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129篇 您的检索式:作者名="Klunk"
    题名 作者 年代 出处 被引量
1美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病源性轻度认知障碍诊断标准推荐显示文摘美国国立老化研究所(NIA)和阿尔茨海默病协会(ADA)组织了一个工作组,负责阿尔茨海默病(AD)痴呆前症状阶段——即本文所称的AD源性轻度认知障碍(MCI)的诊断标准的制订及完善。该工作组制订了以下两套标准:(1)在缺乏相应条件进行先进影像技术及脑脊液检查时,医务人员适用的核心临床标准;(2)适用于包括临床试验在内的科学研究的研究标准。后者纳入了基于影像技术及脑脊液检查的生物标志物的应用。并根据所出现的生物标志物的性质,将最终MCI诊断的确定性程度分为4个级别。而要使生物标志物有效应用于诊断,并在社区医疗服务中规范使用,尚需做大量的工作。McKhann GM Knopman DS Chertkow H Hyman BT Jack CR Jr Kawas CH Klunk WE Koroshetz WJ Manly JJ Mayeux R Mohs RC Morris JC Rossor MN Schehens P Carrillo MC Thies B Weintraub S Phelps CH 贾建平(译) 陆璐(译) 张逸驰(译) 黄丽黄(译) 礼媛(译) 2012中华神经科杂志2012,45,5:51
2美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病痴呆诊断标准的推荐显示文摘由美国国立老化研究所(NIA)和阿尔茨海默病(AD)协会组织了一个工作组,负责修订1984年版AD痴呆的诊断标准。旨在确保修订后的标准具有足够的灵活性,既可供缺乏神经心理学测验、先进的影像技术和脑脊液检查措施的普通医务人员使用,也可供具备上述措施的科研、临床试验的专业研究者使用。新的标准广泛适用于各种原因的痴呆以及专门针对AD痴呆的标准,保留了1984年版标准中的“很可能的AD痴呆”的总体框架。在过去27年的经验基础上,工作组对临床诊断标准做了一些修改,保留了“可能的AD痴呆”的术语,但对其进行了更有针对性的重新定义。在科研用的“很可能的和可能的AD痴呆”的诊断标准中纳入了生物标志物证据。AD痴呆的核心临床标准仍将是临床实践中诊断的基础,但用生物标志物证据来提高AD痴呆诊断的病理生理学特异性也被人们寄予厚望。要实现AD痴呆的生物标志物诊断,还有许多工作摆在面前。McKhann GM Knopman DS Chertkow H Hyman BT Jack CR Jr Kawas CH Klunk WE Koroshetz WJ Manly J J Mayeux R Mohs RC Morris JC Rossor MN Scheltens P Carrillo MC Thies B Weintraub S Phelps CH 贾建平(译) 陆璐(译) 张逸驰(译) 黄丽(译) 韩阅(译) 2012中华神经科杂志2012,45,5:52
3The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease显示文摘Guy M. McKhann David S. Knopman Howard Chertkow Bradley T. Hyman Clifford R. Jack Claudia H. Kawas William E. Klunk Walter J. Koroshetz Jennifer J. Manly Richard Mayeux Richard C. Mohs John C. Morris Martin N. Rossor Philip Scheltens Maria C. Carrillo Bil 2011Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association2011,,3:2
4Uncharged Thioflavin-T Derivatives Bind to Amyloid-beta Protein With High Affinity and Readily Enter the Brain显示文摘Klunk W E Wang Y Huang G F 2001Life Sci2001,69,13:2
5Development of 123I-Labelled Agents for Amyloid Imaging显示文摘Wang Y Klunk W E Huang G F 2003J Labelled Cpd Radiopharm2003,46,1:2
6Synthesis and Evaluation of a Radioiodinated Benzothiazole Derivative as a Radiologand for in vivo Quantitation of Beta-amyloid Deposits in Aging and Alzheimer's Disease显示文摘Wang Y Klunk W E Huang G F 2001J Labelled Cpd Radiopharm2001,,:2
7Effects of alkyl-substituted gamma-butyrolactones and succinimides on the evoked and spontaneous activity of hippocampal slices in vitro 显示文摘FERRENDELLI J A MCKEON A C Klunk W E 1983Exp Neurol1983,82,3:1
8Imaging brain amy?loid in Alzheimer's disease with Pittsburgh Compound-B 显示文摘Klunk WE Engler H Nordberg A 2004Ann Neurol2004,55,:1
9Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B显示文摘Klunk WE Engler H Nordberg A 0,,03:1
10Imaging brain amyloid in Alzheimer's disease with Pittsburgh compound-B显示文摘Klunk WE Engler H Nordberg A 0,,3:1
11Update on amyloid imaging: from healthy aging to Alzheimer' s disease显示文摘Wolk D A Klunk W 2009Curr Neurol Neurosci Rep2009,9,:1
12Imaging β-amyloid plaques and neurofibrillary tangles in the aging human brain显示文摘Mathis CA Wang Y Klunk WE 2004Curr Pharm Des2004,10,:1
13Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease显示文摘Ikonomovic MD Klunk WE Abrahamson EE 0,,06:1
14Imaging beta-aging human brain显示文摘Mathis C A Wang Y Klunk W E 2004Curr Pharm Des2004,10,13:1
15Binding of the positron emission tomography tracer Pittsburgh Compound-B reflects the amount of amyloid-beta in Alzheimer's disease brain but not in transgenic mouse brain显示文摘Klunk WE Lopresti BJ Ikonomovic MD 2005J Neurosci2005,25,10:1
16Kinetic modeling of amy-loid binding in humans using PET imaging and Pittsburgh Com- pound-B 显示文摘Price JC Klunk WE Lopresti BJ 2005J Cereb Blood Flow Metab2005,25,11:1
17The binding of 2- (4'-methylaminophenyl) benzothiazole to postmortem brain homogenates is dominated by the amyloid component显示文摘Klunk WE Wang Y Huang GF 2003J Neurosci2003,23,6:1
18Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B显示文摘Klunk WE Engler H Nordberg A Wang Y 2004Ann Neurol2004,55,:1
19Kinetic modeling of amyloid binding in humans using pET imaging and Pittsburgh Compound-B显示文摘Price JC Klunk WE Lopresti BJ 2005J Cereb BloodFlow Metab2005,25,:1
20Simplified Quantification of Pittsburgh Compound B amyloid imaging PET studies:A comparative analysis显示文摘Lopresti BJ Klunk WE Mathis CA 2005J Nucl Med2005,46,:1
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