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| 1 | Overactive bladder symptom score to evaluate efficacy of solifenacin for the treatment of overactive bladder symptoms显示文摘 | Liu Ming Wang Jianye Yang Yong An Ruihua Wen Jianguo Guan Zhichen Zheng Shaobin Wang Dongwen Song Bo Liao Limin Guo Hongqian Xiao Jiaquan Sun Yinghao Shen Zhoujun Kong Chuize He Dalin Huang Yiran Wang Xiaofeng Zhang Xu Li Hanzhong Huang Jian Zhao Xiaokun Zeng Puqing Song Xishuang Ye Zhangqun | 2014 | Chinese Medical Journal2014，，2： | 7 |
| 2 | Location and size regulation of manganese oxides within mesoporous silica for enhanced antibiotic degradation显示文摘Refractory antibiotics in domestic wastewater are hard to be completely eliminated by conventional methods,and then lead to severe environmental contamination and adverse effects on public health.In present work,advanced oxidation processes(AOPs)are adopted to remove the antibiotic of sul-fachloropyridazine(SCP).Nanosized Mn_(2)O_(3) was fabricated on the SBA-15 material to catalytically acti-vate potassium peroxydisulfate(PDS)to generate reactive oxygen radicals of.OH and SO_(4).for SCP degradation.The effects of location and size of Mn_(2)O_(3) were explored through choosing either the as-made or template free SBA-15 as the precursor of substrate.Great influences from the site and size of Mn_(2)O_(3) on the oxidation activity were discovered.It was found that Mn_(2)O_(3) with a large size at the exterior of SBA-15(Mn-tfSBA)was slightly easier to degrade SCP at a low manganese loading of 1.0-2.0 mmol.g;however,complete SCP removal could only be achieved on the catalyst of Mn_(2)O_(3) with a refined size at the interior of SBA-15(Mn-asSBA).Moreover,the SO_(4).species were revealed to be the decisive radicals in the SCP degradation processes.Exploring the as-made mesoporous silica as a support provides a new idea for the further development of environmentally friendly catalysts. | Min Lu Mengxuan Liu Chunli Xu Yu Yin Lei Shi Hong Wu Aihua Yuan Xiao-Ming Ren Shaobin Wang Hongqi Sun | 2022 | Chinese Journal of Chemical Engineering2022，35，8： | 3 |
| 3 | Carbon-based single atom catalyst: Synthesis, characterization, DFT calculations显示文摘Carbon-based single-atom catalysts(SACs) with atomic sizes of active sites have become the promising candidates for a variety of catalytic systems because of their high atom utilization, and unique electronic structures. Different types of single-atom sites can be fabricated via multiple preparation strategies, which would demonstrate distinct different coordination configurations and electronic features, and ultimately affected the structure-catalysis relationship of SACs in targeted reactions. As a result, it is necessary to identify the active sites of SACs and understand the structure-catalysis relationship of SACs at the atomic scale. In this review, a variety of preparation strategies of carbon-based SACs were documented. Then, the recent development on versatile characterization techniques and computational achievements were summarized regarding in understanding the electronic and geometric characteristics of carbon-based SACs.Finally, major challenges and development directions concerning single-atom sites identification and advanced tools development are discussed to shed light on future research of carbon-based SACs. | Yanan Shang Xiaoguang Duan Shaobin Wang Qinyan Yue Baoyu Gao Xing Xu | 2022 | Chinese Chemical Letters2022，33，2： | 2 |
