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| 1 | Serum manganese superoxide dismutase and thioredoxin are potential prognostic markers for hepatitis C virus-related hepatocellular carcinoma显示文摘AIM:To evaluate the clinical significance of oxidative stress markers in patients with hepatitis C virus(HCV)related hepatocellular carcinoma(HCC).METHODS:Sixty-four consecutive patients who were admitted to Kagoshima University Medical and Dental Hospital were enrolled in this retrospective study.All patients had chronic liver disease(CLD) due to infection with HCV.Thirty patients with HCV-related HCC,34 with HCV-related CLD without HCC(non-HCC),and 20 healthy volunteers(HVs) were enrolled.Possible associations between serum manganese superoxide dismutase(MnSOD) and thioredoxin(TRX) levels and clinical parameters or patient prognosis were analyzed over a mean follow-up period of 31.7 mo.RESULTS:The serum MnSOD levels were significantly higher in patients with HCV-related HCC than in patients without HCC(P = 0.03) or HVs(P < 0.001).Similarly,serum TRX levels were also significantly higher in patients with HCV-related HCC than in patients without HCC(P = 0.04) or HVs(P < 0.01).However,serum levels of MnSOD and TRX were not correlated in patients with HCC.Among patients with HCC,the overall survival rate(OSR) was lower in patients with MnSOD levels ≥ 110 ng/mL than in patients with levels < 110 ng/mL(P = 0.01),and the OSR tended to be lower in patients with TRX levels < 80 ng/mL(P = 0.05).In addition,patient prognosis with HCC was poorest with serum MnSOD levels ≥ 110 ng/mL and serum TRX levels < 80 ng/mL.Furthermore,a multivariate analysis using a Cox proportional hazard model and serum levels of five factors(MnSOD,prothrombin time,serum albumin,serum α-fetoprotein(AFP),and serum des-γ-carboxy prothrombin) revealed that MnSOD levels ≥ 110 ng/mL(risk ratio:4.12,95% confidential interval:1.22-13.88,P = 0.02) and AFP levels ≥ 40 ng/mL(risk ratio:6.75;95% confidential interval:1.70-26.85,P < 0.01) were independent risk factors associated with a poor patient prognosis.CONCLUSION:Serum MnSOD and TRX levels are potential clinical biomarkers that predict patient prognosis in HCV-related HCC. | Tsutomu Tamai Hirofumi Uto Yoichiro Takami Kouhei Oda Akiko Saishoji Masashi Hashiguchi Kotaro Kumagai Takeshi Kure Seiichi Mawatari Akihiro Moriuchi Makoto Oketani Akio Ido Hirohito Tsubouchi | 2011 | World Journal of Gastroenterology2011，17，44： | 7 |
| 2 | Alpha-fetoprotein and des-gamma-carboxy-prothrombin at twenty-four weeks after interferon-based therapy predict hepatocellular carcinoma development显示文摘AIM: To investigate risk factors for development of hepatocellular carcinoma(HCC) in patients with hepatitis C virus-related liver cirrhosis(LC-C).METHODS: To evaluate the relationship between clinical factors including virological response and the development of HCC in patients with LC-C treated with interferon(IFN) and ribavirin, we conducted a multicenter, retrospective study in 14 hospitals in Japan. All patients had compensated LC-C with clinical or histological data available. HCC was diagnosed by the presence of typical hypervascular characteristics on computed tomography and/or magnetic resonance imaging.RESULTS: HCC was diagnosis in 50(21.6%) of 231 LC-C patients during a median observation period of 3.8 years after IFN and ribavirin therapy. Patients who developed HCC were older(P = 0.018) and had higher serum levels of pretreatment alpha-fetoprotein(AFP)(P = 0.038). Multivariate analysis revealed the following independent risk factors for HCC development: history of treatment for HCC [P < 0.001, odds ratio(OR) = 15.27, 95%CI: 4.98-59.51], AFP levels of ≥ 10 ng/m L(P = 0.009, OR = 3.89, 95%CI: 1.38-11.94), and des-γ-carboxy prothrombin(DCP) levels of ≥ 40 m AU/mL at 24 wk after the completion of IFN and ribavirin therapy(P < 0.001, OR = 24.43, 95%CI: 4.11-238.67).CONCLUSION: We suggested that the elevation of AFP and DCP levels at 24 wk after the completion of IFN and ribavirin therapy were strongly associated with the incidence of HCC irrespective of virological response among Japanese LC-C patients. | Satoshi Shakado Shotaro Sakisaka Kazuaki Chayama Takeshi Okanoue Joji Toyoda Namiki Izumi Akihiro Matsumoto Tetsuo Takehara Akio Ido Yoichi Hiasa Kentaro Yoshioka Hideyuki Nomura Yoshiyuki Ueno Masataka Seike Hiromitsu Kumada | 2015 | World Journal of Hepatology2015，7，27： | 3 |
| 3 | Daclatasvir plus asunaprevir for chronic HCV genotype 1b infection显示文摘 | Hiromitsu Kumada Yoshiyuki Suzuki Kenji Ikeda Joji Toyota Yoshiyasu Karino Kazuaki Chayama Yoshiiku Kawakami Akio Ido Kazuhide Yamamoto Koichi Takaguchi Namiki Izumi Kazuhiko Koike Tetsuo Takehara Norifumi Kawada Michio Sata Hidetaka Miyagoshi Timothy Ele | 2014 | Hepatology2014，，6： | 2 |
| 4 | Risk factors for the local recurrence of hepatocellular carcinoma after a single session of percutaneous radiofrequency ablation显示文摘 | Takeshi Hori Kenji Nagata Satoru Hasuike Masaaki Onaga Mizue Motoda Akihiro Moriuchi Hisayoshi Iwakiri Hirofumi Uto Jyunya Kato Akio Ido Katsuhiro Hayashi Hirohito Tsubouchi | 2003 | Journal of Gastroenterology2003，，10： | 1 |
| 5 | Thrombocytopenia Exacerbates Cholestasis-Induced Liver Fibrosis in Mice显示文摘 | Takahiro Kodama Tetsuo Takehara Hayato Hikita Satoshi Shimizu Wei Li Takuya Miyagi Atsushi Hosui Tomohide Tatsumi Hisashi Ishida Seiji Tadokoro Akio Ido Hirohito Tsubouchi Norio Hayashi | 2010 | Gastroenterology2010，，7： | 1 |
| 6 | Transduction of antisense cyclinD1 using two-step gene transfer inhibits growth of rat hepatoma cells 显示文摘 | Hirofumi Uto Akio Ido Akihiro Moriuchi | 2001 | Carcer Reseach2001，61，： | 1 |
| 7 | A case of chronic hepatitis C developing insulin-dependent diabetes mellitus associated with various autoantibodies during interferon therapy显示文摘 | Hirofumi Uto Hitoshi Matsuoka Mitsuhiro Murata Tsuyoshi Okamoto Yoshifumi Miyata Takeshi Hori Akio Ido Shuichi Hirono Katsuhiro Hayashi Hirohito Tsubouchi | 2000 | Diabetes Research and Clinical Practice2000，，2： | 1 |
| 8 | Interleukin-10 or tumor necrosis factor-α polymorphisms and the natural course of hepatitis C virus infection in a hyperendemic area of Japan显示文摘 | Kazunori Kusumoto Hirofumi Uto Katsuhiro Hayashi Yuka Takahama Hiroyuki Nakao Robert Suruki Sherri O. Stuver Akio Ido Hirohito Tsubouchi | 2006 | Cytokine2006，，1： | 1 |
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