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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Stem cell therapy for chronic skin wounds in the era of personalized medicine:From bench to bedside显示文摘With the significant financial burden of chronic cutaneous wounds on the healthcare system,not to the personal burden mention on those individuals afflicted,it has become increasingly essential to improve our clinical treatments.This requires the translation of the most recent benchtop approaches to clinical wound repair as our current treatment modalities have proven insufficient.The most promising potential treatment options rely on stem cellbased therapies.Stem cell proliferation and signaling play crucial roles in every phase of the wound healing process and chronic wounds are often associated with impaired stem cell function.Clinical approaches involving stem cells could thus be utilized in some cases to improve a body’s inhibited healing capacity.We aim to present the laboratory research behind the mechanisms and effects of this technology as well as current clinical trials which showcase their therapeutic potential.Given the current problems and complications presented by chronic wounds,we hope to show that developing the clinical applications of stem cell therapies is the rational next step in improving wound care. | Elam Coalson Elliot Bishop Wei Liu Yixiao Feng Mia Spezia Bo Liu Yi Shen Di Wu Scott Du Alexander J.Li Zhenyu Ye Ling Zhao Daigui Cao Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Rex C.Haydon Lewis Shi Aravind Athiviraham Michael J.Lee Jennifer Moriatis Wolf Guillermo A.Ameer Tong-Chuan He Russell R.Reid | 2019 | Genes & Diseases2019，6，4： | 6 |
| 3 | Impact of a Senior High School Tuition Relief Program on Poor Junior High School Students in Rural China显示文摘A significant gap remains between rural and urban students in the rate of admission to senior high school.One reason for this gap might be the high levels of tuition and fees for senior high school.By reducing students' expectations of attending high school,high levels of tuition and fees could be reducing student academic performance in junior high schools.In this paper we evaluate the impacts of a senior high tuition relief program on the test scores of poor rural seventh grade students in China.We surveyed three counties in Shaanxi Province and exploited the fact that,while the counties are adjacent to one another and share similar characteristics,only one of the three implemented a tuition relief program.Using several alternative estimation strategies,including difference-in-differences,propensity score matching and difference-in-differences matching,we find that the tuition program has a statistically significant and positive impact on the mathematics scores of seventh grade students.More importantly,this program is shown to have a statistically significant and positive effect on the poorest students in the treatment group compared to their wealthier peers. | Xinxin Chen Yaojiang Shi Di Mo James Chu Prashant Loyalka Scott Rozelle | 2013 | China & World Economy2013，21，3： | 3 |
| 4 | Why do some universities generate more start-ups than others?显示文摘 | Dante Di Gregorio Scott Shane | 2002 | Research Policy2002，，2： | 2 |
| 5 | Acid volatile sulfide predicts the acute toxicity of cadmium and nickel in sediments显示文摘 | Di Taro DM Mahony JD Hansen D J Scott KJ Carlson AR Ankley GT | 1992 | Environ- mental Science and Technology1992，26，： | 1 |
| 6 | Toxicity of cadmium in sediments: The role of acid volatile sulfide 显示文摘 | Di Toro D M Mahony J D M B Mayr S M Redmond Hansen D J Scott K J Hicks M S | 1990 | Environmental Toxicology and Chemistry1990，26，1： | 1 |
| 7 | Dropping out: Why are students leaving junior high in China’s poor rural areas?显示文摘 | Hongmei Yi Linxiu Zhang Renfu Luo Yaojiang Shi Di Mo Xinxin Chen Carl Brinton Scott Rozelle | 2011 | International Journal of Educational Development2011，，4： | 1 |
| 8 | The costs of rheumatoid arthritis:an intermational long-term view显示文摘 | Pugner KM Scott DI Hoimes JW | 2000 | Semin Arthritis Rheum2000，39，： | 1 |
| 9 | Continuous feed microbial fuel cell using an air cathode and a disc anode stack for wastewater treatment 显示文摘 | DI LORENZO M SCOTT K CURTIS T P | 2009 | Energy & Fuels2009，23，： | 1 |
| 10 | Why do some universities generate more start-ups than others显示文摘 | Dante Di Gregorio Scott Shane | 2003 | Research Policy2003，，32： | 1 |
| 11 | Why do some universities generate more start -ups than others? 显示文摘 | DANTE DI GREGORIO SCOTT SHANE | 2003 | Research Policy2003，，32： | 1 |
| 12 | Acid volatile sulfide predicts the acute toxicity of cadmium and nickel in sediments 显示文摘 | Di Toro D M Mahony J D Hansen D J Scott K J Carlson A R Ankley G T | 1992 | Environ Sci Technol1992，26，1： | 1 |
| 13 | Assessment Of Myocardial Viability And Left Ventricular Function In Patients Supported By A Left Ventricular Assist Device显示文摘 | Deepak K. Gupta Hicham Skali Jose Rivero Patricia Campbell Leslie Griffin Colleen Smith Courtney Foster Brian Claggett Robert J. Glynn Gregory Couper Michael M. Givertz Mandeep R. Mehra Marcelo Di Carli Scott D. Solomon Marc A Pfeffer | 2014 | Journal of Heart and Lung Transplantation2014，，： | 1 |
| 14 | Expression of inclusion body-associated proteins in Paget's disease of bone显示文摘 | Azzam EA Scott DI Gregory JS | 2009 | Bone2009，44，2： | 1 |
| 15 | Gene expression patterns unveil a new level of molecular heterogeneity in colorectal cancer显示文摘 | Eva Budinska Vlad Popovici Sabine Tejpar Giovanni D’Ario Nicolas Lapique Katarzyna Otylia Sikora Antonio Fabio Di Narzo Pu Yan John Graeme Hodgson Scott Weinrich Fred Bosman Arnaud Roth Mauro Delorenzi | 2013 | J. Pathol2013，，1： | 1 |
| 16 | Why do some universities generate more start-ups than others显示文摘 | DANTE DI GREGORIO SCOTT SHANE | 2003 | Research Policy2003，，32： | 1 |
| 17 | Efficacy and safety of leflunomide compared with placebo and sulphasalazine in active rheumatoid arthritis: a double-blind, randomised,multicentre trial显示文摘 | Kalden JR Scott DI | 1999 | Lancet1999，353，9149： | 1 |
| 18 | Sacrococcygeal chordoma:magnetic resonance imaging and computed tomography显示文摘 | Scott JA Mankin HJ | 1988 | AJR Am J Roentgenol1988，145，1： | 1 |
| 19 | Gene expression patterns unveil a new level of molecular heterogeneity in colorectal cancer显示文摘 | Eva Budinska Vlad Popovici Sabine Tejpar Giovanni D’Ario Nicolas Lapique Katarzyna Otylia Sikora Antonio Fabio Di Narzo Pu Yan John Graeme Hodgson Scott Weinrich Fred Bosman Arnaud Roth Mauro Delorenzi | 2013 | J Pathol2013，，1： | 1 |
| 20 | Detection of Staphylococcus aureus enterotoxin B at femtomolar levels with a miniature integrated two-channel surface plas- mon resonance (SPR)sensor显示文摘 | Alexei N N Scott D S Di K N | 2002 | Biosensors and Bioelectronics2002，17，67： | 1 |
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