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| 1 | Benefits of nucleos(t)ide analog treatments for hepatitis B virus-related cirrhosis显示文摘Chronic hepatitis B infection induces progressive liver disease. Before nucleos(t)ide analogs(NUCs) became established as a safe and effective treatment for hepatitis B,it was difficult to suppress the activity of the hepatitis B virus(HBV). Currently,many patients withhepatitis or cirrhosis associated with HBV are treated with NUCs for an extended period of time,and the effects,benefits,and limitations of these treatments have been apparent. This article reviews HBV-related cirrhosis,its natural course and survival,histological improvement after NUC treatments,treatment effects for decompensated cirrhosis,the incidence of hepatocellular carcinoma(HCC) after NUC treatments,and the efficacy of NUC treatments before and after the treatment of patients for HBV-related HCC. Of particular interest are the histological improvements,including regression of fibrosis,that have been achieved with NUC treatments. Liver function of patients with decompensated cirrhosis has significantly improved regardless of the type of NUC applied,and treatment with NUCs has reduced the incidence of HCC in cirrhotic patients. However,cirrhosis remains the strongest risk factor for HCC occurrence following NUC treatments,and the long-term cumulative incidence of HCC after NUC treatments remains high. When recurrence does occur,it is important to reconsider the treatment modality according to the degree of improved liver function that was achieved. | Koichi Honda Masataka Seike Kazunari Murakami | 2015 | World Journal of Hepatology2015，7，22： | 9 |
| 2 | Lamivudine treatment enabling right hepatectomy for hepatocellular carcinoma in decompensated cirrhosis显示文摘A 69-year-old man was admitted to our hospital in October 2003,for further examination of two liver tumors.He was diagnosed with hepatocellular carcinoma(HCC) arising from decompensated hepatitis B virus(HBV)-related cirrhosis.Long-term lamivudine administration improved liver function dramatically despite repeated treatment for HCC.His Child-Pugh score was 9 points at start of lamivudine treatment,improving to 5 points after 1 year.His indocyanine green at 15 min after injection test score was 48%before lamivudine treat-ment,improving to 22%after 2 years and to 5%after 4 years.Radiofrequency ablation controlled the HCC foci and maintained his liver function.In April 2009,abdominal computed tomography revealed a tumor thrombus in the right portal vein.Since his indocyanine green test results had improved to less than 10%,we performed a right hepatectomy,which was successful.To our knowledge,there have been no documented reports of patients undergoing successful right hepatectomy for HCC arising from decompensated cirrhosis.The findings observed in our patient indicate the importance of nucleoside analogs for treating HBV-related HCC. | Koichi Honda Masataka Seike Shin-ichiro Maehara Koichiro Tahara Hideaki Anai Akira Moriuchi Toyokichi Muro | 2012 | World Journal of Gastroenterology2012，18，20： | 7 |
| 3 | Unique microRNA molecular profiles in lung cancer diagnosis and prognosis显示文摘 | Nozomu Yanaihara Natasha Caplen Elise Bowman Masahiro Seike Kensuke Kumamoto Ming Yi Robert M. Stephens Aikou Okamoto Jun Yokota Tadao Tanaka George Adrian Calin Chang-Gong Liu Carlo M. Croce Curtis C. Harris | 2006 | Cancer Cell2006，，3： | 4 |
