|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Augmenting MNK1/2 activation by c-FMS proteolysis promotes osteoclastogenesis and arthritic bone erosion显示文摘Osteoclasts are bone-resorbing cells that play an essential role in homeostatic bone remodeling and pathological bone erosion.Macrophage colony stimulating factor(M-CSF)is abundant in rheumatoid arthritis(RA).However,the role of M-CSF in arthritic bone erosion is not completely understood.Here,we show that M-CSF can promote osteoclastogenesis by triggering the proteolysis of c-FMS,a receptor for M-CSF,leading to the generation of FMS intracellular domain(FICD)fragments.Increased levels of FICD fragments positively regulated osteoclastogenesis but had no effect on inflammatory responses.Moreover,myeloid cell-specific FICD expression in mice resulted in significantly increased osteoclast-mediated bone resorption in an inflammatory arthritis model.The FICD formed a complex with DAP5,and the FICD/DAP5 axis promoted osteoclast differentiation by activating the MNK1/2/EIF4E pathway and enhancing NFATcl protein expression.Moreover,targeting the MNK1/2 pathway diminished arthritic bone erosion.These results identified a novel role of c-FMS proteolysis in osteoclastogenesis and the pathogenesis of arthritic bone erosion. | Se Hwan Mun Seyeon Bae Steven Zeng Brian Oh Carmen Chai Matthew Jundong Kim Haemin Kim George Kalliolias Chitra Lekha Dahia Younseo Oh Tae-Hwan Kim Jong Dae Ji Kyung-Hyun Park-Min | 2021 | Bone Research2021，9，4： | 2 |
| 2 | Telomere length is shorter in healthy offspring of subjects with coronary artery disease: support for the telomere hypothesis显示文摘 | Brouilette SW Whittaker A Stevens SE van der Harst P Good- all AH Samani NJ | 2008 | Heart2008，94，4： | 1 |
| 3 | Telomere length is shorter in healthy offspring of subjects with coronary artery disease: support for the telomere hypothesis显示文摘 | Brouilette SW Whittaker A Stevens SE | 2008 | Heart2008，94，4： | 1 |
| 4 | The reduction of azo dyes by the intestinal microflora显示文摘 | Chung KT Stevens SE Jr Cerniglia CE | 1992 | Crit Rev Microbiol1992，18，： | 1 |
| 5 | The UKPDS Group: Development and progression of nephropathy in type 2 diabetes: the United Kingdom Prospective Diabetes Study (UKPDS64)显示文摘 | Adler AI Stevens RJ Manley SE | 2003 | Kidney Int2003，63，1： | 1 |
| 6 | Degradation of azo dyes by environmental microdot ganisms and helminthes 显示文摘 | Chung KT Stevens SE Jr | 1993 | Environ Toxicol Chem1993，12，： | 1 |
| 7 | A bacteriocin of Actinobacillus actinomycetemcomitans显示文摘 | Hammond BF Lillard SE Stevens RH | 1987 | Infect Immun1987，55，3： | 1 |
| 8 | Structural analyses reveal two distinct families of nucleoside phosphorylases显示文摘 | Matthew J Pugmire MY Ealicki SE Pugmire Steven E.Ealicki | | 0，，： | 1 |
| 9 | Modified low den sity lipoprotein and eytokines mediate moneyte adhesion to smooth muscle cells 显示文摘 | Thome SA Abbot SE Stevens CR | 1996 | Atherosclerosis1996，127，： | 1 |
| 10 | Development and progression ofnephropathy in type 2 diabetes:the United Kingdom Prospective Diabetes Study(UKPDS 64)显示文摘 | Adler AI Stevens RJ Manley SE | 2003 | Kidney Int2003，63，1： | 1 |
| 11 | Development and progression of nephropathy in type 2 diabetes : the United Kingdom Prospective DiabetesStudy( UKPDS 64 ) 显示文摘 | Adler AI Stevens RJ Manley SE | 2003 | Kidney Int2003，63，1： | 1 |
| 12 | Development and progression of nephropathy in type 2 diabetes: the United Kingdom Prospective Diabetes Study ( UKPDS 64 ) 显示文摘 | Adler AI Stevens R J Manley SE | 2003 | Kidney Int2003，63，1： | 1 |
| 13 | Development andprogression of nephropathy in type 2 diabetes: the UnitedKingdom Prospective Diabetes Study ( UKPDS 64 ) 显示文摘 | Adler Al Stevens RJ Manley SE | 2003 | Kidney Int2003，63，1： | 1 |
| 14 | Prevalence of chronic kidney disease in the United States显示文摘 | Coresh J Se|vin E Stevens LA | 2007 | JAMA2007，298，： | 1 |
| 15 | Development and progression of nephropathy m type 2 diabetes:the United Kingdom Prospective Diabetes Study (UKPDS 64)显示文摘 | Adler AI Stevens RJ Manley SE | 2003 | Kidney Int 63:225-2322003，，： | 1 |
| 16 | Development and progression of nephropathy in type 2 diabetes, the United Kingdom Prospective Diabetes Study (UKPDS 64)显示文摘 | Adler AI Stevens RJ Manley SE | 2003 | Kidney Int2003，63，1： | 1 |
| 17 | Inflammation: A unifying theory for the ori- gin of dry eye syndrome显示文摘 | Steven E Wilson SE | 2003 | Managed Care2003，12，12： | 1 |
| 18 | Glycemic durability of ro- siglitazone, metformin, or glyburide monotherapy显示文摘 | Kahn SE Steven M Haffner | 2006 | N Engl J Med2006，355，23： | 1 |
| 19 | Prosta apoptosis response-4 mediates trophic factor withdrawal-induced apoptosis of hippocampal neurons 显示文摘 | Sic L Chan Steven P Tammariello SE | 1999 | Journal of Neurochemistry1999，73，2： | 1 |
| 20 | Development and progression of nephropathy in type 2 diabetes: the United Kingdom Prospective Diabetes Study (UKPDS 64)显示文摘 | Adler AI Stevens R J Manley SE | 2003 | Kidney Int2003，63，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员