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| 1 | Hepatocellular carcinoma: Therapeutic advances in signaling,epigenetic and immune targets显示文摘Hepatocellular carcinoma(HCC)remains a global medical burden with rising incidence due to chronic viral hepatitis and non-alcoholic fatty liver diseases.Treatment of advanced disease stages is still unsatisfying.Besides first and second generation tyrosine kinase inhibitors,immune checkpoint inhibitors have become central for the treatment of HCC.New modalities like epigenetic therapy using histone deacetylase inhibitors(HDACi)and cell therapy approaches with chimeric antigen receptor T cells(CAR-T cells)are currently under investigation in clinical trials.Development of such novel drugs is closely linked to the availability and improvement of novel preclinical and animal models and the identification of predictive biomarkers.The current status of treatment options for advanced HCC,emerging novel therapeutic approaches and different preclinical models for HCC drug discovery and development are reviewed here. | Daniel Neureiter Sebastian Stintzing Tobias Kiesslich Matthias Ocker | 2019 | World Journal of Gastroenterology2019，25，25： | 4 |
| 2 | Clinical relevance of EGFR- and KRAS-status in colorectal cancer patients treated with monoclonal antibodies directed against the EGFR显示文摘 | Volker Heinemann Sebastian Stintzing Thomas Kirchner Stefan Boeck Andreas Jung | 2008 | Cancer Treatment Reviews2008，，3： | 3 |
| 3 | By-products of plant food processing as a source of functional compounds — recent developments显示文摘 | A Schieber F.C Stintzing R Carle | 2002 | Trends in Food Science & Technology2002，，11： | 2 |
| 4 | Early tumor shrinkage in patients with metastatic colorectal cancer receiving first-line treatment with cetuximab combined with either CAPIRI or CAPOX: An analysis of the German AIO KRK 0104 trial显示文摘 | Dominik P. Modest Ruediger P. Laubender Sebastian Stintzing Clemens Giessen Christoph Schulz Michael Haas Ulrich Mansmann Volker Heinemann | 2013 | Acta Oncologica2013，，5： | 2 |
| 5 | Early tumor shrinkage in patients with metastatic colorectal cancer receiving first - line treatment with cetuximab combined with either CAPIRI or CAPOX : An analysis of the German AIO KRK 0104 trial显示文摘 | Modest DP Laubender RP Stintzing S | 2013 | Acta Oncologica2013，52，5： | 1 |
| 6 | Functional properties of anthocyanins and betalains in plants, food, and in human nutrition 显示文摘 | Stintzing F C Carle R | 2004 | Trends Food Sci Technol2004，15，： | 1 |
| 7 | Clinical relevance of EGFR and KRAS status in coloreetal cancer patients treated with monoclonal antibodies directed against the EGFR 显示文摘 | Heinemann V Stintzing S Kirchner T | 2009 | Cancer Treat Rev2009，35，： | 1 |
| 8 | Effects of processing and storage on juice colour and betacyanin stability of purple pitaya(Hylocereus polyrhizus)juice显示文摘 | HERBACH K M MAIER C STINTZING F C | | 0，，： | 1 |
| 9 | Early tumour shrinkage(ETS) and depth of response(DpR) in the treatment of patients with metastatic colorectal cancer (mCRC) 显示文摘 | Heinemann V Stintzing S Modestet DP | 2015 | Euro J of Cancer2015，，14： | 1 |
| 10 | Percutaneous radiofrequency ablation(RFA)or robotic radiosurgery(RRS)for salvage treatment of colorectal liver metastases显示文摘 | Stintzing S Grothe A Hendrich S | 2013 | Acta Oncol2013，14，： | 1 |
| 11 | By -products of plant food processing as a source of functional compounds - recent developments显示文摘 | Schieber A Stintzing FC Carle R | 2001 | Trends Food Sci Technol2001，，12： | 1 |
| 12 | FOLFIRI plus cetuximab versus FOLFIRI plus bevacizumab as first-line treatment for patients with metastatic colorectal cancer (mCRC): Analysis of patients with KRAS-mutated tumors in the randomized Ger- man AIO study KRK-0306 显示文摘 | Stintzing S Neumann J Jung A | 2011 | J Clin Oncol2011，，： | 1 |
| 13 | Betacyanins in fruits from red-purple pitaya,Hylocereus polyrhizus (Weber) Britton & Rose显示文摘 | Stintzing F C | 2002 | Food Chemistry2002，77，： | 1 |
| 14 | Overexpre-ssion of MMP-9 and tissue factor in unstable carotid plaques associated with chlamydia pneumoniae, inflammation, and apoptosis显示文摘 | Stintzing S Heuschmann P Barbera L | 2005 | Ann Vasc Surg2005，19，3： | 1 |
| 15 | FOLFIRI plus cetuximab versus FOLFIRI plus bevacizumab as first-line treatment for patients with metastatic colorectal cancer-subgroup analysis of patients with KRAS:mutated tumours in the randomised German AIO study KRK-0306显示文摘 | Stintzing S von Weikersthal L F Decker T | 2012 | Annals of oncology2012，23，7： | 1 |
| 16 | Urinary Pharmacokinetics of betalains following consumption of red beet juice in heahhy humans 显示文摘 | Thomas Frank FlorianConrad Stintzing | 2005 | Pharmacological Research2005，52，： | 1 |
| 17 | Time-dependent bioactivity of preparations from cactus pear ( Opuntia ficus indica) and ice plant ( Mesembryanthemum crystallinum ) on human skin fibroblasts and keratinocytes 显示文摘 | DETERS A M MEYER U STINTZING F C | 2012 | J Ethnopharmaco2012，142，2： | 1 |
| 18 | Functional properties of anthoeyanins and betalins in plants, food, and in human nutrition 显示文摘 | Stintzing F C Carle R | 2004 | Trends in Food Science & Technology2004，15，： | 1 |
| 19 | ah Particle sizes of fumed silica 显示文摘 | Barthel H Heinemann M Stintz M et | 1998 | Chemistry Engineering Technology1998，21，9： | 1 |
| 20 | By-products of plant food processing as a source of functional compounds-recent developments显示文摘 | SCHIEBER A STINTZING FC CARLE R | 2001 | Trends in Food & Technology2001，，12： | 1 |
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