| 4 | Genomic evidence of lung carcinogenesis associated with coal smoke in Xuanwei area, China显示文摘Xuanwei area, in southwestern China,harbors the highest female lung cancer rate in the country(Supplementary Table 1) [1]. Epidemiological studies have shown that lung cancer incidence in Xuanwei area is associated with the use of different types of local coal for household cooking and heating [2]. The genomic landscape of Xuanwei female adenocarcinoma(XWFA), the most distinctive feature of lung cancer in Xuanwei, has yet to be elucidated systematically. Here,we provide the fundamental resource of genomic datasets for further exploration of XWFA molecular mechanisms and development of targetable therapy. | Honglei Zhang Chao Liu Li Li Xu Feng Qing Wang Jihua Li Shaobin Xu Shuting Wang Qianlu Yang Zhenghai Shen Jinhua Su Xiaosan Su Ruifen Sun Xuhong Zhou Junliang Wang Yongchun Zhou Baowei Jiao Wanbao Ding Xianbao Cao Yue Wang Yunchao Huang Lianhua Ye | 2021 | National Science Review2021，8，12： | 2 |
| 5 | Application of fluorescence in situ hybridization in the detection of bladder transitional-cell carcinoma: A multi-center clinical study based on Chinese population显示文摘Objective:To evaluate the diagnostic value of fluorescence in situ hybridization(FISH)in bladder cancer.Methods:We enrolled healthy volunteers and patients who were clinically suspected to have bladder cancer and conducted FISH tests and cytology examinations from August 2007 to December 2008.Receiver operating characteristic(ROC)curve analysis was performed and the area under curve(AUC)values were calculated for both the FISH and urine cytology tests.Results:A cohort of 988 healthy volunteers was enrolled to establish a reference range for the normal population.A total of 4807 patients with hematuria were prospectively,randomly enrolled for the simultaneous analysis of urine cytology,FISH testing,and a final diagnosis as determined by the pathologic findings of a biopsy or a surgically-excised specimen.Overall,the sensitivity of FISH in detecting transitional-cell carcinoma was 82.7%,while that of cytology was 33.4%(p<0.001).The sensitivity values of FISH for non-muscle invasive and muscle invasive bladder transitional-cell carcinoma were 81.7%and 89.6%,respectively(p=0.004).The sensitivity values of FISH for low and high grade bladder cancer were 82.6%and 90.1%,respectively(p=0.002).Conclusion:FISH is significantly more sensitive than voided urine cytology for detecting bladder cancer in patients evaluated for gross hematuria at all cancer grades and stages.Higher sensitivity using FISH was obtained in high grade and muscle invasive tumors. | Liqun Zhou Kaiwei Yang Xuesong Li Yi Ding Dawei Mu Hanzhong Li Yong Yan Jinyi Li Dongwen Wang Wei Li Yulong Cong Jiangping Gao Kewei Ma Yajun Xiao Sheng Zhang Hongyi Jiang Weilie Hu Qiang Wei Xunbo Jin Zhichen Guan Qingyong Liu Danfeng Xu Xin Gao Yongguang Jiang Weimin Gan Guang Sun Qing Wang Yanhui Liu Jianquan Hou Liping Xie Xishuang Song Fengshuo Jin Jiafu Feng Ming Cai Zhaozhao Liang Jie Zhang Dingwei Ye Lin Qi Lulin Ma Jianzhong Shou Yuping Dai Jianyong Shao Ye Tian Shizhe Hong Tao Xu Chuize Kong Zefeng Kang Yuexin Liu Xun Qu Benkang Shi Shaobin Zheng Yi Lin Shujie Xia Dong Wei Jianbo Wu Weiling Fu Zhiping Wang Jianbo Liang | 2019 | Asian Journal of Urology2019，6，1： | 2 |
| 6 | Isolation and characterization of a thermophilic Bacillus shackletonii K5 from a biotrickling filter for the production of polyhydroxybutyrate显示文摘Polyhydroxyalkanoates(PHAs) are aliphatic polyesters accumulated intracellularly by both Gram-negative and Gram-positive bacteria. However, compared to the PHAs of Gramnegative bacteria, few endotoxins(lipopolysaccharides, LPS), which would be co-purified with PHAs and cause immunogenic reactions, are found in the PHAs produced by Gram-positive bacteria. A thermophilic Gram-positive bacterium K5, which exhibited good growth and polyhydroxybutyrate(PHB)-accumulating ability, has been isolated and characterized from a biotrickling filter designed for the removal of NOx from flue gas in a coal-fired power plant in China. Based on the biochemical characterization and 16 S rRNA gene sequence(Genbank accession no. JX437933), the strain K5 has been identified as Bacillus shackletonii, which has rarely been reported in the literature, and this report is the first time that B. shackletonii has been found to accumulate PHB. The strain K5 was able to