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| 1 | Seismic behavior of precast concrete coupled shear walls with engineered cementitious composite (ECC) in the critical cast-in-place regions显示文摘The seismic performance of precast reinforced concrete(RC) coupled shear walls is significantly influenced by coupling beams and the beam-to-wall joints during large deformations into plastic ranges.This study investigated the use of engineered cementitious composite(ECC) in the cast-in-place beam-to-wall joints and the upper regions of the composite coupling beams as an innovative method to improve the seismic performance of precast RC coupled shear walls.Two 1/2-scale precast coupled shear walls were tested under reversed cyclic loading and seismic behavior in terms of failure characteristic,mechanical characteristic value,load-displacement hysteresis curves,load-displacement envelope relationship,stiffness degradation,ductility and energy dissipation capacity were evaluated.Research results show that the substitution of concrete with ECC in the critical cast-in-place regions proved to be an effective method to improve the seismic performance of the two-story spatial of precast RC coupled shear walls. | YANG Jian LIANG ShuTing ZHU XiaoJun SUN ChongFang GUO ZhengXing | 2017 | Science China(Technological Sciences)2017，60，8： | 6 |
| 2 | Study on the promotion of lymphocytes in patients with COVID-19 by broad-spectrum chemokine receptor inhibitor vMIP-Ⅱ and its Mechanism of signal transmission in vitro显示文摘Dear Editor,COVID-19 cases showed a significant decrease in the number of peripheral CD4^(+) and CD8^(+)T cells accompanied by overactivation of cells.1 HHV8-derived viral macrophage inflammatory protein vMIP-Ⅱ is the only broad-spectrum chemokine receptor inhibitor that binds to three subtribes of chemokine receptors,which can significantly increase the specific cell immune response in infected organisms and have an effect of reducing plasma viral load on the viremia period.24 Here we report the effect of vMIP-Ⅱ in COVID-19. | Shiyu Li Shuting Liu Zhenyou Jiang Lixia Feng Yong Gao Youyu Chen Anding Xu Wenhua Huang Nuofu Zhang Hanxiao Sun | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 5 |
| 3 | The formation of perovskite multiple quantum well structures for high performance light-emitting diodes显示文摘Recent works showed that high efficient perovskite light-emitting diodes can be achieved from solution-processed,self-organized multiple quantum wells(MQWs)with an energy cascade.We investigate how the mixing of QWs with different band gaps can affect the perovskite LED device performance.We find that the annealing process can significantly affect the constitution of the MQWs films,where the dominant phase can evolve from large band gap QWs to small band gap QWs.The optimal constitution for LED application lies in a transition point of small-n QWs dominant phase to large-n QWs dominant phase,when the MQW film presents highest photoluminescence while still remains uniform film morphology. | Yan Sun Li Zhang Nana Wang Shuting Zhang Yu Cao Yanfeng Miao Mengmeng Xu Hao Zhang Hai Li Chang Yi Jianpu Wang Wei Huang | 2018 | npj Flexible Electronics2018，2，1： | 4 |
| 4 | A Distributed Approach of Big Data Mining for Financial Fraud Detection in a Supply Chain显示文摘Supply Chain Finance(SCF)is important for improving the effectiveness of supply chain capital operations and reducing the overall management cost of a supply chain.In recent years,with the deep integration of supply chain and Internet,Big Data,Artificial Intelligence,Internet of Things,Blockchain,etc.,the efficiency of supply chain financial services can be greatly promoted through building more customized risk pricing models and conducting more rigorous investment decision-making processes.However,with the rapid development of new technologies,the SCF data has been massively increased and new financial fraud behaviors or patterns are becoming more covertly scattered among normal ones.The lack of enough capability to handle the big data