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| 1 | Hepatic steatosis in overweight/obese females: New screening method for those at risk显示文摘AIM: To identify which parameters could help to distinguish the 'metabolically benign obesity', which is not accompanied by insulin resistance (IR) and early atherosclerosis.METHODS: Eighty two of 124 overweight/obese females formed the study population, which was divided into two groups (52 and 30 subjects, respectively) with and without IR according to a HO meostatic Metabolic Assessment (HOMA) cut-off of 2, and were studied in a cross-sectional manner. The main outcome measures were waist circumference, serum uric acid, high-density lipoprotein-cholesterol and triglycerides, alanine amino-transferase, blood pressure and the two imaging para-meters, hepatic steatosis and longitudinal diameter of the spleen, which were measured in relation to the presence/absence of IR. RESULTS: A variable grade of visceral obesity was observed in all subjects with the exception of three.Obesity of a severe grade was represented more in the group of IR individuals (P = 0.01). Hepatic steatosis, revealed at ultrasound, was more pronounced in IR than in non-IR subjects (P = 0.005). The two groups also demonstrated a clear difference in longitudinal spleen diameter and blood pressure, with raised and signif icant values in the IR group. Metabolic syndrome was frequent in the IR group, and was not modified when adjusted for menopause (P = 0.001). At linear regression, the β values of waist circumference and body mass index predicting HOMA were 0.295, P = 0.007 and 0.41, P = 0.0001, respectively. Measures of spleen longitudinal diameter were well predicted by body mass index (BMI) values, β = 0.35, P = 0.01, and by HOMA, β = 0.41, P = 0.0001. Blood pressure was predicted by HOMA values, β = 0.39, P = 0.0001). HOMA and hepatic steatosis were highly associated (rho = 0.34, P = 0.002). Interestingly, IR patients were almost twice as likely to have hepatic steatosis as non-IR patients. Among the MS criteria, blood pressure was very accurate in identifying the presence of IR (AUROC for systolic blood pressure 0.66, cut-off 125 mm of Hg, sensibility 64%, specif icity 75%; AUROC for diastolic blood pressure 0.70, cut-off 85 mm of Hg, sensibility 54.5%, specif icity 75%). CONCLUSION: As health care costs are skyrocketing, reliable and mainly inexpensive tools are advisable to better defi ne subjects who really need to lose weight. | Giovanni Tarantino Genoveffa Pizza Annamaria Colao Fabrizio Pasanisi Paolo Conca Patrizia Colicchio Carmine Finelli Franco Contaldo Carolina Di Somma Silvia Savastano | 2009 | World Journal of Gastroenterology2009，15，45： | 4 |
| 2 | 在煽动性的肠疾病的 Fibrogenesis 和纤维变性: 一样的硬币的好、坏的方面?显示文摘 Fibrogenesis in inflammatory bowel diseases is a complex phenomenon aimed at mucosal repair. However, it may provoke intestinal fibrosis with the development of strictures which require surgery. Therefore, fibrogenesis may be considered as a 'two-faced' process when related to chronic intestinal inflammation. Many types of cells may be converted into the fibrogenic phenotype at different levels of the intestinal wall. A complex interaction of cytokines, adhesion molecules and growth factors is involved in the process. We report an overview of recent advances in molecular mechanisms of stricturizing Crohn’s disease(CD) including the potential role of trasforming growth factor beta, protein kinase C and Ras, Raf and ERK proteins. Fibrotic growth factors such as vascular endothelial growth factor and platelet-derived growth factor, as well as the Endothelial-to-Mesenchymal Transition induced by transforming growth factor-β, are considered. Finally, our experience, focused on tumor necrosis factor α(the main cytokine of inflammatory bowel diseases) and