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| 1 | 四川省雅江县藏区人群绦/囊尾蚴病流行现状显示文摘目的了解四川省雅江县呷拉乡藏族人群绦虫病/囊尾蚴病流行现状。方法通过问卷、体检了解近一年内人群排绦虫史、癫痫发作史、皮下结节以及相关的其他临床表现。对自愿接受治疗的患者用吡喹酮驱除绦虫,用multiplex PCR对虫种进行鉴定。对1例高度怀疑为猪带绦虫患者的粪便标本采用粪-PCR进行检测。用囊液抗原检测血清囊尾蚴病特异性抗体,了解人群囊尾蚴感染水平。结果11.96%(216/1806)的村民近一年内有排绦虫史,1.05%(19/1806)发现皮下结节,0.61%(11/1806)有癫痫发作史。24份虫体标本PCR鉴定结果均为牛带绦虫,1份粪便标本粪-PCR结果为猪带绦虫。4.35%(4/92)人群血清囊尾蚴病抗体阳性。结论牛带绦虫和猪带绦虫共同流行于雅江县呷拉乡,以牛带绦虫为优势虫种。人群囊尾蚴感染率为4.35%。 | 阿斗塔 李调英 陈兴旺 邱加闽 龙昌平 Akira Ito 邱东川 Philip S.Craig Yasuhito Sako | 2007 | 寄生虫病与感染性疾病2007，5，2： | 12 |
| 2 | 四川省凉山彝族地区囊尾蚴病血清学调查(英文)显示文摘目的了解四川省凉山州彝族地区囊尾蚴病感染情况和流行风险因素。方法于2006年对凉山州昭觉县比尔乡的部分居民问卷调查;猪带绦虫尾蚴GPs作为抗原,用ELISA方法检测人、猪血清猪囊尾蚴特异性抗体。结果当地居民继发型癫痫发作率为9.1%(57/626),人、猪血清阳性率分别为7.2%(36/499)、13.9%(14/101)。该病在当地流行的主要原因包括猪放养、不良食肉习惯(坨坨肉)、人无厕所、肉品检疫不严以及经济落后等。结论囊尾蚴病高度流行于四川省彝族地区。为控制该病的流行,必需采取综合性的防治措施,如主动的人群绦虫病筛查和治疗、加强肉食品检疫和人粪管理、改变不良饮食习惯、提倡猪圈养等。 | 陈兴旺 李调英 Akira Ito Yasuhito Sako 邱东川 肖宁 Philips.Craig | 2010 | 寄生虫病与感染性疾病2010，8，2： | 11 |
| 3 | Causative anti-diabetic drugs and the underlying clinical factors for hypoglycemia in patients with diabetes显示文摘Recent clinical trials indicated that the intensive glycemic control do not reduce cardiovascular disease mortality among diabetic patients, challenging a significance of the strict glycemic control in diabetes management. Furthermore, retrospective analysis of the Action to Control Cardiovascular Risk in Diabetes study demonstrated a significant association betweenhypoglycemia and mortality. Here, we systematically reviewed the drug-induced hypoglycemia, and also the underlying clinical factors for hypoglycemia in patients with diabetes. The sulfonylurea use is significantly associated with severe hypoglycemia in patients with type 2 diabetes. The use of biguanide(approximately 45%-76%) and thiazolidinediones(approximately 15%-34%) are also highly associated with the development of severe hypoglycemia. In patients treated with insulin, the intensified insulin therapy is more frequently associated with severe hypoglycemia than the conventional insulin therapy and continuous subcutaneous insulin infusion. Among the underlying clinical factors for development of severe hypoglycemia, low socioeconomic status, aging, longer duration of diabetes, high Hb A1 c and low body mass index, comorbidities are precipitating factors for severe hypoglycemia. Poor cognitive and mental functions are also associated with severe hypoglycemia. | Hidekatsu Yanai Hiroki Adachi Hisayuki Katsuyama Sumie Moriyama Hidetaka Hamasaki Akahito Sako | 2015 | World Journal of Diabetes2015，6，1： | 3 |
| 4 | Comparative performance analysis of stroke correspondence search methods for stroke-order free online multi-stroke character recognition显示文摘为击顺序,免费联机多击字符识别,在一个输入模式之间的 stroke-to-stroke 通讯搜索和一个引用模式起一个重要作用处理击顺序变化。尽管笔划通讯的各种各样的方法被建议了,为澄清那些方法的相对优势的比较学习以前都没被做。在这份报纸,我们第一为解决击顺序变化问题考察途径。然后,笔划通讯的五个代表性的方法由不同的组求婚了,包括立方体搜索( CS ),由两部组成的加权的匹配( BWM ),单个通讯决定( ICD ),稳定的婚姻( SM ),和偏差扩大当模特儿( DE ),试验性地被比较,主要在识别精确性和效率的问候。联机汉字特性数据集上的试验性的结果,证明 99.17% , 99.17% , 96.37% , 98.54% ,和 96.59% 被 CS, BWM, ICD, SM,和 DE 达到,分别地当他们的识别评价。广泛的讨论在他们的相对优势和实物上被做。 | Wenjie CA1 Seiichi UCHIDA Hiroaki SAKOE | 2014 | Frontiers of Computer Science2014，8，5： | 2 |