volumes and mitigate the financial frauds may lead to huge losses in supply chains.In this article,a distributed approach of big data mining is proposed for financial fraud detection in a supply chain,which implements the distributed deep learning model of Convolutional Neural Network(CNN)on big data infrastructure of Apache Spark and Hadoop to speed up the processing of the large dataset in parallel and reduce the processing time significantly.By training and testing on the continually updated SCF dataset,the approach can intelligently and automatically classify the massive data samples and discover the fraudulent financing behaviors,so as to enhance the financial fraud detection with high precision and recall rates,and reduce the losses of frauds in a supply chain. | Hangjun Zhou Guang Sun Sha Fu Xiaoping Fan Wangdong Jiang Shuting Hu Lingjiao Li | 2020 | Computers, Materials & Continua2020，，8： | 3 |
| 5 | Clinical significance of extended high-risk human papillomavirus genotyping and viral load in cervical cancer and precancerous lesions显示文摘Persistent infections with specific high-risk human papillomavirus(HR-HPV)strains are the leading cause of cervical cancer and precancerous lesions.HPV-16 and HPV-18 are associated with more than 70%of cervical cancer.However,with recent widespread vaccination efforts against cervical cancer,the infection rates of HPV-16 and HPV-18 have decreased across all age groups,while the infection rates of other HR-HPV strains have increased.The non-16/18 HR-HPV strains play an important role in cervical lesions.These strains can be identified with extended genotyping,and the 2019 American Society for Colposcopy and Cervical Pathology(ASCCP)guidelines recommended an HPV-based testing to assess the risk of cervical disease in patients.We reviewed and analyzed the clinical benefits of applying extended HR-HPV genotyping,which was published by the International Agency for Research on Cancer(HPV-16,18,31,33,35,39,45,51,52,56,58,59,66,and 68),to cervical cancer screening.This review concluded that cervical cancer screening needs to include extended HR-HPV genotyping.The examination of extended HR-HPV genotyping in cervical intraepithelial lesions and cervical cancers can help guide clinical practices. | Pingping Su Jincheng Ma Lirui Yu Shuting Tang Pengming Sun | 2023 | Gynecology and Obstetrics Clinical Medicine2023，3，1： | 2 |
| 6 | Genomic evidence of lung carcinogenesis associated with coal smoke in Xuanwei area, China显示文摘Xuanwei area, in southwestern China,harbors the highest female lung cancer rate in the country(Supplementary Table 1) [1]. Epidemiological studies have shown that lung cancer incidence in Xuanwei area is associated with the use of different types of local coal for household cooking and heating [2]. The genomic landscape of Xuanwei female adenocarcinoma(XWFA), the most distinctive feature of lung cancer in Xuanwei, has yet to be elucidated systematically. Here,we provide the fundamental resource of genomic datasets for further exploration of XWFA molecular mechanisms and development of targetable therapy. | Honglei Zhang Chao Liu Li Li Xu Feng Qing Wang Jihua Li Shaobin Xu Shuting Wang Qianlu Yang Zhenghai Shen Jinhua Su Xiaosan Su Ruifen Sun Xuhong Zhou Junliang Wang Yongchun Zhou Baowei Jiao Wanbao Ding Xianbao Cao Yue Wang Yunchao Huang Lianhua Ye | 2021 | National Science Review2021，8，12： | 2 |
| 7 | Single-shot AAV-vectored vaccine against SARS-CoV-2 with fast and long-lasting immunity显示文摘Due to the insufficient long-term protection and significant efficacy reduction to new variants of current COVID-19 vaccines,the epidemic prevention and control are still challenging.Here,we employ a capsid and antigen structure engineering(CASE)strategy to manufacture an adenoassociated viral serotype 6-based vaccine(S663V-RBD),which expresses trimeric receptor binding domain(RBD)of spike protein fused with a biological adjuvant RS09.Impressively,the engineered S663V-RBD could rapidly induce a satisfactory RBD-specific IgG titer within 2 weeks and maintain