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您的检索式：作者名="Sluimer J.D."
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| 1 | 记忆门诊的微出血患病率和严重程度研究显示文摘Objective: To determine prevalence and severity of microbleeds (MBs) in a large cohort of patients attending a memory clinic. Methods: The authors consecutively included patients attending their memory clinic between January 2002 and April 2005. They analyzed prevalence and number of MBs according to demographic, diagnostic, and MRI data. Results: The authors included 772 patients (53%men, age 66 ±11). One hundred twenty-seven patients (17%) exhibited at least one MB. The prevalence differed according to diagnostic groups (p < 0.0001): Sixty-five percent of patients with vascular dementia exhibited MBs vs 18%of Alzheimer disease patients, 20%of mild cognitive impairment patients, and 10%of patients with subjective complaints. The presence of MBs was associated with age, white matter hyperintensities, lacunar infarcts, and infarcts. Conclusion: The prevalence of microbleeds (MBs) in a large cohort of patients attending a memory clinic is higher than previously described in community samples and lower than reported in stroke patients. This finding of a relatively high proportion of MBs in Alzheimer disease and mild cognitive impairment provides further evidence for the involvement of vascular factors in neurodegenerative diseases such as Alzheimer disease. | Cordonnier C. Van Der Flier W.M. Sluimer J.D. P. Scheltens 王鹏 | 2006 | 世界核心医学期刊文摘(神经病学分册)2006，2，9： | 8 |
| 2 | 记忆临床病人全脑萎缩率和认知功能损害的纵向MR研究显示文摘目的前瞻胜地研究轻度认知功能障碍(MCI)和阿尔茨海默病(AD)的全脑萎缩率及其与认知功能损害的关系,研究已有基础脑容量与全脑萎缩率,但尚未痴呆的病人发展为痴呆的概率。方法本研究经学术审查委员会批准并取得所有病人书面的知情同意。65例AD病人(女38例,男27例;年龄52~81岁),45例MCI病人(女22例,男23例;年龄56~80岁),27例有主观症状的病人(女12例。男15例;年龄50~87岁),以及10名健康人(女6例,男4例;年龄53-80岁)作为对照纳入研究。2次MR检查时间间隔为(1.8±0.7)a。采用3DT1WI(1.0T,单块采集,168层, | J.D. Sluimer W.M. van der Flier G.B. Karas N.C. Fox P. Scheltens F.Barkhof 郭雪梅(译) 唐光健(校) | 2008 | 国际医学放射学杂志2008，31，5： | 2 |
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