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| 1 | MR扩散加权成像诊断食管癌的效能显示文摘本研究目的是评价DWI对检出食管癌及评估淋巴结的价值,并与组织病理学对照。对连续24例食管癌病人前瞻性进行背景信号抑制的全身扩散加权成像(DWIBS)。将DWIBS影像与T2WI影像融合,由3名有资质的放射科医师独立盲法分析,内容包括原发肿瘤的检出能力及淋巴结状况,并测量原发肿瘤和淋巴结的表观扩散系数(ADC)。原发肿瘤的平均检出率为49.4%,以病人为目标的淋巴结转移检出的敏感度和特异度分别为77.8%和55.6%, | A. Sakurada T. Takahara T.C. Kwee T. Yamashita S. Nasu T. Horie 王萍(译) 刘筠(校) | 2009 | 国际医学放射学杂志2009，32，4： | 40 |
| 2 | Modern imaging techniques for preoperative detection of distant metastases in gastric cancer显示文摘A substantial portion of patients with newly diagnosed gastric cancer has distant metastases(M1 disease).These patients have a very poor prognosis and it is generally accepted that they should be treated with noncurative intent. Because it dramatically changes prognosis and treatment plans, it is very important to diagnose distant metastases. In this article, the definition, pathways, incidence and sites of distant metastases in gastric cancer are described.Subsequently, the current performance of imaging in detecting distant metastases in newly diagnosed gastric cancer is outlined and future prospects are discussed. | Robert M Kwee Thomas C Kwee | 2015 | World Journal of Gastroenterology2015，21，37： | 12 |
| 3 | Role of imaging in predicting response to neoadjuvant chemotherapy in gastric cancer显示文摘With the proven overall benefit of neoadjuvant chemotherapy in patients with locally advanced gastric cancer,there has come a need to discriminate responders from non-responders.In this article,the current role of anatomical and molecular imaging in the prediction of response to neoadjuvant therapy in gastric cancer is outlined and future prospects are discussed. | Robert Michael Kwee Thomas Christian Kwee | 2014 | World Journal of Gastroenterology2014，20，7： | 10 |
| 4 | Scalable synthesis of nanoporous silicon microparticles for highly cyclable lithium-ion batteries显示文摘Nanoporous silicon is a promising anode material for high energy density batteries due to its high cycling stability and high tap density compared to other nanostructured anode materials.However,the high cost of synthesis and low yield of nanoporous silicon limit its practical application.Here,we develop a scalable,low-cost top-down process of controlled oxidation of Mg2Si in the air,followed by HCl removal of MgO to generate nanoporous silicon without the use of HF.By controlling the synthesis conditions,the oxygen content,grain size and yield of the porous silicon are simultaneously optimized from commercial standpoints.In situ environmental transmission electron microscopy reveals the reaction mechanism;the Mg2Si microparticle reacts with O2 to form MgO and Si,while preventing SiO2 formation.Owing to the low oxygen content and microscale secondary structure,the nanoporous silicon delivers a higher initial reversible capacity and initial Coulombic efficiency compared to commercial Si nanoparticles(3,033 mAh/g vs.2,418 mAh/g,84.3%vs.73.1%).Synthesis is highly scalable,and a yield of 90.4%is achieved for the porous Si nanostructure with the capability to make an excess of 10 g per batch.Our synthetic nanoporous silicon is promising for practical applications in next generation lithium-ion batteries. | Jiangyan Wang William Huang Yong Seok Kim You Kyeong Jeong Sang Cheol Kim Jeffrey Heo Hiang Kwee Lee Bofei Liu Jaehou Nah Yi Cui | 2020 | Nano Research2020，13，6： | 9 |
| 5 | Imaging in assessing lymph node status in gastric cancer显示文摘 | Robert Michael Kwee Thomas Christian Kwee | 2009 | Gastric Cancer2009，，1： | 3 |
| 6 | Predicting lymph node status in early gastric cancer显示文摘 | Robert Michael Kwee Thomas Christian Kwee | 2008 | Gastric Cancer2008，，3： | 2 |
| 7 | Dynamics of phytoplankton and picoplankton over a tidal cycle in a subtropical lagoon显示文摘The influences of a tidal cycle on the distribution of autotrophic plankton were investigated in a hyper-eutrophic lagoon designated as a scenic area.Results showed that the highest concentrations of picoplankton and phytoplankton were found in the middle and inner part of the lagoon,irrespective of the tides.The MDS result also revealed that phytoplankton communities,dominated by Ceratium furca,were similar among stations in the inner bay during both flood tides and ebb tides.The time series sampling results at the inlet-outlet channel revealed that almost the same amounts of phytoplankton and picoplankton were carried through the channel during flood and ebb tides,with no trend in nutrient fluctuations except for phosphate which had a net loss from the lagoon.The results showed that tidal cycles do not effectively flush away phytoplankton and picoplankton from the lagoon,and the blooming of phytoand picoplankton is inevitable should the situation stay the same.Steps are needed to alleviate the eutrophication condition instead of depending on the natural process such as tidal cycle. | TEW Kwee Siong MENG Pei-Jie LEE Hung-Jen YE Yi-Xiu KUO Jimmy FANG Lee-Shing CHOU Wei-Rung | 2010 | Chinese Science Bulletin2010，55，23： | 2 |