utilize glucose as carbon source to synthesize PHB at a broad range of temperatures(from 35 to 50 °C), and the ideal temperature was 45 °C. The strain K5 could effectively yield PHB of up to 69.9% of its cell dry weight(CDW)(2.28 g/L) in flask experiments employing glucose as carbon source at 45 °C, followed by 56.8% and 52.3% of its CDW when using sodium succinate and glycerol as carbon source, respectively. For batch cultivation, the strain K5 was able to produce PHB of up to 72.6% of its cell dry weight(9.76 g/L) employing glucose as carbon source at 45 °C and pH 7.0. | Yong Liu Shaobin Huang Yongqing Zhang Fuqian Xu | 2014 | Journal of Environmental Sciences2014，26，7： | 2 |
| 7 | Application of zeolite MCM-22 for basic dye removal from wastewater显示文摘 | Shaobin Wang Huiting Li Longya Xu | 2006 | Journal of Colloid and Interface Science2006，295，： | 1 |
| 8 | Equilibrium morphology of gas–liquid Janus droplets: A numerical analysis of buoyancy effect显示文摘In this article, a theoretical model for predicting the equilibrium morphology of gas–liquid Janus droplets was built. Based on this model, the effects of bubble radius and volume ratio on morphology change was systematically studied. The increase of bubble radius causes the two parts(bubble and oil drop) in Janus droplets tend to merge while the impact of volume ratio is complicated. When volume ratio increases, these two parts firstly tend to merge, then gradually separate. The accuracy of this model was verified by experimental results. | Shaobin Zhang Helen Yan Yuhao Geng Ke Wang Jianhong Xu | 2018 | Chinese Journal of Chemical Engineering2018，26，10： | 1 |
| 9 | Broadband and conformal metamaterial absorber显示文摘在这研究,用二灵活底层的一条新宽带和保角的 metamaterial 吸收器被建议。模拟结果证明建议吸收器从 6.08 ~ 13.04 GHz 和 90% 的高吸收展出了一个吸收乐队,因为它是平面的。因为它的相对吸收带宽是 72.8% ,吸收器是宽带。而且,建议吸收器对 TE 和 TM 波浪的极化感觉迟钝。吸收器是极端薄的;它的全部的厚度仅仅在最低操作频率是 0.07。而且,吸收的不同区域能被 lumping 调整并且分别地装载二个电阻器到 polyimide 电影上。而且与常规微波吸收器相比,当它被弄弯并且遵循目标的表面时,建议吸收器的吸收带宽能被拓宽并且提高。试验性并且模拟结果在同意。因为它的宽带吸收,极化 insensitivity,和灵活底层,建议吸收器是在科学、技术的应用的一个有希望的吸收元素。 | Xiangkun KONG Junyi XU Jin-jun MO Shaobin LIU | 2017 | Frontiers of Optoelectronics2017，10，2： | 1 |
| 10 | Exploring HONO formation and its role in driving secondary pollutants formation during winter in the North China Plain显示文摘Daytime HONO photolysis is an important source of atmospheric hydroxyl radicals(OH).Knowledge of HONO formation chemistry under typical haze conditions,however,is still limited.In the Multiphase chemistry experiment in Fogs and Aerosols in the North China Plain in 2018,we investigated the wintertime HONO formation and its atmospheric implications at a rural site Gucheng.Three different episodes based on atmospheric aerosol loading levels were classified:clean periods(CPs),moderately polluted periods(MPPs)and severely polluted periods(SPPs).Correlation analysis revealed that HONO formation via heteroge.neous conversion of NO_(2)was more efficient on aerosol surfaces than on ground,highlighting the important role of aerosols in promoting HONO formation.Daytime HONO budget analysis indicated a large missing source(with an average production rate of 0.66±0.26,0.97±0.47 and 1.45±0.55 ppbV/hr for CPs,MPPs and SPPs,respectively),which strongly correlated with photo-enhanced reactions(NO_(2)heterogeneous reaction and particulate nitrate photolysis).Average OH formation derived from HONO photolysis reached up to(0.92±0.71),(1.75±1.26)and(1.82±1.47)ppbV/hr in CPs,MPPs and SPPs respectively,much higher than that from O3 photolysis(i.e.,(0.004±0.004),(0.006±0.007)and(0.0035±0.0034)ppbV/hr).Such high OH production rates could markedly regulate the atmospheric oxidation capacity and hence promote the formation of secondary aerosols and pollutants. | Shaobin Zhang Guo Li Nan Ma Yao He Shaowen Zhu Xihao Pan Wenlin Dong Yanyan Zhang Qingwei Luo Jeannine Ditas Uwe Kuhn Yuxuan Zhang Bin Yuan Zelong Wang Peng Cheng Juan Hong Jiangchuan Tao Wanyun Xu Ye Kuang Qiaoqiao Wang Yele Sun Guangsheng Zhou Yafang Cheng Hang Su | 2023 | Journal of Environmental Sciences2023，，10： | 0 |