| 4 | Beh et's disease complicated by multiple aseptic abscesses of the liver and spleen显示文摘Aseptic abscesses are an emergent entity and have been described in inflammatory bowel disease,especially in Crohn's disease,and in other diseases.However,aseptic abscesses associated with Beh et's disease are extremely rare.We report a Japanese male diagnosed with an incomplete type of Beh et's disease who developed multiple aseptic abscesses of the spleen and liver.In 2002,the spleen abscesses were accompanied by paroxysmal oral aphthous ulcers and erythema nodosum.As the patient's response to antibiotic treatment was inadequate,a splenectomy was performed.Severe inflammatory cell infiltration,largely of polymorphonuclear neutrophils,was observed without evidence of bacterial or fungal growth.Although the patient had no history of ocular symptoms or genital ulcers,a diagnosis of incomplete Beh et's disease was made according to the Japanese diagnostic criteria because of the presence of paroxysmal arthritis and epididymitis since 2002.In 2005,multiple liver abscesses developed with right hypochondrial pain and seemed to be attributed to Beh et's disease because the abscesses yielded negative results during a microbiologic investigation and failed to go into remission under antibiotic therapy.Oral prednisone(15 mg/d) was started in May 2006,and the abscesses dramatically disappeared 4 wk after treatment.Although the patient had a relapse of the liver abscesses in association with the tapering of prednisone,the augmentation of prednisone dosage yielded a response.The abscesses of the liver and spleen were strongly suggested to be attributed to Beh et's disease.Clinician should be aware of the existence of aseptic abscesses as uncommon manifestations of Beh et's disease. | Keisuke Maeshima Koji Ishii Megumi Inoue Katsuro Himeno Masataka Seike | 2013 | World Journal of Gastroenterology2013，19，20： | 3 |
| 5 | Alpha-fetoprotein and des-gamma-carboxy-prothrombin at twenty-four weeks after interferon-based therapy predict hepatocellular carcinoma development显示文摘AIM: To investigate risk factors for development of hepatocellular carcinoma(HCC) in patients with hepatitis C virus-related liver cirrhosis(LC-C).METHODS: To evaluate the relationship between clinical factors including virological response and the development of HCC in patients with LC-C treated with interferon(IFN) and ribavirin, we conducted a multicenter, retrospective study in 14 hospitals in Japan. All patients had compensated LC-C with clinical or histological data available. HCC was diagnosed by the presence of typical hypervascular characteristics on computed tomography and/or magnetic resonance imaging.RESULTS: HCC was diagnosis in 50(21.6%) of 231 LC-C patients during a median observation period of 3.8 years after IFN and ribavirin therapy. Patients who developed HCC were older(P = 0.018) and had higher serum levels of pretreatment alpha-fetoprotein(AFP)(P = 0.038). Multivariate analysis revealed the following independent risk factors for HCC development: history of treatment for HCC [P < 0.001, odds ratio(OR) = 15.27, 95%CI: 4.98-59.51], AFP levels of ≥ 10 ng/m L(P = 0.009, OR = 3.89, 95%CI: 1.38-11.94), and des-γ-carboxy prothrombin(DCP) levels of ≥ 40 m AU/mL at 24 wk after the completion of IFN and ribavirin therapy(P < 0.001, OR = 24.43, 95%CI: 4.11-238.67).CONCLUSION: We suggested that the elevation of AFP and DCP levels at 24 wk after the completion of IFN and ribavirin therapy were strongly associated with the incidence of HCC irrespective of virological response among Japanese LC-C patients. | Satoshi Shakado Shotaro Sakisaka Kazuaki Chayama Takeshi Okanoue Joji Toyoda Namiki Izumi Akihiro Matsumoto Tetsuo Takehara Akio Ido Yoichi Hiasa Kentaro Yoshioka Hideyuki Nomura Yoshiyuki Ueno Masataka Seike Hiromitsu Kumada | 2015 | World Journal of Hepatology2015，7，27： | 3 |