the link between syndecan 1(a heparan sulphate adhesion molecule) and basic fibroblast growth factor(a strong stimulator of collagen synthesis) is described. We hypothesize a possible molecular pattern for mucosal healing as well as how its deregulation could be involved in fibrotic complications of CD. A final clinical point is the importance of performing an accurate evaluation of the presence of fibrotic strictures before starting anti-tumor necrosis α treatment, which could worsen the lesions. | Mariabeatrice Principi Floriana Giorgio Giuseppe Losurdo Viviana Neve Antonella Contaldo Alfredo Di Leo Enzo Ierardi | 2013 | World Journal of Gastrointestinal Pathophysiology2013，4，4： | 2 |
| 3 | Obesity epidemics: simple or simplicistic answers? 显示文摘 | Contaldo F Pasanisi F | 2005 | Clin Nutr2005，24，1： | 1 |
| 4 | Nutritional screening and early treatment of malnutrition in cancer patients 显示文摘 | Santarpia L Contaldo F Pasanisi F | 2011 | J Cachexia Sarcopenia Muscle2011，2，： | 1 |
| 5 | Link of nonhemodynamic factors to hemodyoamic determinants of left ventricular hypertrophy 显示文摘 | De Simone G Pesamsi F Contaldo F | 2001 | Hypertension2001，38，1： | 1 |
| 6 | Statins decrease the risk of acute pancreatitis after endoscopic ultrasound fine-needle aspiration of pancreatic cysts显示文摘Background: Basic and clinical studies suggest that statins may prevent and even ameliorate acute pan- creatitis. The present study was to evaluate whether statin decreases the risk of acute pancreatitis in patients undergoing endoscopic ultrasound-guided ne-needle aspiration of pancreatic cysts. Methods: Out of 456 patients with pancreatic cysts referred to our center between 2006 and 2018, 365 were nally included in analyses: 86 were treated with statins and 279 were not at the time of endo- scopic ultrasound ne-needle aspiration. We compared the acute pancreatitis incidence between the two groups, and we also compared other complications such as bleeding and infections. Results: Median age was 64 years [interquartile range (IQR) 62 69] and median cyst size was 24mm (IQR, 21 29). The most frequent histology was intraductal papillary mucinous neoplasm (45.3% and 42.3% in the two groups, respectively;P =0.98). All 13 patients experiencing post-endoscopic ultrasound acute pancreatitis were from the control group (4.7%), of which 3 were classi ed as severe pancreatitis. None of statin users developed post-procedural acute pancreatitis (odds ratio: 0.15;95% con dence interval: 0.03 0.98;P=0.03). No difference was registered with regard to severe pancreatitis and other complications. Conclusions: Statins exert a bene cial role in preventing acute pancreatitis in patients with pancreatic cysts undergoing endoscopic ultrasound-guided ne-needle aspiration. If con rmed in prospective trials, our ndings may pave the way to an extensive use of statins as prophylactic agents in pancreatic inter- ventional endoscopy. | Antonio Facciorusso Vincenzo Rosario Buccino Valentina Del Prete Matteo Antonino Antonella Contaldo Nicola Muscatiello | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，1： | 1 |
| 7 | Factors affecting the quality of bowel preparation for colonoscopy in hard-to-prepare patients:Evidence from the literature显示文摘Adequate bowel cleansing is critical for a high-quality colonoscopy because it affects diagnostic accuracy and adenoma detection.Nevertheless,almost a quarter of procedures are still carried out with suboptimal preparation,resulting in longer procedure times,higher risk of complications,and higher likelihood of missing lesions.Current guidelines recommend high-volume or low-volume polyethylene glycol(PEG)/non-PEG-based split-dose regimens.In patients who have had insufficient bowel cleansing,the colonoscopy should be repeated the same day or the next day with additional bowel