| 5 | Genetic characterization and phylogenetic position of Echinococcus felidis Ortlepp, 1937 (Cestoda: Taeniidae) from the African lion显示文摘 | Marion Hüttner Minoru Nakao Torsten Wassermann Ludwig Siefert Joop D.F. Boomker Anke Dinkel Yasuhito Sako Ute Mackenstedt Thomas Romig Akira Ito | 2007 | International Journal for Parasitology2007，，7： | 2 |
| 6 | Dual mode regulation of migration by lysophosphatidic acid in human gastric cancer cells显示文摘 | Dai Shida Joji Kitayama Hironori Yamaguchi Kotaro Hama Junken Aoki Hiroyuki Arai Hiroharu Yamashita Ken Mori Akihiro Sako Tsuyoshi Konishi Toshiaki Watanabe Teruyuki Sakai Rika Suzuki Hideo Ohta Yoh Takuwa Hirokazu Nagawa | 2004 | Experimental Cell Research2004，，2： | 2 |
| 7 | Preoperative Carcinoembryonic Antigen Level Predicts Prognosis in Patients with Pseudomyxoma Peritonei Treated with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy显示文摘 | Emel Canbay Haruaki Ishibashi Shouzou Sako Akiyoshi Mizumoto Masamitsu Hirano Masumi Ichinose Nobuyuki Takao Yutaka Yonemura | 2013 | World Journal of Surgery2013，，6： | 2 |
| 8 | Enhanced hepatic differentiation in the subpopulation of human amniotic stem cells under 3D multicellular microenvironment显示文摘BACKGROUND To solve the problem of liver transplantation donor insufficiency,an alternative cell transplantation therapy was investigated.We focused on amniotic epithelial cells(AECs)as a cell source because,unlike induced pluripotent stem cells,they are cost-effective and non-tumorigenic.The utilization of AECs in regenerative medicine,however,is in its infancy.A general profile for AECs has not been comprehensively analyzed.Moreover,no hepatic differentiation protocol for AECs has yet been established.To this end,we independently compiled human AEC libraries,purified amniotic stem cells(ASCs),and co-cultured them with mesenchymal stem cells(MSCs)and human umbilical vein endothelial cell(HUVECs)in a 3D system which induces functional hepatic organoids.AIM To characterize AECs and generate functional hepatic organoids from ASCs and other somatic stem cells METHODS AECs,MSCs,and HUVECs were isolated from the placentae and umbilical cords of cesarean section patients.Amnion and primary AEC stemness characteristics and heterogeneity were analyzed by immunocytochemistry,Alkaline phosphatase(AP)staining,and flow cytometry.An adherent AEC subpopulation was selected and evaluated for ASC purification quality by a colony formation assay.AEC transcriptomes were compared with those for other hepatocytes cell sources by bioinformatics.The 2D and 3D culture were compared by relative gene expression using several differentiation protocols.ASCs,MSCs,and HUVECs were combined in a 3D co-culture system to generate hepatic organoids whose structure was compared with a 3D AEC sphere and whose function was elucidated by immunofluorescence imaging,periodic acid Schiff,and an indocyanine green(ICG)test.RESULTS AECs have certain stemness markers such as EPCAM,SSEA4,and E-cadherin.One AEC subpopulation was also either positive for AP staining or expressed the TRA-1-60 and TRA-1-81 stemness markers.Moreover,it could form colonies and its frequency was enhanced ten-fold in the adherent subpopulation after selective primary passage.Bioinformatics analysis of ribose nucleic acid sequencing revealed that the total AEC gene expression was distant from those of pluripotent stem cells and hepatocytes but some gene expression overlapped among these cells.TJP1,associated with epidermal