| 11 | Microbial synthesis of anti-tumor agent oxysophoridine through one step by filamentous fungus显示文摘Sophoridine and oxysophoridine are alkaloids extracted from Chinese traditional medicinewith significant antitumor activities. Computer-aided design and preliminary structure-activity relationship studiesshowed that the biological activity of sophoridine can be improved after oxidation (oxysophoridine) whileits toxicity significantly decreased. A new method to prepare oxysophoridine from natural product Sophoridineby biotransformation was established for the first time except for traditional extraction from plants and chemicalsynthesis. Positive biocatalytic reaction was detected by TLC. Structure of conversion product was elucidatedbased on NMR spectroscopy. Optimizations of reactions including substrate concentration, pH, conversion timeand inoculation quantity were complemented which analyzed by LC-MS. Results showed that filamentous fungusXylariales. sp F005 (CCTCC M2014660) has the capacity of synthetizing oxysophoridine from sophoridinein the selected 37 strains. The yield of oxysophoridine reached highest at conditions pH 6.0, the third day ofconversion time, 5.0 mg substrate and 5% inoculums respectively. The method for preparing oxysophoridinecatalyzed by enzymes with green and sustainable synthetic processes was developed. | Qingfeng Meng Xuan Zhou Xu Ran Song Yan Shaobin Fu | 2019 | Journal of Pharmaceutical and Biopharmaceutical Research2019，1，2： | 0 |
| 12 | Expressions and clinicopathologic significance of five heat shock proteins in esophageal squamous cell carcinoma显示文摘Objective: To investigate the expressions of heat shock protein (hsp) 10, hsp27, hsp60, hsp70 and hsp90α in esophageal squamous cell carcinoma (ESCC) and normal tissues along the incisal margin (TIM), and discuss the clinico- pathologic features about their expressions. Methods: 120 specimens from ESCC and 36 specimens from TIM were made into tissue chips. The presence and the levels of expression of hsp10, hsp27, hsp60, hsp70 and hsp90α were observed on tissue chips by immunohistochemistry EnVisionTM. Their correlations to clinicopathologic features were analyzed. Results: The positive staining rates of hsp10, hsp27, hsp60, hsp70 and hsp90α in ESCC and TIM were 53.8% and 37.5%, 62.0% and 42.1%, 92.7% and 63.2%, 57.9% and 22.2%, 33.7% and 18.5% respectively. There were no statistical significances between the differential expressions of hsp10, hsp27 and hsp90α in ESCC and TIM (P > 0.05), but there were great statistical signifi- cances about hsp60 and hsp70 (P < 0.01). The level of hsp27 declined with the lower grade of differentiation of ESCC (P < 0.05). Except for hsp27, the positive expressions of the other four HSPs had no correlation to the clinicopathologic features of ESCC. Conclusion: The expressions of hsp10, hsp27, hsp60, hsp70 and hsp90α in ESCC and TIM were a common event. The levels of hsp60 and hsp70 in ESCC were higher than those in TIM. The level of hsp27 declined with the lower grade of differentiation of ESCC showed that it may be play a role in the differentiation of ESCC. | Junhui Chen Liming Chen Shaobin Wang Jiexiong Huang Qiancheng Qiu Liyan Xu | 2007 | The Chinese-German Journal of Clinical Oncology2007，6，3： | 0 |
