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| 1 | Adult-to-adult living-donor liver transplantation: The experience of the Université catholique de Louvain显示文摘Background: Liver transplantation is the treatment for end-stage liver diseases and well-selected malignancies. The allograft shortage may be alleviated with living donation. The initial UCLouvain experience of adult living-donor liver transplantation(LDLT) is presented. Methods: A retrospective analysis of 64 adult-to-adult LDLTs performed at our institution between 1998 and 2016 was conducted. The median age of 29(45.3%) females and 35(54.7%) males was 50.2 years(interquartile range, IQR 32.9–57.5). Twenty-two(34.4%) recipients had no portal hypertension. Three(4.7%) patients had a benign and 33(51.6%) a malignant tumor [19(29.7%) hepatocellular cancer, 11(17.2%) secondary cancer and one(1.6%) each hemangioendothelioma, hepatoblastoma and embryonal liver sarcoma]. Median donor and recipient follow-ups were 93 months(IQR 41–159) and 39 months(22–91), respectively. Results: Right and left hemi-livers were implanted in 39(60.9%) and 25(39.1%) cases, respectively. Median weights of right-and left-liver were 810 g(IQR 730–940) and 454 g(IQR 394–534), respectively. Graft-to-recipient weight ratios(GRWRs) were 1.17%(right, IQR 0.98%-1.4%) and 0.77%(left, 0.59%-0.95%). One-and five-year patient survivals were 85% and 71%(right) vs. 84% and 58%(left), respectively. Oneand five-year graft survivals were 74% and 61%(right) vs. 76% and 53%(left), respectively. The patient and graft survival of right and left grafts and of very small( < 0.6%), small(0.6%–0.79%) and large( ≥0.8%) GRWR were similar. Survival of very small grafts was 86% and 86% at 3-and 12-month. No donor died while five(7.8%) developed a Clavien–Dindo complication IIIa, IIIb or IV. Recipient morbidity consisted mainly of biliary and vascular complications; three(4.7%) recipients developed a small-for-size syndrome according to the Kyushu criteria. Conclusions: Adult-to-adult LDLT is a demanding procedure that widens therapeutic possibilities of many hepatobiliary diseases. The donor procedure can be done safely with low morbidity. The recipient operation carries a major morbidity indicating an important learning curve. Shifting the risk from the donor to the recipient, by moving from the larger right-liver to the smaller left-liver grafts, should be further explored as this policy makes donor hepatectomy safer and may stimulate the development of transplant oncology. | Samuele Iesari Milton Eduardo Inostroza Nú?ez Juan Manuel Rico Juri Olga Ciccarelli Eliano Bonaccorsi-Riani Laurent Coubeau Pierre-Fran?ois Laterre Pierre Goffette Chantal De Reyck Beno?t Lengelé Pierre Gianello Jan Lerut | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，2： | 5 |
| 2 | Dual-color deep-tissue three-photon microscopy with a multiband infrared laser显示文摘Multiphoton microscopy combined with genetically encoded fluorescent indicators is a central tool in biology.Threephoton(3P)microscopy with excitation in the short-wavelength infrared(SWIR)water transparency bands at 1.3 and 1.7μm opens up new opportunities for deep-tissue imaging.However,novel strategies are needed to enable in-depth multicolor fluorescence imaging and fully develop such an imaging approach.Here,we report on a novel multiband SWIR source that simultaneously emits ultrashort pulses at 1.3 and 1.7μm that has characteristics optimized for 3P microscopy:sub-70 fs duration,1.25 MHz repetition rate,and μJ-range pulse energy.In turn,we achieve simultaneous 3P excitation of green fluorescent protein(GFP)and red fluorescent proteins(mRFP,mCherry,tdTomato)along with third-harmonic generation.We demonstrate in-depth dual-color 3P imaging in a fixed mouse brain,chick embryo spinal cord,and live adult zebrafish brain,with an improved signal-to-background ratio compared to multicolor twophoton imaging.This development opens the way towards multiparametric imaging deep within scattering tissues. | Khmaies Guesmi Lamiae Abdeladim Samuel Tozer Pierre Mahou Takuma Kumamoto Karolis Jurkus Philippe Rigaud Karine Loulier Nicolas Dray Patrick Georges Marc Hanna Jean Livet Willy Supatto Emmanuel Beaurepaire Frédéric Druon | 2018 | Light(Science & Applications)2018，7，1： | 3 |