| 6 | Structure regulation for ultra-high luminescence quantum yield lanthanide complex and simultaneous detection of cancer marker and ferrous ion显示文摘The exploitation of a highly selective and sensitive probe to detect both cancer marker and metal ion is of great importance.In this work,the 'one stone two bird' agent of 1,10-phenanthroline(phen) is designed to disrupt the polymeric lanthanide MOFs(LnMOFs,[Ln(CHO_(2))_(3)]n,Ln=Tb,la;Eu,1 b,CHO_(2)=formic acid) {[Ln(CHO_(2))_(4)·(C_(2) H_(8) N)]n,Ln=Y,2 a;Gd,2 b;Dy,2 c,C_(2)H_(8) N=dimethylamine}) into a soluble mononuclear species [Ln(phen)_(2)(NO_(3))_(3),Ln=Tb,3 a;Eu,3 b] as well as to provide an antenna for efficient photons absorption,resulting in an ultra-high luminescence quantum yield(QY,90%) europium complex.The luminescence QY is among the highest record of monomeric(zero-dimensional) lanthanide complexes.Furthermore,mononuclear Tb3+complex(3 a) functions as a multiplex sensor towards both Fe^(2+)and cancer marker of 5-hydroxyindole-3-acetic acid(5-HIAA).Importantly,the limit of detection(LOD)for sensing 5-HIAA is an ultra-sensitive value of 1 × 10 s mol/L,which is even lower than that necessary for the early diagnosis of carcinoid tumors.More interestingly,sensing results in simulated urine reveals that 3 a has potential application for early diagnosis in the clinic. | Min Liu Zhifeng Li Jianhui Xiong Yefei Jiang Ting Tang Jinkai Qiu Junwei Yao Seik Weng Ng Chenghui Zeng | 2021 | Journal of Rare Earths2021，39，10： | 3 |
| 7 | Unique microRNA molecular profiles in lung cancer diagnosis and prognosis显示文摘 | Nozomu Yanaihara Natasha Caplen Elise Bowman Masahiro Seike Kensuke Kumamoto Ming Yi Robert M. Stephens Aikou Okamoto Jun Yokota Tadao Tanaka George Adrian Calin Chang-Gong Liu Carlo M. Croce Curtis C. Harris | 2006 | Cancer Cell2006，，3： | 2 |
| 8 | Fluxes of carbon dioxide, methane and nitrous oxide in two contrastive fringing zones of coastal lagoon, Lake Nakaumi, Japan显示文摘 | Mitsuru Hirota Yukiko Senga Yasushi Seike Seiichi Nohara Hidenobu Kunii | 2007 | Chemosphere2007，，3： | 2 |
| 9 | Some Strategies for the Refinement of Disordered Structures with the SHELXL-97 Refinement Program显示文摘Examples of the refinement of disordered structures taken from work published in Acta Crystallographica are presented together with explanations on how the disordered structures are dealt with. The constraint and restraint commands in the SHELXL-97 refinement program that are specific to the particular type of disorder are described. Some ways to divine the hydrogen atoms on water are given in detail. The refinements of the Flack parameters and twinned structures are briefly discussed. | Ng Seik Weng (Department of Chemistry, University of Malaya, Kuala Lumpur 50603, Malaysia) | 2005 | Chinese Journal of Structural Chemistry2005，24，12： | 2 |
| 10 | Indexing Non-merohedrally Twinned Crystals by Bruker'sAPEX2 and Agilent's CrysAlis^(PRO), an Example of a Crystal Structure That Can Be Refined through Either the PLATONRoute or the ‘HKLF 5' Route, and, Simultaneous Data Collection of Two Crystals in a Tw显示文摘The first part of this report describes the data reduction of non-merohedrally twinned crystals measured on Bruker and Agilent area-detector diffractometers. The image frames of methyl-2-aminopyrazine-3-carboxylate were processed with APEX2 to furnish a set of overlapping diffraction indices that were used for solution and refinement. CrysAlisPRO was used for processing the frames of bis(diethyldicarbamato)nickel, which exists in monoclinic and tetragonal polymorphs, and in untwinned and twinned forms. In the second part, the crystal structure of [(3-formyl-4- hydroxyphenyl)methyl]triphenylphosphanium chloride was refined through the ‘HKLF 5'(based on a combined set of diffraction indices) and PLATON(based on one set of diffraction indices) routes to give identical outcomes because the amount