the titer for more than 4 months.Compared to the licensed BBIBP-CorV(Sinopharm,China),a single-dose S663V-RBD induced more endurable and robust immune responses in mice and elicited superior neutralizing antibodies against three typical SARS-CoV-2 pseudoviruses including wild type,C.37(Lambda)and B.1.617.2(Delta).More interestingly,the intramuscular injection of S663V-RBD could overcome pre-existing immunity against the capsid.Given its effectiveness,the CASE-based S663VRBD may provide a new solution for the current and next pandemic. | Fuhua Wu Shuang Luo Yongshun Zhang Yangsen Ou Hairui Wang Zhaofei Guo Chunting He Shuting Bai Penghui He Min Jiang Xiaoyan Chen Guangsheng Du Xun Sun | 2023 | Acta Pharmaceutica Sinica B2023，13，5： | 2 |
| 8 | Exosomes secreted from cardiomyocytes suppress the sensitivity of tumor ferroptosis in ischemic heart failure显示文摘Heart failure(HF)patients in general have a higher risk of developing cancer.Several animal studies have indicated that cardiac remodeling and HF remarkably accelerate tumor progression,highlighting a cause-and-effect relationship between these two disease entities.Targeting ferroptosis,a prevailing form of non-apoptotic cell death,has been considered a promising therapeutic strategy for human cancers.Exosomes critically contribute to proximal and distant organ-organ communications and play crucial roles in regulating diseases in a paracrine manner.However,whether exosomes control the sensitivity of cancer to ferroptosis via regulating the cardiomyocyte-tumor cell crosstalk in ischemic HF has not yet been explored.Here,we demonstrate that myocardial infarction(MI)decreased the sensitivity of cancer cells to the canonical ferroptosis activator erastin or imidazole ketone erastin in a mouse model of xenograft tumor.Post-MI plasma exosomes potently blunted the sensitivity of tumor cells to ferroptosis inducers both in vitro in mouse Lewis lung carcinoma cell line LLC and osteosarcoma cell line K7M2 and in vivo with xenograft tumorigenesis model.The expression of miR-22-3p in cardiomyocytes and plasma-exosomes was significantly upregulated in the failing hearts of mice with chronic MI and of HF patients as well.Incubation of tumor cells with the exosomes isolated from post-MI mouse plasma or overexpression of miR-22-3p alone abrogated erastin-induced ferroptotic cell death in vitro.Cardiomyocyte-enriched miR-22-3p was packaged in exosomes and transferred into tumor cells.Inhibition of cardiomyocyte-specific miR-22-3p by AAV9 sponge increased the sensitivity of cancer cells to ferroptosis.ACSL4,a pro-ferroptotic gene,was experimentally established as a target of miR-22-3p in tumor cells.Taken together,our findings uncovered for the first time that MI suppresses erastin-induced ferroptosis through releasing miR-22-3p-enriched exosomes derived from cardiomyocytes.Therefore,targeting exosome-mediated cardiomyocyte/tumor pathological communication may offer a novel approach for the ferroptosis-based antitumor therapy. | Ye Yuan Zhongting Mei Zhezhe Qu Guanghui Li Shuting Yu Yingqi Liu Kuiwu Liu Zhihua Shen Jiaying Pu Yanquan Wang Changhao Wang Zhiyong Sun Qian Liu Xiaochen Pang Ao Wang Zijing Ren Tong Wang Ying Liu Jinhuan Hong Jiajie Xie Xin Li Zhonghua Wang Weijie Du Baofeng Yang | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 2 |
| 9 | RNA Methylome Reveals the m^(6)A-mediated Regulation of Flavor Metabolites in Tea Leaves under Solar-withering显示文摘The epitranscriptomic mark N6-methyladenosine(m^(6)A),which is the predominant internal modification in RNA,is important for plant responses to diverse stresses.Multiple environmental stresses caused by the tea-withering process can greatly influence the accumulation of specialized metabolites and the formation of tea flavor.However,the effects of the m^(6)A-mediated regulatory mechanism on flavor-related metabolic pathways in tea leaves remain relatively uncharacterized.We performed an integrated RNA methylome and transcriptome analysis to explore the m^(6)Amediated regulatory mechanism and