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| 1 | Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial显示文摘 | Axel Grothey Eric Van Cutsem Alberto Sobrero Salvatore Siena Alfredo Falcone Marc Ychou Yves Humblet Olivier Bouché Laurent Mineur Carlo Barone Antoine Adenis Josep Tabernero Takayuki Yoshino Heinz-Josef Lenz Richard M Goldberg Daniel J Sargent Frank Ciho | 2012 | The Lancet2012，，： | 10 |
| 2 | ERCP for the treatment of bile leak after partial hepatectomy and fenestration for symptomatic polycystic liver disease显示文摘AIM: To describe endoscopic treatment of bile leaks in these patients and to identify risk factors in these patients which can predict the development of bile leaks. METHODS: Retrospective case-control study examining consecutive patients who underwent partial hepatectomy for polycystic liver disease (PLD) and developed a postoperative bile leak managed endoscopically over a ten year period. Each case was matched with two controls with PLD who did not develop a postoperative bile leak. RESULTS: Ten cases underwent partial hepatectomy with fenestration for symptoms including abdominal distention, pain and nausea. Endoscopic retrograde cholangiopancreatography (ERCP) showed anatomic abnormalities in 1 case. A biliary sphincterotomy was performed in 4 cases. A plastic biliary stent was placed with the proximal end at the site of the leak in 9 cases; in 1 case two stents were placed. The overall success rate of ERCP to manage the leak was 90%. There were no significant differences in age, gender, comorbidities, duration of symptoms, history of previous surgery or type of surgery performed between cases and controls. CONCLUSION: ERCP with stent placement is safe and effective for management of post-hepatectomy bile leak in patients with PLD. | Nayantara Coelho-Prabhu David M Nagorney Todd H Baron | 2012 | World Journal of Gastroenterology2012，18，28： | 6 |
| 3 | 序列地震图:核幔边界区域的散射全景图显示文摘了解核幔边界区域的各向异性对于了解俯冲板块的命运、热点火山成因和原始地球化学储集层的性质均具有重要意义。传统上,地球物理学家通过对地震图的人工解读,从高信噪比的信号中获取核幔边界区域的结构信息。但是,传统的方法在采样欠佳区域中的实用性受到限制,并且没有利用跨越不同路径的波形数据集的全部统计能力。 | 夏群科(编译) Kim D Lekic V Ménard B Baron D Taghizadeh-Pop M | 2020 | 矿物岩石地球化学通报2020，39，4： | 3 |
| 4 | 炎症反应与药物治疗在脑动脉瘤治疗中的作用(英文)显示文摘Intracranial aneurysms remain important clinical concern. There is relatively low risk of rupture of symptomless aneurysms incidentally found in MRA or CTA performed due to other indications. Not all of the intracranial aneurysms should or can be treated with neurosurgery intervention or endovascular embolization. Clinical strategy for small, symptomless, unruptured aneurysms is still questionable. Mechanisms underlying aneurysms formation,progression and rupture are poorly understood. Inflammation is one of the factors suspected to participate in these processes. Therefore the aim of this manuscript is to present current state of knowledge about the role of inflammation in the formation and progression of intracranial aneurysms and in their rupture process. Current knowledge about possible pharmacological treatment of intracranial aneurysms will also be presented. Macrophages infiltration seems to participate in the formation of intracranial aneurysms. Inhibition of signals sent by macrophages may prevent the aneurysms formation. Inflammation present in the wall of the aneurysm seems to be also related to the aneurysm's rupture risk. However it does not seem to be the only cause of the degeneration,but it can be a possible target of drug therapy. Some preliminary studies in humans indicate the potential role of aspirin as a factor that decrease the level of inflammation and lower the risk of rupture of intracranial aneurysms. However further research including a greater number of subjects and a prospective randomized design are necessary to assess the role of aspirin in preventing strategy for small,symptomless,unruptured intracranial aneurysms. | Gruszka W Zbroszczyk M Komenda J Gruszczyńska K Baron J | 2018 | 中华神经外科疾病研究杂志2018，17，5： | 3 |
