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| 1 | Integrated genomic analysis identifies deregulated JAK/STAT-MYC-biosynthesis axis in aggressive NK-cell leukemia显示文摘好攻击的 NK 房间白血病(ANKL ) 是在从亚洲的人之中是更流行的 NK 房间瘤的一种稀罕形式并且中央并且南美洲。病人们通常在天以内死到月,甚至在收到迅速的治疗学的管理以后。这里,我们由集成整个染色体执行了 ANKL 的第一全面研究, transcriptome 并且定序指向,象功能的试金一样的 cytokine 数组。在 JAK-STAT 小径的变化在 48% 被识别(14/29 ) ANKL 病人,当细胞外的 STAT3 激发器 IL10 被 56 褶层的一般水准提高时(P < 0.0001 ) 在检查的所有病人的血浆。另外的经常变异的基因包括的 TP53 (34%) , TET2 (28%) , CREBBP (21%) 和 MLL2 (21%) 。耐心的 NK 白血病房间在多重新陈代谢的小径显示出 STAT3 phosphorylation, MYC 表示和 transcriptional 活动的突出的激活。机能上地, STAT3 激活和 MYC 表示为 ANKL 房间的增长和幸存是批评的。发信号的 STAT 调整了发信号的 MYC 抄写节目,和两 STAT, MYC 抄写被要求维持核苷酸合成和 glycolysis 的激活。一起, JAK-STAT 小径在 ANKL 为 genomic 改变和 IL10 刺激代表一个主要目标。这最新发现的 JAK/STAT-MYC-biosynthesis 轴可以在对待白血病的这种子类型为新奇治疗学的策略的发展提供机会。 | Liang Huang Dan Liu Na Wang Shaoping Ling Yuting Tang Jun Wu Lingtong Hao Hui Luo Xuelian Hu Lingshuang Sheng Lijun Zhu Di Wang Yi Luo Zhen Shang Min Xiao Xia Mao Kuangguo Zhou Lihua Cao Lili Dong Xinchang Zheng Pinpin Sui Jianlin He Shanlan Mo Jin Yan Qilin Ao Lugui Qiu Hongsheng Zhou Qifa Liu Hongyu Zhang Jianyong Li Jie Jin Li Fu Weili Zhao Jieping Chen Xin Du Guoliang Qing Hudan Liu Xin Liu Gang Huang Ding Ma Jianfeng Zhou Qian-fei Wang | 2018 | Cell Research2018，28，2： | 5 |
| 2 | A new anti-diabetic sesquiterpenoid from Acorus calamus显示文摘新 sesquiterpenoid, 1,5-guaiane-4,10-diol-6-one (1 ) ,从 Acorus 省藤属的植物的根茎的 70% EtOH 摘录被孤立。结构在分光镜的方法上被决定,特别 2D NMR 技术。1 的绝对配置被它的 ECD 光谱的 TDDFT 量化学药品计算证实。在 HepG2 房间的一个调停胰岛素的葡萄糖消费模型上加重 1 项显示出的有希望的反糖尿病的活动。 | Chang Xin Zhou Di Qiao You You Yan Hao Shu Wu Jian Xia Mo Li She Gan | 2012 | Chinese Chemical Letters2012，23，10： | 3 |
| 3 | Direct C–H amination for indole synthesis from N-Ts-2-Styrylaniline derivatives catalyzed by copper salt显示文摘A direct C–H amination reaction of N-Ts-2-Styrylaniline derivatives to realize the synthesis of indole derivatives was developed in the presence of copper salt. A variety of N-Ts-2-Styrylaniline derivatives were transformed into the corresponding indole products in good to excellent yield under mild conditions with the oxidation of potassium persulfate. | Di Chen Han-Jie Mo Ding-Ben Chen Jian-Guo Yang | 2015 | Chinese Chemical Letters2015，26，8： | 3 |
| 4 | Impact of a Senior High School Tuition Relief Program on Poor Junior High School Students in Rural China显示文摘A significant gap remains between rural and urban students in the rate of admission to senior high school.One reason for this gap might be the high levels of tuition and fees for senior high school.By reducing students' expectations of attending high school,high levels of tuition and fees could be reducing student academic performance in junior high schools.In this paper we evaluate the impacts of a senior high tuition relief program on the test scores of poor rural seventh grade students in China.We surveyed three counties in Shaanxi Province and exploited the fact that,while the counties are adjacent to one another and share similar characteristics,only one of the three implemented a tuition relief program.Using several alternative estimation strategies,including difference-in-differences,propensity score matching and difference-in-differences matching,we find that the tuition program has a statistically significant and positive impact on the mathematics scores of seventh grade students.More importantly,this program is shown to have a statistically significant and positive effect on the poorest students in the treatment group compared to their wealthier peers. | Xinxin Chen Yaojiang Shi Di Mo James Chu Prashant Loyalka Scott Rozelle | 2013 | China & World Economy2013，21，3： | 3 |
| 5 | RGD-hirudin-based low molecular weight peptide prevents blood coagulation via subcutaneous injection显示文摘Thromboembolic disease is a common cardio-cerebral vascular disease that threatens human life and health.Thrombin not only affects the exogenous coagulation pathway,but also the endogenous pathway.Thus,it becomes one of the most important targets of anticoagulant drugs.RGD-hirudin is an anticoagulant drug targeting thrombin,but it can only be administered intravenously.We designed a low molecular weight peptide based on RGD-hirudin that could prevent blood clots.We first used NMR to identify the key amino acid residues of RGD-hirudin that interacted with