its effects on flavonoid and terpenoid metabolism in tea(Camellia sinensis)leaves under solar-withering conditions.Dynamic changes in global m^(6)A level in tea leaves were mainly controlled by two m^(6)A erasers(CsALKBH4A and CsALKBH4B)during solar-withering treatments.Differentially methylated peak-associated genes following solarwithering treatments with different shading rates were assigned to terpenoid biosynthesis and spliceosome pathways.Further analyses indicated that CsALKBH4-driven RNA demethylation can directly affect the accumulation of volatile terpenoids by mediating the stability and abundance of terpenoid biosynthesis-related transcripts and also indirectly influence the flavonoid,catechin,and theaflavin contents by triggering alternative splicing-mediated regulation.Our findings revealed a novel layer of epitranscriptomic gene regulation in tea flavor-related metabolic pathways and established a link between the m^(6)A-mediated regulatory mechanism and the formation of tea flavor under solar-withering conditions. | Chen Zhu Shuting Zhang Chengzhe Zhou Caiyun Tian Biying Shi Kai Xu Linjie Huang Yun Sun Yuling Lin Zhongxiong Lai Yuqiong Guo | 2023 | Genomics, Proteomics & Bioinformatics2023，21，4： | 2 |
| 10 | Low-bandgap conjugated polymers based on benzodipyrrolidone with reliable unipolar electron mobility exceeding 1 cm^(2) V^(-1)s^(-1)显示文摘The employment of an intrinsic quinoidal building block,benzodipyrrolidone(BDP),on constructing conjugated polymers(PBDP-2F and PBDP-2CN)with high electron mobility and unipolar transport characteristic in polyethylenimine ethoxylated(PEIE)modified organic field-effect transistors(OFETs)is reported.The intrinsic quinoidal characteristic and excellent coplanarity of BDP can lower the lowest unoccupied molecular orbital(LUMO)levels and improve ordered interchain packing of the resulting polymers in solid states,which are favorable for electron-injection and transport.By using PEIE as the interlayer to block the hole injection,unipolar n-type transport characteristics with high electron mobility of 0.58 and 1.01 cm^(2) V^(-1)s^(-1)were achieved by the OFETs based on PBDP-2F and PBDP-2CN,respectively.More importantly,the extracted mobilities are highly reliable with the reliability factor of above 80%.To the best of our knowledge,PBDP-2CN is the very first quinoid-based conjugated polymer with reliable electron mobility exceeding 1 cm^(2) V^(-1)s^(-1).This work represents a significant step in exploring intrinsic quinoidal CPs for application in n-channel OFETs and logic complementary circuits. | Mingqun Yang Tian Du Xuxia Zhao Xuelong Huang Langheng Pan Shuting Pang Haoran Tang Zhongxiang Peng Long Ye Yunfeng Deng Mingliang Sun Chunhui Duan Fei Huang Yong Cao | 2021 | Science China Chemistry2021，64，7： | 1 |
| 11 | Development and transdifferentiation into inner hair cells require Tbx2显示文摘Atohl is essential for the development of both outer hair cells(OHCs)and inner hair cells(IHCs)in the mammalian co chlea.Whereas Ikzf2 is necessary for OHC development,the key gene re quired for IHC development remains unknown.We found that deletion of Tbx2 in neonatal IHCs led to their transdifferentiation into OHCs by repressing 26.7%of IHC genes and inducing 56.3%of OHC genes,including Ikzf2.More importantly,persistent expression of Tbx2 coupled with transient Atohl expression effe ctively reprogrammed non-sensory supporting cells into new IHCs expressing the functional IHC marker vGlut3.The differentiation status of these new IHCs was considerably more advanced than that previously reported.Thus,Tbx2 is essential for IHC development and co-upregulation of Tbx2 with Atohl in supporting cells represents a new approach for treating deafness related to IHC degeneration. | Zhenghong Bi Xiang Li Minhui Ren Yunpeng Gu Tong Zhu Shuting Li Guangqin Wang Suhong Sun Yuwei Sun Zhiyong Liu | 2022 | National Science Review2022，9，12： | 1 |