| 5 | Survival after inflammatory bowel disease-associated colorectal cancer in the Colon Cancer Family Registry显示文摘AIM: To investigate the survival of individuals with colorectal cancer (CRC) with inflammatory bowel disease (IBD-associated CRC) compared to that of individuals without IBD diagnosed with CRC. METHODS: Epidemiologic, clinical, and follow-up data were obtained from the Colon Cancer Family Registry (Colon CFR). IBD-associated cases were identified from self-report of physician diagnosis. For a subset of participants, medical records were examined to confirm self-report of IBD. Cox proportional hazards regression was applied to estimate adjusted hazard ratios (aHR) and 95%CI of mortality, comparing IBD-associated to non-IBD-associated CRC, adjusted for age at CRC diagnosis, sex, Colon CFR phase, and number of prior endoscopies. Following imputation to complete CRC stage information, adjustment for CRC stage was examined. RESULTS: A total of 7202 CRC cases, including 250 cases of IBD-associated CRC, were analyzed. Over a twelve year follow-up period following CRC diagnosis, 2013 and 74 deaths occurred among non-IBD associated CRC and IBD-associated CRC patients, respectively. The difference in survival between IBD-associated and non-IBD CRC cases was not statistically significant (aHR = 1.08; 95%CI: 0.85-1.36). However, the assumption of proportional hazards necessary for valid inference from Cox regression was not met over the entire follow-up period, and we therefore limited analyses to within five years after CRC diagnosis when the assumption of proportional hazards was met. Over this period, there was evidence of worse prognosis for IBD-associated CRC (aHR = 1.36; 95%CI: 1.05-1.76). Results were similar when adjusted for CRC stage, or restricted to IBD confirmed in medical records. CONCLUSION: These results support the hypothesis that IBD-associated CRC has a worse prognosis than non-IBD-associated CRC. | Scott V Adams Dennis J Ahnen John A Baron Peter T Campbell Steven Gallinger William M Grady Loic LeMarchand Noralane M Lindor John D Potter Polly A Newcomb | 2013 | World Journal of Gastroenterology2013，19，21： | 2 |
| 6 | Proteolytic cascade enzymes increase in focal cerebral ischemia in rat显示文摘 | Rosenberg GA Navratil M Barone F | 1996 | Journal of Cerebral Blood Flow and Metabolism1996，16，： | 2 |
| 7 | Docetaxel and oxaliplatin combination in second-line treatment of patients with advanced gastric cancer显示文摘 | Barone C Basso M Schinzari G | 2007 | Gastric Cancer2007，10，2： | 1 |
| 8 | Medical complications of surgical treatment of adult spinal deformity and how to avoid them显示文摘 | Baron E M Albert T J | 2006 | Spine2006，31，19： | 1 |
| 9 | Inhibition of IFN-gamma-induced STAT1 tyrosine phosphorylation by human CMV is mediated by SHP2 显示文摘 | Baron M Davignon J L | 2008 | Immunol2008，181，8： | 1 |
| 10 | A new definition of cavities for the computation of solvation free energies by the polarizable continuum model显示文摘 | Barone V Cossi M Tomasi J | 1997 | J Chem Phys1997，107，8： | 1 |
| 11 | Exploring the sequences pace for tetracycline dependent transcriptional activators: novel mutations yield expanded range and sensitivity 显示文摘 | Urlinger S Baron U Thellmann M | 2000 | Proc NatlAead Sci USA2000，97，14： | 1 |
| 12 | Comparison of the immu-nogenicity and safety of Cervarix and Gardasil human papilloma-virus(HPV)cervical cancer vaccines in health women aged 18-45 years显示文摘 | Einstein MH Baron M Levin MJ | 2009 | Hum Vaccin2009，5，10： | 1 |
| 13 | Preoperative diagnosis of renal angiomyolipoma显示文摘 | Baron M Leiter E Brendler H | 1977 | J Urol1977，117，6： | 1 |
| 14 | The moderator-mediator vairable distinction in social psychological research:conceptual,strategic,and statistical considerations显示文摘 | BARON R M KENNY D A | 1986 | J Pers Soc Psychol1986，51，6： | 1 |
| 15 | The moderator - mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations 显示文摘 | Baron R M Kenny D A | 1986 | Journal of Personality and Social Psychology1986，51，： | 1 |
| 16 | The moderator-mediator variable distinction in social psychological research: Concep- tual, strategic, and statistical considerations 显示文摘 | Baron R M Kenny D A | 1986 | Journal of Personality and Social Psychology1986，51，6： | 1 |
| 17 | Pancreaticobiliary and duode- nal perforations after periampullary endoscopic proce- dures : diagnosis and management显示文摘 | Fatima J Baron T H Topazian M D Houghton S G Iqbal C W Ott B J | 2007 | Arch Surg2007，142，： | 1 |
| 18 | Effects of arsenic on cell metabolism and cell proliferation: Cytogenetic and biochemical studies显示文摘 | Petres J Baron D Hagedorn M | 1977 | Environmental Health Perspectives1977，19，： | 1 |
| 19 | Dopamine-,L-DOPA-,adrenaline-,and noradrenaline-induced growth of Au nanoparticles:Assays for the detection of neurotransmitters and of tyrosinase activity显示文摘 | Baron R Zayats M Willner I | 2005 | Anal Chem2005，77，： | 1 |
| 20 | Advances in imm,- nology and rheumatoid arlhrilis pathogenesis显示文摘 | Valesini G Barone F Bompane D et M | 2004 | Reumatismo2004，56，： | 1 |
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