| 3 | A new approach for routing and wavelength assignment for permanent and reliable wavelength paths in wide all optical WDM networks 显示文摘 | Zyanel Abdellah Pierre Samuel Guennoun Zouhair | 2008 | Photonic Network Communications2008，15，1： | 1 |
| 4 | Evaluating the Performance of Fast Handover for Hierarchical MIPv6 in Cellular Networks显示文摘 | Li Jun ZHANG Samuel PIERRE | 2008 | Journal of Networks2008，3，5： | 1 |
| 5 | QoSNET: An integrated QoS network for routing protocols in large scale wireless sensor networks 显示文摘 | Houngbadji Therence Pierre Samuel | 2010 | Computer Communications2010，33，11： | 1 |
| 6 | Aortic stiffness is reduced beyond blood pressure lowering by short-term and long-term antihypertensive treatment: a meta-analysis of individual data in 294 patients显示文摘 | Kim-Thanh Ong Samuel Delerme Bruno Pannier Michel E Safar Athanase Benetos Stéphane Laurent Pierre Boutouyrie | 2011 | Journal of Hypertension2011，，6： | 1 |
| 7 | Towards a modular methodology for designing software in telecommunication network planning 显示文摘 | Samuel Pierre | 1999 | Advances in Engineering Software1999，30，1： | 1 |
| 8 | Ant-based routing for wireless multimedia sensor networks using multiple QoS me- trics显示文摘 | Cobo Luis Quintero Alejandro Pierre Samuel | 2010 | Computer Networks2010，54，17： | 1 |
| 9 | Meso-Rex bypass for the management of extrahepatic portal vein obstruction in adults(with video)显示文摘Background:Extrahepatic portal vein obstruction(EHPVO)results in severe portal hypertension(PHT)leading to severely compromised quality of life.Often,pharmacological and endoscopic management is unable to solve this problem.Restoring hepatic portal flow using meso-Rex bypass(MRB)may solve it.This procedure,uncommon in adult patients,is considered the treatment of choice for EHPVO in children.Methods:From 1997 to 2018,8 male and 6 female adults,with a median age of 51 years(range 22-66)underwent MRB procedure for EHPVO at the University Hospitals Saint-Luc in Brussels,Belgium.Symp-toms of PHT were life altering in all but one patient and consisted of repetitive gastro-intestinal bleedings,sepsis due to portal biliopathy,and/or severe abdominal discomfort.The surgical technique consisted in interposition of a free venous graft or of a prosthetic graft between the superior mesenteric vein and the Rex recess of the left portal vein.Results:Median operative time was 500 min(range 300-730).Median follow-up duration was 22 months(range 2-169).One patient died due to hemorrhagic shock following percutaneous transluminal interven-tion for early graft thrombosis.Major morbidity,defined as Clavien-Dindo score≥III,was 35.7%(5/14).Shunt patency at last follow-up was 64.3%(9/14):85.7%(6/7)of pure venous grafts and only 42.9%(3/7)of prosthetic graft.Symptom relief was achieved in 85.7%(12/14)who became asymptomatic after MRB.Conclusions:Adult EHPVO represents a difficult clinical condition that leads to severely compromised quality of life and possible life-threatening complications.In such patients,MRB represents the only and last resort to restore physiological portal vein flow.Although successful in a majority of patients,this procedure is associated with major morbidity and mortality and should be done in tertiary centers expe-rienced with vascular liver surgery to get the best results. | Martin Brichard Samuele Iesari Jan Lerut Raymond Reding Pierre Goffette Laurent Coubeau | 2022 | Hepatobiliary & Pancreatic Diseases International2022，21，1： | 1 |
| 10 | The use of inductively coupled plasma mass spectrometry (ICP-MS) for the determination of toxic and essential elements in different types of food samples显示文摘 | Elene P. Nardi Fábio S. Evangelista Luciano Tormen Tatiana D. Saint′Pierre Adilson J. Curtius Samuel S. de Souza Fernando Barbosa | 2008 | Food Chemistry2008，，3： | 1 |