| 12 | Manipulations of micro/nanoparticles using gigahertz acoustic streaming tweezers显示文摘Contactless acoustic manipulation of micro/nanoscale particles has attracted considerable attention owing to its near independence of the physical and chemical properties of the targets,making it universally applicable to almost all biological systems.Thin-film bulk acoustic wave(BAW)resonators operating at gigahertz(GHz)frequencies have been demonstrated to generate localized high-speed microvortices through acoustic streaming effects.Benefitting from the strong drag forces of the high-speed vortices,BAW-enabled GHz acoustic streaming tweezers(AST)have been applied to the trapping and enrichment of particles ranging in size from micrometers to less than 100 nm.However,the behavior of particles in such 3D microvortex systems is still largely unknown.In this work,the particle behavior(trapping,enrichment,and separation)in GHz AST is studied by theoretical analyses,3D simulations,and microparticle tracking experiments.It is found that the particle motion in the vortices is determined mainly by the balance between the acoustic streaming drag force and the acoustic radiation force.This work can provide basic design principles for AST-based lab-on-a-chip systems for a variety of applications. | Hang Wu Zifan Tang Rui You Shuting Pan Wenpeng Liu Hongxiang Zhang Tiechuan Li Yang Yang Chongling Sun Wei Pang Xuexin Duan | 2022 | Nanotechnology and Precision Engineering2022，5，2： | 1 |
| 13 | Kine tic study for Fe(NO3 )3catalyzed hemicellulose hydrolysis of different corn stover silages 显示文摘 | SUN Youshan LU Xuebin ZHANG Shuting | 2011 | Bioresource Technolo- gy2011，102，3： | 1 |
| 14 | The biornim etic +decrease plasma in sulin cholesterol,and triglyserides in healthy and type Ⅱ diabetic rat but not type Ⅰ diabetic rat 显示文摘 | Sun Y J Clodfelder B J Shute A A | 2002 | J Biol Inorg chem2002，7，： | 1 |
| 15 | Prevalence of Congenital Heart Disease at Extremely High Altitudes in Tibet and the Establishment of a New Free Treatment Model显示文摘Background: This study aimed to illustrate the prevalence of CHD by screening children in extremely high-altitudeareas (over 4000 m to even 5000 m above sea level) and explore an aid model for early diagnosis and treatmentfor the Tibetan population. Methods: A total of 2242 students from different schools in Ngamring County,Xigaze City, Tibet from September 2019 to September 2020 were selected for screening. The students were examinedthrough the inquiry of their current medical history and family history, cardiac auscultation and a physicalexamination, in order to screen out the suspected cases of CHD, and then the suspected cases were confirmed bycardiac color ultrasound examinations. After that, positive patients were be transferred to Shandong Province forfree treatment. Results: The prevalence of CHD among children in Ngamring County was 3.70% (83 cases),which is the highest incidence rate ever reported. The most common type of CHD was patent ductus arteriosus(PDA), accounting for 55.42% of the total number of cases screened, followed by atrial septal defect (ASD) andventricular septal defect (VSD), accounting for 28.92% and 12.05%, respectively. The prevalence of CHD in childrenat high altitude was significantly higher than that in children at low altitude. The children with CHD weretransferred to Shandong Province for surgery, the operations were successful and their recoveries went well.Conclusions: The results show that high altitude is closely related to the prevalence of CHD, and the incidencein Ngamring County is much higher than that in previous reports. | Shuting Chang Guanzhao Zhang Nengjun Sun Xinpeng Yuan Qingting Wang Lin Zhu Feiyue Zhang Yu Xiu Yang Dong Yonghong Chen Zhanpeng Zhao Xiao Liu Qiang Shao Xiaofeng Xu Anshun Wang Mengjiao Li Bo Li | 2022 | Congenital Heart Disease2022，17，6： | 1 |
| 16 | The relationship between the chemistry and biological activity of the bisphosphonates显示文摘 | Ebetino F H Hogan A Sun Shuting | 2011 | Bone2011，，49： | 1 |
| 17 | The biomimetic+ decrease plasma insulin, cholesterol,and triglycerides in healthy and type Ⅱ diabetic rats but not type Ⅰ diabetic rats显示文摘 | SUN Y J CLODFELDER B J SHUTE A A | 2002 | J Biol Inorg Chem2002，7，： | 1 |