| 13 | Clinical significance of heat shock protein 10 in large bowel carcinoma显示文摘Objective:To investigate the expression of heat shock protein 10(HSP10)during genesis and development of large bowel carcinoma and discuss the clinical significance about its expression.Methods:The expression of HSP10 was observed in specimens from normal colonic mucosa(NC),colorectal adenomas(CA)and colorectal adenocarcinomas(CAC) by immunohistochemistry EnVisionTM.Its correlations to clinicopathologic features,as well as to postoperative survival time of large bowel carcinoma patients were analyzed.Results:The expression of HSP10 was common in normal colonic mucosa, colorectal adenomas and adenocarcinomas and more intensive in colorectal adenomas and adenocarcinomas than that in normal colonic mucosa(P<0.001).The positive expression of HSP10 had no correlation to clinicopathologic features,includ- ing age,gender,primary tumor,infiltrating of regional lymph node,metastasis,clinical stage and histopathology of large bowel carcinoma patients,as well as to their postoperative survival time.Conclusion:HSP10 was overexpressed in the early stage of colorectal adenocarcinoma suggesting that it could serve as an index for early diagnosis of large bowl carcinoma.The positive expression of HSP10 had no correlation to clinicopathologic features or postoperative survival time of large bowel carcinoma patients. | Junhui Chen Liming Chen Shaobin Wang Jiexiong Huang Qiancheng Oiu Liyan Xu | 2007 | The Chinese-German Journal of Clinical Oncology2007，6，4： | 0 |
| 14 | Synthesis of Acridinium Photocatalysts via Site-Selective C–H Alkylation显示文摘Acridinium dyes have been broadly used as photocatalysts,but it remains synthetically challenging to fine-tune their catalytic performance by functionalization of their structural cores.Acridinium photocatalysts are usually prepared through de novo synthesis,which involves difficult steps and requires sensitive organometallic reagents. | Hong Yan Jinshuai Song Shaobin Zhu Hai-Chao Xu | 2021 | CCS Chemistry2021，3，12： | 0 |
| 15 | BCR-ABL1 is a secondary event after JAK2V617F in a patient with essential thrombocythemia who develop chronic myeloid leukemia显示文摘Several cases such as myeloproliferative neoplasms(MPN)with the coexistence of JAK2 and BCR-ABL have been reported.However,cases of transformation of essential thrombocythemia(ET)into chronic myeloid leukemia(CML)during the disease progression were rarely reported.Here,we report the case of a patient with JAK2 V617F-positive ET who subsequently acquired BCR–ABL1,which transformed the disease into CML after 10 years from the initial diagnosis.In this study,we dynamically monitored JAK2 V617F and BCR-ABL and observed multiple gene mutations,including IDH2,IDH1,ASXL1,KRAS,and RUNX1.It is important to be aware of this potentially clone evolution in disease progression. | Yanqing Zhang Hailiang Bi Ying Wang Long Chen Jiaqi Pan Ping Xu Wei Wang Shaobin Yang | 2022 | Blood Science2022，4，4： | 0 |
| 16 | Selecting small molecule DNA aptamers with significant conformational changes for constructing transcriptional switches and biosensors显示文摘Small molecule aptamers discovered by traditional selection methods usually lack conformational changes upon target binding.This limits the use of aptamers as molecular probes for small molecule detection and regulatory elements of genetic circuits.Here,we report a new method called capture and in vitro transcription-systematic evolution of ligands by exponential enrichment(CIVT-SELEX)to select DNA aptamers that can not only bind to small molecule ligands but also undergo significant conformational changes.Through this method,we select a structure-switching aptamer of uridine-5′-diphosphate(UDP).Taking advantage of its conformational changes,we first construct a UDP-responsive transcriptional switch by inserting the aptamer in a genetic circuit and demonstrate that it can respond to the addition of UDP and regulate the transcription of downstream genes.We also build a UDP aptamer-based biosensor that can be used for active glycosyltransferase screening.We believe this method can provide a universal platform for selecting small molecule aptamers with conformational changes and expand the use of aptamers in small molecule detection and genetic regulation. | Shaobin Guo Jingjing Lin Lujie Lin Wen Xu Yan Guo Zipeng Xu Chunhua Lu Xianai Shi Lanlan Chen Huanghao Yang | 2023 | Science China Chemistry2023，66，5： | 0 |
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