunotherapeutic effects of aqueous extract of turmeric rhizome in CCl_4 intoxicated Swiss albino mice.Methods:first group of mice(n=5) received CCl_4 treatment at a dose of 0.5 mL/kg bw(i.p.) for 7 days.Second group was fed orally the aqueous extract of turmeric at a dose of 50 mg/kg bw for IS days.The third group was given both the turmeric extract(for 15 days,orally) and CCl_4(for last 7 days,i.p.).The fourth group was kept as a control.To study the liver function,the transaminase enzymes(SGOT and SGPT) and bilirubin level were measured in the serum of respective groups.For assaying the immunotherapeutic action of Curcuma longa(C.longa),non specific host response parameters like morphological alteration,phagocytosis,nitric oxide release,myeloperoxidase release and intracellular killing capacity of peritoneal macrophages were studied from the respective groups.Results:The result of present study suggested that CCl_4 administration increased the level of SCOT and SGPT and bilirubin level in serum.However,the aqueous extract of turmeric reduced the level of SGOT, SCFT and bilirubin in CCl_4 intoxicated mice.Apart from damaging the liver system,CCl_4 also reduced non specific host response parameters like morphological alteration,phagocytosis, nitric oxide release,myeloperoxidase release and intracellular killing capacity of peritoneal macrophages.Administration of aqueous extract of C.longa offered significant protection from these damaging actions of CCl_4 on the non specific host response in the peritoneal macrophages of CCl_4 intoxicated mice.Conclusions:In conclusion,the present study suggests that C.longa has immunotherapeutic properties along with its ability to ameliorate hepatotoxicity. | Mahuya Sengupta Gauri Dutta Sharma Biswajit Chakraborty | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，3： | 11 |
| 2 | mmunomodulatory properties of silver nanoparticles ontribute to anticancer strategy for murine fibrosarcoma显示文摘 | Biswajit Chakraborty Ramkrishna Pal Mohammed Ali Leichombam Mohindro Singh Dewan Shahidur Rahman Sujit Kumar Ghosh Mahuya Sengupta | 2016 | Cellular & Molecular Immunology2016，13，2： | 3 |
| 3 | Anticancer efficacy of noble metal nanoparticles relies on reprogramming tumor-associated macrophages through redox pathways and pro-inflammatory cytokine cascades显示文摘The use of the optoelectronic properties of noble metal nanoparticles has given a new dimension to the realm of cancer diagnosis and therapy(theranostics).The multifunctional catalytic properties and surface plasmon resonance of noble metal nanoparticles(NPs)along with their facile surface chemistry gives them an edge in the field of biology,including for immunotherapeutic applications.In a previous study,we reported the anticancer efficacy of silver NPs coated with murine serum albumin against fibrosarcoma in an in vivo mouse model,highlighting their role in eliciting oxystress and immune interference.In addition to addressing the bioavailability and toxicity parameters,our study reported that there was a significant reduction in the size,as well as a delay in the incidence of tumors with AgNP-MSA treatment.Transmission electron micrographs revealed AgNP-MSA uptake by sentinel immune cells associated with the tumor along with the downregulation of pro-tumorigenic inflammatory cytokines,such as TNF-α,IL-6 and IL-1β. | Mahuya Sengupta Ramkrishna Pal Anupam Nath Biswajit Chakraborty Leichombam Mohindro Singh Biswajit Das Sujit Kumar Ghosh | 2018 | Cellular & Molecular Immunology2018，15，12： | 0 |
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