| 18 | 2007 China(Changzhou) international Animation and Digital Arts Festival显示文摘LOCATED in the hinter- land of the Yangtze River Delta,Changzhou is one of the most prosperous places in southern China. At the end of September 2007,the city presented a brand-new animated face to the world,with the 4th China (Chang- zhou) International Animation and Dig- ital Arts Festival,held in the local China Dinosaur Park. | SUN SHUTING | 2007 | China Today2007，56，12： | 0 |
| 19 | Evidence of bisphosphonate-conjugated sitafloxacin eradication of established methicillin-resistant S.aureus infection with osseointegration in murine models of implant-associated osteomyelitis显示文摘Eradication of MRSA osteomyelitis requires elimination of distinct biofilms.To overcome this,we developed bisphosphonateconjugated sitafloxacin(BCS,BV600072)and hydroxybisphosphonate-conjugate sitafloxacin(HBCS,BV63072),which achieve“target-and-release”drug delivery proximal to the bone infection and have prophylactic efficacy against MRSA static biofilm in vitro and in vivo.Here we evaluated their therapeutic efficacy in a murine 1-stage exchange femoral plate model with bioluminescent MRSA(USA300LAC::lux).Osteomyelitis was confirmed by CFU on the explants and longitudinal bioluminescent imaging(BLI)after debridement and implant exchange surgery on day 7,and mice were randomized into seven groups:1)Baseline(harvested at day7,no treatment);2)HPBP(bisphosphonate control for BCS)+vancomycin;3)HPHBP(hydroxybisphosphonate control for HBCS)+vancomycin;4)vancomycin;5)sitafloxacin;6)BCS+vancomycin;and 7)HBCS+vancomycin.BLI confirmed infection persisted in all groups except for mice treated with BCS or HBCS+vancomycin.Radiology revealed catastrophic femur fractures in all groups except mice treated with BCS or HBCS+vancomycin,which also displayed decreases in peri-implant bone loss,osteoclast numbers,and biofilm.To confirm this,we assessed the efficacy of vancomycin,sitafloxacin,and HBCS monotherapy in a transtibial implant model.The results showed complete lack of vancomycin efficacy while all mice treated with HBCS had evidence of infection control,and some had evidence of osseous integrated septic implants,suggestive of biofilm eradication.Taken together these studies demonstrate that HBCS adjuvant with standard of care debridement and vancomycin therapy has the potential to eradicate MRSA osteomyelitis. | Youliang Ren Jason Weeks Thomas Xue Joshua Rainbolt Karen L.de Mesy Bentley Ye Shu Yuting Liu Elysia Masters Philip Cherian Charles E.McKenna Jeffrey Neighbors Frank H.Ebetino Edward M.Schwarz Shuting Sun Chao Xie | 2023 | Bone Research2023，11，4： | 0 |
| 20 | Protection of the Geographical Indication Right and New Plant Variety Right of Green Chinese Onion in China显示文摘Geographical indication right and new plant variety right are important agricultural intellectual property.This article researches the current situation on protection of geographical indication right of green Chinese onion resources and new plant variety right.And it puts forward the following measures for improvement:(i)Promoting the implementation of geographical indication product protection based on the national quality system;(ii)Establishing the national quality standards of geographical indication green Chinese onion,in order to improve quality standardization;(iii)Encouraging more enterprises within the scope of protection of geographical indication to use special signs of geographical indication;(iv)Unifying the green Chinese onion brands within the scope of protection of geographical indication;(v)Achieving the dual protection of geographical indication right and new variety right of green Chinese onion;(vi)Developing the tourism resources on geographical indication green Chinese onion,to develop tourism agriculture. | Zai HU Shuting WANG Zhiguo SUN Wanzhen XIONG Limin HUANG | 2013 | Asian Agricultural Research2013，5，11： | 0 |
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