| 8 | Metabolic positron emission tomography imaging of cancer:Pairing lipid metabolism with glycolysis显示文摘The limitations of fluorine-18 fluorodeoxy-D-glucose(FDG)in detecting some cancers has prompted a longstandin search for other positron emission tomography(PET tracers to complement the imaging of glycolysis i oncology, with much attention paid to lipogenesis base on observations that the production of various lipid an lipid-containing compounds is increased in most cancers Radiolabeled analogs of choline and acetate have now been used as oncologic PET probes for over a decade showing convincingly improved detection sensitivit over FDG for certain cancers. However, neither cholin nor acetate have been thoroughly validated as lipogeni biomarkers, and while acetyl-Co A produced from acetat is used in de-novo lipogenesis to synthesize fatty acids acetate is also consumed by various other syntheti and metabolic pathways, with recent experimenta observations challenging the assumption that lipogenesi is its predominant role in all cancers. Since tumor detected by acetate PET are also frequently detected b choline PET, imaging of choline metabolism might serv as an alternative albeit indirect marker of lipogenesis particularly if the fatty acids produced in cancer cell are mainly destined for membrane synthesis throug incorporation into phosphatidylcholines. Aerobic glycolysi may or may not coincide with changes in lipid metabolism resulting in combinatorial metabolic phenotypes that ma have different prognostic or therapeutic implications Consequently, PET imaging using dual metabolic tracers in addition to being diagnostically superior to imagin with individual tracers, could eventually play a greate role in supporting precision medicine, as efforts t develop small-molecule metabolic pathway inhibitors ar coming to fruition. To prepare for this advent, clinical an translational studies of metabolic PET tracers must g beyond simply estimating tracer diagnostic utility, and aim to uncover potential therapeutic avenues associated wit these metabolic alterations. | Sandi A Kwee John Lim | 2016 | World Journal of Radiology2016，8，11： | 2 |
| 9 | Aging women with polycystic ovary syndrome who achieve regular menstrual cycles have a smaller follicle cohort than those who continue to have irregular cycles显示文摘 | Elting MW Kwee J Korsen TJ | 2003 | Fertil Steril2003，79，5： | 1 |
| 10 | Ultra-high-b-valuediffusion-weighted MR imaging for the detection of prostatecancer: evaluation in 201 cases with histopathologicalcorrelation显示文摘 | Katahira K Takahara T Kwee TC | 2011 | Eur Radiol2011，211，： | 1 |
| 11 | Protein aggregates seem to playa key role among the parameters influencing the antigenicity of inter-feron alpha (IFN-a ) in normal and transgenic mice 显示文摘 | Braun A Kwee L Labow MA | 1997 | PharmRes1997，14，10： | 1 |
| 12 | The influence of top management team's corporate governance orientation on strategic renewal trajectories 显示文摘 | Kwee Z Van den Bosch F A J Volberda H W | 2011 | Journal of Management Studies2011，48，5： | 1 |
| 13 | FDG PET/CT in carcinoma of unknownprimary显示文摘 | Kwee T C Basu S Cheng G | 2010 | Eur J Nucl Med Mol Imaging2010，37，3： | 1 |
| 14 | Comparison of apparent diffusion coefficients and distributed diffusion coefficients in high-grade gliomas显示文摘 | Kwee TC Galba CJ Tsien C | 2010 | J Magn Reson Imaging2010，31，3： | 1 |
| 15 | Emotion recognition and acoustic analysis from speech signal显示文摘 | Chang Hyun Park Kwee Bo Sim | 2003 | Proceedings of the International Joint Conference on Neural Networks2003，4，： | 1 |
| 16 | Comparison of endocrine tests with respect to their predictive value on the outcome of ovarian hyperstimulation in IVF treatment:results of a prospective randomized study显示文摘 | Kwee J Elting MW Schats R | 2003 | Hum Reprod2003，18，7： | 1 |
| 17 | Prediction of tumor response to neoadjuvant therapy in patients with esophageal cancer with use of lSF FDG PET: a sys- tematic review显示文摘 | Kwee RM | 2010 | Radiology2010，254，： | 1 |
| 18 | Ovarian volume and antral follicle count for the prediction of low and hyper responders with in vitro fertilization显示文摘 | Kwee J Elting ME Schats R | | 0，，： | 1 |
| 19 | Whole-body diffusion-weight- ed magnetic resonance imaging 显示文摘 | Kwee TC Takahara T Ochiai R | 2009 | Eur J Radiol2009，70，3： | 1 |
| 20 | A systematic review of testspredicting ovarian reserve and IVF outcome显示文摘 | Broekmans F Kwee J Hendriks D | 2006 | Human Reprod Update2006，12，6： | 1 |
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