| 11 | On the planning of wireless sensor networks: energy-efficient clustering under the joint routing and coverage constraint显示文摘 | Ali Chamam Samuel Pierre | 2009 | IEEE Transctions on Mobile Computing2009，8，8： | 1 |
| 12 | Mobile computing and ubiquitous networking:concept,techonolgies and challenges显示文摘 | Samuel Pierre | 2001 | Telematics and Informatics2001，18，： | 1 |
| 13 | A Distributed Energy-Effi- cient Clustering Protocol for Wireless Sensor Networks 显示文摘 | ALI CHAMAM SAMUEL PIERRE | 2010 | Com- puters and Electrical Engineering2010，36，： | 1 |
| 14 | An isoflavan-quinone and a flavonol from Millettia laurentii 显示文摘 | Pierre Kamnaing Samuel NY Fanso Free Augustin E Nkengfack et ai | 1999 | Phytochemistry1999，51，6： | 1 |
| 15 | A Tabu Search Approach for Assigning Cells to Switches in Cellular Mobile Networks显示文摘 | Samuel Pierre Fabien Houéto | 2002 | Computer Communications2002，25，5： | 1 |
| 16 | Erectile function after WSTll vascular-targeted photodynamic therapy for low-risk prostate cancer treatment显示文摘Vascular-targeted photodynamic therapy(VTP)using padeliporfin is currently assessed as a low-risk prostate cancer(LRPCa)treatment.The aim of this study was to assess erectile function outcomes of VTP for LRPCa treatment.We prospectively included all patients treated with VTP for LRPCa.The primary endpoint was the post-treatment International Index of Erectile Function score(IIEF5 score)evolution(at 6 months,12 months,and then every year for 5 years).Secondary endpoints were the need of erectile dysfunction(ED)treatment and its efficacy.Eighty-two men were included.The median follow-up was 68(range:6-89)months.There was a 3-point significant decrease in the median IIEF5 score between baseline and at 6 months post-VTP(23[range:1-25]vs 20[range:1-25],P=0.005).There was a 1-point decrease at 1 year and 2 years post-VTP compared to baseline(22[range:2-25]and 22[range:0-25],P<0.005).There was no significant difference at 3,4,and 5 years compared to baseline.Twenty-seven(32.9%)patients received ED treatment:phosphodiesterase type-5 inhibitors(PDEI5;n=18),intracavernous injections(ICI;n=9),and intra-urethral gel(n=1).The median IIEF5 score statistically significantly increased after ED treatment(7[range:0-24]vs 21[range:1-25],P<0.001).ED treatment was efficient for 75%of the patients.There was no statistically significant difference between IIEF5 score at baseline and after ED treatment(P=0.443).Forty-six patients were totally potent before VTP and among them,13 needed ED treatment post-VTP with a success rate of 69.2%.VTP induced minimal changes in erectile function with a 3-point and a 1-point reduction in the IIEF5 score at 6 months and at 1 year,respectively.When required,ED treatment was efficient. | Samuel Chelly Pierre Maulaz Pierre Bigot Abdel Rahmene Azzouzi Souhil Lebdai | 2020 | Asian Journal of Andrology2020，22，5： | 1 |
| 17 | Evaluation of population (NONMEM) pharmacokinetic parameter estimates显示文摘 | Samuel Vozeh Pierre O. Maitre Donald R. Stanski | 1990 | Journal of Pharmacokinetics and Biopharmaceutics1990，，2： | 1 |
| 18 | Effectiveness of Telaprevir or Boceprevir in Treatment-Experienced Patients With HCV Genotype 1 Infection and Cirrhosis显示文摘 | Christophe Hezode Helene Fontaine Celine Dorival Fabien Zoulim Dominique Larrey Valerie Canva Victor De Ledinghen Thierry Poynard Didier Samuel Marc Bourliere Laurent Alric Jean–Jacques Raabe Jean–Pierre Zarski Patrick Marcellin Ghassan Riachi Pierre–Henr | 2014 | Gastroenterology2014，，： | 1 |
| 19 | Ant-based routing for wireless multimedia sensor networks using multiple QoS metrics 显示文摘 | Luis Cobo Alejandro Quintero Samuel Pierre | 2010 | Computer Networks2010，54，17： | 1 |
| 20 | Effects of tirofiban plus heparin versus heparin alone on troponin i levels in patients with acute coronary syndromes显示文摘 | James L Januzzi Samuel S Hahn Claudia U Chae Robert Giugliano Kent Lewandrowski Pierre Theroux Ik-Kyung Jang | 2000 | The American Journal of Cardiology2000，，7： | 1 |
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