growth factor receptor,and MET,associated with hepatocyte growth factor receptor,were upregulated and may be important for hepatic differentiation.In conventional flat culture,the cells turned unviable and did not readily differentiate into hepatocytes.In 3D culture,however,hepatic gene expression of the AEC sphere was elevated even under a two-step differentiation protocol.Furthermore,the organoids derived from the MSC and HUVEC co-culture showed 3D structure with polarity,hepatic-like glycogen storage,and ICG absorption/elimination.CONCLUSION Human amniotic epithelial cells are heterogeneous and certain subpopulations have high stemness.Under a 3D co-culture system,functional hepatic organoids were generated in a multicellular microenvironment. | Kinji Furuya Yun-Wen Zheng Daisuke Sako Kenichi Iwasaki Dong-Xu Zheng Jian-Yun Ge Li-Ping Liu Tomoaki Furuta Kazunori Akimoto Hiroya Yagi Hiromi Hamada Hiroko Isoda Tatsuya Oda Nobuhiro Ohkohchi | 2019 | World Journal of Stem Cells2019，11，9： | 2 |
| 9 | The mitochondrial genome of the tapeworm Taenia solium:a finding of the abbreviated stop codon U显示文摘 | Nakao M Sako Y Ito A | 2003 | J Parasitol2003，89，3： | 1 |
| 10 | Supplier relations in Japan and United States: are they converging? 显示文摘 | HELPER S SAKO M | 1995 | Sloan Management Review1995，36，2： | 1 |
| 11 | Dynamic Programming Algorithm Optimization for Spoken Word Recognition显示文摘 | Hiroaki Sakoe Deibi Chiba | 1978 | IEEE Transactions on Acoustics Speech And Signal Processing1978，26，1： | 1 |
| 12 | Dynamic programming algorithm optimization for spoken word recognition显示文摘 | Sakoe H Chiba S | | 0，，01： | 1 |
| 13 | Effects of free fatty acid onlS- cell function :a possible involement of peroxisome prolixferator-acti- rated receptors-cmr pancreastic/duodenal bomebox显示文摘 | Yoshikawa H Tajiri Y Sako Y | 2001 | Metabolism2001，50，5： | 1 |
| 14 | Synthesis and properties of novel crown ether-annelated At,5'-diaza-9'-(1,3-dithiole-2-ylidene)-fluorenes and their ruthenium(Ⅱ)complexes显示文摘 | SAKO K KAKEHI T NAKANO S | 2014 | Tetrahedron Letters2014，55，3： | 1 |
| 15 | Subacute panencephalitis associated with chronic graft-versus-host disease 显示文摘 | Iwasaki Y Sako K Ohara Y | 1993 | Acta Neuropathol1993，85，5： | 1 |
| 16 | Perceptions of school environment among japanese junior high school, nonattendant, and juvenile delinquent smdents显示文摘 | Sonomi Hirata Toshihiko Sako | 1999 | Learning Environments Research1999，，1： | 1 |
| 17 | Alveolar Echinococcosis:characterization of diagnostic antigen Era18 and serological evaluation of recombinant Em18显示文摘 | Sako Y Nakao M Nakaya K | 2002 | J Clin Microbiol2002，40，8： | 1 |
| 18 | Diagnosis and treatment of progressive space-occupying radiation necrosis following stereotactic radiosurgery for brain metastasis:value of proton magnetic resonance spectroscopy显示文摘 | Kimura T Sako K Tohyyama Y | 2003 | Acta Neurochir(Wien)2003，145，7： | 1 |
| 19 | In vivo singlevoxel proton MR spectroscopy in brain lesions with ring-like enhancement显示文摘 | Kimura T Sako K Gotch T | 2001 | NMR Biomed2001，14，6： | 1 |
| 20 | Simultaneous determination of phosphate esters and phthalate esters in clean room air and indoor air by gas chromatography-mass spectrometry 显示文摘 | Toda H Sako K Yagome Y | 2004 | Analytica Chimica Acta2004，519，： | 1 |
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