cleansing as a salvage option.A strategy that includes a prolonged low-fiber diet,a split preparation regimen,and a colonoscopy within 5 h of the end of preparation may increase cleansing success rates in the elderly.Furthermore,even though no specific product is specifically recommended in the other cases for difficult-to-prepare patients,clinical evidence suggests that 1-L PEG plus ascorbic acid preparation are associated with higher cleansing success in hospitalized and inflammatory bowel disease patients.Patients with severe renal insufficiency(creatinine clearance<30 mL/min)should be prepared with isotonic high volume PEG solutions.Few data on cirrhotic patients are currently available,and no trials have been conducted in this population.An accurate characterization of procedural and patient variables may lead to a more personalized approach to bowel preparation,especially in patients undergoing resection of left colon lesions,where intestinal preparation has a poor outcome.The purpose of this review was to summarize the evidence on the risk factors influencing the quality of bowel cleansing in difficult-to-prepare patients,as well as strategies to improve colonoscopy preparation in these patients. | Endrit Shahini Emanuele Sinagra Alessandro Vitello Rocco Ranaldo Antonella Contaldo Antonio Facciorusso Marcello Maida | 2023 | World Journal of Gastroenterology2023，29，11： | 1 |
| 8 | Link of nonhemodynamic factors to hemodynamic determinants of left ventricular hypertrophy显示文摘 | De Simone G Pasanisi F Contaldo F | 2001 | Hypertension2001，38，1： | 1 |
| 9 | Prevention of reperfusion injury and microcirculation failure in macrosteatotic mouse liver by n -3 fatty acids显示文摘 | EL - BADRY AM MORITZ W CONTALDO C | 2007 | Hepatology2007，45，4： | 1 |
| 10 | Hemoglobin vesicles reduce hypoxia-related inflammation in critically ischemic hamster flap tissue显示文摘 | Plock JA Tromp AE Contaldo C | 2007 | Crit Care Med2007，35，3： | 1 |
| 11 | Nutritional screening and early treatment of malnutrition in cancer patients显示文摘 | Santarpia L Contaldo F Pasanisi F | 2011 | J Cach Sarcop Muscl2011，2，1： | 1 |
| 12 | link of nonhemo-dynamic factors to hemodynamic determinants of left ventricular hypertrophy显示文摘 | DE SIMONE G PASANISI F CONTALDO F | 2001 | Hypertension2001，38，： | 1 |
| 13 | Prevention of reperfusion injury and microcireulatory failure in macrosteatotic mouse liver by omega-3 fatty acids 显示文摘 | EI-Badry AM Moritz W Contaldo C | 2007 | Hepatology2007，45，4： | 1 |
| 14 | Link of nonhemodynamic fac- tors to hemodynamic determinants of left ventricular hypertrophy 显示文摘 | de Simone G Pasanisi F Contaldo F | 2001 | Hypertension2001，38，1： | 1 |
| 15 | Improved skin flap survival after local heat preconditioning in pigs显示文摘 | Harder Y Contaldo C Klenk J | 2004 | J Surg Res2004，119，1： | 1 |
| 16 | The influence of local and systemic preconditioning on oxygenation,metabolism and surviv-al in critically ischaemic skin flaps in pigs显示文摘 | Contaldo C Harder Y Plock J | | 0，，11： | 1 |
| 17 | Prevention of reperfusion injury and microcirculatory failure in macrosteatotic mouse liver by omega-3fatty acids显示文摘 | El-Badry AM Moritz W Contaldo C | 2007 | Hepatology2007，45，4： | 1 |
| 18 | Preconditioning with monophosphoryl lipid A improves survival of critically ischemic tissue 显示文摘 | HARDER Y CONTALDO C KLENK J | 2005 | Anesth Analg2005，100，： | 1 |
| 19 | Expression levels of insulin receptor substrate-1 modulate the osteoblastic differentiation of mesenchymal stem cells and osteosarcoma cells 显示文摘 | Contaldo C Myers TJ Zucchini C | 2014 | Growth Factors2014，32，1： | 1 |
| 20 | Butyrylcholinesterase as a prognostic marker: a review of the literature 显示文摘 | Santarpia L Grandone I Contaldo F | 2013 | J Cachexia Sarcopenia Muscle2013，4，1： | 1 |
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