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| 1 | phytoestrogens/insoluble fibers and colonic estrogen receptor β: randomized, double-blind, placebo-controlled study显示文摘AIM:To assess the safety and effect of the supplementation of a patented blend of dietary phytoestrogens and insoluble fibers on estrogen receptor (ER)-β and biological parameters in sporadic colonic adenomas. METHODS:A randomized, double-blind placebo-controlled trial was performed. Patients scheduled to undergo surveillance colonoscopy for previous sporadic colonic adenomas were identified, and 60 eligible patients were randomized to placebo or active dietary intervention (ADI) twice a day, for 60 d before surveillance colonoscopy. ADI was a mixture of 175 mg milk thistle extract, 20 mg secoisolariciresinol and 750 mg oat fiber extract. ER-β and ER-α expression, apoptosis and proliferation (Ki-67 LI) were assessed in colon samples. RESULTS:No adverse event related to ADI was recorded. ADI administration showed a significant increases in ER-β protein (0.822 ± 0.08 vs 0.768 ± 0.10, P = 0.04) and a general trend to an increase in ER-β LI (39.222 ± 2.69vs 37.708 ± 5.31,P = 0.06), ER-β/ER-α LI ratio (6.564 ± 10.04 vs 2.437 ± 1.53, P = 0.06), terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (35.592 ± 14.97 vs 31.541 ± 11.54, P = 0.07) and Ki-67 (53.923 ± 20.91 vs 44.833 ± 10.38, P = 0.07) approximating statistical significance. A significant increase of ER-β protein (0.805 ± 0.13 vs 0.773 ± 0.13,P = 0.04), mRNA (2.278 ± 1.19vs 1.105 ± 1.07, P < 0.02) and LI (47.533 ± 15.47 vs 34.875 ± 16.67,P < 0.05) and a decrease of ER-α protein (0.423 ± 0.06vs 0.532 ± 0.11,P < 0.02) as well as a trend to increase of ER-β/ER-α protein in ADI vs placebo group were observed in patients without polyps (1.734 ± 0.20 vs 1.571 ± 0.42, P = 0.07). CONCLUSION:The role of ER-β on the control of apoptosis, and its amenability to dietary intervention, are supported in our study. | Mariabeatrice Principi Alfredo Di Leo Maria Pricci Maria Principia Scavo Raffaella Guido Sabina Tanzi Domenico Piscitelli Antonio Pisani Enzo Ierardi Maria Cristina Comelli Michele Barone | 2013 | World Journal of Gastroenterology2013，19，27： | 3 |
| 2 | Intestinal microbiota in patients with nonalcoholic fatty liver disease显示文摘 | Marialena Mouzaki Elena M. Comelli Bianca M. Arendt Julia Bonengel Scott K. Fung Sandra E. Fischer Ian D. McGilvray Johane P. Allard | 2013 | Hepatology2013，，1： | 2 |
| 3 | Rhabdomyolysis: historical background, clinical, diagnostic and therapeutic features显示文摘 | Gianfranco Cervellin Ivan Comelli Giuseppe Lippi | 2010 | Clinical Chemistry and Laboratory Medicine2010，，6： | 2 |
| 4 | Optical recognition of motor vehicle license plates显示文摘 | Paolo Comelli Paolo Ferragina Mario Notturno Granieri | 1995 | IEEE Trans Vehicular Technology1995，44，4： | 2 |
| 5 | Antihyperalgesic effect of a Cannabis sativa extract in a rat model of neuropathic pain: mechanisms involved显示文摘 | Comelli F Giagnoni G Bettoni I Colleoni M Costa B | 2008 | Phytother Res2008，22，8： | 1 |
| 6 | Optical recognition of motor vehicle license plates 显示文摘 | COMELLI P FERRAGINA P GRANIERI M N | 1995 | IEEE Transactions on Vehicular Technology1995，44，4： | 1 |
| 7 | Microembolic signals and carotid plaque morphology:a study of 71 patients with moderate or high grade carotid stenosis显示文摘 | Comelli M Vassileva E | 2003 | Aeta Neurol Scand2003，108，： | 1 |
| 8 | Microembolic signals and carotid plaque morphology:a study of 71 patients with moderate or high grade carotid stenosis显示文摘 | Comelli M Vassileva E | 2003 | Acta Neurol Scand2003，108，： | 1 |
| 9 | Opti-cal Recognition of Motor Vehicle License Plates显示文摘 | Paolo Comelli Paolo Ferragina Mario Notturrrno Granieri | 1995 | IEEE Transactions on Vehicular Technology1995，44，4： | 1 |
| 10 | Optical recognition of motor vehicle license plates显示文摘 | COMELLI P FERRAGINA P | | 0，，04： | 1 |
| 11 | Stage financing and role of convertible securities 显示文摘 | Comelli F Yosha O | 2003 | The Review of Economic Studies2003，70，： | 1 |
| 12 | Effect of nerve growth factor on neuronal plasticity of the kitten visual cortex显示文摘 | Carmignoto G Canella R Candeo P Comelli MC Maffei L | 1993 | J Physiol1993，464，： | 1 |
| 13 | Hydrogen production from glycerol on Ni/Al 2 O 3 cata-lyst显示文摘 | Sánchez Esteban A D’Angelo Miguel A Comelli Raúl A | 2010 | International Journal of Hydrogen Energy2010，35，： | 1 |
| 14 | α-Pinene isomerization to Camphene-Effect of Thermal Treat- ment on Sulfated Zireonia 显示文摘 | COMELLI N A PONZI E N PONZI M I | 2006 | Chem Eng J2006，，117： | 1 |
| 15 | Time-resolved fluorescence spectroscopy and imaging of proteinaceous binders used in paintings 显示文摘 | Nevin A Comelli D Valentini G | 2007 | Anal Bioanal Chem2007，388，8： | 1 |
| 16 | Optical recognition of motor vehicle license plates显示文摘 | Paolo Comelli Paolo Ferragina Mario Notturno Granieri | 1995 | IEEE Trans Vehicular Technology1995，44，4： | 1 |
| 17 | Platinum supported WOx-ZrO2 : Effect of calcination temperature and tungsten loading显示文摘 | VAUDAGNA S R CANAVESE S A COMELLI R A | 1998 | Appl Catal A1998，168，1： | 1 |
| 18 | A filamin-, ac tinin-, and telethonin binding protein of the Z-disc of skeletal muscle 显示文摘 | Faulkner G Pallavicini A Comelli A | 2000 | BiolChem2000，275，41： | 1 |
| 19 | Time-resolved fluorescence imaging in biology and medicine显示文摘 | Cubeddu RD Comelli CD Andrea | 2002 | J Phys D2002，35，： | 1 |
| 20 | Stage financing and the role of convertible securities显示文摘 | Comelli F | 2003 | Review of Economic Studies2003，，70： | 1 |
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