of overlap of the twin domains is small. For the third part, in a proof-of-concept investigation, the diffraction pattern of untwinned and twinned 4-{(E)-(4-aminophenyl)diazenyl]phenylamine was recorded simultaneously in one run; the three domains could be indexed and the crystal structure satisfactorily refined. The refinement was identical to those derived from independent measurements; the crystal structure features two independent centrosymmetric molecules, one of which is ordered and the other whole-molecule-disordered. This two-in-one run opens up the possibility that two or more crystals having different atomic compositions can be measured simultaneously if their reciprocal lattices do not overlap significantly. | NG Seik Weng | 2014 | Chinese Journal of Structural Chemistry2014，33，2： | 2 |
| 11 | Bevacizumab plus chemotherapy for advanced non-squamous non-small-cell lung cancer with malignant pleural effusion显示文摘 | Kazuhiro Kitamura Kaoru Kubota Masahiro Ando Satoshi Takahashi Nobuhiko Nishijima Teppei Sugano Masaru Toyokawa Koji Miwa Seiji Kosaihira Rintaro Noro Yuji Minegishi Masahiro Seike Akinobu Yoshimura Akihiko Gemma | 2013 | Cancer Chemotherapy and Pharmacology2013，，2： | 2 |
| 12 | 6-四氮唑-2-吡啶甲酸配合物的原位合成与氢键拓扑网络研究显示文摘用2,6-二氰基吡啶与叠氮化钠在水热条件下原位合成了5种6一四氮唑.2-吡啶甲酸配合物:【Ni2(tepc)2(H2O)2】(1),[CO2(tepc)2(H2O)4]·2H2O(2),【CO2(tepc)2(H2O)4】·4H2O(3),【Cu2(tepc)2(H2O)2](4)和{【Mn(tepc)(H20)2]·2H2O}n(5)(tepc=6一(tetrazol-5-y1)picolinate).这些配合物中配体均以三齿螯合的方式与金属离子配位.配合物1-4形成了双核离散型配合物,双核分子通过氢键作用连接成三维超分子结构.配合物5中的单核螯合单元间通过Mn-O配位键连接成为一维配位聚合物链,链间通过氢键连接成为整个配合物的晶体结构.氢键拓扑网络分析表明,配合物1和2可简化成NaCI型的6-连接pcu拓扑网,配合物3则可简化成一种8.连接hex拓扑网,配合物4可简化成一种新型双结点十连接拓扑网络(3^10.4^26·5^8·6)(3^8.4^26.5^10.6),配合物5则可简化成一种新型的(5,10)双结点三维网络(3^2·4^7.5)(3^4.4^21.5^13.6^7).本文不仅详细地分析了这些配合物晶体结构中氢键与拓扑网络之间的关系,而且还讨论了氰基的水解反应与四氮唑成环反应间的关系,以及金属离子的电子特征、结晶条件与晶体结构之间的关系. | 杨英宜 詹顺泽 李冕 李丹 NG Seik Weng | 2013 | 中国科学:化学2013，43，10： | 2 |
| 13 | MiR-134/487b/655 Cluster Regulates TGF-β-Induced Epithelial-Mesenchymal Transition and Drug Resistance to Gefitinib by Targeting MAGI2 in Lung Adenocarcinoma Cells显示文摘 | Kitamura K Seike M Okano T | 2014 | Mol Cancer Ther2014，13，2： | 1 |
| 14 | Interaction between lung cancer cells and astrocytes via specific inflammatory cytokines in the microenvironment of brain metastasis显示文摘 | Seike T | | 0，，01： | 1 |
| 15 | Early postoperative evaluation of secondary bone grafting into the alveolar cleft and its effects on subsequent orthodontic treatment显示文摘 | Seike T Hashimoto I Matsumoto K | 2012 | J Med Invest2012，59，12： | 1 |
| 16 | The role of immune cells in brain metastasis of lung cancer cells and neuron-tumor cell interaction显示文摘 | NODA M SEIKE T FUJITA K | 2000 | Neurosurgery2000，46，4： | 1 |
| 17 | Fluxes of carbon di- oxide, methane and nitrous oxide in two contrastive fringing zones of coastal lagoon, Lake Nakaumi, Japan显示文摘 | Hirota M Senga Y Seike Y Nohara S | 2007 | Chemosphere2007，68，： | 1 |
| 18 | Successful cerebral artery stent placement for total occlusion of the vertebrobassilar artery in patient suffering from acute: case report显示文摘 | Mori T Kazita K Seike M | 1999 | J Neurosurgery1999，19，5： | 1 |
| 19 | Efficacy and safety of eltrombopag in Japanese patients with chronic liver disease and thrombocytopenia: a randomized, open-label, phase II study显示文摘 | Takumi Kawaguchi Atsumasa Komori Masataka Seike Shigetoshi Fujiyama Hiroshi Watanabe Masatoshi Tanaka Shotaro Sakisaka Makoto Nakamuta Yutaka Sasaki Makoto Oketani Toshihiro Hattori Koichi Katsura Michio Sata | 2012 | Journal of Gastroenterology2012，，12： | 1 |
| 20 | Reopening of maeular holes in highly myopic eyes with retinal detachments显示文摘 | Seike C Kusaka S Sakagami K | 1997 | Retina1997，17，： | 1 |
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