thrombin.Then,we designed a novel direct thrombin inhibitor peptide(DTIP)based on the structure and function of RGD-hirudin using homology modeling.Molecular docking showed that the targeting and binding of DTIP with thrombin were similar to those of RGD-hirudin,suggesting DTIP interacted directly with thrombin.The active amino acids of DTIP were identified by alanine scanning,and mutants were successfully constructed.In blood clotting time tests in vitro,we found that aPTT,PT,and TT in the rat plasma added with DTIP were greatly prolonged than in that added with the mutants.Subcutaneous injection of DTIP in rats also could significantly prolong the clotting time.Thrombelastography analysis revealed that DTIP significantly delayed blood coagulation.Bio-layer interferometry study showed that there were no significant differences between DTIP and the mutants in thrombin affinity constants,suggesting that it might bind to other sites of thrombin rather than to its active center.Our results demonstrate that DTIP with low molecular weight can prevent thrombosis via subcutaneous injection. | Ya-ran Li Yi-nong Huang Bing Zhao Meng-fang Wu Tian-yu Li Yan-ling Zhang Di Chen Min Yu Wei Mo | 2020 | Acta Pharmacologica Sinica2020，41，6： | 2 |
| 6 | Electronic and optrcal properties of three phases of titanium dioxide: futile anatase and brookite 显示文摘 | MO SHANG DI CHING W Y | 1995 | Phys Rev B1995，51，13： | 1 |
| 7 | Properties of putative cardiac and non-cardiac neurones in the rat stellate ganglion显示文摘 | Mo N Wallis DI Watson A | 1994 | J Auton Nerv Syst1994，47，12： | 1 |
| 8 | Phar-macokinetics of intraperitoneeal hyperthermic perfusion with mitoxantrone in orarian caner显示文摘 | Nicoletto MO Di Filippo F Padrini R | | 0，，06： | 1 |
| 9 | Failure of a reinforced triple course of hepatitis B vaccination in patients transplanted for HBV-related cirrhosis 显示文摘 | Angelico M Di Paolo D Trinito MO | 2002 | Hepatology2002，35，1： | 1 |
| 10 | Maintenance of class III trifurcated molars versus implant placement in regenerated extraction sockets: long-term results of 2 cases 显示文摘 | Zafiropoulos GG di Prisco MO Deli G | 2011 | J Oral Implantol2011，37，3： | 1 |
| 11 | Properties of putative cardiac and non-cardiac neurons in the rat stellate ganglion显示文摘 | Mo N Wallis DI Watson A | 1994 | J Auton Nerv Syst1994，47，12： | 1 |
| 12 | Bone Acquisition in Healthy Young Females Is Reciprocally Related to Marrow Adiposity显示文摘 | Natascia Di Iorgi Ashley O. Mo Kate Grimm Tishya A. L. Wren Frederick Dorey Vicente Gilsanz | 2010 | The Journal of Clinical Endocrinology & Metabolism2010，，6： | 1 |
| 13 | Dropping out: Why are students leaving junior high in China’s poor rural areas?显示文摘 | Hongmei Yi Linxiu Zhang Renfu Luo Yaojiang Shi Di Mo Xinxin Chen Carl Brinton Scott Rozelle | 2011 | International Journal of Educational Development2011，，4： | 1 |
| 14 | Failure of a reinforced triple course of hepatitis B vaccination in patients transplanted for HBV-related cirrhosis显示文摘 | Angelico M Di Paolo D Trinito MO | 2002 | Hepatol2002，35，1： | 1 |
| 15 | The use of chest X-rays for surveillance of bacterial pneumonias in children in Latin America 显示文摘 | Lagos R di Fabio JL Mo~nne K | 2013 | Rev Panam Salud Publica2013，13，5： | 1 |
| 16 | Maintenance after a complex orthoperio treatment in a case of generalized aggressive periodontitis : 7 - year result显示文摘 | Zafiropoulos GG di Priseo MO Deli G | 2010 | Int Acad Periodontol2010，12，4： | 1 |
| 17 | Failure of a reinforced triple course of hepatitis B vaccination in patients transplanted for HBV- related cirrhosis显示文摘 | Angelico M Di Paolo D Trinito MO | 2002 | Hepatology2002，35，1： | 1 |
| 18 | Electronic and optical properties of three phase of titanium diopxide: Rutile, anatase, and brookite显示文摘 | Shang - Di Mo Ching W Y | 1995 | Physical Review B1995，51，13： | 1 |
| 19 | Organochlorine pesticides and polychlorinated biphenyl residues in reared and wild dicentrarchus labrax from the Mediterranean Sea ( Sicily, Italy ) 显示文摘 | Lo Turco V Di Bella G Pera La L Come F Macri B Mo Dugo G | 2007 | Environmental Monitoring and Assessment2007，152，： | 1 |
| 20 | Failure of a reinforced triple course of hepatitis B vaccination in patient transplanted for HBVrelated cirrhosis 显示文摘 | Angeloco M di Paolo D Trinito MO | 2002 | Hepatology2002，35，1： | 1 |
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